• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.5
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• pp.56-62
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• 2007

In order to compare subjective and objective assessments, a passenger car was driven at several speeds over several road profiles. To measure the acceleration signals experienced by the seated subject who provided an subjective assessment, four triaxial translational accelerometers and one triaxial gyro sensor were mounted on the steering wheel and on the passenger seat and floor, respectively. Correlations were determined between the measured accelerations and the subjective assessments of 3 expert subjects and 9 general subjects using psychophysical power law.

• Journal of Biomedical Engineering Research
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• v.25 no.4
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• pp.301-307
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• 2004

An inverse dynamic model of lower limbs is presented to calculate joint moments during gait. The model is composed of 4 segments with 3 translational joints and 12 revolute joints. The inverse dynamic method is based on Newton-Euler formalism. Kinematic data are obtained from 3 dimensional trajectories of markers collected by a motion analysis system. External forces applied on the foot are measured synchronously using force plate. The use of developed model makes it possible to calculate joint moments for variation of parameters.

• Journal of Korean Neurosurgical Society
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• v.57 no.6
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• pp.428-431
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• 2015

Various approaches have been attempted in translational moyamoya disease research. One promising material for modeling and treating this disease is vascular progenitor cells, which can be acquired and expanded from patient peripheral blood. These cells may provide a novel experimental model and enable us to obtain insights regarding moyamoya disease pathogenesis. We briefly present the recent accomplishments in regard to the studies of vascular progenitor cells in moyamoya disease.

• Structural Monitoring and Maintenance
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• v.3 no.2
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• pp.157-174
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• 2016

Based on classical viscoelastic damper, a brand-new damper is designed by the change of simple construction to implement vibration control for both translational vibration and rotational vibration simultaneously. Theoretic analysis has been carried out on the restoring force model and the control parameters. Two improved models are presented to obtain high simulation precision. The influence of the size, shape of the viscoelastic material, the ambient temperature and the response frequency on the vibration control effect is analyzed. The numerical results show that the new type viscoelastic damper is capable of mitigating the multi-dimensional seismic response of offshore platform and the response control effect has complicated relations with aforementioned related factors.

• Mass Spectrometry Letters
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• v.7 no.4
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• pp.85-90
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• 2016

Post-translational modifications (PTMs) of proteins regulate self-renewal and differentiation in embryonic stem cells (ESCs). Nitration of tyrosine residues of proteins in ESCs modulates their downstream pathways, which can affect self-renewal and differentiation. However, protein tyrosine nitration (PTN) in ESCs has been rarely studied. We reviewed 23 nitrated sites in stem cell proteins. Functional enrichment analysis showed that these nitrated proteins are involved in signal transduction, cell adhesion and migration, and cell proliferation in ESCs. Comparison between the nitrated and known phosphorylated sites revealed that 7 nitrated sites had overlapping phosphorylated sites, indicating functional links of PTNs to their associated signaling pathways in ESCs. Therefore, nitrated proteome provides a basis for understanding potential roles of PTN in self-renewal and differentiation of ESCs.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3275-3279
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• 2012

Recently, population-based studies of type 2 diabetes patients have provided evidence that metformin treatment is associated with a reduced cancer incidence and mortality, but its mode of action remains unclear. Here we report effects of metformin on hepatocellular carcinoma (HCC) Hep-G2 cells and details of molecular mechanisms of metformin activity. Our research indicates that metformin displays anticancer activity against HCC through inhibition of the mTOR translational pathway in an AMPK-independent manner, leading to G1 arrest in the cell-cycle and subsequent cell apoptosis through the mitochondrion-dependent pathway. Furthermore, we showed that metformin strongly attenuated colony formation and dramatically inhibited Hep-G2 tumor growth in vivo. In conclusion, our studies suggested that metformin might have potential as a cytotoxic drug in the prevention and treatment of HCC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2379-2381
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• 2014

It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to l imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.

• Journal of Microbiology and Biotechnology
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• v.14 no.1
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• pp.162-166
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• 2004

Phage P22 tailspike is a thermostable homotrimeric protein, and temperature-sensitive folding (tsf) and global suppressor mutations affect its folding yields at elevated temperatures. We earlier suggested that the folding of the tailspike protein in Escherichia coli requires an unidentified molecular chaperone. Accordingly, in the present study, the interactions of purified DnaK, DnaJ, and GrpE heat-shock proteins with the tailspike protein were investigated during the translation and folding of the protein. The cotranslational addition of DnaJ to the tailspike protein resulted in the arrest of folding, when Dnak and GrpE were missing. However, the presence of DnaK, DnaJ, and GrpE had no effect on the folding yield of the tails pike protein, thus, providing evidence for the binding of the nascent tailspike protein with DnaJ protein, a member of DnaK chaperoning cycle.

• Journal of Biomedical Engineering Research
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• v.11 no.1
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• pp.31-38
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• 1990

Image correction of the fluorescein angiogram with the low contrast and geometrically distorted is studied. The procedure is divided into two steps : A template matching step and a geometrical transformation step. Based on the sequential similiarity detection algorithm, more Improved matching results are obtained with edge enhanced image. For the reference points and the corresponding matchimg points, the geometrical transformationss by the use of the average value of the X, Y translational shifts and a pair of these points, respectively are described. Then the corrected images are obtained using bilinear interpolation. It is proven that the usefullness of this study for the image correction of the ocular fundus fluoresceln angiogram with low contrast and geometrically distorted mainly due to the eye movements.

• Journal of Korean Association for Spatial Structures
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• v.3 no.3 s.9
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• pp.95-103
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• 2003

Frame is one of the most commonly used structural systems for the resistance of applied loads. Many researchers have recently conducted their studies to investigate the effect of several parameters such as the connection flexibility, boundary condition of each support, beam-to-column stiffness ratio. These parameters play important roles on the characteristic behavior of frames. A simplified spring model is proposed to obtain the story drifts of frames with various beam-to-column connection stiffnesses in this research. A point bracing system with adequate spring stiffness is also suggested to establish the relationship between the applied load and the resisting translational spring stiffness within the limit state of story drift.