• Title/Summary/Keyword: Top cross test

Search Result 63, Processing Time 0.024 seconds

Development of a Rapid Automated Fluorescent Lateral Flow Immunoassay to Detect Hepatitis B Surface Antigen (HBsAg), Antibody to HBsAg, and Antibody to Hepatitis C

  • Ryu, Ji Hyeong;Kwon, Minsuk;Moon, Joung-Dae;Hwang, Min-Woong;Lee, Jeong-Min;Park, Ki-Hyun;Yun, So Jeong;Bae, Hyun Jin;Choi, Aeran;Lee, Hyeyoung;Jung, Bongsu;Jeong, Juhee;Han, Kyungja;Kim, Yonggoo;Oh, Eun-Jee
    • Annals of Laboratory Medicine
    • /
    • v.38 no.6
    • /
    • pp.578-584
    • /
    • 2018
  • Background: Accurate, rapid, and cost-effective screening tests for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection may be useful in laboratories that cannot afford automated chemiluminescent immunoassays (CLIAs). We evaluated the diagnostic performance of a novel rapid automated fluorescent lateral flow immunoassay (LFIA). Methods: A fluorescent LFIA using a small bench-top fluorescence reader, Automated Fluorescent Immunoassay System (AFIAS; Boditech Med Inc., Chuncheon, Korea), was developed for qualitative detection of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), and antibody to HCV (anti-HCV) within 20 minutes. We compared the diagnostic performance of AFIAS with that of automated CLIAs-Elecsys (Roche Diagnostics GmbH, Penzberg, Germany) and ARCHITECT (Abbott Laboratories, Abbott Park, IL, USA)-using 20 seroconversion panels and 3,500 clinical serum samples. Results: Evaluation with the seroconversion panels demonstrated that AFIAS had adequate sensitivity for HBsAg and anti-HCV detection. From the clinical samples, AFIAS sensitivity and specificity were 99.8% and 99.3% for the HBsAg test, 100.0% and 100.0% for the anti-HBs test, and 98.8% and 99.1% for the anti-HCV test, respectively. Its agreement rates with the Elecsys HBsAg, anti-HBs, and anti-HCV detection assays were 99.4%, 100.0%, and 99.0%, respectively. AFIAS detected all samples with HBsAg genotypes A-F and H and anti-HCV genotypes 1, 1a, 1b, 2a, 2b, 4, and 6. Cross-reactivity with other infections was not observed. Conclusions: The AFIAS HBsAg, anti-HBs, and anti-HCV tests demonstrated diagnostic performance equivalent to current automated CLIAs. AFIAS could be used for a large-scale HBV or HCV screening in low-resource laboratories or low-to middle-income areas.

A Corpus-based Study of Translation Universals in English Translations of Korean Newspaper Texts (한국 신문의 영어 번역에 나타난 번역 보편소의 코퍼스 기반 분석)

  • Goh, Gwang-Yoon;Lee, Younghee (Cheri)
    • Cross-Cultural Studies
    • /
    • v.45
    • /
    • pp.109-143
    • /
    • 2016
  • This article examines distinctive linguistic shifts of translational English in an effort to verify the validity of the translation universals hypotheses, including simplification, explicitation, normalization and leveling-out, which have been most heavily explored to date. A large-scale study involving comparable corpora of translated and non-translated English newspaper texts has been carried out to typify particular linguistic attributes inherent in translated texts. The main findings are as follows. First, by employing the parameters of STTR, top-to-bottom frequency words, and mean values of sentence lengths, the translational instances of simplification have been detected across the translated English newspaper corpora. In contrast, the portion of function words produced contrary results, which in turn suggests that this feature might not constitute an effective test of the hypothesis. Second, it was found that the use of connectives was more salient in original English newspaper texts than translated English texts, being incompatible with the explicitation hypothesis. Third, as an indicator of translational normalization, lexical bundles were found to be more pervasive in translated texts than in non-translated texts, which is expected from and therefore support the normalization hypothesis. Finally, the standard deviations of both STTR and mean sentence lengths turned out to be higher in translated texts, indicating that the translated English newspaper texts were less leveled out within the same corpus group, which is opposed to what the leveling-out hypothesis postulates. Overall, the results suggest that not all four hypotheses may qualify for the label translation universals, or at least that some translational predictors are not feasible enough to evaluate the effectiveness of the translation universals hypotheses.

Development Length of GFRP Bars (GFRP 보강근의 정착길이 설계식 제안)

  • Ha, Sang-Su;Choi, Dong-Uk
    • Journal of the Korea Concrete Institute
    • /
    • v.22 no.1
    • /
    • pp.131-141
    • /
    • 2010
  • The objective of this study was to propose a development length equation for GFRP bars. A total of 104 modified pullout tests were completed while the test variables were embedment length (15, 30, $45d_b$), net cover thickness ($0.5{\sim}2.0d_b$), top-cast bar effect, different GFRP bar types (K2KR, K3KR and AsUS), and bar diameters (10, 13, 16 mm). Average bond stresses were determined based on modified pullout test results. Two variable linear regression analysis was performed of the average bond stresses. Utilizing 5% fractile concept, a conservative development length design equation was derived. The design equation derived in this study was compared to the ACI 440 committee equation. The cross-comparison revealed that the current equation resulted in shorter development lengths than those determined by the ACI 440 equation when the net cover thickness was large (greater than $1.0d_b$). On the other hand, when the net cover thickness was small (equal to or less than $1.0d_b$), the development lengths required by the current equation were larger than those by the ACI equation. The bond stresses were significantly influenced by the cover thicknesses. The current equation results in development lengths that are more economical when the cover thickness is large, and more conservative lengths when the cover thickness is small than the ACI 440 committee equation.

A Comparative Study on the Perceptions of Nursing Students and Clinical Instructors on the Importance of Learning Contents of Nursing Management and Practical Experience (간호관리학실습 교과내용에 대한 중요도와 실습 경험에 대한 간호대학생과 임상현장지도자의 인식 비교 연구)

  • Koo, OK-Hee;Hong, Sung-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.22 no.6
    • /
    • pp.90-99
    • /
    • 2021
  • This study was conducted to provide basic data for improving nursing management practice by comparing and analyzing the perceptions of nursing students and clinical instructors about the importance of the learning contents of nursing management and their practical experience. The final 343 copies were analyzed using the Mann-Whitney test and cross-analysis, targeting 4th-grade students and clinical instructors at three universities. Both nursing students and clinical instructors recognized 'communication', 'interpersonal relationship', 'responsibility', 'trust', and 'morality' as important factors in the evaluation items of practice. Among the top 10 most importantly recognized items among nursing-management practice learning content, six items ('infection control', 'nursing record management', 'patient nursing management', 'drug management', 'patient safety', and 'nursing malpractice') were matched in the two groups. Moreover, clinical instructors recognized that interpersonal relationships and relationship ethics were important, while nursing students chose legal responsibility. As a result of the practical experience analysis between the two groups, nursing students had high experience of indirect participation, but the clinical instructors had a high experience of direct instruction. A plan is needed to reduce the difference by establishing an organic partnership relationship between the university and practice institutions and increase the experience of direct practice of nursing students.

The Case Study on the Design, Construction, Quality Control of Deep Cement Mixing Method (심층혼합처리공법(DCM)의 설계, 시공 및 품질관리 사례 연구)

  • Kim, Byung-Il;Park, Eon-Sang;Han, Sang-Jae
    • Journal of the Korean Geosynthetics Society
    • /
    • v.20 no.4
    • /
    • pp.19-32
    • /
    • 2021
  • In this study, evaluation and consideration of domestic/overseas design, construction, and quality control performed by the authors on the deep cement mixing method were performed, and improvements for the development of the DCM method were suggested in the future. As a result of this study, it was found that the cross-sectional area correction for strength is required during the laboratory test of mix proportion, and caution is required because the extrapolation method may lead to different results from the actual one. Applicable design methods should be selected in consideration of both the improvement ratio and the type of improvement during design, and it was confirmed that the allowable compressive strength to which the safety factor was applied refers to the standard value for stability review and not the design parameters. In the case of the stress concentration ratio, rather than applying a conventional value, it was possible to perform economical design by calculating the experimental and theoretical stress concentration ratio reflecting the design conditions. In the case where pre-boring is expected during construction, if the increased water content is not large compared to the original, there were cases where a major problem did not occur even if the result that did not consider the increase in water content was used. In addition, it was confirmed that when the ratio of the top treatment length to the improved length is high, a small amount of design cement contents per unit length can be injected during construction. In the case of quality control, it was evaluated that D/4~2D/4 for single-axis and D/4 point for multi-axis were optimal for coring of grouting mixtures. As an item for quality control, it is judged that the standard that considers the TCR along with the unconfined compressive strength of grouting mixtures is more suitable for the domestic situation.

Detection of Surface Changes by the 6th North Korea Nuclear Test Using High-resolution Satellite Imagery (고해상도 위성영상을 활용한 북한 6차 핵실험 이후 지표변화 관측)

  • Lee, Won-Jin;Sun, Jongsun;Jung, Hyung-Sup;Park, Sun-Cheon;Lee, Duk Kee;Oh, Kwan-Young
    • Korean Journal of Remote Sensing
    • /
    • v.34 no.6_4
    • /
    • pp.1479-1488
    • /
    • 2018
  • On September 3rd 2017, strong artificial seismic signals from North Korea were detected in KMA (Korea Meteorological Administration) seismic network. The location of the epicenter was estimated to be Punggye-ri nuclear test site and it was the most powerful to date. The event was not studied well due to accessibility and geodetic measurements. Therefore, we used remote sensing data to analyze surface changes around Mt. Mantap area. First of all, we tried to detect surface deformation using InSAR method with Advanced Land Observation Satellite-2 (ALOS-2). Even though ALOS-2 data used L-band long wavelength, it was not working well for this particular case because of decorrelation on interferogram. The main reason would be large deformation near the Mt. Mantap area. To overcome this limitation of decorrelation, we applied offset tracking method to measure deformation. However, this method is affected by window kernel size. So we applied various window sizes from 32 to 224 in 16 steps. We could retrieve 2D surface deformation of about 3 m in maximum in the west side of Mt. Mantap. Second, we used Pleiadas-A/B high resolution satellite optical images which were acquired before and after the 6th nuclear test. We detected widespread surface damage around the top of Mt. Mantap such as landslide and suspected collapse area. This phenomenon may be caused by a very strong underground nuclear explosion test. High-resolution satellite images could be used to analyze non-accessible area.

Evaluation of General Dentists' and Dental Specialists' Knowledge about Oral Cancer in South Khorasan-Iran 2014

  • Akbari, Narjes;Raeesi, Vajehallah;Khazaei, Tahereh;Ramezanzadeh, Khaironnesa;Ebrahimipour, Sediqe
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.16
    • /
    • pp.6987-6990
    • /
    • 2015
  • Background: Oral cancer is one of the most prevalent cancers and one of the top ten causes of death in the whole world. Most oral cancers are diagnosed at late stages. Since dentists play a critical role in early detection of oral cancer, they should be knowledgeable and skillful in oral cancer diagnosis. The aim of this study was to survey dentist knowledge about oral cancer in Southern Khorasan Province. Materials and Methods: This descriptive, cross-sectional study was conducted with dentists who participated in an in-service educational program at the Faculty of Dentistry of Birjand University of Medical Sciences in spring 2014. A questionnaire including demographic information with 11 questions regarding oral cancer was prepared. The participants were required to be complete the questionnaires within a specific time span. The data were analyzed using SPSS 15 software by t-test and one-way ANOVA at 0.05 confidence level. Results: A total of 73 dentists out of 80 answered the questionnaires - 36 (49.3%) were females and 37 (50.7%) were males. Total mean score of knowledge was $7.91{\pm}1$ of 11. Mean scores of knowledge of male and female participants were $7.70{\pm}1.83$ and $8.13{\pm}1.94$ respectively. Mean knowledge score of general dentists was $7.41{\pm}1.79$ and of dental specialists was $9.44{\pm}1.0$ In spite of higher knowledge score of women compared to men and general dentists compared to dental specialists, these differences were not statistically significant (p=0.09). Tukey testing showed a significant difference between groups with 1-4 years of experience (8.74) and over twenty years of experience (6.50) ( p=0.001). Conclusions: Considering the good knowledge level of young dentists and the specialists and the importance of early diagnosis of oral cancer, it seems necessary to pay more attention to academic education for dentistry students, as well as holding retraining courses for experienced dentists, so that their knowledge not be reduced over time.

XRCC1 Gene Polymorphism, Clinicopathological Characteristics and Stomach Cancer Survival in Thailand

  • Putthanachote, Nuntiput;Promthet, Supannee;Suwanrungruan, Krittika;Chopjitt, Peechanika;Wiangnon, Surapon;Chen, Li-Sheng;Yen, Ming-Fang;Chen, Tony Hsiu-Hsi
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.14
    • /
    • pp.6111-6116
    • /
    • 2015
  • Background: Stomach cancer is one of leading causes of death worldwide. In Thailand, the incidence and mortality of stomach cancer are in the top ten for cancers. Effects of DNA repair gene X-ray repair cross complementary protein 1 (XRCC1) polymorphisms and clinicopathological characteristics on survival of stomach cancer in Thailand have not been previously reported. The aim of this study was to investigate the effects of XRCC1 gene and clinicopathological characteristics on survival of stomach cancer patients in Thailand. Materials and Methods: Data and blood samples were collected from 101 newly diagnosed stomach cancer cases pathologically confirmed and recruited during 2002 to 2006 and followed-up for vital status until 31 October 2012. Genotype analysis was performed using real-time PCR-HRM. The data were analyzed using the Kaplan-Meier method to yield cumulative survival curve, log-rank test to assess statistical difference of survival and Cox proportional hazard models to estimate adjusted hazard ratio. Results: The total followed-up times were 2,070 person-months, and the mortality rate was 4.3 per 100 person-months. The median survival time after diagnosis was 8.07 months. The cumulative 1-, 3-, 5-years survival rates were 40.4%, 15.2 % and 10.1 % respectively. After adjustment, tumour stage were associated with an increased risk of death (p= 0.036). The XRCC1 Gln339Arg, Arg/Arg homozygote was also associated with increased risk but statistically this was non-significant. Conclusions: In addition to tumour stage, which is an important prognostic factor affecting to the survival of stomach cancer patients, the genetic variant Gln339Arg in XRCC1 may non-significantly contribute to risk of stomach cancer death among Thai people. Larger studies with different populations are need to verify ours findings.

A Study on the Efficiency of Container Ports in the Mediterranean Sea (지중해 컨테이너항만의 효율성 분석에 관한 연구)

  • Ibrahim, Ousama Ibrahim Hassan;Kim, Hyun Deok
    • Journal of Korea Port Economic Association
    • /
    • v.37 no.2
    • /
    • pp.91-105
    • /
    • 2021
  • The current increasing size of container vessels affects the container port's situation. The containerization has changed the inter-modal handling process, which brought more flexibility and comfortableness in the shipping industry sector. Thus, it is very crucial to analyze the efficiency of container ports in the regional sphere. Such kind of efficiency analysis provide a powerful management tool for port operators and shipping managers in the Mediterranean market, and it also helps to form an information for planning new regional and national port operations. This paper aims to analyze the ports' technical efficiency of Mediterranean major container ports. It is conducted to establish the model of port performance and efficiency through the empirical test of the various factors. Regarding to the panel data collected from the 48 DMUs (decision making units), this study attempts to provide the empirical basis of the port efficiency relative to another factors in the total port performance. Due to the complexity of the various activities carried out at container ports, the study focuses only on the technical efficiency at the level of the Mediterranean container port. Unlike the practice of cross-sectional data analysis, originally established by Charnes et al. (1985), the panel data in DEA window analysis applications are used. The main focus of this study is the relative technical efficiency of 12 container ports from 7 countries in the Mediterranean market. The selection of ports under study is based on their high handling capability and rankings in World Top 100 (Containerization International, 2018).

A STUDY ON THE BOND STRENGTHS BETWEEN GLASS IONOMER CEMENT BASES AND COMPOSITE RESINS (글래스 아이오노머 이장재와 복합레진간의 결합강도에 관한 연구)

  • Kim, Min-Hee;Kim, Shin;Jeong, Tae-Sung
    • Journal of the korean academy of Pediatric Dentistry
    • /
    • v.26 no.3
    • /
    • pp.520-527
    • /
    • 1999
  • For the purpose of providing some suggestions in selection of filling materials used in 'sandwich technique', the bond strengths between glass ionomer cement bases and composite resins were investigated and compared. For lining materials, 'Vitrebond' and 'Ketac-fil' were used. Using these two as bases, 10 of each following resins were built up on the top ; Z-100 (light curing resin) Clear-fil (chemical curing resin), Bis-core (dual cure resin), Dyract (compomer), therfore 10 specimens of each group and total of 80 specimens were made. After storing specimens in $37^{\circ}C$ deionized water for 24 hours, the shear bond strengths were measured under universal testing machine with 50 kg of full load scale and 1mm/min of cross-head speed and obtained the results as follows : 1. Over Vitrebond base, Z-100 showed the lowest bond strength but the other three did not show any difference in bond strength. 2. Over Ketac-fil base, Clear-fil showed the highest bond strength followed by Dyract, Bis-core, and Z-100 showed the lowest bond strengths. 3. Whereas Clear-fil showed the similar bond strengths on the Vitrebond base as other resins, it showed the highest bond strength on Ketac-fil base, which showed some difference in bond strength by differing GIC bases. 4. The bond strengths between base materials and composite resin showed a stronger resin-dependence tendency in cases with Ketac-fil bases rather than with Vitrebond bases.

  • PDF