• Title/Summary/Keyword: Transitional age

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KNOCKDOWN OF IGF-1R BY ANTISENSE OLIGODEOXYNUCLEOTIDE AUGUMENTS THE SENSITIVITY OF BLADDER CANCER CELLS TO MMC

  • Wu, Shu-Fang;Sun, Hong-Zhi;Tu, Zeng-Hong
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.203-204
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    • 2001
  • Background and Aim: Transitional cell carcinoma (TCC) of the bladder represents the fifth most prevalent malignancy in Western population, with peak incidence found in males of the 50- to 70-year-old age group. A major problem in the management of bladder cancer is the low sensitivity of a large proportion (approximately 40%) among bladder tumors to chemotherapy and the high risk for recurrence of bladder tumors after transurethral resection.(omitted)

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Early gonadal maturation and vitellogenin mRNA expression in Siberian sturgeon Acipenser baerii cultured in a semi-closed water recirculating system in Korea

  • Park, Chulhong;Gong, Seung Pyo;Choi, Youn Hee;Kim, Ki Hong;Nam, Yoon Kwon
    • Journal of Animal Reproduction and Biotechnology
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    • v.35 no.3
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    • pp.279-288
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    • 2020
  • Changes of gonadal morphology and mRNA expression patterns of vitellogenin were investigated in Siberian sturgeon Acipenser baerii (Chondrostei) during its early gonadal maturation period. Early differentiations and morphological transitions of both ovaries and testes appeared to occur actively until the age of 3 years, however from then on, the maturation patterns to full maturity were largely gender-dependent, in which males showed a faster progression of maturation than did females while females experienced a steady-state progress with a lagged interval before entering the final maturation. Expression of vitellogenin mRNAs are closely correlated with transitional patterns of gonadal appearances. In both females and males, hepatic mRNA levels of vitellogenin exponentially increased in the earliest interval (up to 1-year-old). However, in subsequent periods, vitellogenin expression in females continued to increase with age, whereas in males, the expression stabilized at a younger age. Nevertheless, at the age older than or equal to 7-year-old, fully matured individuals showed a quite low level of vitellogenin expression in both females and males. Collectively, results from this study could be useful as a fundamental guideline to address the gonad maturation of this sturgeon species, which is helpful for making practical decisions about farming practices and management for caviar production on local sturgeon farms.

Axial Seamount Basalts in P3 Segment of Phoenix Ridge, Drake Passage, Antarctica: K-Ar Age Determination and Geochemistry (남극 드레이크 해협 피닉스 해령 P3구역 축부 해저현무암: K-Ar 연대측정과 지구화학)

  • Lee, Jong-Ik;Hur, Soon-Do;Lee, Mi-Jung;Kim, Kyu-Jung;Nagao, Keisuke
    • Ocean and Polar Research
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    • v.25 no.1
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    • pp.107-118
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    • 2003
  • The axial seamount basalts in the P3 segment of the Phoenix Ridge were obtained from dredging and the K-Ar age determination and whole-rock geochemical analyses have been done for understanding their origin. The K-Ar ages for PRS basalts sampled from 1,000m below sea level are 2.6-2.2 Ma and those for PR3 basalts from 800m are 1.6-1.5 Ma. The younger ages towards the crest of the seamount indicate that this submarine volcano has been grown by central eruptions. The youngest age of about 1.5 Ma for PR3 basalts corresponds to the final eruption period of this volcano. The seamount basalts contain small amounts of normative quartz and olivine. They have transitional geochemical nature between alkaline- and subalkaline-series basalts. Trace and rare earth elements compositions of the seamount basalts are very similar to those of ocean island basalts (OIB), and indicate that this seamount has been formed by a hotspot activity, not in association with a seafloor spreading. The melting degree from the source has decreased with time, and finally the volcanic activity has stopped when the basaltic magma reached mild alkaline composition.

Interpretation of Firing Temperature and Material Characteristics of the Potteries Excavated from the Nongseori Site in Giheung, Korea (기흥 농서리유적 출토 토기의 재료과학적 특성과 소성온도 해석)

  • Gim, Ran-Hui;Lee, Sun-Myeong;Jang, So-Young;Lee, Chan-Hee
    • Journal of Conservation Science
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    • v.25 no.3
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    • pp.255-271
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    • 2009
  • This study was examined interpretation of making techniques and provenance interpretation of raw materials for the potteries from the Nongseori site in Giheung based on archaeometric characteristics. The potteries are classified into three groups according to the archaeological age. The texture of Neolithic age potteries is sandy soil added a lot of temper such as talc and mica, and Bronze age potteries contain sandy materials which occur naturally include quartz, orthoclase, plagioclase and mica. On the other hand, Proto-three Kingdom Age potteries made of silty soil that sift out coarse minerals from the clay. But all pottery and soil samples in the study were very similar patterns with geochemical evolution trend. This result is sufficient evidence that all pottery samples were produced using the same raw materials from the host rocks around of the site area. The Neolithic age potteries had loose texture and fired probably about 700 to $760^{\circ}C$. The Bronze age potteries had experienced firing about 850 to $900^{\circ}C$. And Proto-three Kingdom Age potteries had compact textured and fired from 900 to $1,050^{\circ}C$. The making techniques of potteries are not represented discontinuation characteristics about the periodic time sequences, and are suggested that revealed a transitional change patterns for production techniques.

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Humus Analysis for the Geomorphic Development and Climatic Environment Change of Alluvial Plain in Hampyeongcheon Basin during the Late Holocene (휴무스분석을 이용한 함평천 유역의 홀로세 후기 충적평야의 지형발달과 기후환경변화)

  • Jung, Hea-Kyung;Kim, Cheong-Bin
    • Journal of the Korean earth science society
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    • v.33 no.4
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    • pp.320-328
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    • 2012
  • To investigate geomorphic development of alluvial plains and climatic environment change during the late Holocene carbon dating, soil organic carbon analysis and humus analysis of sediments from alluvial plain of Hampyeongcheon basin were performed. The lowest peat layer was formed under warm and humid climates, which is considered to correspond to the Atlantic period in the Holocene. Yellowish brown sandy clay layer was deposited in the natural levee, which we think were deposited in the generally warm and dry climates. The carbon dating age is 1,879-1,532 BC, and this period correspond to the Sub-boreal period in the Holocene. Light brown clay layer is assumed to have been deposited in transitional environment from the natural levee to the back marsh. The climatic environment was warm and humid, which is considered as transitional period from the Sub-boreal to the Sub-Atlantic in the Holocene. Light yellowish brown and light brown clay layer of the upper part are regarded as sediments of the back marsh. Light yellowish brown clay layer was deposited in the cold and dry climates, which is considered to correspond to the Sub-Atlantic period in the Holocene. Light brown clay layer was deposited in the warm and dry climates. The carbon dating age is 211-427 AD, this period corresponds to the Post Roman Warm Period in the Holocene.

Anal Fistula and Perianal Abscess in Pediatric and Adolescent Patients (소아 및 청년층의 치루와 항문주위농양)

  • Kim, Soong-Chul;Kim, Jin-Cheon;Kim, In-Koo
    • Advances in pediatric surgery
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    • v.1 no.1
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    • pp.40-45
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    • 1995
  • Anal fistula and perianal abscess in pediatric patients have been reported to have several characteristics, e.g. prevalent in less than 2 years of age, male preponderance, straight course of tract, and low type of fistula. We performed a retrospective study of twenty nine pediatric patients to see these characteristics comparing with the transitional age group of adolescents. Between June 1989 and December 1993, twenty-nine pediatric (<15year-old) and sixteen adolescent patients(${\geqq}$15, <25 year-old) with anal fistula and perianal abscess were treated by surgical intervention. Perianal abscess and anal fistula in the pediatric group had the predilection for male(100%), age less than two years (72.4%), low type(100%), and lateral localization(87.5%). But the features of the adolescent group were similar to those of adult. Twenty-one(87.5%) and 10(66.7%) enteric bacterial colonies were isolated from 16 pediatric and 11 adolescent patients, respectively. Considering the predominance of low type and the organisms cultured in the pediatric group, crypt-glandular infection seems to be a major preceding event. Incision and drainage were sufficient for cure in 15 among 16 perianal abscesses, and fistulas were cured by either fistulotomy or fistulotomy in all the 14 patients. The importance of effective drainage of perianal abscess and fistulotomy including internal opening cannot be overemphasized.

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A Study on the Architecture Scales Used in the Unified Silla Era (통일신라시대(統一新羅時代) 건물지(建物址)에 적용(適用)된 척도(尺度)에 관한 고찰(考察))

  • Kim, Young-Pil;Park, Kang-Chul
    • Journal of architectural history
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    • v.17 no.4
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    • pp.7-23
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    • 2008
  • This study is examine the scales applied to buildings in the age of Unified Silla through construction sites excavated and its results are as follows; First, scales used in the age of Unified Silla were varied like Jucheok, Dangcheok and Hancheok, but it was generally accepted that Dangcheok was used in Yeongjocheok Since it was found that the scales applied to Dabotap at the Bulguksa temple and main building of the Gameunsa temple belonged to Goguryeo, Yeongjocheok scale used early in the age of Unified Silla was transitional and it was thought that Goguryeocheok and Dangcheok were used togethar. Second, according to actual rulers in Korea, china and Japan, the length of Dangcheok(ruler used in Chinese Tang era) mostly belonged to the extent of $29.25cm\;{\sim}\;30.5cm$(central value: 29,71cm). Third, plane features of main building of temple are assumed that it had five rooms in front compartment until the 7th century and then it was diversified to three, five and seven compartment. The size of compartment was same in the scale of front Eokan and Hyeopkan until late 7th century, but since then the dimension of Eokan tended to be wider than Hyeopkan. It was judged that the front Eokan used triple scales like 9, 12, 15, 18 cheok. Fourth, the length of residential structures was 17.5cheok${\sim}$36cheok and Bcheok was commonly used for front side of structure, The length of official structures was 8.4cheok${\sim}$36.3cheok which is similar to residential structures. However it has been confirmed that each of 9cheok, 12cheok, and 15cheok has been used for Eokan and Hyeopkan which gave presumption that triple scales was used for the measure.

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The Influencing Factors of Subjective Health and Health-Related Quality of Life in Middle-Aged Women (중년여성의 주관적 건강 및 건강관련 삶의 질 영향요인)

  • Park, Hye-Seon;Kim, Sang-Mi
    • The Journal of the Convergence on Culture Technology
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    • v.10 no.3
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    • pp.121-130
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    • 2024
  • This study utilized data from 1,068 women aged 40-59, drawn from the 8th Korea National Health and Nutrition Examination Survey (KNHANES) conducted in 2020, to investigate factors impacting subjective health perception and health-related quality of life. Methodologically, STATA 15.0 was employed for complex sample mean and standard deviation calculations, complex sample weighted percentages, complex sample t-tests, and multiple regression analyses. Common factors influencing both subjective health and health-related quality of life included education level, household size, depression, and stress. Age, binge drinking, and physical activity were identified as factors influencing subjective health perception. Insurance type, employment status, and sleep disorders emerged as factors impacting health-related quality of life. Recognizing middle age as a crucial transitional phase into old age, the development of health policy programs aimed at enhancing subjective health and health-related quality of life during this period is deemed essential.

A Study of Pattern Generation Technique & Expressive Characteristics of Digital Ornament (디지털 오너먼트의 패턴생성기법 및 표현특성 연구)

  • Han, Hea-Shin;Kim, Moon-Duck
    • Korean Institute of Interior Design Journal
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    • v.19 no.5
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    • pp.83-94
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    • 2010
  • Conventionally, ornament has developed around linear thinking based on Euclidean geometry, and been explained as simple and lucid natural Euclidean geometrical phenomena. The modular arrangement with vertical, horizontal and diagonal grids has been an organizing principle of classical ornament, but in digital era ornament is found not to be explained only with the principle of traditional arrangement due to the seemingly irregular complex forms. In that sense, this study presents the concept of digital ornament and examined the backgrounds of ornament in digital age, that are complex system and non-Euclidean geometry. Accordingly, the present study takes an approach by dividing new formal types of ornament into algorithmic form, hybrid form and dynamic form to find out a principle of pattern organization. Lately, architects who actively use computer for their architectural designs take the algorithmic strategies in nature and create various and complex patterns by simple rules. The patterns are not the repetition of the same, but the production of singularities. In addition, hybrid form by morphing shows a topologically flexible evolutionary transformation, and is used to create in-between transitional shapes from the source to target. Finally, the patterns by the interaction between the system components which are corresponded to the embedded forces emerge from dynamic simulation of the natural environment. Rather than objects itself, focus is given to the process of generating forms, and the ornamental patterns as the revelation of such implicit order provide not just the formal beauty but also spatial pathways for lights and air, maximizing the effects of lights.

The Third Year-Report on the Dental Caries Prevalence of "K" Primary School Children and Their Annual Comparisons ("K" 국민학교(國民學校) 학동(學童)의 치아우식증(齒牙齲蝕症) 이환추이(罹患推移)에 대(對)한 제3차년도(第三次年度) 보고(報告))

  • Paik, Tong-Jun;Yoon, Doo-Keun
    • Journal of the korean academy of Pediatric Dentistry
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    • v.2 no.1
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    • pp.35-46
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    • 1975
  • The third year dental caries survey of "K" primary school children was performed in June 1975, and evaluated their transitional trends of three consecutive past years, statistically. 1,421 children (782 boys and 639 girls) 6 to 12 years of age was surveyed at the third year. The results were as follows: 1) The average df person rate was 89.97%(boy 88.19%, girl 92.42%). It showed significant increment(P<0.005) compare to 1973 and nonsignificant to 1974. 2) The average dft index was 3.82(boy 3.76, girl 3.90). It showed nonsignificant difference compare to 1973 and 1974. 3) The average DMF person rate was 66.57%(boy 63.84%, girl 69.89%). It showed significant decrement(P<0.005) compare to 1973 and 1974. 4) The average DMFT index was 2.03(boy 1.88, girl 2.20). It showed significant decrement(P<0.005) compare to 1973 and 1974. 5) The sexual difference of df and DMF person rates, female showed a little higher value than male. It showed significant difference(P<0.005). 6) The increment of df and DMF person rates, the 7 to 8 year group showed the most and the 7 to 8 year group showed the least.

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