• 한국콘텐츠학회논문지
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• 제21권3호
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• pp.314-323
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• 2021

이 연구의 목적은 국내거주 건강보험 가입 외국인의 국적 및 자격유형별 의료이용현황을 분석하는 것이다. 2018년 건강보험 가입 외국인 중 보험료 결측인원을 제외한 1,058,886명을 분석대상으로 선정하였다. 분석결과, 의료를 한 번이라도 이용한 사람은 822,267명으로, 의료이용률은 약 78%임을 확인할 수 있었다. 이용 인원 수가 많은 국가는 중국, 베트남, 미국 순이었다. 1인당 총 진료비는 입원과 외래에 관계없이 미국이 가장 높았다. 자격유형별로는 지역가입자의 1인당 진료건수, 외래진료비, 입원진료비가 가장 높았으며, 1인당 입원 일수는 직장피부양자가 가장 높았다. 마지막으로 중국인과 지역가입자는 다른 그룹에 비해 납부한 보험료 대비 많은 혜택을 누리고 있음을 확인할 수 있었다. 이 연구는 외국인 건강보험 당연적용제도 시행 이전 자료를 사용함으로 인해 현재 상황을 정확히 보여주고 있지 못하지만, 추후 변화에 대한 비교분석을 위한 기초자료를 만들었다는 점에 그 의의가 있다.

• 한국산학기술학회논문지
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• 제22권3호
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• pp.688-696
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• 2021

본 연구는 피부미용 프랜차이즈 시스템의 개발을 위한 기초자료를 제공할 목적으로 한국과 미국의 피부미용 프랜차이즈 현황, 개설비용 및 서비스 내용을 조사하고 비교 분석하였다. 피부미용 프랜차이즈 현황 비교 분석 결과 한국과 미국 모두 주력 아이템은 페이셜 케어와 바디 케어이며 가맹점 수는 한국이 평균 54개로 미국의 평균 361개보다 적으나 이것은 프랜차이즈 시장 규모, 국토의 면적과 인구 등의 영향이 크다고 판단되었다. 개설 비용 비교 분석 결과 미국의 가맹비는 한국의 최대 가맹비보다 약1.5배 높으며 로열티는 한국이 20-60만원(월), 미국은 연간 매출액의 5-6%를 지급하며 Net Worth Requirement, Cash Requirement 등 개인 자산 확인을 필요로 하였다. 미국은 스파를 운영하는 업체가 많아 비용적인 부분에서 한국과 차이가 있었고, 교육 시스템에 대해 한국은 비용, 미국은 시간으로 정해져 있었다. 프랜차이즈에서 제공하는 서비스 내용 비교 결과 양국 모든 업체에서 페이셜 케어와 바디 케어를 중심으로 하고 있으며 한국은 대부분 브라이달 케어, 연구소를 운영하며 미국은 왁싱과 남성 관리, 핫 스톤, 스파 서비스를 추가로 운영하고 있었다. 양국 간의 기후나 인종 등의 차이와 함께 사회문화적인 분위기와 피부미용을 대하는 양국 간의 인식의 차이, 특히 개방도의 차이가 반영된 결과라고 판단된다. 향후 본 연구의 결과를 바탕으로 국내 피부미용 프랜차이즈 시스템을 발전적으로 보완한다면 해외 미용산업 프랜차이즈 시장에서 성장 가능할 것으로 전망된다.

• 대한지역사회영양학회지
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• 제27권5호
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• pp.406-421
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• 2022

Objectives: The purpose of this study was to investigate the blood biochemical characteristics, comorbidities, dietary intake, and other risk factors leading to poor glycated hemoglobin (HbA1c) control in elderly Korean diabetes patients over 65 years of age. Methods: Data from the 4^th (2007-2009) and the 7^th (2016-2018) Korea National Health and Nutrition Examination Surveys (KNHANES) were used. Socio-demographic characteristics (age, gender, region, household income, education level, marital status, nutrition education, diabetes duration and diabetes treatment), lifestyle characteristics (drinking, smoking, regular walking, and subjective health perception), anthropometric characteristics (height, weight, and waist circumference), blood biochemical characteristics (HbA1c, high- density lipoprotein cholesterol, triglycerides, total cholesterol, blood urea nitrogen, and blood creatinine), co-morbidities (obesity, hypertension, hypercholesterolemia, hypertriglyceridemia, and anemia), energy and nutrients intake, food group intake, and HbA1c control-related risk factors were compared. Results: Compared to the 4^th survey, the 7^th survey showed an increase in diabetes prevalence among men, an increase in the prevalence of diabetes in the older patients, and an increase in the duration of diabetes. The energy ratio from carbohydrate consumption in the 7^th survey was lower than in the 4^th. Compared to the 4^th survey, thiamine and riboflavin intake had improved, and the intakes of vitamin A, vitamin C, and niacin had worsened in the 7^th. A comparison of food group intakes showed that there was a decrease in the consumption of whole grains, potatoes, and milk and an increase in the intake of beverages and alcoholic beverages. The risk factors for poor control of HbA1c were the duration of diabetes and co-morbid hypertriglyceridemia in the 4^th survey, whereas subjective health perception, obesity, and hypercholesterolemia as co-morbidities were found to be risk factors in the 7^th in addition to the risk factors highlighted in the 4^th survey. Conclusions: For the future management of elderly Korean diabetes patients, greater care is indicated for men over 75 years, and those with low levels of education. It is necessary to increase the intake of milk and vegetables, and reduce the intake of beverages and alcoholic beverages. In addition, it is necessary to reduce the incidence of obesity, hypercholesterolemia, and hypertriglyceridemia for proper control of blood sugar.

• Journal of Animal Science and Technology
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• 제64권1호
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• pp.10-22
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• 2022

We studied the effects of Saccharomyces cerevisiae boulardii CNCM I-1079 (LSB) supplemented to lactating sows on reproductive traits and farrowing duration and to piglets from day 7 of life on post-weaning performance and IgG concentration. Ninety-six Landrace × Yorkshire sows started the trial 5 days before the expected farrowing date. Sows were distributed into 2 groups according to parity number and backfat thickness: control (CON: regular lactation diet) and LSB (CON + LSB at 2 × 10⁹ colony forming units [CFU]/kg of feed). Seven days after birth, litters were randomly selected from each group and supplemented creep feed with or without LSB at 2 × 10⁹ CFU/kg. At weaning, piglets from CON sows were shifted to a commercial farm and allocated to 14 pens in groups of 25 piglets/pen according to the creep feed supplemented during lactation. Piglets followed a 3-phase feeding program: creep, pre-starter and starter, with or without LSB at 2 × 10⁹ CFU/kg LSB in creep and pre-starter, and 1 × 10⁹ CFU/kg LSB in starter. The piglets were vaccinated against classical swine fever on days 41 and 72 of life. One day before each vaccination and at the end of the trial, blood samples were collected from 15 randomly selected piglets per treatment and assessed for total IgG. Supplemented sows with non-supplemented litters displayed the lowest backfat thickness loss during lactation (p < 0.05). The LSB supplementation shortened farrowing duration (p < 0.05) and increased feed intake (p < 0.05) during the first week of lactation. The LSB-fed piglets were heavier at the end of creep (p < 0.05), pre-starter (p < 0.05), and the trial (p < 0.05); grew faster during creep (p < 0.05), starter (p < 0.05), and overall (p < 0.05); and displayed an improved feed conversion ratio during creep (p < 0.05). Total IgG content was higher at days 40 (p < 0.05) and 71 (p < 0.05) in LSB-fed piglets. We conclude that supplementing sows with Saccharomyces cerevisiae boulardii CNCM I-1079 from late gestation until weaning shortens farrowing duration, increases feed intake, and minimizes backfat losses during lactation. When supplemented to piglet diet, post-weaning performance is improved. This improvement observed could be linked to a better immune status, as suggested by the higher IgG.

• 대한두경부종양학회지
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• 제37권2호
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• pp.43-50
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• 2021

Background/Objectives: Shoulder function is an important aspect of health related quality of life (QOL). Neck dissection impairment index (NDII) is a simple shoulder-specific questionnaire. This study aimed to evaluate the association between QOL and NDII in patients who underwent neck dissection to validate the Korean version of NDII. Materials & Methods: This study enrolled 74 patients with head and neck cancer who underwent neck dissection from December 2013 to April 2014. Patients completed questionnaires on QOL including the European Organization of Research and Treatment of Cancer 30-item Core QOL questionnaire (EORTC QLQ-C30) and NDII which was translated into Korean. Validity was evaluated by calculating the Pearson correlation coefficient between NDII and EORTC QLQ-C30. Results: We compared preoperative, postoperative within a week, 1st and 3rd months NDII scores. The total NDII scores were 14.7, 47.4, 33.7 and 34.3 each. Clinical variables including gender, site of primary tumor, performing revision neck dissection, radiotherapy and flap reconstruction were not significantly associated with NDII. However NDII mean score of patients who underwent unilateral neck dissection over 3 levels is most increased after operation. During all periods NDII scores were significantly associated with functioning score. Although other scores are lower correlation than function scores, global health status scores and symptom scores are also correlation with NDII. Conclusion: NDII was valid instrument and can be used not only in the clinical practice to assess shoulder dysfunction but also in the simple instrument to evaluate global QOL in Korea patients with having neck dissection.

• Journal of Nutrition and Health
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• 제55권5호
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• pp.558-571
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• 2022

본 연구에서는 우리나라 성인 중 AD를 앓고 있는 사람들의 식이 섭취량을 분석하여 이들의 식습관이 AD발병 위험과 관련이 있는지 분석하고자 하였다. 활용한 자료는 제7기 국민건강영양조사 (2016-2018년) 자료로서, 참가자 중 19-64세 성인 10,571명을 AD군 (n = 366)과 non-AD군 (n = 10,205)으로 나누어 영양소 섭취 현황과 식생활평가지수 점수를 비교·분석하였다. 그 결과, AD군의 1일 총 에너지섭취량은 non-AD군보다 많았고, 단백질 에너지섭취비율, 섭취에너지 1,000 kcal 당 단백질, 인, 철, 칼륨 섭취량이 AD군이 non-AD군보다 유의미하게 낮았다. 식생활평가지수 총점을 비교했을 때에는, AD군의 총 채소류, 김치 및 장아찌류를 제외한 채소류, 고기·생선·달걀·콩류 섭취점수가 non-AD군보다 낮았다. 연구대상자의 식생활평가지수와 AD 위험도와의 관계를 분석했을 때, AD 위험도는 총 채소류, 김치 및 장아찌류를 제외한 채소류, 고기·생선·달걀·콩류 섭취 점수가 증가할수록 감소하였다. 결론적으로, 성인 AD환자들은 채소류와 단백질 식품 섭취가 낮았는데, 이들 식품군의 높은 섭취는 낮은 AD 위험과 관련이 있음을 확인한 바, 추후 성인 AD 관리 및 치료 시 채소류와 단백질 식품의 충분한 섭취에 대해 강조해야 할 것이다.

• 생태와환경
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• 제55권2호
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• pp.111-119
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• 2022

충주호의 지류인 제천천 하류에서 주기적으로 발생하는 남조류 과다증식의 현황과 오염원을 분석하였다. 2015년 10월 18일과 2016년 9월 25일에 제천천 하류의 명서낚시터지점(GPS; 37°03'25.5"N, 128°03'13.6"E)에서 클로로필 a의 농도는 각각 399.2, 184.8 mg m^-3이었으며, 남조류독소인 microcystins의 농도는 각각 124.09, 79.71 ㎍ L^-1이었다. 명서낚시터 지점에서 남조류 과다증식은 충주호의 수위 및 수위변화와 매우 밀접한 관계가 있는 것으로 나타났다. 즉 수온이 남조류 성장에 적합한 조건에서 충주호 수위가 상승하여 수체가 정체되는 시기에 남조류 과다증식이 발생한다. 제천천에 위치한 환경부의 수질측정망 자료를 분석한 결과, 제천하수종말처리장이 위치한 장평천이 주요 오염 지류인 것으로 나타났다.

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.127-138
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• 2023

Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer's disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine's screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (Tau_RD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC₅₀ of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 Tau_RD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 Tau_RD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 Tau_RD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.

• Animal Bioscience
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• 제36권6호
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• pp.869-878
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• 2023

Objective: Hyperketonemia remains a major metabolic issue of serious milk production and a major health concern in early lactation cows. Oral supplementation of glucose precursors (GP) can be used to prevent hyperketonemia in dairy cows. The objective of this study was to compare the beneficial effects of orally supplementing a mixture of GP on metabolic health indicators and milk production status of primiparous (PP) and multiparous (MP) dairy cows. Methods: Twenty-eight Holstein cows were blocked by expected date of parturition, previous lactation yield, and parity. The cows were randomly allocated to one of the four treatment groups (n = 7 cows/group) based on their parity and GP supplementation: i) PP cows fed basal diet only (PP-CON), ii) PP cows with oral supplementation of GP (PP-GP), iii) MP cows fed basal diet only (MP-CON), and iv) MP cows with oral supplementation of GP (MP-GP). Glucose precursor (glycoline liquid) was orally drenched (300 mL/d) in GP cows from 7 days prepartum through 7 days postpartum. Other than GP supplementation, all cows were fed similar pre- and postpartum basal diets. Results: In both pre- and postpartum periods, serum glucose concentration was increased, whereas β-hydroxybutyrate and free fatty acids were decreased in GP cows compared with the CON cows. Milk yield and milk components were statistically not different between GP and CON cows over the first 9 week of lactation. The yield of actual milk, energy-corrected milk, 63-days cumulative milk, colostrum yield, and calf birth weight remained higher in MP cows compared with PP cows. Conclusion: Oral drenching of GP around calving can be recommended to successfully improve the metabolic health and reduce the negative effects of hyperketonemia not only in MP but also in PP dairy cows.

• 대한중풍순환신경학회지
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• 제17권1호
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• pp.29-38
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• 2016

This case report is to show the effects of Traditional Korean medicine (TKM) on the patient with delayed encephalopathy after carbon monoxide poisoning. A patient with delayed encephalopathy after carbon monoxide poisoning occurs rarely and only a few cases have been reported. We treated a patient with cognitive deficit, gait disturbance was treated with herbal medicine(Boshiniknoe-tang-gami), acupuncture, moxibustion. We evaluated the improvements of symptoms by Korean Version of Mini Mental Status Examination score(K-MMSE), Modified Barthel Index(MBI) and Glasgow Coma Scale(GCS). After 3 weeks, total score of K-MMSE was increased from 12 to 17 and it was maintained to week 6. After 6 weeks, total score of MBI was increased from 30 to 86. And GCS was increased from 11 to 14. This report proved effect of Traditional Korean medicine on the improvement of delayed encephalopathy after carbon monoxide poisoning