• BMB Reports
• /
• v.51 no.2
• /
• pp.65-72
• /
• 2018

The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. The EndMT process is tightly controlled by diverse signaling networks, similar to the epithelial to mesenchymal transition. Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. Thus, it is highly important to understand the molecular basis of miRNA control of EndMT. This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases.

• Asian-Australasian Journal of Animal Sciences
• /
• v.23 no.3
• /
• pp.372-378
• /
• 2010

The objective of this study was to investigate the effects of an oral drench of propylene glycol (PG) on milk production, serum metabolites and reproductive performance during the transition period of animals. Twenty-four 2-3 multiparous Holstein cows (average body weight 565 kg, body condition score about 3.6, at the $9^{th}$ month of gestation) were selected, blocked, and then randomly assigned into a PG and a control group. The control and the PG group cows were orally drenched with water or 50 ml sugarcane molasses mixed with 500 ml PG from 7 days pre-partum to 30 days post-partum, respectively. Experimental results indicated that the oral drench PG had no effect on dry matter intake (DMI). The milk yield of the PG group was significantly higher than that of the control group (p<0.05), whereas milk fat content, milk protein and somatic cell counts (SCC) were not significantly different between groups. Concentration of plasma glucose in the PG group was significantly higher than that of the control group (p<0.05). Conversely, the concentrations of non-esterified fatty acids (NEFA), and blood urea nitrogen (BUN) in the PG group were lower than those of the control group (p<0.05). Concentrations of insulin and ketone bodies were not significantly difference between groups. Body condition score (BCS) in the PG group was significantly higher than that of the control group (p<0.05). In reproductive performance there was no difference between groups. The experimental results indicate that supplementation of PG during the transition period of dairy cows can supply energy rapidly, resulting in reduced catabolism of body tissue and increased milk yield.

• Journal of Aerospace System Engineering
• /
• v.1 no.2
• /
• pp.6-12
• /
• 2007

Flight modes of automatic flight control system for light general aviation flight deck. Garmin G1000, were realized using Stateflow. In developing aircraft, it is difficult to verify the operational flight program in particular branch statement because developer can not see any visual logical steam. So, Stateflow has been used to visualize logical stream, transition from one flight mode to another flight mode. The performance was approved by applying flight mode transition conditions of G1000 to proposed transition system that is composed of states, switches, events, data and transition conditions. DURMI-II was used as 6-DOF simulation model.

• The Journal of the Korea Contents Association
• /
• v.11 no.10
• /
• pp.49-58
• /
• 2011

Fault Tree Analysis(FTA) builds fault trees to perform safety analysis of systems. However, building fault trees depends on domain knowledge and expertize on target systems and consumes lots of time and efforts. In this paper, we propose a technique that builds fault trees systematically based on state-transition models which are software design artifacts. For the end, this paper identifies conditions that should be satisfied to guarantee safety of state-transition models and develop templates for fault tree construction. This paper also describes the results of appling the proposed method to railway crossing control system.

• 한국전산유체공학회:학술대회논문집
• /
• 2009.04a
• /
• pp.43-50
• /
• 2009

In order to reduce the download around Smart UAV(SUAV) at hovering and transition mode, flow control using synthetic jet has been performed. Many of the complex tilt rotor flow features are captured including wing leading and trailing edge separation, and the large region of separated flow beneath the wing. First, in order to control the trailing edge separation, synthetic jet is located at 30, 95% of flap chord length. The flow control using synthetic jet on flap shows that stall characteristics depending on several mode can be improved through separation vortices resizing. Also, a flap jet and a 0.01c jet which control the separation efficiently are applied at the same time at each test case because controlling the leading edge separation is essential for download reduction. As a result, time averaged download is reduced about 18% comparing with no control case at hovering mode and 48% at transition mode. These research results show that if flow control using leading edge jet and trailing edge jet is used effectively to the SUAV in overall flight mode, flight performance and stability can be improved.

• Korean Journal of Adult Nursing
• /
• v.16 no.3
• /
• pp.421-431
• /
• 2004

Purpose: The study was performed to investigate the predictors associated transition with each stage of exercise behavior based to the Transtheoretical Model, and to provide basic data for exercise behavior programs for middle aged women. Methods: The subjects consisted of 434 women residing in B city by convenience sampling. The collected data were analyzed with multiple logistic regression using SPSS/WIN program. Results: The predictors of transition from precontemplation to contemplation were consciousness raising(OR=2.095, 95% CI: 1.305-3.363), Reinforcement management(OR= 1.903, 95% CI: 1.107-3.271), Stimulus control (OR=2.176, 95% CI:1.239-3.820), Menstrual status (OR=5.327, 95% CI: 1.110-25.562). The predictors of transition from contemplation to preparation were Helping relationship(OR= 1.671, 95% CI: 1.065-2.662), Pros(OR=2.500, 95% CI: 1.254-4.982), Perceived Health status (OR=.178, 95% CI: .041-.770). The predictor of transition from preparation to action was Stimulus control(OR=1.918, 95% CI: 1.103- 3.336). The predictors of transition from action to maintenance were Consciousness raising(OR= 1.939, 95% CI: 1.031-3.647), Dramatic relief (OR=2.249, 95% CI: 1.025-4.931). Conclusions: Adequate examination on the factors, which can predict the transitional stages of change exercise behaviors among middle aged women, which is presented in this study. The results of this study will become the pillar of exercise intervention program planning and application.

• The Journal of Advanced Prosthodontics
• /
• v.5 no.2
• /
• pp.110-117
• /
• 2013

PURPOSE. Polymethyl methacrylate (PMMA) is the most commonly used denture base material despite typically low in strength. The purpose of this study was to improve the physical properties of the PMMA based denture base resins (QC-20, Dentsply Ltd., Addlestone, UK; Stellon, AD International Ltd, Dentsply, Switzerland; Acron MC; GC Lab Technologies Inc., Alsip, Japan) by copolymerization mechanism. MATERIALS AND METHODS. Control group specimens were prepared according to the manufacturer recommendations. In the copolymer groups; resins were prepared with 5%, 10%, 15% and 20% acrylamide (AAm) (Merck, Hohenbrunn, Germany) content according to the moleculer weight ratio, respectively. Chemical structure was characterized by a Bruker Vertex-70 Fourier transform infrared spectroscopy (FTIR) (Bruker Optics Inc., Ettlingen, Germany). Hardness was determined using an universal hardness tester (Struers Duramin, Struers A/S, Ballerup, Denmark) equipped with a Vickers diamond penetrator. The glass transition temperature ($T_g$) of control and copolymers were evaluated by Perkin Elmer Diamond DSC (Perkin Elmer, Massachusetts,USA). Statistical analyses were carried out using the statistical package SPSS for Windows, version 15.0 (SPSS, Chicago, IL, USA). The results were tested regarding the normality of distribution with the Shapiro Wilk test. Data were analyzed using ANOVA with post-hoc Tukey test (P<.01). RESULTS. The copolymer synthesis was confirmed by FTIR spectroscopy. Glass transition temperature of the copolymer groups were higher than the control groups of the resins. The 10%, 15% and 20% copolymer groups of Stellon presented significantly higher than the control group in terms of hardness. 15% and 20% copolymer groups of Acron MC showed significantly higher hardness values when compared to the control group of the resin. Acrylamide addition did not affect the hardness of the QC-20 resin significantly. CONCLUSION. Within the limitation of this study, it can be concluded that copolymerization of PMMA with AAm increased the hardness value and glass transition temperature of PMMA denture base resins.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.12 no.4
• /
• pp.575-584
• /
• 2017

It is suggested the circuit network to analyze the time response of control system. And it is analyzed the interrelation for classical control and modern control by the transfer function and the state equation. Without complicated integration of state transition equation, it is suggested to possible time response by combining the state transition matrix and the transfer function. A source program is coded to display the time response according to the unit-step and the sinusoidal input. Transient response is analyzed in the unit-step input and phase difference between current and voltage is analyzed in sinusoidal input. As writing the suggested contents in transient response or state-space analysis, it is improved the understanding for control engineering and ability for system design.

• Progress in Superconductivity
• /
• v.3 no.1
• /
• pp.5-12
• /
• 2001

Our experimental research focuses on manipulating pinning deflects to alter the phase diagram of vortex matter, creating new vortex phases. Vortex matter offers a unique opportunity for creating and studying these novel phase transitions through precise control of thermal, pinning and elastic energies. The vortex melting transition in untwinned YB $a_2$C $u_3$ $O_{7-}$ $\delta$/ crystals is investigated in the presence of disorder induced by particle irradiation. We focus on the low disorder regime, where a glassy state and a lattice state can be realized in the same phase diagram. We follow the evolution of the first order vortex melting transition line into a continuous transition line as disorder is increased by irradiation. The transformation is marked by an upward shift in the lower critical point on the melting line. With columnar deflects induced by heavy ion irradiation, we find a second order Bose glass transition line separating the vortex liquid from a Bose glass below the lower critical point. Furthermore, we find an upper threshold of columnar defect concentration beyond which the lower critical point and the first order melting line disappear together. With point deflect clusters induced by proton irradiation, we find evidence for a continuous thermodynamic transition below the lower critical point..

• Proceedings of the Korean Magnestics Society Conference
• /
• 2013.12a
• /
• pp.165-165
• /
• 2013