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Influence of Diode Laser (808 nm) on a Rat Anterior Cruciate Ligament Transection Model of Osteoarthritis  

Park, Seongkyu (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Minar, Maruf (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Hwang, Yawon (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Kim, Somin (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Park, Minhyeok (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Choi, Seok-Hwa (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Kim, Gonhyung (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University)
Publication Information
Journal of Veterinary Clinics / v.30, no.5, 2013 , pp. 346-352 More about this Journal
Abstract
The study was aimed to investigate the influence of diode laser on osteoarthritis (OA) of stifle joint induced by anterior cruciate ligament transection (ACLT). Sixty 10-week-old male Sprague-Dawley rats were used in this study. Right stifle joint was operated to create ACLT or sham. There were five study groups: control, Sham, ACLT, ACLT + Laser irradiation (ACLT+L) and ACLT + meloxicam administration (ACLT+M). Low-level laser therapy (LLLT) was applied at the operated stifle joint twice a week using an 808-nm indium-gallium-arsenide (InGaAs) diode laser during 8-week experimental period. Radiographical, gross morphological and histopathological findings were examined at 2, 4 and 8 weeks post-surgery. Radiography, CBC and chemistry tests showed no significant difference between groups. ACLT+L group showed remarkable cartilage damages compared with sham group morphologically and histopathologically at 2, 4 and 8 weeks after surgery. ACLT+M group also had more cartilage damages compared with sham group. Low-level laser therapy (LLLT) showed limitation to prevent progression of OA in the rat anterior cruciate ligament transection models; on the contrary it accelerated cartilage damage. It is assumed that the aggravating results of LLLT in this study might be due to excessive unstable movement of stifle joint from the pain-relieving effect of LLLT, rather than direct damaging effect of irradiation since LLLT did not affect cell viability.
Keywords
osteoarthritis; low-level laser therapy; anterior cruciate ligament transection; pain-relieving effect;
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1 Brosseau L, Welch V, Wells G, Tugwell P, de Bie R, Gam A, Harman K, Shea B, Morin M. Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis. J Rheumatol 2000; 27: 1961-1969.
2 Almeida-Lopes L, Rigau J, Zangaro RA, Guidugli-Neto J, Jaeger MM. Comparison of the low level laser therapy effects on cultured human gingival fibroblasts proliferation using different irradiance and same fluence. Lasers Surg Med 2001; 29: 179-184.   DOI
3 Arzi B, Wisner ER, Huey DJ, Kass PH, Hu J, Athanasiou KA. A proposed model of naturally occurring osteoarthritis in the domestic rabbit. Lab Anim (NY) 2012; 41: 20-25.   DOI
4 Bjordal JM, Couppe C, Chow RT, Tuner J, Ljunggren EA. A systematic review of low level laser therapy with locationspecific doses for pain from chronic joint disorders. Aust J Physiother 2003; 49: 107-116.   DOI
5 Carmona L, Ballina J, Gabriel R, Laffon A. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey. Ann Rheum Dis 2001; 60: 1040-1045.   DOI
6 Cho HJ, Lim SC, Kim SG, Kim YS, Kang SS, Choi SH, Cho YS, Bae CS. Effect of low-level laser therapy on osteoarthropathy in rabbit. In Vivo 2004; 18: 585-591.
7 Hayami T, Pickarski M, Wesolowski GA, McLane J, Bone A, Destefano J, Rodan GA, Duong le T. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum 2004; 50: 1193-1206.   DOI
8 Demirag B, Aydemir F, Danis M, Ermutlu C. Incidence of meniscal and osteochondral lesions in patients undergoing delayed anterior cruciate ligament reconstruction. Acta Orthop Traumatol Turc 2011; 45: 348-352.
9 Esteves Junior I, Masson IB, Oshima CT, Paiotti AP, Liebano RE, Plapler H. Low-level laser irradiation, cyclooxygenase-2 (COX-2) expression and necrosis of random skin flaps in rats. Lasers Med Sci 2012; 27: 655-660.   DOI
10 Freire M, Robertson I, Bondell HD, Brown J, Hash J, Pease AP, Lascelles BD. Radiographic evaluation of feline appendicular degenerative joint disease vs. Macroscopic appearance of articular cartilage. Vet Radiol Ultrasound 2011; 52: 239-247.   DOI
11 Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong le T. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 2006; 38: 234-243.   DOI
12 Henson FM, Vincent TA. Alterations in the vimentin cytoskeleton in response to single impact load in an in vitro model of cartilage damage in the rat. BMC Musculoskelet Disord 2008; 9: 94.   DOI
13 Huang YY, Chen AC, Carroll JD, Hamblin MR. Biphasic dose response in low level light therapy. Dose Response 2009; 7: 358-383.   DOI
14 Jia YL, Guo ZY. Effect of low-power He-Ne laser irradiation on rabbit articular chondrocytes in vitro. Lasers Surg Med 2004; 34: 323-328.   DOI
15 Karu TI, Pyatibrat LV, Kalendo GS, Esenaliev RO. Effects of monochromatic low-intensity light and laser irradiation on adhesion of HeLa cells in vitro. Lasers Surg Med 1996; 18: 171-177.   DOI
16 Impellizeri JA, Tetrick MA, Muir P. Effect of weight reduction on clinical signs of lameness in dogs with hip osteoarthritis. J Am Vet Med Assoc 2000; 216: 1089-1091.   DOI
17 Jansen EJ, Emans PJ, Van Rhijn LW, Bulstra SK, Kuijer R. Development of partial-thickness articular cartilage injury in a rabbit model. Clin Orthop Relat Res 2008; 466: 487-494.   DOI
18 Lee BS, Lin, Y.W., Chia, J.S., Hsieh, T.T., Chen, M.H., Lin, C.P., Lan, W.H. Bactericidal effects of diode laser on Streptococcus mutans after irradiation through different thickness of dentin. Laser Surg Med 2006; 38: 62-69.   DOI
19 Lin YS, Huang MH, Chai CY. Effects of helium-neon laser on the mucopolysaccharide induction in experimental osteoarthritic cartilage. Osteoarthritis Cartilage 2006; 14: 377-383.   DOI
20 Mayahara K, Yamaguchi A, Sakaguchi M, Igarashi Y, Shimizu N. Effect of Ga-Al-As laser irradiation on COX-2 and cPLA2-alpha expression in compressed human periodontal ligament cells. Lasers Surg Med 2010; 42: 489-493.   DOI
21 Messner K, Fahlgren A, Ross I, Andersson B. Simultaneous changes in bone mineral density and articular cartilage in a rabbit meniscectomy model of knee osteoarthrosis. Osteoarthritis Cartilage 2000; 8: 197-206.   DOI
22 Soffa AJ, Markel MD, Converse LJ, Massa KL, Bogdanske JJ, Dillingham MF. Treatment of inflammatory arthritis by synovial ablation: a comparison of the holmium: YAG laser, electrocautery, and mechanical ablation in a rabbit model. Lasers Surg Med 1996; 19: 143-151.   DOI
23 Mester E, Mester AF, Mester A. The biomedical effects of laser application. Lasers Surg Med 1985; 5: 31-39.   DOI
24 Ulugol A, Unalan H, Dokmeci I, Kokino S. Comparison of the effects of tenoxicam and mid-laser irradiation on chronic adjuvant arthritis in rats. Clin Exp Rheumatol 1997; 15: 83-86.
25 Pelletier JP, Lajeunesse D, Hilal G, Jovanovic D, Fernandes JC, Martel-Pelletier J. Carprofen reduces the structural changes and the abnormal subchondral bone metabolism of experimental osteoarthritis. Osteoarthritis Cartilage 1999; 7: 327-328.   DOI
26 Sakurai Y, Yamaguchi M, Abiko Y. Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 2000; 108: 29-34.   DOI
27 Son J, Kim YB, Ge Z, Choi SH, Kim G. Bone healing effects of diode laser (808 nm) on a rat tibial fracture model. In Vivo 2012; 26: 703-709.
28 Wu JY, Wang YH, Wang GJ, Ho ML, Wang CZ, Yeh ML, Chen CH. Low-power GaAlAs laser irradiation promotes the proliferation and osteogenic differentiation of stem cells via IGF1 and BMP2. PLoS One 2012; 7: e44027.   DOI