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Effect of Astragali radix Extract on Acetaminophen-induced Hepatotoxicity in Mice  

Lee Young Sun (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark)
Han Ok Kyung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark)
Jean Tae Won (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark)
Lee Eun Sil (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark)
Kim Kwang Joong (College of Oriental Medicine, Kyungsan, University)
Park Chan Woo (Kyongju Oriental Hospital, Gyeongju)
Kim Hyo Jung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark, College of Oriental Medicine, Kyungsan, University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 707-713 More about this Journal
Abstract
Astragali radix (AR) is one of the oldest and mast frequently used crude drug for traditional medicine in many Asian countries. This study designed to investigate the hepatoprotective effects of the aqueous extracted AR (ARE) against acetaminophen (APAP)-induced hepatic damage in ICR mice. APAP at the dose of 450 mg/kg i.p produced liver damage in ICR mice. Serum enzyme activities of alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenese was dramatically decreased up to control level by pretreatment of ARE. However, hepatic glutathione level did not show a significant change between the tested groups. We also investigated TNF α mRNA gene expression on APAP-induced liver damage by RT-PCR. APAP dramatically induced TNF α mRNA gene expression in ICR mice. Pretreatment of mice with ARE led to a marked decrease of TNF α mRNA gene expression. These data indicate that 1) ARE has clearly revealed a hepatoprotective effect against APAP-induced hepatic damage in ICR mice, and 2) the protective effect of ARE may be, in part, associated with the regulation of TNF α mRNA gene expression.
Keywords
Astragali radix; acetaminophen; hepatoprotective; RT-PCR; TNF α;
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  • Reference
1 Differences in immunomodulating effects between wild and cultured Panax ginseng. /
[ Mizuno M;Yamada J;Terai H;Kozukue N;Lee YS;Tsuchida H. ] / Biochem. Biophys. Res. Commun.   ScienceOn
2 /
[ Gerlach U.;Bergmeyer, H. U.(Ed.) ] / Methods of Enzymatic Analysis.
3 Poly ADP-ribosylation of a 90kDa protein is involved in TNF-alpha-mediated cytotoxicity. /
[ Agarwal S;Piersco N. ] / J. Immunol.
4 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. /
[ Reitman S;Frankel S. ] / Am. J. Clin. Pathol.
5 Tissue sulfhydryl groups. /
[ Ellman GL. ] / Arch. Biochem. Biophys.   ScienceOn
6 /
[ 김정제 ] / 동의간계내과학
7 인진호수침이 CCl4 중독 손상간에 미치는 영향. /
[ 안창범;이명종;김갑성;문국진;윤종화 ] / 대한침구학회지
8 소시호고탕가청피 약침이 CCl4로 중독된 Rat에 미치는 영향. /
[ 박신화;이준무;권기녹 ] / 대한침구학회지
9 생간탕이 CCl4 및 d-galactosamine에 의해 유발된 실험적 흰쥐 간 장해에 미치는 영향. /
[ 이창규 ] / 경희대학원 논문집
10 Levels of acetaminophen and its metabolites in mouse tissues after a toxic dose. /
[ Fischer LJ;Green MD;Harman AW. ] / J. Pharmacol. Exp. Ther.
11 Models of liver disease. /
[ McLean A.; Karger, B.A(Ed.) ] / New Trends in the Therapy of Liver Diseases.
12 Natural products and plants as liver protecting drugs. /
[ Handa S;Sharma A;Chakraborti K. ] / Fitoterapia
13 Role of proinflammatory cytokines in acetaminophen hepatotoxicity. /
[ Blazka ME;Wilmer JL;Holladay SD;Wilson RE;Luster MI. ] / Toxicol. Appl. Pharmacol.
14 Involvement of Protein kinase C-r in IL-1b induced cyclooxygenase-2 expression in human pulmonary epithelial cells. /
[ Lin CH;Sheu SY;Lee HM;Lee WS;Ko WC;Sheu JR. ] / Mol. Pharmaco.
15 /
[ 김광혁 외 ] / 세포<TEX>$\cdot$</TEX>분자 면역학
16 The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride. /
[ Simeonova PP;Gallucci RM;Hulderman T;Wilson R;Kommineni C;Rao M;Luster MI. ] / Toxicol Appl Pharmacol.   ScienceOn
17 /
[ 정보섭;신민교 ] / 도해향약(생약) 대사전(식물편)
18 Kampo(Japanese herbal) medicines: a review of their immunomodulatory activities. /
[ Borchers AT;Sakai S;Henderson GL;Harkey MR; Keen CL;Stern JS;Terasawa K;Gershwin ME;Shosaiko-to;other ] / J. Ethnopharmacol.   ScienceOn
19 수종의 전통약제가 일차 배양 흰쥐 간세포에서 CCl4 유발 세포독성에 미치는 영향. /
[ 김영숙;박기현 ] / 생약학회지
20 황기의 간기능 보호성분. /
[ 백남인;김영숙;경종수;박기현 ] / 생약학회지
21 Carbon tetrachloride로 유발된 흰쥐의 간손상에 미치는 황기의 효과. /
[ 김미려 ] / 동서의학
22 간수, 기문혈의 당귀 약침자극이 acetaminophen으로 유발된 흰쥐의 손상간에 미치는 영향. /
[ 박경미;문진영;안준철;최미정;남경; 임종국 ] / 한의학 연구소 논문집
23 간독성물질들이 아세트아미노펜 대사와 배설에 미치는 영향. /
[ 박기숙;서경원;정태천;황세진;김효정 ] / 응용약물학회지
24 Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity. /
[ Snawder JE;Roe AL;Benson RW;Roberts DW. ] / Biochem. Biophys. Res. Commun.   ScienceOn
25 Mitochondrial ATPase: a target for paracetamol-induced hepatotoxicity. /
[ Parmar D;Ahmed G;Khandkar M;Katyare S. ] / Euro. J. Pharmacol.   ScienceOn
26 식품을 이용한 화학적 암예방. /
[ 서영준 ] / 식품과학과 산업
27 Effects of Ginseng Saponin on the Cytokine Gene Expression in Human Immune System. /
[ 박종욱;한인숙;서성일;백원기;서민호;배지현;최병길 ] / 고려인삼학회지
28 Enhancement of the immune response in mice by Astragalus membranaceus extracts. /
[ Zhao KS;Mancini C;Doria G. ] / Immunopharmacology   ScienceOn
29 Influence of Angelicae gigantis Radix on the Immune System(I)-T-independent B Cell Proliferation. /
[ 조성기;문혜선;윤연숙;홍석일;함용호;정인성;박은규 ] / 대한면역학회지
30 Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl- N'-butanolnitrosoamine. /
[ Kurashige S;Akuzawa Y;Endo F. ] / Cancer Invest.
31 /
[ Robbins LS;Cotran RS. ] / Pathological basis of disease.
32 Detection and evaluation of chemically induced liver injury. /
[ Plaa GL;Hewitt WR.;Hayes, A. W. (Ed.) ] / Principles and methods of toxicology.
33 Relation of Ca++ accumulation and lipid peroxidation with CCl4-induced toxicity in the rat liver. /
[ Yamamoto H. ] / Pharmacol. Toxicol.   ScienceOn
34 Effect of polysaccharide peptide(PSP) on glutathione and protection against paracetamol-induced hepatotoxicity in the rat. /
[ Yeung JH;Chiu LC;Ooi VE. ] / Methods Find. Exp. Clin. Pharmacol.
35 iagnosis, Control of Progress and Therapy, Diseases of Liver. /
[ Ellen, Schmidt FW.;Bergmeyer, H. U.(Ed.), ] / Method of Enzymatic Analysis.
36 Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. /
[ Lee KJ;You HJ;Park SJ;Kim YS;Chung YC;Jeong TC;Jeong HG. ] / Cancer Lett.   ScienceOn
37 Biochemistry of reduction of nitro heterocycles. /
[ Biaglow JE;Varnes ME;Roizen-Towle L;Clark EP;Epp ER;Astor MB;Hall EJ. ] / Biochem. Pharmacol   ScienceOn
38 Glutathione-dependent protection by rat liver microsomal protein against lipid peroxidation. /
[ Burk RF. ] / Biochim. Biophys. Acta.
39 Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention. /
[ Vermeulen NP;Bessems JG;Van de Straat R. ] / Drug Metab. Rev.   ScienceOn
40 Selective protein arylation and acetaminophen-induced hepatotoxicity. /
[ Cohen SD;Khairallah EA. ] / Drug Metab. Rev.   ScienceOn
41 Effects of Astrgali Radix on the Function of murine Immunocytes in Vivo and in Vitro. /
[ 송봉근;이언정;김형균;진선두;김성재;김동혁 ] / 대한본초학회지(본초분과학회지)
42 Effects of Poligon Multifri Radix on Immunosuppretion Induced by Methotrexate in Rat. /
[ 김일영;이상재;김광호 ] / 대한예방한의학회지
43 사군자탕 및 사물탕이 methotrexate로 유발된 흰쥐의 면역기능저하에 미치는 영향. /
[ 최윤정 ] / 동국대학교대학원 박사학위논문