• Korean Journal of Clinical Pharmacy
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• v.32 no.3
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• pp.191-203
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• 2022

Background: Direct-acting antivirals are recommended for the treatment of chronic hepatitis C virus in Korea. However, evaluation of direct-acting antiviral regimens in a real-world setting is limited. The aims of this study were to investigate the effectiveness and safety of direct-acting antiviral treatment in Korean patients infected with chronic hepatitis C virus genotype 1b or 2 at a tertiary care hospital. Methods: This was a retrospective study conducted with patient data obtained between August 2015 and August 2019 at Jeonbuk National University Hospital. The primary effectiveness endpoint was sustained virological response 12 weeks post-treatment (SVR12) via intention-to-treat (ITT) and modified intention-to-treat (mITT) analyses. Results: Of the 270 patients, 47.0% were infected with genotype 1b and 53.0% with genotype 2. ITT analysis revealed that SVR12 was achieved in 78.9% of all patients, 77.2% in genotype 1b patients, and 80.4% in genotype 2 patients. Of the 21.1% of all patients who did not achieve SVR12, the majority of treatment failures were non-virologic failures (19.7%). mITT analysis revealed that SVR12 was achieved in 98.2% of all patients, 98.0% in genotype 1b patients, and 98.3% in genotype 2 patients. Almost half of all patients experienced one or more adverse events (43.3%), leading to 2.6% discontinuing scheduled treatment. The most common adverse event was anemia. Conclusions: Direct-acting antiviral-based treatment regimens showed high effectiveness and safety. Non-virological factors, such as premature treatment discontinuation due to adverse events or loss of follow-up, were the major disruptors in achieving SVR12.

• The Journal of Internal Korean Medicine
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• v.32 no.2
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• pp.278-287
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• 2011

Objectives : The object of this study was to observe the nephroprotective effects of Sojongchobisunki-tang (SCST), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure. Methods : Three different dosages of SCST were orally administered once a day for 23 days before cisplatin treatment (5 mg/kg, single intraperitoneally administered) and 5 days after cisplatin treatment (once a day for 28 days). 6 groups, of 8 rats per group were used in the present study after 7 days of acclimatization. Changes of the body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes of the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg of which the effects on cisplatin-induced acute renal failures are already confirmed. Results : Acute renal failure induced by cisplatin were induced by oxidative stress and related lipid peroxidation in the present study. However, these acute renal failures and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment at all three different dosages of SCST extracts. Conclusions : This study suggests that SCST extracts showed favorable effects on the cisplatin-induced rat ARF.

• The Journal of Advanced Prosthodontics
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• v.9 no.5
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• pp.364-370
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• 2017

PURPOSE. To explore the influence of different surface conditionings on surface changes and the influence of surface treatments and aging on the bond strengths of composites to non-aged and aged resin nanoceramics. MATERIALS AND METHODS. Rectangular-shaped non-aged and aged (5000 thermocycles) resin nanoceramic specimens (Lava Ultimate) (n=63, each) were divided into 3 groups according to surface treatments (untreated, air abrasion, or silica coating) (n=21). The surface roughness was measured and scanning electron microscopy was used to examine one specimen from each group. Afterwards, the specimens were repaired with a composite resin (Filtek Z550) and half were sent for aging (5000 thermocycles, n=10, each). Shear bond strengths and failure types were evaluated. Roughness and bond strength were investigated by two- and three-way analysis of variance, respectively. The correlation between the roughness and bond strength was investigated by Pearson's correlation test. RESULTS. Surface-treated samples had higher roughness compared with the untreated specimens (P=.000). For the non-aged resin nanoceramic groups, aging was a significant factor for bond strength; for the aged resin nanoceramic groups, surface treatment and aging were significant factors. The failures were mostly adhesive after thermal cycling, except in the non-aged untreated group and the aged air-abraded group, which had mostly mixed failures. Roughness and bond strength were positively correlated (P=.003). CONCLUSION. Surface treatment is not required for the repair of non-aged resin nanoceramic; for the repair of aged resin nanoceramic restorations, air abrasion is recommended.

• Education of Primary School Mathematics
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• v.18 no.2
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• pp.123-139
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• 2015

The purpose of this study was to investigate the effects of the experiences of productive failures on students' mathematical problem solving abilities and mathematical dispositions. The experiment was conducted with two groups. The treatment group was applied with the productive mathematics failure program, and the comparative group was taught with traditional mathematics lessons. In this study, for quantitative analysis, the students were tested their understanding of mathematical concepts, mathematical reasoning abilities, students' various strategies and mathematical dispositions before and after using the program. For qualitative analysis, the researchers analyzed the discussion processes of the students, students's activity worksheets, and conducted interviews with selected students. The results showed the followings. First, use of productive failures showed students' enhancement in problem solving abilities. Second, the students who experienced productive failures positively affected the changes in students' mathematical dispositions. Along with the more detailed research on productive mathematical failures, the research results should be included in the development of mathematics textbooks and teaching and learning mathematics.

• Nuclear Engineering and Technology
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• v.44 no.5
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• pp.471-482
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• 2012

To assess the risk of nuclear power plant operation and to determine the risk impact of digital systems, there is a need to quantitatively assess the reliability of the digital systems in a justifiable manner. The Probabilistic Risk Analysis (PRA) is a tool which can reveal shortcomings of the NPP design in general and PRA analysts have not had sufficient guiding principles in modelling particular digital components malfunctions. Currently digital I&C systems are mostly analyzed simply and conventionally in PRA, based on failure mode and effects analysis and fault tree modelling. More dynamic approaches are still in the trial stage and can be difficult to apply in full scale PRA-models. As basic events CPU failures, application software failures and common cause failures (CCF) between identical components are modelled.The primary goal is to model dependencies. However, it is not clear which failure modes or system parts CCF:s should be postulated for. A clear distinction can be made between the treatment of protection and control systems. There is a general consensus that protection systems shall be included in PRA, while control systems can be treated in a limited manner. OECD/NEA CSNI Working Group on Risk Assessment (WGRisk) has set up a task group, called DIGREL, to develop taxonomy of failure modes of digital components for the purposes of PRA. The taxonomy is aimed to be the basis of future modelling and quantification efforts. It will also help to define a structure for data collection and to review PRA studies.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8549-8556
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• 2014

Head and neck squamous cell carcinoma (HNSCC) is one of the world top ten most common cancers with its highest occurrence in the Indian subcontinent and different aggressive and etiological behavioural patterns. The scenario is only getting worst with the 5 year survival rates dropping to 50%, persistent treatment failures and frequent cases of relapse/recurrence. One of the major reasons for these failures is the presence of cancer stem cells (CSCs), a small population of cancer cells that are highly tumourigenic, capable of self-renewal and have the ability to differentiate into cells that constitute the bulk of tumours. Notably, recent evidence suggests that cancer stem cells are especially resistant to conventional therapy and are the "drivers" of local recurrence and metastatic spread. Specific markers for this population have been investigated in HNSCC in the hope of developing a deeper understanding of their role in oral cancer pathogenesis, elucidating novel biomarkers for early diagnosis and newer therapeutic strategies. This review covers the fundamental relevance of almost all the CSC biomarkers established to date with a special emphasis on their impact in the process of oral tumourigenesis and their potential role in improving the diagnosis, prognosis and treatment of OSCC patients.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.05c
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• pp.221-224
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• 2001

In connection with the monitoring of insulation degradation of large power apparatus in order to predict their unexpected service failures, a statistical treatment, such as phase resolved partial discharge analysis(PRPDA), has been established for the on-line monitoring system during the past decades. However, this method has shown some inconveniences to distinguish the nature of the PD source in power apparatus. In this regard, a novel approach based on the chaotic analysis(CAPD) is proposed describing the fundamental ideas, outcomes and different view points from conventional PRPDA. In order to make a model for the possible defects causing sudden failures in service, several types of specimen were prepared. And partial discharge signals, originated from those samples, were measured and analysed by means of PRPDA and CAPD respectively. Throughout this paper, it seems that the correlation between the consecutive PD pulses depending on the nature of PD could be investigated by CAPD. Therefore, it could be considered that the nature of PD source can be distinguished more distinctively when the PRPDA is combined with CAPD.

• Proceedings of the IEEK Conference
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• 2001.09a
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• pp.975-979
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• 2001

In connection with the monitoring of the insulation degradation of large power apparatus in order to predict their expected service failures, a statistical treatment, such as phase resolved partial discharge analysis (PRPDA), has been established for the on-line monitoring system during the past decades. However, this method has shown some inconveniences to identify the nature of the PD source in power apparatus. In this regard, a novel approach based on the chaotic analysis (CAPD) is proposed describing the fundamental ideas, outcomes and different viewpoints from the conventional PRPDA. As a model for the possible defects causing sudden failures in service, three types of specimen are prepared. And partial discharge signals, originated from those samples, are measured and analyzed by means of CAPD. Throughout this work, it seems that the correlation between the consecutive PD pulses, depending on the nature of PD, could be clarified by CAPD. Thereffre, it could be considered that the nature of PD source can be identified more distinctively when the CAPD is combined with PRPDA.

• Plant Journal
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• v.6 no.3
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• pp.53-61
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• 2010

This paper presents failure analysis on weld-joint of the waterwall tubes in USC boilers. Visual inspections were performed to find out the characteristics of the fracture. Additionally both microscopic characteristics and hardness test were carried out on failed tube samples. Failures seem to happen mainly because the welding process such as preheating and PWHT(post-weld heat treatment) was not conducted strictly. Thus, this paper has the purpose to describe the main cause of the poor welding process and to explain how to prevent similar failures in those weld-joints.

• Journal of Dental Anesthesia and Pain Medicine
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• v.21 no.2
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• pp.87-98
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• 2021

Patients with disabilities have difficulties tolerating in-office dental treatment due to limitations relating to cooperation and/or physical problems. Therefore, they often require general anesthesia or sedation to facilitate safe treatment. When deciding on dental treatment under general anesthesia, the plan should be carefully determined because compared to general patients, patients with disabilities are more likely to experience anesthetic complications because of their underlying medical conditions and potential drug interactions. Clinicians prefer simpler and more aggressive dental treatment procedures, such as extraction, since patients with impairment have difficulty maintaining oral hygiene, resulting in a high incidence of recurrent caries or restorative failures. This study aimed to review the available literature and discuss what dentists and anesthesiologists should consider when providing dental treatment to patients with severe disability under general anesthesia.