• 한국수정란이식학회지
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• 제25권1호
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• pp.35-42
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• 2010

Many studies propose that dysfunction of mitochondrial proton-translocating NADH-ubiquinone oxidoreductase (complex I) is associated with neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. Mammalian mitochondrial proton-translocating NADH-quinone oxidoreductase (complex I) consists of at least 46 different subunits. In contrast, the NDI1 gene of Saccharomyces cerevisiae is a single subunit rotenone-insensitive NADH-quinone oxidoreductase that is located on the matrix side of the inner mitochondrial membrane. With a recombinant adeno-associated virus vector carrying the NDI1 gene (rAAV-NDI1) as the gene delivery method, we were able to attain high transduction efficiencies even in the human epithelial cervical cancer cells that are difficult to transfect by lipofection or calcium phosphate precipitation methods. Using a rAAV-NDI1, we demonstrated that the Ndi1 enzyme is successfully expressed in HeLa cells. The expressed Ndi1 enzyme was recognized to be localized in mitochondria by confocal immunofluorescence microscopic analyses and immunoblotting. Using digitonin-permeabilized cells, it was shown that the NADH oxidase activity of the NDI1-transduced HeLa cells were not affected by rotenone which is inhibitor of complex I, but was inhibited by flavone and antimycin A. The NDI1-transduced cells were able to grow in media containing rotenone. In contrast, control cells that did not receive the NDI1 gene failed to survive. In particular, in the NDI1-transduced cells, the yeast enzyme becomes integrated into the human respiratory chain. It is concluded that the NDI1 gene provides a potentially useful tool for gene therapy of mitochondrial diseases caused by complex I deficiency.

• 한국진공학회지
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• 제16권5호
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• pp.366-370
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• 2007

밀도가 높고 주기적으로 배열된 나노 크기의 기공이 25nm 두께의 실리콘 산화막 기판위에 형성 되었다. 나노미터 크기의 패턴을 형성시키기 위해서 자기조립물질을 사용했으며 폴리스티렌(PS) 바탕에 벌집형태로 평행하게 배열된 실린더 모양의 폴리메틸메타아크릴레이트(PMMA)의 구조를 형성하였다. 폴리메틸메타아크릴레이트를 아세트산으로 제거하여 폴리스티렌만 남아있는 나노크기의 마스크를 만들었다. 폴리스티렌으로 이루어진 나노패턴의 지름은 $8{\sim}30nm$ 였고 높이는 40nm였으며, 패턴과 패턴사이의 간격은 60nm였다. 형성된 패턴을 실리콘 산화막 위에 전사시키기 위해 불소 기반의 화학 반응성 식각을 사용하였다. 실리콘 산화막에 형성된 기공의 지름은 $9{\sim}33nm$였다. 실리콘 산화막을 불산으로 제거하여 실리콘에 형성된 기공을 관찰하였고, 실리콘기판에 형성된 기공의 지름은 $6{\sim}22nm$였다. 형성된 기공의 크기는 폴리메틸메타아크릴레이트의 분자량과 관계가 있음을 알 수 있었다.

• 반도체디스플레이기술학회지
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• 제22권2호
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• pp.1-5
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• 2023

In the past, display devices have undergone many changes, such as plasma TVs and LCDs, and have continued to develop. Recently, new display technologies, such as Organic Light Emitting Diode displays and Inorganic Light Emitting Diode displays, have been developed. Among them, Micro LED displays have the potential to improve performance more than LCDs and OLEDs, but a lot of effort and time are needed until the mass production technology (transfer and bonding) of Micro LED displays is developed. We have developed a new Micro LED display light source that can be produced using existing transfer and bonding process technologies to enable faster commercialization of Micro LED in the industry. This light source is TFT deposition on LED. TFT deposition on LED has the advantage of being able to produce displays using existing process technology, making early commercialization of display application products possible. In this study, we applied the Active Driving method to verify the performance of TFT deposition on LED as a display to determine its commercialization potential. Additionally, to facilitate faster application of Micro LED in the industry, we applied TFT deposition on LED to Optical Wireless Communication systems, which are widely used in application service areas such as safety/security and sensors, to verify its communication performance. The experimental results confirmed that TFT deposition on LED is not only capable of AM driving but can also be applied to OWC systems.

• 한국콘텐츠학회논문지
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• 제11권12호
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• pp.814-821
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• 2011

256 다중 검출기 전산화단층촬영 (multi detector computed tomography, MDCT)에서 두개부 전용 팬톰을 이용하여 분해능 파라메터와 재구성 필터의 영상 품질을 평가하고자 하였다. 사용한 장비는 256 MDCT 을 사용하였으며 philips system head phantom을 이용하여 Extended Brilliance Workspace에서 영상의 질 평가를 측정하였다. 장비에서 지원하고 있는 분해능 파라메터와 재구성 필터가 화질에 미치는 영향을 알아보기 위해서 검사조건을 $512{\times}512$ matrix, $128{\times}0.625$ mm beam collimation, 120 kVp, 250 mAs, 0.5 sec, 250 mm field of view (FOV), 절편 두께와 절편 간격은 5 mm, 1.0 pitch로 동일하게 적용하였다. 분해능 파라메터은 'Standard', 'High', 'Ultrahigh'로 구분하여 적용하였으며, 재구성 필터는 'A', 'B', 'C', 'D', 'UA', 'UB', 'UC' 등으로 바꿔가면서 영상을 재구성하여 노이즈, 균일도, 직선성, 변조전달함수 (modulation transfer function, MTF)의 50%와 10%를 측정하였다. 그 결과 'High' 분해능은 균일도, 직선성, MTF 50%와 10%에서 우수하였다. 'UA', 'UB' 재구성 필터는 균일도와 노이즈 평가에서 양호했으며 'C'재구성 필터는 직선성과 MTF 50%와 10%에서 양호하였다.

• 전자공학회논문지CI
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• 제48권1호
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• pp.90-100
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• 2011

본 연구에서는 연산 부하가 매우 큰 Bio-FET 시뮬레이션을 위해 낮은 비용으로 대규모 병렬처리 환경 구축이 가능한 최신 그래픽 프로세서(GPU)를 이용해서 선형 방정식 해법을 수행하기 위한 병렬 Bi-CG(Bi-Conjugate Gradient) 방식을 제안한다. 제안하는 병렬 방식에서는 반도체 소자 시뮬레이션, 전산유체역학(CFD), 열전달 시뮬레이션 등을 포함한 다양한 분야에서 많은 연산량이 집중되어 전체 시뮬레이션에 필요한 시간을 증가시키는 포아송(Poisson) 방정식의 해를 병렬 방식으로 구한다. 그 결과, 이 논문의 테스트에서 사용된 FDM 3차원 문제 공간에서 단일 CPU 대비 연산 속도가 최대 30 배 이상 증가했다. 실제 구현은 NVIDIA의 태슬라 아키텍처(Tesla Architecture) 기반 GPU에서 범용 목적으로 병렬 프로그래밍이 가능한 NVIDIA사의 CUDA(Compute Unified Device Architecture) 환경에서 수행되었으며 기존 연구가 주로 32 비트 정밀도(single floating point) 실수 범위에서 수행된 것과는 달리 본 연구는 64 비트 정밀도(double floating point) 실수 범위로 수행되어 Bi-CG 해법의 수렴성을 개선했다. 특히, CUDA는 비교적 코딩이 쉬운 반면, 최적화가 어려운 특성이 있어 본 논문에서는 제안하는 Bi-CG 해법에서의 최적화 방향도 논의한다.

• 수산해양기술연구
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• 제20권1호
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• pp.43-48
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• 1984

본 연구에서는 보의 전달매트릭스법을 적용함에 있어서 균일단면보의 분할방법과 이에 의한 수치계산의 결과를 엄밀해에 비교하여, 가장 가까운 값을 얻을 수 있는 방법을 제시하고, 이를 불균일단면을 가지거나, 여기에 임의의 하중이 작용하는 보에도 적용하여, 수치계산의 결과를 실험치와 비교하였다. 또한 진동수 방정식의 근사해를 구하기 위한 3가지 반복법에 대해 그 실용성을 검토하여 가장 효율적인 방법을 아울러 제시하였다. 그 결과를 요약하면 다음과 같다. 1. 균일단면에 있어서 질량의 분배방법은 방법 3이 가장 정도가 좋으며 이 경우 분할수 6이상이면 어떠한 경계조건에서든지 엄밀해에 거의 일치한다. 2. 상기1의 분할수 및 질량의 분배방법은 불균일단면을 가지거나 임의의 위치에 임의의 하중이 작용하는 경우에도 그대로 적용할 수 있다. 3. 진동수 방정식의 근사해를 구하는 반복법은 FPM이 가장 효율적이다. 4. 질량분배에 대한 방법 3과 FPM을 조합하여 수치계산을 행함으로써 종래의 전달매트릭스법에 비해 연산시간을 훨씬 단축시킬 수 있다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.2913-2917
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• 2007

Turbocharger has been widely used in many passenger cars in application with diesel engines because of high power and fuel efficiency. However, flow-induced noise (whoosh or hissing noise) which is generated within the compressor during its operation at marginal surge line can deteriorate noise characteristics. Hissing noise excitation was associated with the generation of turbulence within the turbocharger compressor and radiated through the transmission path in turbocharger system. In this study, a sharp-edged reactive-type muffler was devised and installed in the transmission path to reduce the hissing noise. Acoustic and fluid dynamic characteristics for the muffler were investigated which is related to the unsteadiness of turbulence and pressure in turbocharger system. A transfer matrix method was used to analyze the transmission loss of the muffler. Simple expansion muffler with extended tube of the reactive type is proposed for the reduction of high frequency component noise. Turbulence computation was carried out by a standard ${\kappa}-{\varepsilon}$ model. An optimal design condition of the muffler was obtained by extensive acoustic and fluid dynamic analysis on the engine dynamometer with anechoic chamber. A significant reduction of the hissing noise was achieved at the optimal design of the muffler as compared with the conventional turbocharger system.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2002년도 춘계학술발표대회 논문집
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• pp.69-72
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• 2002

The high temperature deformation behavior of SiCp/2124Al composite and 2124Al alloy was investigated by hot compression test in a temperature ranged $400~475^{\circ}C$ over a strain rate ranged $10^{-3}~1s^{-1}$. The billets of 2124Al alloy and SiCp/2124Al composite were fabricated by vacuum hot pressing process. The stress-strain curve during high temperature deformation exhibited a peak stress, and then the flow stress decreased gradually into a steady state stress with increasing the strain. It was found that the flow-softening behavior was attributed to the dynamic recovery, local dynamic recrystallization and dynamic precipitation during the deformation. The precipitation phases were identified as S' and S by TEM diffraction pattern. Base on the TEM inspection, the relationship between the Z-H parameter and subgrain size was found based on the experiment data. The dependence of flow stress on temperature and strain rate could be formulated well by a hyperbolic-sinusoidal relationship using the Zener-Hollomon parameter.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 춘계학술대회논문집
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• pp.925-934
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• 2005

The dynamic response due to the unbalance and crack and the quasi-static response due to gravity are analytically derived based on the complex transfer matrix. The additional slope is expressed as function of the bending moment at crack position based on the fracture mechanics concept, and inversely the bending moment is expressed as function of the additional slope at the crack position. At each angle step during the shaft revolution, the additional slope and bending moment are calculated by an iterative method. The transient behavior is considered by introducing Fourier series expansion concept for the additional slope. Simulation is carried out for a simple rotor similar to those available in the literature and comparison of the basic crack behavior is shown. Using the additional slope, the cracked rotor behavior is explained with the crack depth increased: the magnitude of the additional slope increases and the closed crack duration during a revolution decreases as the crack depth increases. The direction of unbalance is also shown as a factor to affect the crack breathing. Whirl orbits are shown near the sub-critical speed ranges of the rotor.

• International Journal of Control, Automation, and Systems
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• 제3권spc2호
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• pp.322-333
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• 2005

This paper proposes a combination of the Thyristor Controlled Series Capacitor (TCSC) and Static Var Compensator (SVC) installation for enhancing the damping performance of a power system. The developed scheme employs a damping controller which coordinates measurement signals with control signals to control the TCSC and SVC. The coordinated control method is based on the application of projective controls. Controller performance over a range of operating conditions is investigated through simulation studies on a single-machine infinite-bus power system. The linear analysis and nonlinear simulation results show that the proposed controller can significantly improve the damping performance of the power system and hence, increase its power transfer capabilities. In this paper, a current injection model of TCSC is developed and incorporated in the transmission system model. By using equivalent injected currents at terminal buses to simulate a TCSC no modification of the bus admittance matrix is required at each iteration.