• Journal of Korean Neurosurgical Society
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• v.61 no.1
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• pp.66-74
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• 2018

Objective : The aim of this study was to identify the susceptibility genes responsible for lumbar spondylosis (LS) in Korean patients. Methods : Data from 1427 subjects were made available for radiographic grading and genome wide association studies (GWAS) analysis. Lateral lumbar spine radiographs were obtained and the various degrees of degenerative change were semi-quantitatively scored. A pilot GWAS was performed using the AffymetrixGenome-Wide Human single-nucleotide polymorphisms (SNPs), 500K array. A total of 352228 SNPs were analyzed and the association between the SNPs and case-control status was analyzed by stepwise logistic regression analyses. Results : The top 100 SNPs with a cutoff p-value of less than $3.7{\times}10^{-4}$ were selected for joint space narrowing, while a cutoff p-value of $6.0{\times}10^{-4}$ was applied to osteophytes and the Kellgren-Lawrence (K-L) osteoarthritis grade. The SNPs with the strongest effect on disc space narrowing, osteophytes, and K-L grade were serine incorporator 1 (rs155467, odds ratio [OR]=17.58, $p=1.6{\times}10^{-4}$), stromal interaction molecule 2 (STIM1, rs210781, OR=5.53, $p=5{\times}10^{-4}$), and transient receptor potential cation channel, subfamily C (rs11224760, OR=3.99, $p=4.8{\times}10^{-4}$), respectively. Leucine-rich repeat-containing G protein-coupled receptor 4 was significantly associated with both disc space narrowing and osteophytes (rs1979400, OR=2.01, $p=1.1{\times}10^{-4}$ for disc space narrowing, OR=1.79, $p=3{\times}10^{-4}$ for osteophytes), while zinc finger and BTB domain containing 7C was significantly and negatively associated with both osteophytes and a K-L grade >2 (rs12457004,OR=0.25, $p=5.8{\times}10^{-4}$ and OR=0.27, $p=5.3{\times}10^{-4}$, respectively). Conclusion : We identified SNPs that potentially contribute to the pathogenesis of LS. This is the first report of a GWAS in an Asian population.

• Journal of the Korean Society of Propulsion Engineers
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• v.13 no.5
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• pp.57-63
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• 2009

A modeling and simulation program for an environmental control system (ECS) of a pod installed under wings of an aircraft was developed in order to estimate the system‘s performance during a flight. First, through the system configuration analysis in the main operational condition of the aircraft system, an ECS configuration adopting an air cycle machine (ACM) was selected. Therefore the modeling program was developed to simulate the ECS with an ACM. Second, the sensitivity analyses on performance variation of main components were conducted to complete the conceptual design of the ECS. A design point for the system and its components was obtained through the analysis with the modeling and simulation program. The design point for the system and components was obtained through the analysis with the modeling and simulation program. Third, in order to study the feasibility of the ECS configuration, off-design performances of the ECS on various flight conditions, such as take off, maneuver, cruise and landing etc were estimated. Dynamic characteristics were analyzed by transient performance evaluations.

• Ocean Systems Engineering
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• v.7 no.3
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• pp.179-193
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• 2017

Dynamic response analysis of offshore triceratops with stiffened buoyant legs under impact and non-impact waves is presented. Triceratops is relatively new-generation complaint platform being explored in the recent past for its suitability in ultra-deep waters. Buoyant legs support the deck through ball joints, which partially isolate the deck by not transferring rotation from legs to the deck. Buoyant legs are interconnected using equally spaced stiffeners, inducing more integral action in dispersing the encountered wave loads. Two typical nonlinear waves under very high sea state are used to simulate impact and non-impact waves. Parameters of JONSWAP spectrum are chosen to produce waves with high vertical and horizontal asymmetries. Impact waves are simulated by steep, front asymmetric waves while non-impact waves are simulated using Stokes nonlinear irregular waves. Based on the numerical analyses presented, it is seen that the platform experiences both steady state (springing) and transient response (ringing) of high amplitudes. Response of the deck shows significant reduction in rotational degrees-of-freedom due to isolation offered by ball joints. Weak-asymmetric waves, resulting in non-impact waves cause steady state response. Beat phenomenon is noticed in almost all degrees-of-freedom but values in sway, roll and yaw are considerably low as angle of incidence is zero degrees. Impact waves cause response in higher frequencies; bursting nature of pitch response is a clear manifestation of the effect of impact waves on buoyant legs. Non-impact waves cause response similar to that of a beating phenomenon in all active degrees-of-freedom, which otherwise would not be present under normal loading. Power spectral density plots show energy content of response for a wide bandwidth of frequencies, indicating an alarming behaviour apart from being highly nonlinear. Heave, being one of the stiff degrees-of-freedom is triggered under non-impact waves, which resulted in tether tension variation under non-impact waves as well. Reduced deck response aids functional requirements of triceratops even under impact and non-impact waves. Stiffened group of buoyant legs enable a monolithic behaviour, enhancing stiffness in vertical plane.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.1
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• pp.132-138
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• 2011

A micromachined silicon accelerometer capable of surviving and detecting very high accelerations(up to 200,000 times the gravitational acceleration) is necessary for a high impact accelerometer for earth-penetration weapons applications. We adopted as a reference model a piezoresistive type silicon micromachined high-shock accelerometer with a bonded hinge structure and performed structural analyses such as stress, modal, and transient dynamic responses and sensor sensitivity simulation for the selected device using piezoresistive-structural coupled-field analysis. In addition, structural optimization was introduced to improve the performances of the accelerometer against the initial design of the reference model. The design objective here was to maximize the sensor sensitivity subject to a set of design constraints on the impact endurance of the structure, dynamic characteristics, the fundamental frequency and the transverse sensitivities by changing the dimensions of the width, sensing beams, and hinges which have significant effects on the performances. Through the optimization, we could increase the sensor sensitivity by more than 70% from the initial value of $0.267{\mu}V/G$ satisfying all the imposed design constraints. The suggested simulation and optimization have been proved very successful to design high impact microaccelerometers and therefore can be easily applied to develop and improve other piezoresistive type sensors and actuators.

• Journal of Korean Neurosurgical Society
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• v.60 no.6
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• pp.738-748
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• 2017

Objective : We present our experience of microvascular decompression (MVD) for glossopharyngeal neuralgia (GPN) and evaluate the postoperative outcomes in accordance with four different operative techniques during MVD. Methods : In total, 30 patients with intractable primary typical GPN who underwent MVD without rhizotomy and were followed for more than 2 years were included in the analysis. Each MVD was performed using one of four different surgical techniques : interposition of Teflon pieces, transposition of offending vessels using Teflon pieces, transposition of offending vessels using a fibrin-glue-coated Teflon sling, and removal of offending veins. Results : The posterior inferior cerebellar artery was responsible for neurovascular compression in 27 of 30 (90%) patients, either by itself or in combination with other vessels. The location of compression on the glossopharyngeal nerve varied; the root entry zone (REZ) only (63.3%) was most common, followed by both the REZ and distal portion (26.7%) and the distal portion alone (10.0%). In terms of detailed surgical techniques during MVD, the offending vessels were transposed in 24 (80%) patients, either using additional insulation, offered by Teflon pieces (15 patients), or using a fibrin glue-coated Teflon sling (9 patients). Simple insertion of Teflon pieces and removal of a small vein were also performed in five and one patient, respectively. During the 2 years following MVD, 29 of 30 (96.7%) patients were asymptomatic or experienced only occasional pain that did not require medication. Temporary hemodynamic instability occurred in two patients during MVD, and seven patients experienced transient postoperative complications. Neither persistent morbidity nor mortality was reported. Conclusion : This study demonstrates that MVD without rhizotomy is a safe and effective treatment option for GPN.

• Proceedings of the KIEE Conference
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• 2005.11b
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• pp.46-48
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• 2005

This paper discusses a probabilistic method for power system security assessment. The security analysis relates to the ability of the electric power systems to survive sudden disturbances such as electric short circuits or unanticipated loss of system elements. It consists of both steady state and dynamic security analyses, which are not two separate issues but should be considered together. In steady state security analysis including voltage security analysis, the analysis checks that the system is operated within security limits by OPF (optimal power flow) after the transition to a new operating point. Until now, many utilities have difficulty in including dynamic aspects due to computational capabilities. On the other hand. dynamic security analysis is required to ensure that the transition may lead to an acceptable operating condition. Transient stability, which is the ability of power systems to maintain synchronism when subjected to a large disturbance. is a principal component in dynamic security analysis. Usually any loss of synchronism may cause additional outages and make the present steady state analysis of the post-contingency condition inadequate for unstable cases. This is the reason for the need of dynamic studies in power systems. Probabilistic criterion can be used to recognize the probabilistic nature of system components while considering system security. In this approach. we do not have to assign any predetermined margin of safety. A comprehensive conceptual framework for probabilistic static and dynamic assessment is presented in this paper. The simulation results of the Western System Coordinating Council (WSCC) system compare an analytical method with Monte-Carlo simulation (MCS).

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.3
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• pp.245-252
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• 2016

The development of Top-Mounted In-Core Instrumentation(TM-ICI) is an ongoing project to reduce the risk due to severe accidents by inserting the instrumentation into a reactor closure head instead of a reactor bottom head. As part of this project, environmental fatigue analyses for TM-ICI nozzle have been performed using two methods of NUREG/CR-6909 and Code Case N-761. TM-ICI nozzle is subjected to transient loads for level A, level B and test conditions that should be evaluated for a fatigue analysis. It is found that a cumulative usage factor considering reactor coolant environment for TM-ICI nozzle is evaluated as less than 1, which is ASME Code allowable criteria of a fatigue analysis.

• Journal of the Korean Geotechnical Society
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• v.19 no.1
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• pp.41-49
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• 2003

Rainfall-induced landslides in a weathered granite soil slope usually happen on shallow slip surfaces above the groundwater table. The pore-water pressure of soil above the groundwater table is usually negative. This negative pore-water pressure (or matric suction) has been found to make a large contribution to the slope stability. Therefore, the variation of in-situ matric suction profiles with time elapse in a soil slope should be understood. In this study, a field measurement program was carried out from June to August, 2001 in order to monitor in-situ matric suctions and volumetric water contents in a weathered granite soil slope. Finite-element transient seepage analyses are also conducted using SEEP/W. The influence of climatic conditions on the variation of in-situ matric suctions could be found to decrease rapidly with the change of depth. It could be found that decrement of matric suction induced by precipitation is affected not only by the amount and duration of rainfalls but also by the initial matric suction just prior to rainstorms. The soil-water characteristic from the field monitoring tends toward the wetting path of SWCC obtained from the laboratory test.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.8
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• pp.653-660
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• 2015

In this study, we conduct power performance and load analyses of two different types of vertical-axis tidal-current turbines using the computational fluid dynamics (CFD) method. To analyze the power output and loads, we perform transient CFD simulations considering the cavitation model using ANSYS CFX. The averaged power output of an H-type rotor was 7.47 kW and 67.6 kW in normal and extreme operating conditions, respectively, which did not satisfy the initial design conditions. However, in the case of the helical-type rotor, the power output under normal and extreme conditions were close to the expected values. The cavitation, which may cause instantaneous power fluctuation, occurred repeatedly at the suction side of the rotors. In order to guarantee a more stable power supply and to prevent fatigue failure, we require a design that minimizes cavitation.

• Atmosphere
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• v.25 no.3
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• pp.435-447
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• 2015

This study explores the synoptic characteristics of cold days over South Korea and their relationship with large-scale climate variability. The cold day, which is different from cold surge, is defined when daily-mean surface air temperature, averaged over 11 KMA stations, is colder than 1-percentile temperature in each year by considering its long-term trend over 1960~2012. Such event is detected by quantile regression and the related synoptic patterns are identified in reanalysis data. Composite geopotential height anomalies at 500 hPa show that cold days are often preceded by positive anomalies in high latitudes and negative anomalies in midlatitudes on the west of Korea. While the formers are quasi-stationary and quasi-barotropic, and often qualified as blocking highs, the latters are associated with transient cyclones. At cold days, the north-south dipole in geopotential height anomalies becomes west-east dipole in the lower troposphere as high-latitude anticyclone expands equatorward to the Northern China and mid-latitude cyclone moves eastward and rapidly develops over the East Sea. The resulting northerlies cause cold days in Korea. By performing composite analyses of large-scale climate indices, it is further found that the occurrence of these cold days are preferable when the Arctic Oscillation is in its negative phase and/or East Asian monsoon circulation and Siberian high are anomalously strong.