• Title/Summary/Keyword: Transport Chain

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Genetic and Environmental Control of Salmonella Invasion

  • Altier, Craig
    • Journal of Microbiology
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    • 제43권spc1호
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    • pp.85-92
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    • 2005
  • An early step in the pathogenesis of non-typhoidal Salmonella species is the ability to penetrate the intestinal epithelial monolayer. This process of cell invasion requires the production and transport of secreted effector proteins by a type III secretion apparatus encoded in Salmonella pathogenicity island I (SPI-1). The control of invasion involves a number of genetic regulators and environmental stimuli in complex relationships. SPI-1 itself encodes several transcriptional regulators (HilA, HilD, HilC, and InvF) with overlapping sets of target genes. These regulators are, in turn, controlled by both positive and regulators outside SPI-1, including the two-component regulators BarA/SirA and PhoP/Q, and the csr post-transcriptional control system. Additionally, several environmental conditions are known to regulate invasion, including pH, osmolarity, oxygen tension, bile, $Mg^{2+}$ concentration, and short chain fatty acids. This review will discuss the current understanding of invasion control, with emphasis on the interaction of environmental factors with genetic regulators that leads to productive infection.

Monitoring and Tracking Model of Logistics Based on ICT network

  • Cho, Sokpal;Chung, Heechang
    • 한국정보통신학회:학술대회논문집
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    • 한국정보통신학회 2016년도 추계학술대회
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    • pp.489-492
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    • 2016
  • Transportation in the logistics, many business organizations are engaged in monitoring and tracking the vehicles in order to improve logistics services, reduce expenses and secure security in cargo transportation. It is saving time and money by tracking and monitoring vehicles which transport cargo in supply chain of logistics. Therefore the main issue of delivery flow is to improve services, and ensure the safety in transportation system. This article suggests the tracking and monitoring model to keep safety transports on ICT network. It focuses on precise delivery control by monitoring and tracking vehicles to save time and costs. The status of product movement is analyzed for proper decision making. The vehicle embedded with RFID is automatically tracked in the movement process by tracking and monitoring model. The main role keeps safety tracking to reduce costs and to deliver products at proper time and location.

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환자 익명성 보장을 위한 블록체인 알고리즘 (Block Chain Algorithm to Ensure Patient Anonymity)

  • 조영복;우성희
    • 한국정보통신학회:학술대회논문집
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    • 한국정보통신학회 2019년도 춘계학술대회
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    • pp.358-362
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    • 2019
  • 본 논문에서는 블록체인 기반의 환자익명성 보장을 위한 알고리즘을 제안하였다. 환자의 익명성과 의사와 환자 사이 연계 불가성 지원을 위해서 신원증명용 주소와 별개로 스텔스 주소를 사용하였다. 또한 의무기록을 사용함에 있어 그 해쉬 값 등 사용 정보를 블록에 입력하여 의무기록의 무결성과 투명성을 보장 한다.

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Fatty acid uptake and oxidation in skeletal muscle

  • Yun, Hea-Yeon;Tamura, Tomohiro;Lim, Kiwon
    • 운동영양학회지
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    • 제16권1호
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    • pp.1-9
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    • 2012
  • Long chain fatty acids (LCFAs) are transported into cells via plasma transporters, are activated to fatty acyl-CoA by fatty acyl-CoA synthase (ACS), and enter mitochondria via the carnitine system (CPT1/CACT/CPT2). The mitochondrial carnitine system plays an obligatory role in β-oxidation of LCFAs by catalyzing their transport into the mitochondrial matrix. Fatty acyl-CoAs are oxidized via the β-oxidation pathway, which results in the production of acetyl-CoA. The acetyl-CoA can be imported into the tricarboxylic acid (TCA) cycle for oxidation in the mitochondrial matrix or can be used for malonyl-CoA synthesis by acetyl-CoA carboxylase 2 (ACC2) in the cytoplasm. In skeletal muscle, ACC2 catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, which is a potent endogenous inhibitor of carnitine palmitoyltransferase 1 (CPT1). Thus, ACC2 indirectly inhibits the influx of fatty acids into the mitochondria. Fatty acid metabolism can also be regulated by malonyl-CoA-mediated inhibition of CPT1.

Draft Genome Sequence of the Neodothiora populina-Like Yeast Strain JAF-11, Which Produces the Biosurfactant myo-Inositol Lipids

  • Jeong-Seon Kim;Parthiban Subramanian;Seunghwan Kim;Jun Heo;Bong-Sik Yun;Yiseul Kim
    • 한국미생물·생명공학회지
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    • 제51권3호
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    • pp.328-331
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    • 2023
  • Genomic information of biotechnologically and industrially important microorganisms provides the basis for understanding their metabolic potential. Here, we report the draft genome sequence of the Neodothiora populina-like yeast strain JAF-11 capable of producing biosurfactant myo-inositol lipids. The draft genome contained genes associated with secondary metabolite biosynthesis, including transport and metabolism of lipids, which are a major component of fungal surfactants. Identification of myo-inositol and acyl chain synthesis genes in the draft genome corresponded to the specific biosurfactant produced by strain JAF-11. Further experimental studies could help to elucidate the genes responsible for the production of biosurfactant by strain JAF-11.

A study on the Regulatory Environment of the French Distribution Industry and the Intermarche's Management strategies

  • Choi, In-Sik;Lee, Sang-Youn
    • 산경연구논집
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    • 제3권1호
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    • pp.7-16
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    • 2012
  • Despite the enforcement of SSM control laws such as 'the Law of Developing the Distribution Industry (LDDI)' and 'the Law of Promoting Mutual Cooperation between Large and Small/medium Enterprises (LPMC)' stipulating the business adjustment system, the number of super-supermarkets (SSMs) has ever been expanding in Korea. In France, however, Super Centers are being regulated most strongly and directly in the whole Europe viewing that there is not a single SSM in Paris, which is emphasized to be the outcome from French government's regulation exerted on the opening of large scale retail stores. In France, the authority to approve store opening is deeply centralized and the store opening regulation is a socio-economic regulation driven by economic laws whereas EU strongly regulates the distribution industry. To control the French distribution industry, such seven laws and regulations as Commission départementale d'urbanisme commercial guidelines (CDLIC) (1969), the Royer Law (1973), the Doubin Law (1990), the Sapin Law (1993), the Raffarin Law (1996), solidarite et renouvellement urbains (SRU) (2000), and Loi de modernisation de l'économie (LME) (2009) have been promulgated one by one since the amendment of the Fontanet guidelines, through which commercial adjustment laws and regulations have been complemented and reinforced while regulatory measures have been taken. Even in the course of forming such strong regulatory laws, InterMarche, the largest supermarket chain in France, has been in existence as a global enterprise specialized in retail distribution with over 4,000 stores in Europe. InterMarche's business can be divided largely into two segments of food and non-food. As a supermarket chain, InterMarche's food segment has 2,300 stores in Europe and as a hard-discounter store chain in France, Netto has 420 stores. Restaumarch is a chain of traditional family restaurants and the steak house restaurant chain of Poivre Rouge has 4 restaurants currently. In addition, there are others like Ecomarche which is a supermarket chain for small and medium cities. In the non-food segment, the DIY and gardening chain of Bricomarche has a total of 620 stores in Europe. And the car-related chain of Roady has a total of 158 stores in Europe. There is the clothing chain of Veti as well. In view of InterMarche's management strategies, since its distribution strategy is to sell goods at cheap prices, buying goods cheap only is not enough. In other words, in order to sell goods cheap, it is all important to buy goods cheap, manage them cheap, systemize them cheap, and transport them cheap. In quality assurance, InterMarche has guaranteed the purchase safety for consumers by providing its own private brand products. InterMarche has 90 private brands of its own, thus being the retailer with the largest number of distributor brands in France. In view of its IT service strategy, InterMarche is utilizing a high performance IT system so as to obtainas much of the market information as possible and also to find out the best locations for opening stores. In its global expansion strategy of international alliance, InterMarche has established the ALDIS group together with the distribution enterprises of both Spain and Germany in order to expand its food purchase, whereas in the non-food segment, it has established the ARENA group in alliance with 11 international distribution enterprises. Such strategies of InterMarche have been intended to find out the consumer needs for both price and quality of goods and to secure the purchase and supply networks which are closely localized. It is necessary to cope promptly with the constantly changing circumstances through being unified with relevant regions and by providing diversified customer services as well. In view of the InterMarche's positive policy for promoting local partnerships as well as the assistance for enhancing the local economic structure, implications are existing for those retail distributors of our country.

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통행연계 변수를 중심으로 한 경기도 버스정류장 유형 구분 (Classification and Profiling of Bus Stops in Gyeong-gi Province on the Basis of Trip Chain Variables)

  • 빈미영;정의석;이원도;조창현
    • 한국경제지리학회지
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    • 제15권2호
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    • pp.332-342
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    • 2012
  • 본 연구는 합리적 버스 환승체계 구축을 위한 버스정류장의 환승센터로서의 유형 구분에 목적을 두고 있다. 이 분야 기존 연구는 주로 버스정류장 이용 수요의 특성과 버스정류장을 역세권으로 보았을 때 주변의 토지이용 특성을 확인하고, 이를 근거로 정류장의 유형을 구분한 후 구분된 유형들 각각의 특성을 요약하는 방식으로 진행되었다. 이러한 전통적 역세권 연구들의 공통적인 문제점은 대표적 연구 변수인 토지이용 특성과 정류장 이용 특성 등 횡단면적 snapshot의 특성만을 고려하여 환승의 본질인 통행 연계의 detail을 확보하지 못한다는 데 있다. 이에 본 연구에서는 환승통행 발생 정류장의 기능 구분을 위해 통행연계 변수로서 교통수단연계, 경유지연계, 이용시간연계 등의 변수 값이 각 정류장이 환승센터로서의 특성을 고려할 때 어느 정도와 방향인지를 확인토록 한다. 이를 위해 2009년 4월 20일 월요일 하루 동안 경기도 버스에 승하차한 통행 샘플을 분석하였다. 분석 결과 버스정류장은 연계성 관련 변수를 기준으로 비교적 뚜렷한 구분이 가능하였다. 이러한 결과는 환승센터 입지 선정이나 설계에 유용한 정보를 줄 것으로 기대된다.

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오이 떡잎의 발달에서 지방 대사관련 유전자의 발현과 아세틸 단위체의 2차 경로 가능성 (Metabolic Gene Expression in Lipid Metabolism during Cotyledon Development in Cucumbers and the Possibility of a Secondary Transport Route of Acetyl Units)

  • 차현정;김대재
    • 생명과학회지
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    • 제24권10호
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    • pp.1055-1062
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    • 2014
  • 본 연구는 떡잎의 발달 동안 지방의 유동 및 대사와 관련된 오이 유전자들의 발현을 조사하여 유전자의 활성을 비교하고자 하였으며, 글라이옥시좀과 미토콘드리아 사이의 탄소원(아세틸 단위)의 가능한 경로를 탐색하고자 하였다. 네 곳의 세포 내 소기관인 글라이옥시좀(퍼옥시좀), 미토콘드리아, 엽록체 및 세포질에서 작동하는 중요 대사경로의 10개 유전자들이 조사되었다. 나아가 암소에서 발아한 유식물체의 발아 초기 반응과 이후 3일간 빛을 주었을 때의 반응을 조사하였다. 역전사-중합효소연쇄반응(RT-PCR)에 따르면, 유식물체의 발달 동안에 저장지방의 유동과 관련된 Thio2, ICL 및 MS 유전자는 항상 유사한 유전자 발현 양상을 나타냈다. 오이의 발아 초기에 BOU 유전자와 함께 ICL 및 MS 유전자의 공조된 발현은 퍼옥시좀과 미톤콘드리아 사이에 아세틸 단위의 2차 통로의 존재 가능성에 대한 강한 증거이다. 앞서 보고된 연구에서 보여준 BOU 활성에서처럼 BOU 유전자는 빛 의존성으로 암소에서는 세포막의 미약한 발달로 인하여 활성이 저하됨을 암시한다. 나머지의 유전자들은 떡잎이 초록색으로 발달하고 노쇠화 할 때까지 떡잎의 전 발달 기간 동안에 활성을 나타냈다. 본 연구에서는 아세틸 단위의 운반에 대한 새로운 추가적 제안으로써 지방 저장 종자의 발아와 오이 떡잎의 발달과 관련된 유전자의 발현을 통해 처음으로 확인하였다.

Expression of genes related to lipid transport in meat-type ducks divergent for low or high residual feed intake

  • Jin, Sihua;Xu, Yuan;Zang, He;Yang, Lei;Lin, Zhiqiang;Li, Yongsheng;Geng, Zhaoyu
    • Asian-Australasian Journal of Animal Sciences
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    • 제33권3호
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    • pp.416-423
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    • 2020
  • Objective: This study examined the effects of divergence in residual feed intake (RFI) on expression profiles of key genes related to lipid transport in the liver and duodenal epithelium and their associations with feed efficiency traits in meat-type ducks. Methods: A total of 1,000 male ducks with similar body weight (1,042.1±87.2 g) were used in this study, and their individual RFI was calculated from 21 to 42 d of age. Finally, the 10 highest RFI (HRFI) and 10 lowest RFI (LRFI) ducks were chosen for examining the expression of key genes related to lipid transport in the liver and duodenal epithelium using quantitative polymerase chain reaction. Results: In the liver, expression levels of albumin (ALB), CD36 molecule (CD36), fatty acid hydroxylase domain containing 2 (FAXDC2), and choline kinase alpha (CHKA) were significantly higher in LRFI ducks than in HRFI ducks (p<0.01); negative correlations (p<0.05) between expression levels of ALB, CD36, FAXDC2, and CHKA and RFI were detected in the liver. Additionally, ALB expression was strongly positively correlated (p<0.05) with CD36, FAXDC2, CHKA, and apolipoprotein H (APOH) expression in the liver. In duodenal epithelium, we found that mRNA levels of ALB, CD36, FAXDC2, and APOH were significantly higher in LRFI ducks than in HRFI ducks (p<0.01); RFI was strongly negatively correlated (p<0.05) with ALB, FAXDC2, and APOH expression, while ALB expression was strongly positively correlated with APOH expression (p<0.01) in duodenal epithelium. Furthermore, expression levels of both ALB and FAXDC2 genes were significantly associated with feed conversion ratio and RFI in both liver and duodenal epithelium (p<0.05). Conclusion: Our findings therefore suggest that ALB and FAXDC2 genes might be used as potential gene markers designed to improve feed efficiency in future meat-type duck breeding programs.

Iron(III)-p-toluenesulfonate로 합성된 Poly(3,4-ethylenedioxythiophene)의 전하전달현상에 미치는 유기용매의 영향 (Solvent Effects on the Charge Transport Behavior in Poly(3,4-ethylenedioxythiophene) Synthesized with Iron (III) -p-toluenesulfonate)

  • 박창모;김태영;김원중;김윤상;서광석
    • 폴리머
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    • 제29권4호
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    • pp.363-367
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    • 2005
  • Iron(III)p-toluenesulfonate를 개시제로 한 3,4-ethylenedioxyaiophene(EDOT)의 중합과정시 여러 가지 유기용매를 첨가했을 때 poly(3,4-ethylenedioxythiophene)(PEDOT)의 전하이동특성이 어떻게 변하는지에 대해 연구하였다. 첨가한 유기용매의 종류는 MeOH, EtOH등의 알콜류와 Acetone, MEK등의 케톤류였으며, 직류 전기전도도 측정시 280 K에서 전도도는 MeOH를 첨가한 시료가 19.5 S/cm로 가장 높았으며, MEK를 첨가한 시료는 $2.2{\times}10^{-9}$S/cm로 각기 다른 전도도를 나타내었다. 유기용매 첨가에 따른 전기전도도의 변화를 설명하기 위해 X-ray diffraction(XRD)를 통한 PEDOT의 구조적 변화를 관찰하였으며, 알콜류를 첨가했을 경우 결정화도가 증가하는 반면, 케톤류의 유기용매를 첨가했을 경우에는 무정형 구조를 가지는 것을 관찰하였다. 또한 X-ray photoelectron spectoscopyocpy(XPS)를 이용하여 S(2p) 피크를 분석한 결과 케톤류를 첨가한 시료의 경우 다른 시료에 비해 도핑레벨이 매우 낮음을 관찰하였다. 이는 유기용매와 PEDOT의 상대이온인 p-toluenesulfonate와의 상호작용으로 인한 것으로 중합시 유기용매의 첨가에 따라 PEDOT의 도핑효율 및 구조가 변화하고 결과적으로 전기전도도가 변화하는 것을 확인하였다.