• 한국보건간호학회지
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• 제19권1호
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• pp.129-138
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• 2005

As the patients who need to undergo liver transplant operation continues to grow. the number of livers that are donated can not keep pace with the demand. With the development of surgery skills, the necessity for operations from living donors is increasing. Nevertheless, satisfactory research has been conducted on the factors which generally affect the living donors. In this article. therefore. researchers focused on the factors which generally affect the donating liver donor in order to design a plan for recommending liver donation from living donors. The subjects were 91 living liver donors in C university hospital from October 1. 2000 to December 31. 2003. The results on the uncertainty of living donor, by test sheet. were analyzed with SAS program. The final results were as follows: 1. The uncertainty of the living donors was 51.54 marks per full credit 100. 2. The factor with the greatest effect on donation was the possibility of survival of the donor, followed by the admission period. marriage status and age. In recommending the living donation, the rate of donor survival after the operation was 5.2 times higher than death, 5.2 times higher when the admission period was under 20 days. 5.0 times higher when married. and 27.3 times higher when the family-related donation was very active at the age of 20s than in the 50s. These results suggest that all medical staffs should care for living donors with more interest and activity to give them the least complaints in admission and the lowest possibilities for complication. To enhance the survival rate and improve the surgical success rate. on-going monitoring should include regular health-checks. and continual efforts and education should be made to care for the health condition of the living donors after donation.

• International Journal of Oral Biology
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• 제34권1호
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• pp.29-36
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• 2009

Cyclosporin A (CsA) has been used clinically as an immunosuppressive drug to prevent organ transplant rejection and in basic research as a mitochondrial permeability blocker. It has been reported that CsA has a protective role in severed neurons and a neurotrophic effect in neuronal cells. However, the molecular mechanisms underlying the stimulation of neuronal cell proliferation by CsA have not yet been elucidated. In our current study, we investigated CsA responsive proteins in PC12 cells using a systematic proteomic approach. The viability of these cells following CsA treatment increased in a dose- and time-dependent manner. Proteins in the CsA-treated PC12 cells were profiled by two-dimensional gel electrophoresis (2-DE) and identified by matrix-assisted laser desorption ionization time-of flight (MALDI-TOF) and electrospray ionization quadupole time-of-flight mass spectrometries (EIQ-TOFMS). This differential expression analysis showed significant changes for 10 proteins (6 up-regulated and 4 down-regulated) upon CsA treatment that were related to cell proliferation, metabolism and the stress response. These proteomics data further our understanding of the proliferation mechanisms of PC12 cells exposed to CsA and demonstrate that our methodology has potential to further elucidate the mechanisms and pathways involved.

• 한국응용곤충학회지
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• 제15권2호
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• pp.57-60
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• 1976

새로운 침투성 살균제 EL-291 (5-Methyl-1,2,4-tri-azolo(3, 4-b) benzothiazole, $75\%$ 수화제)의 벼 도열병 방제효과를 구명코저 온실검정과 포장시험을 실시하였다. EL-291은 병원균 접종후 살포보다 접종전 살포시 효과가 뚜렷하여 현저한 예방효과를 나타냈으나 가스가민, 벤레이트 상반된 반응을 나타내어 치료제로서 작용했다. 잎 도열병방제효과는 EL-291과 가스가민, 벤레이트간에 차이가 없었으나 이들 약제의 2회 살포에 비해 EL-291은 근침처리 또는 1회 살포한 것이므로 사용이 간편하고 경제적이라 할 수 있겠다. 이삭도열병에서도 1회 살포한 EL-291이 2회 살포한 가스가민, 벤레이트보다 월등히 효과가 좋았으며 수량도 EL-291 처리구가 더 많았다.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(역학)
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• pp.206-233
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• 1994

The Medical Research Council has for some years encouraged collaborative clinical trials in leukaemia and other cancers, reporting the results in the medical literature. One unreported result which deserves such publication is the development of the expertise to design and analyse such trials. This report was prepared by a group of British and American statisticians, but it is intended for people without any statistical expertise. Part!, which appears in this issue, discusses the design of such trials; Part II, which will appear separately in the January 1977 issue of the Journal, gives full instructions for the statistical analysis of such trials by means of life tables and the logrank test, including a worked example, and discusses the interpretation of trial results, including brief reports of particular trials. Both parts of this report are relevant to all clinical trials which study time to death, and would be equally relevant to clinical trials which study time to other particular classes of untoward event: first stroke, perhaps, or first relapse, metastasis, disease recurrence, thrombosis, transplant rejection, or death from a particular cause. Part I, in this issue, collects together ideas that have mostly already appeared in the medical literature, but Part II, next month, is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration. Such trials include the majority of all clinical trials of cancer therapy; in cancer trials, however, it may be preferable to use these statistical methods to study time to local recurrence of tumour, or to study time to detectable metastatic spread, in addition to studying total survival. Solid tumours can be staged at diagnosis; if this, or any other available information in some other disease is an important determinant of outcome, it can be used to make the overall logrank test for the whole heterogeneous trial population more sensitive, and more intuitively satisfactory, for it will then only be necessary to compare like with like, and not, by chance, Stage I with Stage III.

• 한국임상약학회지
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• 제12권1호
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• pp.13-21
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• 2002

After the introduction of cyclosporin, the graft survival rate of renal transplant and patients' life expectancy have been greatly improved. However, cyclosporin is known to cause several undesirable side effects, one of which is hyperuricemia, which may subsequently cause gouty nephropathy and graft dysfunction. The purpose of this study was to evaluate the frequency and predisposing factors of hyperuricemia in cyclosporin-treated patients within one year of kidney transplantation and uricosuric efficacy of benzbromarone. The patients who were treated with cyclosporin after kidney transplantation in 1998 and the patients who were treated with benzbromarone for the control of cyclosporin-induced hyperuricemia in 1999 were investigated retrospectively. Among the 76 patients in cyclosporin-treated patients in 1998, hyperuricemia occurred in 55 patients $(72.4\%)$ and the mean time from kidney transplantation to occurrence of hyperuicemia was $5.0\pm8.0$ months. In 1999, 22 patients were treated with benzbromarone for hyperuricemia and their mean time from kidney transplantation to occurrence of hyperuricemia was $4.5\pm10.4$ months. Acute rejection developed in one patient $(4.8\%)$ out of 21 normo-uricemic patients and 11 patients $(20.0\%)$ out of 55 hyperuricemic patients in 1998. The difference of rejection rate in these two groups was significant (p<0.001). There was no difference of rejection rate between before and after treatment of benzbromarone. Cyclosporin trough levels did not show a significant correlation with the serum uric acid levels among the three groups. However, hyperuricemic patients showed significantly higher serum creatinine levels than patients with normal uric acid levels (p<0.001). Benzbromarone decreased serum uric acid levels from $8.3\pm2.3\;mg/dl\;to\;5.1\pm2.0\;mg/dl$ (p<0.0001) and normalizing serum uric acid in all of 22 patients. Except for one patient $(4.5\%)$ who experienced diarrhea, no significant side effect was noted.

• 한국통신학회논문지
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• 제36권7B호
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• pp.834-840
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• 2011

현대사회에서 만성질환은 고령인구의 건강한 삶을 위협하는 요소이며 당뇨 및 고혈압은 신장 기능의 파괴를 초래하고 악화될 경우 혈액투석, 인공장기, 장기이식술 등의 치료를 받아야 하는 위험한 질환이다. 따라서 본 논문에서는 당뇨 및 고혈압 환자들을 대상으로 혈액투석 치료에 따른 성대 진동 요소의 변화를 측정하여 혈액투석 치료가 성대 진동에 미치는 영향을 연구하였다. 이를 위해 발음에 문제가 없는 당뇨 및 고혈압 환자들을 피실험자로 선정하고 이들의 혈액투석 전과 후의 음성을 수집하여 성대 진동과 관련된 Jitter 및 Shimmer 분석 요소를 적용하여 변화되는 정도를 비교, 분석하는 실험을 수행하였다. 결론적으로 당뇨 및 고혈압 환자를 대상으로 한 혈액 투석 치료가 신장 기능의 향상에 도움이 되는 것을 성대 진동의 안정성이 향상되는 실험 결과로 도출하였다.

• 생물환경조절학회지
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• 제10권1호
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• pp.55-60
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• 2001

일몰 후 적색 및 원적색 광처리가 토마토 묘 소질에 미치는 효과를 조사하기 위해 24일간의 광처리 기간동안 12일 간격으로 묘의 초장, 제1절간장, 줄기직경을 측정하였고, 실험 마지막 날에는 묘의 뿌리와 줄기를 분리 건조하여 각 건물중을 측정하였다. 적색광 처리는 식물의 초장을 억제시키는 것으로 나타났고, 원적색광 식물의 초장신장을 촉진하는 결과를 보였다. 적색 및 원적색광 처리가 식물의 초장에 미치는 효과는 광처리 시간이 10분 또는 20분이든 큰 차이가 없었다. 또한, 적색광 처리된 식물의 줄기직경이 대조구 및 원적색광 처리된 식물의 줄기 직경보다 큰 것으로 나타났다. 적색광 처리는 원적색광 처리 및 대조구에 비해 줄기·뿌리의 건물중비가 작았다. 토마토 묘의 충실도에 미치는 광처리 효과는 적색광 처리가 가장 우수한 것으로 나타났고, 원적색광 처리된 묘의 충실도가 가장 낮았으며 광처리 없는 대조구는 그 중간정도의 충실도를 나타내었다.

• 한국약용작물학회지
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• 제23권2호
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• pp.150-154
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• 2015

Physiological disorders such as symptoms in leaf colored with brown spots are so many occurred in ginseng garden cultivated with paddy soil. This study was carried out to inhibit the symptoms of brown-colored leaf in 3-year-old ginseng by fertilizing calcium hydroxide [$Ca(OH)_2$] of 100 ~ 400 kg per 10a on paddy soil before transplant of seedling. Soil pH was rapidly increased, while Fe was decreased in soil by the increase of application level of calcium hydroxide. Soil pH was increased from 4.53 to 6.18 when calcium hydroxide was fertilized at level of 100kg per 10a. The content of Fe in ginseng leaf was decreased more than the control by fertilizing calcium hydroxide in soil. Ratio of brown-colored leaf and plant height and leaf area were decreased by the increase of calcium hydroxide. Ratio of survived root and yield of root showed the peak at the application level of 100 kg per 10a, and both of them were gradually decreased by the increase of calcium hydroxide. The decrease of missing plant rate above the application level of 200 kg per 10a had a negative effect on the decrease of yield of root.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권1호
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• pp.44-53
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• 2016

Purpose: Parenteral nutrition (PN) not only provides nutritional support but also plays a crucial role in the treatment of children with intestinal failure. The aim of this study was to evaluate the clinical significance and clinical outcomes of long-term PN. Methods: Retrospective cohort study was conducted using the medical records of patients treated at Seoul National University Children's Hospital. This study included 19 patients who received PN for over six months. Most patients received home PN. Results: The indications for PN included short bowel syndrome, chronic intestinal pseudo-obstruction, and intractable diarrhea of infancy. The median age of PN initiation was 1.3 years, and the median treatment duration was 2.9 years. Two patients were weaned from PN; 14 continued to receive PN with enteral feedings; and 3 patients died. The overall survival rates at 2 and 5 years were 93.3% and 84.0%, respectively. The incidence of catheter-related bloodstream infections was 2.7/1,000 catheter-days and was associated with younger age at PN initiation and lower initial height Z-score. Six patients developed catheter-related central vein thrombosis, with an incidence of 0.25/1,000 catheter-days. Eleven patients experienced PN-associated liver disease (PNALD), and one patient underwent multi-visceral transplant. The patients with PNALD exhibited lower final heights and body weight Z-scores. All patients experienced micronutrient deficiencies transiently while receiving PN. Conclusion: PN is an important and safe treatment for pediatric intestinal failure. PNALD was linked to final anthropometric poor outcomes. Micronutrient deficiencies were common. Anthropometric measurements and micronutrient levels must be monitored for successful PN completion.

• 대한두경부종양학회지
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• 제24권1호
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• pp.64-68
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• 2008

Purpose：The chronic use of immunosuppressive therapy in transplant recipients can increase the long-term risk of carcinoma. The aim of this study was to determine the incidence, biological behaviors, and treatment outcomes in PTC(papillary thyroid carcinoma) in renal allograft recipients. Material and Methods：The present study examined the incidence and biological behavior of PTCs in RA recipients. A total of 1,739 RA patients treated between January 1986 and December 1999 were followed-up for a median 137(84-238) months. During the follow-up period, 129(7.4%) recipients were identified as having posttransplant malignancies. Of those, 12(0.7%) had PTCs, and these comprised six male and six female patients with a median age of 41(23-57) years. Results：Nine cases(incidentalomas) were diagnosed based on ultrasonography(US) screening. Eight of those nine were TNM stage I, and two of the three clinical carcinomas were TNM stage IVa. During a median follow-up of 94(18-159) months, two(16.7%) PTC patients developed loco-regional recurrence, but no patients showed distant metastasis. Posttransplant PTC showed no gender bias, and was often associated with aggressive lymphatic metastasis. However, most incidentalomas showed a favorable treatment outcome. Conclusion：In conclusion, routine surveillance of the thyroid gland using US screening is recommended to ensure early detection, treatment and favorable prognosis in RA patients with PTC.