• Nuclear Engineering and Technology
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• v.54 no.9
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• pp.3478-3487
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• 2022

In this study, we incorporate an anisotropic scattering scheme involving spherical harmonics into the method of characteristics (MOC). The neutron transport solution in a light water reactor can be significantly improved because of the impact of an anisotropic scattering source with the MOC flat source approximation. Several problems are selected to verify the proposed scheme and investigate its effects and accuracy. The MOC anisotropic scattering source is based on the expansion of spherical harmonics with Legendre polynomial functions. The angular flux, scattering source, and cross section are expanded in terms of the surface spherical harmonics. Later, the polynomial is expanded to achieve the odd and even parity of the source components. Ultimately, the MOC angular and scalar fluxes are calculated from a combination of two sources. This paper presents various numerical examples that represent the hot and cold conditions of a reactor core with boron concentration, burnable absorbers, and control rod materials, with and without a reflector or baffle. Moreover, a small critical core problem is considered which involves significant neutron leakage at room temperature. We demonstrate that an anisotropic scattering source significantly improves solution accuracy for the small core high-leakage problem, as well as for practical large core analyses.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.170-175
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• 1998

Transporting a large table using multiple robotic agents requires at least two group behaviors of homing and herding which are to bo coordinated in a proper sequence. Existing GP methods for multi-agent learning are not practical enough to find an optimal solution in this domain. To evolve this kind of complex cooperative behavior we use a novel method called fitness switching. This method maintains a pool of basis fitness functions each of which corresponds to a primitive group behavior. The basis functions are then progressively combined into more complex fitness functions to co-evolve more complex behavior. The performance of the presented method is compared with that of two conventional methods. Experimental results show that coevolutionary fitness switching provides an effective mechanism for evolving complex emergent behavior which may not be solved by simple genetic programming.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1998.11a
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• pp.500-506
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• 1998

This paper proposes an extension scheme of the well-known Berkeley Socket Interface for supporting QoS-provided multipeer multimedia communications. The current BSD Socket Interface has been TCP/IP-centric historically and the protocol suite was developed for the peer-to-peer best effort data communications. In order to support multiparty multimedia applications, such key functions as group management, QoS control, and reliable multicast transport should be exploited in the current simple unicast communication architecture and the well-known interface should be extended to cover the functions. This paper proposes a few new API functions and some changes in the current APIs.

• Bulletin of the Korean Mathematical Society
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• v.59 no.4
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• pp.811-825
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• 2022

Given a compact subset P ⊂ (ℝ⁺)^d and a compact set K in ℂ^d. We concern with the Bernstein-Markov properties of the triple (P, K, 𝜇) where 𝜇 is a finite positive Borel measure with compact support K. Our approach uses (global) P-extremal functions which is inspired by the classical case (when P = Σ the unit simplex) in [7].

• Biotechnology and Bioprocess Engineering:BBE
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• v.8 no.5
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• pp.279-285
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• 2003

Lidocaine and galactose loading tests were performed on a bioartificial liver (BAL), an extracorporeal medical device incorporating living hepatocytes in a cartridge without a transport barrier across the membranes. The concentration changes were analyzed using pharmacokinetic equations to evaluate the efficacy and limitation of the proposed method. Lidocaine and galactose were found to be suitable drugs for a quantitative evaluation of the BAL functions, as they did not interact with the plasma proteins or blood vessels, making their concentrations easy to determine. The drug concentration changes after drug loading were easily analyzed using pharmacokinetic equations, and the BAL functions quantitatively expressed by pharmacokinetic parameters, such as the clearance (CL) and galactose elimination capacity (GEC). In addition, these two drugs have already been used in clinical tests to evaluate human liver functions over long periods, and lidocaine CL values and GEC values reported for a normal human liver. Thus, a comparison of the CL and GEC values for the BAL and a natural liver revealed what proportion of normal liver functions could be replaced by the BAL.

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.98-116
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• 2022

The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset GSE64714 to explore previously unidentified functions of RhoA. Comparative gene expression analysis revealed 545 differentially expressed genes in RhoA-null cells versus controls. Gene set enrichment analysis (GSEA) was conducted with three gene set collections: (1) the hallmark, (2) the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and (3) the Gene Ontology Biological Process. GSEA results showed that RhoA is related strongly to diverse pathways: cell cycle/growth, DNA repair, metabolism, keratinization, response to fungus, and vesicular transport. These functions were verified by heatmap analysis, KEGG pathway diagramming, and direct acyclic graphing. The use of multiple gene set collections restricted the leakage of information extracted. However, gene sets from individual collections are heterogenous in gene element composition, number, and the contextual meaning embraced in names. Indeed, there was a limit to deriving functions with high accuracy and reliability simply from gene set names. The comparison of multiple gene set collections showed that although the gene sets had similar names, the gene elements were extremely heterogeneous. Thus, the type of collection chosen and the analytical context influence the interpretation of GSEA results. Nonetheless, the analyses of multiple collections made it possible to derive robust and consistent function identifications. This study confirmed several well-described roles of RhoA and revealed less explored functions, suggesting future research directions.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.5 no.1 s.9
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• pp.31-43
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• 2006

As of March 2005, the standard of traffic signal controllers became effective. The standard presents specifications and functions of a traffic signal controller which collects traffic information, sends it to the traffic control center, and controls traffic signal with adequate traffic signal timing provided by the traffic control center. Since the controllers by the previous standard lack parts compatibility and have different control functions and communication protocol, the maintenance cost has been increased. Also, some important functions like conflict detection have not worked out perfectly. To overcome these disadvantages, first of all, this standard secures hardware compatibility. Conflict detection method has been enhanced. Communication protocol to the traffic control center was included in the standard. With this standard, independent maintenance system and prompt treatment of hardware malfunctions becomes possible. Also, the unified intersection traffic control method will increase traffic safety.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.6
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• pp.299-312
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• 2023

Recently, the electronic control unit (ECU) has been integrating several functions into one beyond simple convenience functions. Accordingly, ECUs have more functions and external interfaces than before, and various cybersecurity problems are arising. The United Nations Economic Commission for Europe (UNECE) World Forum for Harmonization of Vehicle Regulations (WP.29) issued UN Regulation No.155 to establish international standards for vehicle cybersecurity management systems in light of the growing threats to vehicle cybersecurity. According to international standards, vehicle manufacturers are required to establish a Cybersecurity Management System (CSMS) and receive a Vehicle Type Approval (VTA). However, opinions were raised that the implementation period should be adjusted because domestic preparations for this are insufficient. Therefore, in this paper, we propose a web-based solution that maps a checklist to check the status of CSMS in the requirement and various vehicle security companies and solutions to mitigate the identified gap.

• Molecules and Cells
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• v.43 no.4
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• pp.313-322
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• 2020

Eukaryotes transport biomolecules between intracellular organelles and between cells and the environment via vesicle trafficking. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE proteins) play pivotal roles in vesicle and membrane trafficking. These proteins are categorized as Qa, Qb, Qc, and R SNAREs and form a complex that induces vesicle fusion for targeting of vesicle cargos. As the core components of the SNARE complex, the SNAP25 Qbc SNAREs perform various functions related to cellular homeostasis. The Arabidopsis thaliana SNAP25 homolog AtSNAP33 interacts with Qa and R SNAREs and plays a key role in cytokinesis and in triggering innate immune responses. However, other Arabidopsis SNAP25 homologs, such as AtSNAP29 and AtSNAP30, are not well studied; this includes their localization, interactions, structures, and functions. Here, we discuss three biological functions of plant SNAP25 orthologs in the context of AtSNAP33 and highlight recent findings on SNAP25 orthologs in various plants. We propose future directions for determining the roles of the less well-characterized AtSNAP29 and AtSNAP30 proteins.

• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.293-302
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• 2002

The classical concept for iron uptake into mammalian cells has been the endocytosis of transferrin( $T_{f}$ )-bound F $e^{3+}$ via the $T_{f}$ - $T_{f}$ receptor cycle. In this case, we could not explain the uptake of F $e^{2＋}$ ion and the export of iron from endosome. Studies on iron transport revealed that other transport system exists in epithelial cells of the intestine. One of non- $T_{f}$ -receptor-mediated transport systems is Nramp2/DMT1/DCT1 which transports M $n^{＋＋}$, $Mg^{＋＋}$, Z $n^{＋＋}$, $Co^{＋＋}$, N $i^{＋＋}$ or C $u^{＋＋}$ ion as well as F $e^{+2}$ ion. DMT1 was cloned from intestines of iron-deficient rats and shown to be a hydrogen ion-coupled iron transporter and a protein regulated by absorbed dietary iron. DMT1 is founded in other cells such as cortical and hippocampal glial cells as well as endothelial cells in duodenum. Two F $e^{3+}$ ion bound to transferrin( $T_{f}$ ) are taken up via the $T_{f}$ - $T_{f}$ receptor cycle in the intestinal epithelial cell. F $e^{3+}$ in endosome was converted to F $e^{2＋}$ ion, and then exported to cytosol via DMT1. F $e^{2＋}$ ion is taken up into cytosol via DMT1. Several other transporters such as FET, FRE, CCC2, AFT1, SMF, FTR, ZER, ZIP, ZnT and CTR have been reported recently and dysfunction of the transporters are related with diseases containing Wilson's disease, Menkes disease and hemochromatosis. Evidences from several studies strongly suggest that DMT1 is the major transporter of iron in the intestine and functions critically in transport of other metal ions.