Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.203-204
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- 2001
KNOCKDOWN OF IGF-1R BY ANTISENSE OLIGODEOXYNUCLEOTIDE AUGUMENTS THE SENSITIVITY OF BLADDER CANCER CELLS TO MMC
- Wu, Shu-Fang (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences) ;
- Sun, Hong-Zhi (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Science) ;
- Tu, Zeng-Hong (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences)
- Published : 2001.10.01
Abstract
Background and Aim: Transitional cell carcinoma (TCC) of the bladder represents the fifth most prevalent malignancy in Western population, with peak incidence found in males of the 50- to 70-year-old age group. A major problem in the management of bladder cancer is the low sensitivity of a large proportion (approximately 40%) among bladder tumors to chemotherapy and the high risk for recurrence of bladder tumors after transurethral resection.(omitted)
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