• Journal of Chest Surgery
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• 제7권1호
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• pp.109-116
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• 1974

Eleven cases of peripheral arterial injuries treated at Korea University Woo Sok Hospital during these 3 years and 3 months from Feb. 1971Eleven cases of peripheral arterial injuries treated at Korea University Woo Sok Hospital during these 3 years and 3 months from Feb. 1971 to May 1974 were reviewed. Common causes of injuries were stab wound, automobile accidents and iatrogenic injuries during operation. Of the 11 arterial injuries 3 were femoral artery which` was the commonest in frequency and the next was 2 cases of brachial artery. The most frequent type of injury was transection. Laceration, contusion and spasm was also recognized. The need to operate immediately following an injury was emphasized. Operative procedures were end to end anastomosis and saphenous vein graft in 5 and 2 cases, respectively. Other cases were undergone multiple suture ligature due to staphyllococcal infection, insertion of polyethylene catheter, and lateral suture after thromboendarterectomy. Fractures and extensive soft tissue damage associated with arterial injuries with widespread destruction of the collateral circulation aggravated the situation and complicated the amputation of lower extremity in 4 cases. The factors influencing the amputation were time lag, presence of associated injuries and complications.[KTCS 1974;1:109-116] Common causes of injuries were stab wound, automobile accidents and iatrogenic injuries during operation. Of the 11 arterial injuries 3 were femoral artery which` was the commonest in frequency and the next was 2 cases of brachial artery. The most frequent type of injury was transection. Laceration, contusion and spasm was also recognized. The need to operate immediately following an injury was emphasized. Operative procedures were end to end anastomosis and saphenous vein graft in 5 and 2 cases, respectively. Other cases were undergone multiple suture ligature due to staphyllococcal infection, insertion of polyethylene catheter, and lateral suture after thromboendarterectomy. Fractures and extensive soft tissue damage associated with arterial injuries with widespread destruction of the collateral circulation aggravated the situation and complicated the amputation of lower extremity in 4 cases. The factors influencing the amputation were time lag, presence of associated injuries and complications.

• 한국임상수의학회지
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• 제27권3호
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• pp.295-298
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• 2010

5살의 중성화된 수컷 풍산 개가 서혜부에 지속적인 출혈 증상으로 내원하였다. 내원 5일 전에 멧돼지에게 공격을 받은 병력을 가지고 있었으며, 양성 요도 조영술에서 막성 요도의 파열과 요도 피부 누공이 있음을 확인 하였다. 수술 중 요도 카테터를 장착하여서 요도와 요도 피부 누공을 확인 하였고, 오줌의 누출로 인해 발생한 괴사 조직과 손상된 조직을 제거 하였다. 요도 카테터를 장착하여 요도 문합술을 실시하였다. 술 후 한달 째 배뇨장애나 혈뇨 증상이 없이, 정상적인 배뇨를 유지하였으며, 수술 후 2 달째 실시한 역행성 양성 요도 조영술에서 요도 협착 소견을 보이지 않았다.

• Journal of Microbiology and Biotechnology
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• 제22권2호
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• pp.274-282
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• 2012

The object of this study was to assess the efficacy of Polycan from Aureobasidium pullulans SM-2001, which is composed mostly of beta-1,3-1,6-glucan, on osteoarthritis (OA)-induced by anterior cruciate ligament transection and partial medial meniscectomy (ACLT&PMM). Three different dosages of Polycan (85, 42.5, and 21.25 mg/kg) were orally administered once a day for 84 days to male rats a week after ACLT&PMM surgery. Changes in the circumference and maximum extension angle of each knee, and in cartilage histopathology were assessed using Mankin scores 12 weeks after Polycan administration. In addition, cartilage proliferation was evaluated using bromodeoxyuridine (BrdU). As the result of ACLT&PMM, classic OA was induced with increases in maximum extension angles, edematous knees changes, and capsule thickness, as well as decreases in chondrocyte proliferation, cartilages degenerative changes, and loss of articular cartilage. However, these changes (except for capsule thickness) were markedly inhibited in all Polycan- and diclofenac sodium-treated groups compared with OA control. Although diclofenac sodium did not influence BrdU uptake, BrdU-immunoreactive cells were increased with all dosages of Polycan, which means that Polycan treatment induced proliferation of chondrocytes in the surface articular cartilage of the tibia and femur. The results obtained in this study suggest that 84 days of continuous oral treatment of three different dosages of Polycan led to lesser degrees of articular stiffness and histological cartilage damage compared with OA controls 91 days after OA inducement, suggesting that the optimal Polycan dosage to treat OA is 42.5 mg/kg based on the present study.

• Journal of Microbiology and Biotechnology
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• 제31권10호
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• pp.1401-1408
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• 2021

This study examined whether the oral administration of low-molecular-weight collagen peptide (LMCP) containing 3% Gly-Pro-Hyp with >15% tripeptide (Gly-X-Y) content could ameliorate osteoarthritis (OA) progression using a rabbit anterior cruciate ligament transection (ACLT) model of induced OA and chondrocytes isolated from a patient with OA. Oral LMCP administration (100 or 200 mg/kg/day) for 12 weeks ameliorated cartilage damage and reduced the loss of proteoglycan compared to the findings in the ACLT control group, resulting in dose-dependent (p < 0.05) improvements of the OARSI score in hematoxylin & eosin (H&E) and Safranin O staining. In micro-computed tomography analysis, LMCP also significantly (p < 0.05) suppressed the deterioration of the microstructure in tibial subchondral bone during OA progression. The elevation of IL-1β and IL-6 concentrations in synovial fluid following OA induction was dose-dependently (p < 0.05) reduced by LMCP treatment. Furthermore, immunohistochemistry illustrated that LMCP significantly (p < 0.05) upregulated type II collagen and downregulated matrix metalloproteinase-13 in cartilage tissue. Consistent with the in vivo results, LMCP significantly (p < 0.05) increased the mRNA expression of COL2A1 and ACAN in chondrocytes isolated from a patient with OA regardless of the conditions for IL-1β induction. These findings suggest that LMCP has potential as a therapeutic treatment for OA that stimulates cartilage regeneration.

• 한국임상수의학회지
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• 제30권5호
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• pp.346-352
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• 2013

본 연구는 다이오드레이저가 골관절염에 주는 영향을 평가하기 위해 실시되었다. 연구에는 10주령의 수컷 Sprague-Dawley 랫드 60마리를 사용하였고 전십자인대의 절단 (ACLT)으로 골관절염을 유발하였다. 대조군, sham군, ACLT군, ACLT와 레이저조사를 병행한 군 (ACLT+L), ACLT와 meloxicam 투약을 병행한 군 (ACLT+M)의 다섯 개의 실험군으로 나누어 연구를 진행하였다. 8주간의 연구 기간 동안 808-nm indium-gallium-arsenide (InGaAs) 다이오드레이저 조사 방법으로 Low-level laser therapy (LLLT)를 일주일에 두 번 랫드의 수술 한 오른쪽 다리에 조사하였다. 수술 후 2주, 4주, 8주에 방사선학적, 형태학적, 조직병리학적 평가를 실시하였다. 8주에 실시한 방사선학적 평가와 일반 혈액검사, 혈청 화학 검사에서는 군 간의 유의한 차이가 나타나지 않았다. 형택학적 방법과 조직병리학적 방법으로 수술 후 2주, 4주, 8주의 ACLT+L 군과 sham 군을 비교 했을 때 ACLT+L 군에서 유의하게 연골의 손상정도가 높은 것으로 나타났다. ACLT+M 군 또한 sham 군과 비교했을 때 연골의 손상이 심한 것으로 나타났다. LLLT는 ACLT 모델에서 골관절염을 예방하는 효과는 제한적이었으며, 오히려 연골의 손상을 가속화 시키는 것으로 평가 되었다. LLLT가 세포의 생존에는 영향을 주지 않으므로 레이져에 의한 직접적인 연골손상 발생보다는 레이저의 통증완화효과로 인해 불안정한 무릎관절을 계속해서 사용함으로써 연골의 손상이 가속화 된 것으로 생각 된다.

• Journal of Chest Surgery
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• 제27권9호
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• pp.793-797
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• 1994

Constrictive pericarditis is often accompanied with ~brothorax and deterioration of cardiac, hemodynamic functions. Surgical relief of fibrous peel causes remarkable improvement in pulmonary, cardiac, hemodynamic function, and subjective symptoms. We experienced 4 cases of constrictive pericarditis combined with bilateral ~brothorax after bilateral pleural effusion caused by tuberculosis and non-specific inflammation. Pleural decortication and pericardiectomy were done at the same time through anterolateral thoracotomy with sternal transection[3 patients] and median sternotomy incision[l patient]. Low cardiac output was the most common complication. With left anterolateral thoracotomy, we could prevent the hypotension from massive retraction for dissecting by median sternotomy, which was good for dissecting from anterior wall of left ventricle to posterior wall of left ventricle and surrounding phrenic nerve. It was enough to dissect the portion being through hard to dissect, right atrium, SVC and IVC.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.279-283
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• 2001

Cationic lipid emulsion system consisting of 1, 2-dioleoyl-sn-slycero-3-trimethyl-ammonium-propane(DOTAP) and plasmin DNA with various counterions in the lipid headgroups were prepared. The transfection activity of the cationic lipid emulsion systems was then investigated in vitro and in vivo. The complex formation of plasmid DNA lipid emulsion was affected by the counterions through charged headgroup repulsion and also by the salt concen-tration in the media. As such , the transfection activity of the DOTAP emulsion system can be controlled by changing the counterions.

• Journal of Chest Surgery
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• 제18권3호
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• pp.461-465
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• 1985

Rupture of the aorta following blunt trauma of the thorax may occur more frequently than has generally been recognized. Actual complete transection of the aorta usually results in immediate death but varying degrees of lesser disruption permit increased chance of survival. Chronic traumatic aneurysms are so designated following a period of 3 months from the traumatic incident. The exact time required for the acute process and hematoma to convert into an aneurysm is unknown. Because a thoracic surgeon encounters so few of these aneurysms, it is difficult for him to arrive at sound dicta of management from his personal experience. It is not surprising that controversy exists concerning the therapeutic approach to the aneurysm which is asymptomatic and is discovered months or years after the causative injury. In the hope of improving the surgical treatment of patients with this condition, we reported one case with chronic traumatic aneurysm of the descending thoracic aorta.

• Advances in pediatric surgery
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• 제2권2호
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• pp.100-101
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• 1996

Infantile hypertrophic pyloric stenosis is one of the most common disorders requiring surgical therapy during the first few weeks of life. Although the pyloromyotomy, reported by Fredet and Ramstedt, was accepted as a standard procedure of choice, various laparotomy incisions have been reported by several authors. Currently, the most commonly used transverse or right upper quadrant incisions, offer many advantages, but is not without drawbacks. The authors utilized the circumumbilical skin incision and upper subcutaneous dissection followed by vertical division of linea alba in 16 cases of infantile hypertrophic pyloric stenosis. This incision avoids transection of rectus muscle and offers a much better cosmetic result. We prefer this procedure because of acceptable scar and no additional wound complication.

• 한국임상수의학회지
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• 제31권1호
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• pp.61-65
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• 2014

The study aimed at determining the feasibility of three portal totally Laparoscopic cryptorchidectomy in small breed dogs. Four right sided and one left sided abdomen retained testicles in five dogs weighing 2.2~8.7 kg were retrieved successfully. Pampiniform plexus and vas deference were ligated and transected with Hem-o-lock/monopolar electrocauterization (1/5), or ultrasonic scalpel (4/5) and the latter provided more easy, quick and safe hemostasis and transection. The resected testis was easily removed through a insertion site. Mean surgical time was $19.9{\pm}15.2$ minutes and when the abdominal cavity was explored again, there were no major complications. The patient recovered favorably without unwilling events. This is the case report of laparoscopic cryptorchidectomies in small breed dogs weigh less than 10 kg. Laparoscopic cryptorchidectomy could be considered as an alternative in small animal surgery.