• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6423-6427
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• 2012

Background: Functional single nucleotide polymorphisms of x-ray repair cross-complementing protein 1 (XRCC1) have been suspected to contribute to uterine cervical cancer risk for a long time; however, most previous case-control studies were small sized and biased. Additionally, recent studies suggested that XRCC1 polymorphisms could be a biomarker of response to platinum-based chemotherapy. Methods: A comprehensive search was conducted to retrieve eligible studies and odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to measure association strength. Results: A total of 13 studies were identified and analyzed. We found that the Arg194Trp polymorphism (Trp vs. Arg, OR=1.342, 95% CI: 1.176) was associated with increased risk of cervical cancer, while no significant association was found with Arg280His (His vs. Arg, OR=1.059, 95% CI: 0.863, 1.299) or Arg399Gln (Gln vs. Arg, OR=1.144, 95% CI: 0.938, 1.394). As for response to platinum-based chemotherapy, the variant XRCC1 399Gln allele (Gln vs. Arg, OR=0.345, 95% CI: 0.163, 0.729) was linked with a poor response; however, the Arg194Trp polymorphism (TrpArg vs. ArgArg, OR=6.421, 95% CI: 1.573, 26.205) predicted a good response. Conclusion: The Arg194Trp polymorphism of XRCC1 increases risk of cervical cancer; the variant 399Gln allele predicts poor response to platinum-based chemotherapy, while the Arg194Trp polymorphism indicates a good response.

• Mass Spectrometry Letters
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• v.13 no.3
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• pp.84-94
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• 2022

Neoadjuvant chemoradiotherapy (nCRT) is a standard therapy used for locally advanced rectal cancer prior to surgery, which can more effectively reduce the locoregional recurrence rate and radiation toxicity compared to postoperative chemoradiotherapy. The response of patients to nCRT varies, and thus, robust biomarkers for predicting a pathological complete response are necessary. This study aimed to identify possible biomarkers involved in the complete response/non-response of rectal cancer patients to nCRT. Comparative proteomic analysis was performed on rectal tissue samples before and after nCRT. Proteins were extracted for label-free proteomic analysis. Western blot and real-time PCR were performed using rectal cancer cell line SNU-503 and radiation-resistant rectal cancer cell line SNU-503R80Gy. A total of 135 up- and 93 down-regulated proteins were identified in the complete response group. Six possible biomarkers were selected to evaluate the expression of proteins and mRNA in SNU-503 and SNU-503R80Gy cell lines. Lyso-phosphatidylcholine acyltransferase 2, annexin A13, aldo-ketose reductase family 1 member B1, and cathelicidin antimicrobial peptide appeared to be potential biomarkers for predicting a pathological complete response to nCRT. This study identified differentially expressed proteins and some potential biomarkers in the complete response group, which would be further validated in future studies.

• The Korean Journal of Community Living Science
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• v.16 no.1
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• pp.3-14
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• 2005

The importance of time grows greater these days. For that reason, much research has been conducted to investigate time use. In particular, time spent in housework has been a focus in the human ecology. This study aimed to look into the field of research about time spent in housework from 1991 to 2004. To conduct the inquiry, 35 research projects were analyzed by subject. It turned out that most of the research studied the actual state of time use and related variables. Secondly, the research was classified by the measurement method, such as who wrote the time log or questionnaire, what type of response the researcher wanted and what kind of recording method was used. In 30 research projects, respondents wrote in their time logs and questionnaires by themselves. A few research projects presented certain types of behavior as examples of the actions in everyday life. For the recording method, 22 of the projects employed the time log method and 11 used questionnaires. Thirdly, all the research was categorized by the respondent of each project. 14 projects were targeted .at housewives and 14 were for married couples. Lastly, the definition of time spent in housework was used to consider these 35 studies. Most of the research studies defined the 'time spent in housework' as the total amount of the time spent in eating, clothing, housing, family care and household management.

• Journal of Sensor Science and Technology
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• v.23 no.1
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• pp.42-45
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• 2014

Recently, tremendous application utilizing electrospun nanofibers have been actively reported due to its several advantages, such as high surface to volume ratio, simple fabrication and high-throughput manufacturing. In this paper, we developed highly sensitive and consistent nanofiber humidity sensor by electrospinning. The humidity sensor was fabricated by rapid electrospinning (~2 sec) $TiO_2$/PVP/LiCl mixed solution on the micro-interdigitated electrode. In order to evaluate the humidity sensing performances, we measured current response using DC bias voltage under various relative humidity levels. The results show fast response / recovery time and marginal hysteresis as well as long-term stability. In addition, with the aid of micro-interdigitated electrode, we can reduce a total resistance of the sensor and increase the total reaction area of nanofibers across the electrodes resulting in high sensitivity and enhanced current level. Therefore, we expect that the electrospun nanofiber array for humidity sensor can be feasible and promising for diverse humidity sensing application.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.25 no.2
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• pp.11-18
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• 2002

Psychological and physiological effects of the simulator sickness could be important bias factors for the sensibility evaluation. The purpose of the present study was to clear the differences of psychophysiological responses due to individual sensitivity of simulator sickness. The present experiment tried to investigate the simulator sickness objectively by observing the change of the simulator sickness for the different level of sickness groups (sick and non_sick group). The subjective evaluations using Simulator Sickness Questionnaire (SSQ) and physiological responses were measured every five minutes when they were driving as 60km/h in the driving graphic simulator. Response level of the subjective evaluation for all subjects on the simulator sickness was linearly increased with time for every item, and the response level of sick group was bigger than that of non_sick group. When the analysis on central nervous system was done separately on the sick and the non_sick group, there was significant difference in the parameter $\theta$/total at Fz and Cz. Although the analysis on autonomic nervous system for all subjects showed the increased activation of sympathetic nervous system, there was no significant difference between the sick and non_sick group. In summary, it is necessary to select the subjects who feel less simulator sickness in order to be accurate sensibility evaluation. The parameters to distinguish between the sick and non_sick group were the change on $\theta$/total and subjective evaluation using SSQ.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2002.09a
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• pp.91-97
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• 2002

Total stress analysis method and nonlinear constitutive models have been used to analyze a dynamic performance of Dams but, there is some limitation in analysis, for example, effects of build up of pore pressure and generations of permanent deformations. Therefore considering these limitations, which is mentioned before, dynamic behavior characteristics of dams and response acceleration characteristics was analyzed in time domain, applying an elasto-plastic constitutive model and effective analysis method.

• Earthquakes and Structures
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• v.14 no.5
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• pp.437-447
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• 2018

Computational cost is one of the major obstacles for detailed risk analysis of structures. This paper puts forward a methodology for efficient probabilistic seismic loss assessment of structures using the Endurance Time (ET) analysis and the first-order reliability method (FORM). The ET analysis efficiently yields the structural responses for a continuous range of intensities through a single response-history analysis. Taking advantage of this property of ET, FORM is employed to estimate the annual rate of exceedance for the loss components. The proposed approach is an amalgamation of two analysis approaches, ET and FORM, that significantly lower the computational costs. This makes it possible to evaluate the seismic risk of complex systems. The probability distribution of losses due to the structural and non-structural damage as well as injuries and fatalities of a prototype structure are estimated using the proposed methodology. This methodology is an alternative to the prevalent risk analysis framework of the total probability theorem. Hence, the risk estimates of the proposed approach are compared with those from the total probability theorem as a benchmark. The results indicate a satisfactory agreement between the two methods while a significantly lower computational demand for the proposed approach.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3D
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• pp.409-416
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• 2006

Real-time traveler information disseminated through Variable Message Signs (VMS) is known to have effects on driver route choice decisions. In the past, many studies have attempted to optimize the system performance using VMS message content as the primary control variable of driver route choice. This research proposes a VMS information provision optimization model which searches the best combination of VMS message contents and display sequence to minimize the total travel time on a highway network considered. The driver route choice models under VMS information provision are developed using a stated preference (SP) survey data in order to realistically capture driver response behavior. The genetic algorithm (GA) is used to find the optimal VMS information provision strategies which consists of the VMS message contents and the sequence of message display. In the process of the GA module, the system performance is measured using micro traffic simulation. The experiment results highlight the capability of the proposed model to search the optimal solution in an efficient way. The results show that the traveler information conveyed via VMS can reduce the total travel time on a highway network. They also suggest that as the frequency of VMS message update gets shorter, a smaller number of VMS message contents performs better to reduce the total travel time, all other things being equal.

• Food Science and Preservation
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• v.24 no.5
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• pp.623-630
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• 2017

Functional compounds including flavonoids, anthocyanins, polyphneols and antioxidants were extracted from blue honeysuckle (Lonicera caerulea L.) using highly efficient microwave-assisted extraction. And extraction process was modeled and optimized according to response surface methodology (RSM). The independent variables ($X_n$) were ethanol concentration ($X_1$: 0, 25, 50, 75, 100%), irradiation time ($X_2$: 1, 3, 5, 7, 9 min), and microwave power ($X_3$: 60, 120, 180, 240, 300 W). Dependent variables ($Y_n$) were total flavonoid contents ($Y_1$), total anthocyanin contents ($Y_2$), total polyphenol contents ($Y_3$) and antioxidant activity ($Y_4$). Four-dimensional response surface plots were generated based on the fitted second-order polynomial models to get optimal conditions. Estimated optimal conditions for 4 responses were ethanol concentration of 54-72%, irradiation time of 7.1-7.6 min, and microwave power of 243-251 W. Ridge analysis predicted the maximal responses of total flavonoid content, total anthocyanin content, total polyphenol content and antioxidant activity were 38.00 mg RE/g, 6.80 mg CGE/g, 14.90 mg GAE/g, 89.10%, respectively. Verification experiment was carried out at predicted optimal conditions and experimental values for total flavonoid content, total anthocyanin content, total polyphenol content and antioxidant activity were 38.10 mg RE/g, 6.72 mg CGE/g, 14.91 mg GAE/g and 89.13%, respectively. No significant difference was observed between predicted and experimental values, indicating good fitness of fitted model and successful application of RSM.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.4
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• pp.65-75
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• 1993

Presented is a method for nonstationary response analysis of an offshore guyed tower subjected to strong earthquake motions under moderate random waves and current loadings. By taking the time varying envelope function and the auto-correlation function of the ground acceleration in terms of complex exponential functions, an analytical procedure is developed for computing time varying variances of the tower response. The stationary responses due to small random waves are obtained by using frequency domain method, and the results are combined with the nonstationary results due to earthquakes. Finally, the expected maximum responses are estimated. Through the example analyses, the nonstationary method developed in this study is verified, and the contributions of the earthquake, wave and current loadings to the total maximum response are investigated.