• 한방비만학회지
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• 제22권2호
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• pp.136-146
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• 2022

Objectives: The objective of this study is to evaluate weight change and analyze adverse events in overweight and obese women with polycystic ovary syndrome (PCOS) who were prescribed with Gamitaeeumjowee-tang. Methods: A retrospective chart review was conducted for medical records of patients with PCOS, who were administered with Gamitaeeumjowee-tang for a period of 12 weeks between January 2019 and December 2021. Outcomes were total weight loss/weight loss rate, the percentage of patients who lost more than 5% and 10% of their baseline weight. Adverse events (AEs) reported by patients were evaluated by severity, causality and system-organ classes. Results: A total of sixty-seven patients were included (mean±standard deviation, Age 28.78±5.25 years, weight 76.78±12.84 kg, body mass index 29.2±4.26 kg/m²). The average total weight loss in PCOS patients was 6.57±3.07 kg and the average weight loss rate was 8.55±3.65%. The percentage of patients with more than 5% and 10% weight loss compared to their baseline weight was 86.56% and 25.37% respectively. The analysis of adverse events are as follows: Causality assessment with World Health Organization-Uppsala Monitoring Centre of AEs showed 'Unlikely' was the most common (71.7%) and severity evaluations with Common Terminology Criteria for Adverse Events showed almost all symptoms were mild (98.9%). Conclusions: Gamitaeeumjowee-tang helps to lose weight of PCOS patients, which is overweight or obese, and no serious adverse events have occurred. Additional well-designed clinical studies are recommended.

• 디지털융복합연구
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• 제12권11호
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• pp.617-623
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• 2014

본 연구는 전통의학문헌에 나타난 재래닭 관련 의안을 분석하여 재래닭의 약리작용 성분을 정리하는데 목표를 두고 있다. 민간치료 자료의 처방과 기존의 한의서에 기술된 다양한 재래 닭 처방과의 상이성 및 공통점을 찾아 분석하여 과학적 검증이 가능한 내용에 대하여 정리하고자 한다. 분석된 내용을 구분 정리하여 DB를 구축하고, 전통의서에 수재된 처방, 한약, 생약 및 특수 치료 방법에 대한 유용성 평가를 통하여 닭 관련 제품개발과 다양한 기능성 식품개발의 근거를 마련하고자 한다. 또한, 국가 지식자원의 지속적인 확충과 전문인력 양성 및 지식문화 관련사업의 부가가치 창출을 통한 미래 신성장 동력산업을 육성하고자 한다. 재래닭 관련 처방지식에 대한 검색 및 정보 관리체계의 정형화가 난해하므로 규격화, 개념화, 형식화한 전통의학 재래닭 처방지식 DB를 구축하여 다학제간의 연구시스템을 통한 고의학 서적의 약학적 유용성을 평가하고 대체의학이나 기능성 식품개발의 실용화 방안을 제시하고자 한다.

• 응용통계연구
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• 제30권3호
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• pp.487-501
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• 2017

최근 산업의 생산공정에서는 머신비전시스템을 통하여 제품의 품질특성치에 대한 정보를 이미지 데이터로 제공하는 경우가 많다. 따라서 산업과 의학 현장에서 이미지 데이터의 모니터링을 위해 관리도 절차의 필요성이 많이 대두되고 있다. 이미지 데이터를 모니터링하는 관리도 절차는 전통적으로 사용하는 관리도 절차와 유사한 점도 있지만, 데이터의 구조를 비롯하여 각 이미지에서 ROI를 설정하여 관리도 절차를 적용하는 등 서로 다른 점도 많이 있다. 이 논문에서는 생산공정에서 제공되는 이미지 데이터에 대해 관리도를 사용하는 절차를 소개하고, 이미지 또는 ROI 크기의 확대와 축소가 제품의 이상원인을 탐지하는데 어떠한 영향이 주는지를 모의실험을 통하여 알아보았고 각 관리도의 성능 또한 비교하였다.

• 한방재활의학과학회지
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• 제32권1호
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• pp.89-106
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• 2022

Objectives In this study, a scoping review was conducted to inform decision-making related to traditional Korean medicine for people with disabilities in the future. Methods Seven databases were searched to find previous studies on traditional Korean medicine for people with disabilities. Studies published until August 2021 were considered. Using the methodology of scoping review, research on traditional Korean medicine for people with disabilities was reviewed with the following steps: 1) drawing research questions, 2) searching for related studies, 3) selecting studies, 4) extracting data, and 5) analyzing and reporting results. Results Out of 2,072 studies, 7 research papers and 10 reports were finally selected. The research papers included 5 cases studies, 1 survey study, and 1 chart review. Most studies used herbal medicine and acupuncture treatment, but the reports on the interventions were not detailed. The reports included policy studies, project performance guidelines, and project results reports, and most of the evaluation indicators tended to be standardized. Conclusions This study reviewed the literature on traditional Korean medicine for people with disabilities. It presents future directions for clinical research on traditional Korean medicine for people with disabilities and can be used to inform healthcare policies and clinical practice. In the future, quantitative research such as clinical trials, meta-analysis, and health insurance big data analysis is needed to understand the current status and effects of traditional Korean medicine for people with disabilities. In addition, qualitative research is necessary to identify unmet demands of traditional Korean medicine for people with disabilities.

• 대한약침학회지
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• 제21권3호
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• pp.195-202
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• 2018

Objectives: The study was to survey use of electronic medical records in subjects of Korean medicine doctors working for Korean medicine organizations and to contemplate ways to develop utilization of electronic medical records. Methods: On August 2017, it conducted online self-reported survey on subjects of Korean medicine doctors at Korean hospitals and clinics who agreed to participate in the study. A total 40 doctors in hospital and 279 doctors in clinic were included. The surveyed contents include kinds of electronic chart, reason for not using electronic medical records and problems with creation of medical records. Results: It finds that 100% of those working at Korean medicine hospitals and 86.4% of those at Korean medicine clinics have used electronic medical records. Subjects answered the biggest reason for not using electronic medical records was inconvenience. The most serious problems with creation of electronic medical records at Korean medicine organizations found in the study include there was no method of creation of medical records and no standardized terminology for use in electronic medical records. Conclusion: For utilization of electronic medical records at Korean medicine organizations, standardization of terminology, development of EMR in favour of its users and development of strategy that motivates use of EMR are required.

• 대한한방내과학회지
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• 제41권1호
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• pp.69-80
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• 2020

Objective: The aim of this study was to report the improvement of stroke symptoms in patients using Mokdanpisaback-san. Methods: This study was carried out on patients hospitalized at the Department of Korean Internal Medicine of Jecheon Korean Medicine Hospital of Semyung University from October 2014 to September 2019. A retrospective study was performed on 43 patients who were diagnosed with stroke and Soyangin and treated with Mokdanpisaback-san. Results & Conclusion: 1. Mokdanpisaback-san is effective in improving various symptoms of stroke, including dysarthria, dysphagia, movement disorder, paresthesia, quadriplegia, and dizziness. 2. Mokdanpisaback-san significantly improves the motor disorders of stroke, including lower extremity muscle strength, standing, and walking disorders. 3. Mokdanpisaback-san does not affect the liver or kidney function.

• 대한지역사회작업치료학회지
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• 제5권1호
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• pp.23-34
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• 2015

목적 : 신경근 전기자극치료와 함께 적용된 자가 삼킴 운동이 삼킴 장애 환자의 삼킴 기능 향상에 미치는 효과를 알아보고자 하였다. 연구방법 : 2013년 5월부터 2015년 4월까지 서울 소재 A 종합병원에서 삼킴 장애로 진단받아 삼킴 재활치료가 의뢰된 입원 환자들을 대조군과 실험군으로 나누었다. 두 군 모두 VitalStim을 이용해 신경근 전기자극치료를 받는 60분 동안 30분간 삼킴 재활치료를 받았고, 실험군은 추가적으로 남는 30분간 자가 삼킴 운동 프로그램을 시행하였다. 중재는 3주간 주 5회 진행되었다. 의무기록 열람을 통해 대상자들의 일반적 정보를 조사하였고, 중재 전후 삼킴 기능의 변화를 알아보기 위해 비디오 투시 삼킴 장애 검사와 침습-흡인 척도를 시행하였다. 결과 : 중재 전 두 군의 삼킴 기능에 유의한 차이가 없었다. 중재 전후 대조군은 비디오 투시 삼킴 장애 척도 총점, 조롱박오목의 잔여물과 흡인에서 유의한 차이를 보였고, 실험군은 비디오 투시 삼킴 장애 척도 총점, 후두개계곡의 잔여물, 조롱박오목의 잔여물에서 유의한 차이를 보였다(p<.05). 중재 전후 대조군과 실험군의 삼킴 기능 차이를 비교한 결과 유의한 차이가 없었다. 결론 : 신경근 전기자극치료와 함께 적용된 삼킴 재활치료 또는 삼킴 재활치료와 자가 삼킴 운동이 삼킴 장애 환자의 인후두 기능 향상에 유의한 영향을 미침을 알 수 있었으나 추가적으로 적용된 자가 삼킴 운동이 유의한 변수로 작용하지 않음을 알 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7221-7227
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• 2013

Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.

• 대한한의학회지
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• 제40권2호
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• pp.119-132
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• 2019

Purpose: This study was conducted to collect and analyze real world data to evaluate the effectiveness and safety of comprehensive traditional Korean Medicine treatment on quality of life, anorexia and cachexia of cancer patients. Methods: We analyzed medical records of 62 cancer patients admitted to O-I Dang Korean Medicine Hospital from February 2018 to February 2019. The primary outcome was a change score in the Anorexia/Cachexia Subscale of Functional Assessment of Anorexia/Cachexia Therapy (FAACT). The secondary outcomes were Functional Assessment of Cancer Therapy-General (FACT-G), Trial Outcome Index(TOI) of FAACT, 11 point Pain Intensity Numeric Rating Score (11 PI-NRS) and Patient Global Impression of Change (PGIC) and adverse event. Results: Cachexia and quality of life in cancer patients assessed by FAACT, increased by $5.59{\pm}14.83$ (p=0.004) after treatment. PI-NRS was reduced by $2.10{\pm}1.81$ (p<0.001) and TOI and FACT-G total scores were increased by $5.17{\pm}11.70$ (p=0.001) and $3.59{\pm}10.94$ (p=0.012), respectively. These results were also clinically meaningful assessed via minimal clinically important difference (MCID). There was no severe adverse event. Conclusion: These findings suggest that comprehensive traditional Korean Medicine treatment might be effective and safe strategy for improving quality of life, anorexia, cachexia and pain of cancer patients. Further advanced studies with controlled group and more participants with rigorous design are needed to ensure these findings.

• Journal of Acupuncture Research
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• 제33권2호
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• pp.61-76
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• 2016

Objectives : This study was designed to clarify population-social characteristics that influence the utilization patterns of hospitalized patients in a traditional korean hospital, thereby providing clinical data which would help further improvements of traditional korean medical service in particular the Acupuncture and Moxibustion. Methods : We investigated population-social characteristics and annual utilization patterns of all patients who were hospitalized for more than 24 hours in a Korean Medical Hospital from January 2005 to December 2014. The obtained data were recorded in the EMR chart and statistical analysis was performed using SPSS 21.0. Additionally, data from the patients admitted to the department of Acupuncture and Moxibustion were analyzed separately. Results : 1. All inpatients had a significant annual difference in age, gender, hospitalized department, and disease code annually but not in re-hospitalization number. Inpatients of the department of Acupuncture and Moxibustion also varied in their age, gender, and disease code annually, but not in re-hospitalization number. 2. Pearson correlation analysis on all inpatients showed that the mean days of hospital treatments had a negative correlation with all variables except medical care insurance. Total cost, cost per day per person and recuperation cost had a positive correlation with all variables except medical care insurance. There was no meaningful relationship between nonrecuperation cost and the variables. 3. Stepwise multiple regression analysis on all inpatients showed that the mean days of hospital treatments had a negative correlation with all variables except automobile insurance. The total hospitalization costs had a positive correlation with both general insurance and medical care insurance. Cost per day per person and recuperation cost had a positive correlation with the females. There was no meaningful relationship between non-recuperation cost and the variables. 4. Pearson correlation analysis on inpatients of the department of Acupuncture and Moxibustion inpatients showed that the mean days of hospital treatments had a positive correlation with all variables except general insurance and automobile insurance. Total cost and recuperation cost had a positive correlation with all variables except medical care insurance, and cost per day per person had a positive correlation with females and general insurance. There was no meaningful relationship between non-recuperation cost and the variables. 5. Stepwise multiple regression analysis on inpatients of the department of Acupuncture and Moxibustion inpatients, the mean days of hospital treatments, total cost, cost per day per person and recuperation cost had a positive correlation with general insurance. There was no meaningful relationship between non-recuperation cost and the variables. Conclusion : Population-social characteristics of inpatients annually varies, and the change influences the utilization pattern.