• 한국한의학연구원논문집
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• 제10권1호
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• pp.81-95
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• 2004

The discussion of intellectual property protection with TK, GR in WIPO begin Herbal medicines get a important basis in a development of modern new medicine. For the protection of intellectual property, we set up this study. For the protection of intellectual property with herbal medicines, We analyze as follows. First, we analyze the specific theory and character of traditional herbal medicines. Second, we analyze the existing system on protecting them in Korea. The intellectual property protection with herbal medicines must maintain the specific character of that. We must select the basic traditional herbal medicines. The next, we must protect from intellectual property on add and subtract, combine, create of the traditional herbal medicines. In order that we must construct database on the Herbal medicines.

• 동의생리병리학회지
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• 제18권5호
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• pp.1387-1390
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• 2004

This study was carried out to investigate the solubility of the ingredients of the bilestone in the solution of the traditional oriental medicines. The cholesterol and the calcium carbonate(CaCO₃) were chosen as the ingredients of the bilestone. Coicis Semen, Polygonum aviculare L, Maydis Stigmata, Allium tuberosum Rottler, and Raphanus sativa var. hortensis for. acanthiformis Makino were studied as the oriental medicines for the bilestone. The cholesterol had showed no solubility in all solutions of the traditional oriental medicines, but the calcium carbonate had showed the good solubility in all solutions of the traditional oriental medicines except Coicis Semen.

• Natural Product Sciences
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• 제17권1호
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• pp.33-37
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• 2011

The plant species reported here are used by traditional healers in Gabon for different ailments such as wounds, malaria, fever, gonorrhea or diarrhea. The aim of this study was to evaluate the antimicrobial activities of 7 plants (Strombosiopsis tetrandra, Tetraberlinia bifoliolata, Dichapetalum barbatum, Guibourtia demeusii, Dacryodes normandii, Manniophytum fulvum, Paropsia grewoides) against different strains of both Methicillin-Resistant Staphylococcus aureus (MRSA) and Salmonella. Disc diffusion was first used to determine the antimicrobial effectiveness of the plants' ethanolic extracts. Then the minimum inhibitory concentrations of the crude extracts of either leaves or stem barks of the 7 plants were determined using broth micro-dilution. The ethanolic plant extracts showed very good activity against both MRSA and Salmonella strains where the MICs ranged from $250\;{\mu}g/ml$ to $1000\;{\mu}g/ml$. The study shows that many of the tested plants used by Gabonese traditional healers have antimicrobial activities and give support to their traditional use.

• 대한예방한의학회지
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• 제5권1호
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• pp.57-75
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• 2001

This study was conducted to improve the current regulation guidelines for developing traditional Korean medicines with effectiveness and productivity, in order to cope with the upcoming ICH on specifications on oriental herbal drugs. Also, major purposes of this study are to motivate R&D and to pioneer foreign markets for domestic herbal drug companies. First, after examining concepts of traditional Korean medicines and comparing the numbers and differentiation of herbal drugs registered on Pharmacopeia among Korea, China, and Japan, the current new drug development requirements for traditional Korean medicines were reviewed in detail, followed by comparison of foreign regulation systems including USA, EU, China, and Japan. Second, empirical cases on failure of development for new traditional Korean medicines under the current regulation system in the domestic companies including Dong-A, Kwangdong, and Samchondang, were collected and analyzed. As a result, hanbangsaengyak, the new category for traditional Korean medicines was newly developed on the basis of scientification of data between saengyak and hanyak, from the perspectives of harmonization between oriental medicine and western medicine and of balance between food and drug, in terms of industrialization, publicity, modernization, and effectiveness of administration. In addition, the new regulation requirements for the new hanbangsaengyak preparations were discussed by establishing principles of reinforcing preclinical test and of simplifying clinical trials in Korea. Finally, the further researches to articulate the complete specifications for pre-clinical and clinical requirements for traditional Korean medicines were strongly suggested.

• Advances in Traditional Medicine
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• 제1권1호
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• pp.1-7
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• 2000

Although Oriental medicines have long been used effectively in treating many diseases throughout the world, the pharmacological mechanisms of most Oriental medicines used have not been defined. As part of our continuing search for biologically active antiallergic drugs from natural sources, Oriental medicines were analyzed. Some Oriental medicines have been used against various allergic diseases for generations, and still occupies an important place in traditional medicine in Korea. It is also still unclear how Oriental medicine prevents allergic disease in experimental animal models. Some Korean folk medicines inhibited the mast cell-mediated allergic reaction. This review summarizes the effective folk medicine in experimental effect of allergic reaction. Potential antiallergic folk medicines include: Poncirus trifoliata; Siegesbeckia glabrescence; Solanum lyratum; Aquilaria agallocha; Ulmi radicis; Polygonum tinctorium; Hwanglyun-Haedok-Tang; Rehmannia glutinosa; Kum- Hwag-San; Syzygium aromaticm; Spirulina platensis; Sosiho-Tang; Sinomenium acutum; Schizonepta tenuifolia; Shini-San; Magnoliae flos; Sochungryoung-Tang; Oryza sativa; Cryptotympana atrata; Salviae radix; Rosa davurica; Asiasari radix; Chung-Dae-San; and Cichorium intybus. Understanding the mechanisms of action for these Oriental medicines can permit drug development and laying of the ground-work for evaluating potential synergistic effects by addition and subtraction of prescriptions.

• Journal of Evidence-Based Herbal Medicine
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• 제1권2호
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• pp.35-43
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• 2008

Herbal medicines have an accurate effect on atopic dermatitis, and at the same time, they hardly have adverse reactions. However, herbal medicines are difficult to be quantitatively analyzed due to low-quality preparation and types. In addition, herbal medicines have raised many problems as they have not been standardized and their active components have not been analyzed. Patients with atopic dermatitis began to recognize the effectivity and safety of herbal medicines. Accordingly, standardization, biological analyses, animal experiments and clinical trials should be generally performed in order that herbal medicines may be recognized all over the world. A standard, which is to objectively judge the curative effect of atopic dermatitis, should be established as soon as possible. Case studies and RCTs (Randomized Controlled Trials) should be actively performed on the basis of rigid clinical trial design to the end that the curative effect of herbal medicines is recognized all the world over.

• 동의생리병리학회지
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• 제17권6호
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• pp.1528-1532
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• 2003

To investigate the antioxidant capacity of traditional Korean medicines, water extracts from 57 species were tested on their antioxidant activity using radical scavenging effects against ABTSㆍ+. Of which, Rhus javanica, Caesalpinia sappan, Rosa rugosa, Spatholobus suberectus, and Magnolia obovata showed strong antioxidant capacities at 10㎍ concentration. Therefore, antioxidant capacities of 5 traditional medicine extracts in the different concentration (1㎍, 5㎍, and 10㎍) were determined. The 5 traditional medicine extracts was detected in antioxidant capacity dose dependently. R. javanica was showed the highest antioxidant capacity, the antioxidant activity at 1 ㎍ of herbal extract being 0.85 mM TE. At the same time, the antiperoxidation effects of these 5 medicines were determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was strong inhibited by S, suberectus, R. rugosa, and M. obovata. Extract of C. sappan was showed the highest inhibition against lipid peroxidation compared with 4 herbal extracts in vitro. These traditional medicines are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders such as Alzheimer's disease.

• 동의생리병리학회지
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• 제16권4호
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• pp.707-713
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• 2002

Astragali radix (AR) is one of the oldest and mast frequently used crude drug for traditional medicine in many Asian countries. This study designed to investigate the hepatoprotective effects of the aqueous extracted AR (ARE) against acetaminophen (APAP)-induced hepatic damage in ICR mice. APAP at the dose of 450 mg/kg i.p produced liver damage in ICR mice. Serum enzyme activities of alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenese was dramatically decreased up to control level by pretreatment of ARE. However, hepatic glutathione level did not show a significant change between the tested groups. We also investigated TNF α mRNA gene expression on APAP-induced liver damage by RT-PCR. APAP dramatically induced TNF α mRNA gene expression in ICR mice. Pretreatment of mice with ARE led to a marked decrease of TNF α mRNA gene expression. These data indicate that 1) ARE has clearly revealed a hepatoprotective effect against APAP-induced hepatic damage in ICR mice, and 2) the protective effect of ARE may be, in part, associated with the regulation of TNF α mRNA gene expression.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.17-28
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• 2011

This study was conducted to analyze the status of the traditional medicines registered by the Chinese state as intangible cultural heritages, and of Chinese acupuncture and moxibustion registered by UNESCO as world intangible cultural heritages in 2010, in connection with the need to have Traditional Korean Medicine skills similarly registered as world intangible cultural heritage items. Since UNESCO's adoption of the Convention on the Safeguarding of Intangible Cultural Heritages in 2003, the Chinese government has pushed ahead with efforts to explore and protect intangible cultural heritage items and have them registered as world intangible cultural heritages. Thus, Benchaogangmu (本草綱目) and Huangdineijing (黃帝內經) were listed on UNESCO's Memory of the World Register while Chinese acupuncture and moxibustion were registered as world intangible cultural heritage properties. For Traditional Korean Medicine skills to be listed as world intangible cultural heritage properties, steps should be taken first to include the skills in the list of domestic intangible cultural heritage items and to make further explorations in the sector. Such efforts are also important in terms of the need to establish the legitimacy of Traditional Korean Medicines.

• 한국한의학연구원논문집
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• 제14권3호
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• pp.173-182
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• 2008

"EuiBangShinGam" is a classic on oriental medicines written by Han Byung Lyun with the pen name Shin Oh in 1913. It was written under the base of the writer's own experience as well as in the light of 36 other classics on oriental medicines such as "DongEuiBoGam", Introduction to Medicine, and Complete Works of Jingyue. In an attempt to avoid difficult theories and list only the essential informations and formulas for clinical purposes, it attained its own characteristics of not only reorganizing DongEuiBoGam in a pragmatic way but also explaining diseases classified in western medicines in oriental medicines' point of view as well as suggesting medicine formulas regarding such explanations. As a result, it is a complete and efficient medical classic through which one can gain knowledge in both classic oriental medicines and combination of western and oriental medicines. Its special features are making a separate chapter for cholera and phthisis, which is also a contagious disease, and trying in the chapter to explain the disease s in words of oriental medicines; listing details of nine major epidemic and matching them with the diseases known in oriental medicines: and recording a case of enforcing sterilization and preventive injection against contagious diseases. Han Byung Lyun, the writ er of the book, was born in northern province of Ham Gyoung, Woong Bu, and the date of death is unknown. He is one of the eight members who conceived and started the idea of organizing the Organization of Practioners of Oriental Medicines, which was a nationwide organization under the motive of restoring Oriental Medicines against the policy under the colonial government of Japan. Living a era of Japanese Imperialism, he stressed the need to accept western medicines if its beneficial to oriental medicines in order to develop oriental medicines for progressive causes. This reflects that he was a person who tried in various ways to extend oriental medicines to another level by facing up to the reality and coming up with a measure to cope up with it. In fact, he was a oriental medicine doctor who tried to protect oriental medicines by founding academic organizations, publishing academic magazines, and writing himself many papers related to oriental medicines. EuiBangShinGam can he summarized as a classic on traditional korean medicine through which one can find out about realities of Japan Imperialism and the attempts of oriental medicine practitioners under the colonial policies of Japan to make oriental medicines more developed by adding one's own thoughts as well as keeping the old, and adjusting to such situations.