• Journal of Ginseng Research
• /
• v.45 no.2
• /
• pp.273-286
• /
• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• Journal of Korean Medical classics
• /
• v.23 no.1
• /
• pp.11-13
• /
• 2010

In this article, the concept of body fluid is explained in three aspects: the word meaning of body fluid, the origins of the definitions of the body fluid concept and the connotation and extension of body fluid. Investigating data about the time Hwangjenaegyeong(黃帝內經) was written, the author discovers that the meaning of "Aek(液)" is clear, but there are still questions about the meaning of "Jin(津)". The concept of body fluid derived from observation of life phenomenon and ancient philosophy on the "water". The concept of body fluid should be expressed as that body fluid is a general term for all normal liquids in the body. Within the meridians, as the composition of blood components; outside the meridians, constituting the intrinsic body fluids of various organs and tissues. This is the main part of body fluid, coming from diet, constituting the human body and maintaining human life activities, playing the roles of moistening and nourishing various of organs and tissues of the body. In addition, Interstitial fluid, all kinds of normal liquid secretion and metabolic products, such as sweat, tears, nasal discharge, saliva, slobber, gastric juice, intestinal fluid, urine, joint fluid, latex and so on, both belong to body fluid.

• Journal of Information Management
• /
• v.40 no.4
• /
• pp.93-108
• /
• 2009

In order to achieve the growth of traditional Chinese medicine, the chinese government has annually released "China Statistical Yearbook of Chinese Medicine" to the world since "State Administration of Traditional Chinese Medicine of the People's Republic of China" established in 1988. It is believed that the chinese government intends to secure the early dominance of the global medical market by systematic management of its own medicine infrastructures. Although the statistics of "China Statistical Yearbook of Chinese Medicine" weren't systematically organized at the beginning, it has becoming richer, more systematic, and more standardized in the data construction and system as time has passed. Furthermore, we can take a look at China's effort to take the initiative of oriental medicine by expanding investment in several core areas - medicine resources, operation of medical instruments, service, medicine education, medicine science research, and working expenses. This article will show how china has been trying to develop the chinese medicine, focusing on two parts. One is specific analysis of the book "China Statistical Yearbook of Chinese Medicine". It is divided into analysis of its construction system, the degree of data construction, and its statistical system. The other is analysis of annual changes in areas of medicine resources, operation of medical instruments, service, medicine education, medicine science research, and working expenses.

• Journal of Korean Academy of Nursing Administration
• /
• v.8 no.4
• /
• pp.585-594
• /
• 2002

Purpose : This study was to analyze on current Study situations were oriental-western hospital NMS of Korea ${\cdot}$ China. Method : This study was descriptive-comparative investigation. Study subjects were Korean(44) and Chinese(47) hospitals' NMS. Nursing division of Xi Yean Hospital of China Academy of Traditional Chinese Medicine collected raw data. Result : Hospital NMS of 44 Korean and 47 Chinese has been analyzed and results were as follows; Current situations of Korean NMS(47.7%) belonged to the Director of hospital while Chinese belonged to diagnosis and treatment division(78.7%), and to the nurse-vise superintendent(14.9%). Chinese NMS divided in nursing administration, and technology management that has unique type of simultaneous development in chinese medical and nursing practice. Korean(72%) and Chinese(43.3%) nursing division, and Chinese nursing unit(33.3%) operated inservice education. And Korea(43.2%) and China(80.9%) evaluated by written examination after education. Details of performed oriental nursing practices were similar between Korea and China. Conclusion : There were different of NMS, inservice education, but similar to oriental nursing practices between Korea and China.

• The Journal of Korean Medicine
• /
• v.17 no.2 s.32
• /
• pp.17-33
• /
• 1996

Chinese medical science with long history has experience and theory of cure and prevention as well as the perfect different system with western medicine. Western medical science also was introduced in recent times and has been used in fast development in China extensively. Therefore only China that coexist oriental and western medicine is used the term, the integration of oriental and western medicine. Its object is to make better treatment and prevention value with utilizing their strong point and weak point. That is, its great principle is to develop through interchange together without interference in the other science. For mutual growth of both medical science, national concern and support, medical staffs, administrative system and a lot of fruits, etc should be arranged simultaneously. This paper was obtained the as follows. 1. The system of public health administration is composed a sanitary department for a western medicine and a managing agency for a chinese one in the center. There are each local organization under the control both agency in the locality 2. The importance of the integration of chinese and western medicine is to get the merit of special chinese system through the interchange of both medicine and union with modem science and chinese pharmacy. 3. It is the long term and great project. So its important study field is illness treatment and cure, oriental medical remedy and theory, acupuncture and moxibution etc. 4. It makes steady progress in all the healthy medical field. It has studied its foundation, the education of medical staffs, scientific study and strengthening of skill management considerably. 5. The products are the development of new chinese medicines and many researches about traditional chinese medical science. In brief, the integration of chinese and western medical science is the historical stream. Besides it will contribute toward the cure and prevention of human illness for future 21 century.

• The Korean Journal of Physiology and Pharmacology
• /
• v.27 no.6
• /
• pp.521-531
• /
• 2023

Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration-dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 µM, 19.7 ± 0.4 µM, and 24.5 ± 2.1 µM, while the maximal effect (E_max) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.

• Journal of Korean Medical classics
• /
• v.19 no.3
• /
• pp.427-431
• /
• 2006

From 51 monographs of case record in Qing Dynasty, we chose 29 monographs in which tongue diagnosis applied to Warm disease. Then extracted all the case records and got 488 cases from them. In according to the classification of tongue diagnosis in teaching material of TCM diagnosis of higher TCM schools education, we had a statistic analysis on the 488 cases. Results show that the recording rate of tongue coating was highest, 65.16%. From high to low sequentially, the frequency of different fur was yellow fur, white fur and black fur. During $1850{\sim}1911$ of Qing Dynasty, the description of tongue coating changed that the proportion of white fur, yellow fur and compound fur was increased. On the contrary, the proportion of black fur was decreased. The recording rate of the color of tongue was 23.16%, in which the rate of red tongue and crimson tongue were higher. The recording rate of fur character was 37.7%. During $1850{\sim}1911$ of Qing Dynasty, the recording rate of greasy fur was increased to the first. The application of tongue diagnosis involves the warm-heat species of Warm Disease, damp-heat species of Warm Disease and pestilence.

• Korean Journal of Oriental Medicine
• /
• v.2 no.1
• /
• pp.104-128
• /
• 1996

In the ancient times, the medical practice relied primarily upon human instincts and experiences at the same time, shaman's incantations were widely believed to cure diseases, the workings of evil spirits supposedly. For the period from the Old Chosun through Samhan(三韓), Chinese refugees brought a long medical knowledge and skills of the continent. New Chinese medicine, traditional practices and incantations were generally used at this time. In Samhan, however, the last was the most important, performed by a Chongoon(天君). Medicine and the medical system were arranged by the period of the Three Countries(三國時代). No definite record concerning Koguryo remains now. As for Paekje, however, history shows that they set up the system under the Chinese influence, assigning medical posts such as Euibaksa(醫博士, medical doctor), Chaeyaksa(採藥師, pharmacist), and Jukeumsa(呪禁師, medicine man) within Yakbu(藥部, department of medicine). Scientifically advanced, they sent experts to Japan, giving a tremendous influence on the development of the science in ancient Japan. After the unification of the three countries, Shilla(新羅) had theri own system after the model of Dang(唐). This system of the Unified Shilla was continued down to Koryo(高麗) and became the backbone of the future ones.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6649-6651
• /
• 2013

Background: Mdm2 binds to the amino-terminus of p53 to induce its degradation and a single nucleotide polymorphism in the MDM2 promoter region (T309G) has been reported to increase the risk of several carcinomas, such as gastric cancer. However, the results of published studies to analyze the association between MDM2 T309G and gastric cancer havve often conflicted. Methods: To better illustrate the filiation between MDM2 T309G and gastric cancer, we performed a meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the relationship. The pooled ORs were performed for 4 models, additive, recessive, co-dominant model, and dominant. Results: Nine published case-control studies including 3,225 gastric cancer cases and 4,118 controls were identified. The MDM2 T309G polymorphism was associated with a significantly increased risk of gastric cancer risk when all studies were pooled into the meta-analysis (GG versus TT, OR=1.57; 95%CI=1.57-2.12; p=0.003) and GG versus GT/TT, OR=1.52; 95%CI=1.217-1.90; p<0.001). Furthermore, Egger's test did not show any evidence of publication bias (P = 0.608 for GG versus TT). Conclusion: Our results suggest that the MDM2 T309G polymorphism is indeed associated with a significantly increased risk of gastric cancer.

• The Journal of Korean Medicine
• /
• v.31 no.1
• /
• pp.57-68
• /
• 2010

Objectives: Standard is a unified criterion for some repeated things or concepts in a certain scope. It is fundamental to implement standardization in English translation of traditional Korean medicine (TKM) formulae to promote progress in the evaluation of TKM and also to serve in enhancing the efficiency in studies of medical formulae. Methods: We undertook literature research on current Korean and Chinese medicinal formulae in English translation, analyzing 485 Korean formulae and 464 Chinese. We also undertook a comparative study of 102 common English translation of both Korean and Chinese, proposing a constant and effective methods for English translation of medical formulae. Results: To have a precise English translation we classified medical formulae nomenclature in advance. We found that formulae naming can be fundamentally classified into 6 forms which are (a) Materia Medica + Preparation Form, (b) Materia Medica + Indication + Preparation Form, (c) Materia Medica Numbers + Preparation Form, (d) Indication + Preparation Form, (e) Concept + Preparation Form, and (f) Miscellaneous. Based on these findings we could determine that these 6 types ((a)-(f)) can all be translated into English by (1) Materia Medica + Preparation Form and (2) Indication + Preparation Form + of (with) + Materia Medica schemes. In regard to translation of Indication it can follow Noun+~ing participle form. Conclusion: This research provides a common method of TKM medicinal formulae English translation for better understanding, education, training, practice and research in TKM. Consequently, English translation using these methods can serve as the initial study for standardization of TKM medicinal formulae.