• 한국한의학연구원논문집
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• 제8권2호통권9호
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• pp.23-35
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• 2002

통과대명청대진단학발전사적고찰(通過對明淸代診斷學發展史的考察), 득도료여하결론(得到了如下結論):도료명대(到了明代), 출현료대량적유관망진적전문서적(出現了大量的有關望診的專門書籍), 정차(井且), 개시대소아지문진행요망진연구(開始對小兒指紋進行了望診硏究), 환유(還有), 대설진적발전이경유료탁월인식(對舌診的發展已經有了卓越認識). 명대적사진화변증학설적발전여오우가적(明代的四診和辨證學說的發展與吳又可的) ${\ulcorner}$온역론(溫疫論)${\lrcorner}$ 개시거두적온병학설적발전유밀녕접적연계(開始據頭的溫病學說的發展有密接的連繫). 도료명대(到了明代), 이경대륙경변증(已經對六經辨證), 장부변증화팔강변증유료계통면완선적변증체계(臟腑辨證和八綱辨證有了系統面完善的辨證體系), 특별시개시출현료온병변증(特別是開始出現了溫病辨證). 대우청대적망진적발전특징(對于淸代的望診的發展特徵), 가이귀납위대우설진적대량적연구화유관망진적전문서적적출현(可以歸納爲對于舌診的大量的硏究和有關望診的專門書籍的出現). 특별시수착온병학설약발전면공동발전적설진적만화야흔돌출.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2011년도 제43차 동계학술발표논문집 19권1호
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• pp.253-256
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• 2011

본 논문은 기존의 디지털 설진 시스템이 아닌 임베디드 환경에서의 실시간 설진 진단 방법을 제안한다. 임의의 환경에서 얻어낸 이미지에서 혀 영역의 추출과 추출된 영역에서의 혀의 상태를 진단하는데는 많은 어려움이 있다. 다양한 조명환경에서의 영상으로부터 혀 영역을 추출해 내는 방법으로는 ASM을 이용하는 방법이 있는데 이는 검출률이 낮아 정확도가 떨어진다. 이를 보완하기 위해 본 논문에서는 ASM과 물체 외곽 정보 복원에 기반을 둔 컬러 분산 스테이크 기법을 사용하여 정확도를 개선하는 방법을 제안한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1985-1986
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• 2008

혀의 상태는 인체 내부의 생리적 병리적 특성의 변화를 나타내므로, 한의학에서 중요한 지수가 된다. 한의학에서 설진 방법은 환자의 설질과 설태의 변화를 관찰함으로써 질병을 진찰하는 방법이므로, 편리할 뿐만 아니라 비침습적이고, 널리 쓰이고 있다. 그러나 설진은 광원, 환자의 자세, 한의사의 상태와 같은 검사 환경에 의해 영향을 받는다. 표준화된 진단을 위한 자동 진단 시스템을 개발하기 위하여 질병의 예후를 판단할 수 있는 설태 분류 방법은 필수적이지만, 컬러의 경계가 모호하므로 설태와 설질을 구분하기는 매우 어렵다. 이 논문에서 분할된 설체 내에서 컬러를 계층적으로 분류하여 설태를 분류하는 방법을 제안한다. 또한 설태 영역을 정확하게 분할하도록 하였다. 제안된 방법은 표준화된 진단을 가능하도록 한다.

• Annals of Clinical Neurophysiology
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• 제8권1호
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• pp.74-77
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• 2006

Repetitive nerve stimulation is a simple and widely used technique to demonstrate neuromuscular transmission defect. A significant decremental response for repetitive hypoglossal nerve stimulation was obtained from the surface recordings in the tongue of a patient with dysarthria and dysphagia. Repetitive hypoglossal nerve stimulation test may be useful in diagnosis of myasthenia gravis with bulbar symptoms only. We utilized repetitive hypoglossal nerve stimulation with tongue recordings and diagnosed a case of myasthenia gravis.

• 대한약침학회지
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• 제13권4호
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• pp.91-107
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• 2010

Objectives : The purpose of this study was to analyze the propensity and find out the Syndrome Differentiation of teeth-mark tongue by taking survey and body examinations with 178 male patients. 164 patients out of 178 were checked up on Heart Rate Variability (HRV), Accelerated Photoplethysmograpy (APG), Body Composition. This study was also planned to find out the distinctive characteristics of teeth-mark tongue diagnosis and compare differences between Qi-Deficiency and Accumulation of Dampness and Phlegm patients group. Methods : The questionnaire was carried out targeting 178 male with teeth-mark tongue respondents among who had Oriental Health Examination and patients from the 3rd oriental-internal medicine department in Dongeui Hospital from $1^{st}$, March 2005 to $30^{th}$, April 2010. Only 164 patients were checked on HRV, APG and Body composition examinations. Results : It showed that 86 patients had Qi-Deficiency and 78 had Dampness and Phlegm but 14 couldn't be categorized. The major symptoms of Qi-Deficiency compared to Dampness and Phlegm were 'Frequent running nose', 'Soft stool', 'Chronic fatigue', and 'Eyestrain'. On the contrary, Dampness and Phlegm's dominant symptoms were 'Chest discomfort', 'Feeling bloated', 'Back pain', 'Feeling sluggish', and 'Itchy skin'. However, all symptoms were not matched with the Syndrome Differentiation of Qi-Deficiency or Dampness and Phlegm. It also showed that teeth-mark tongue patients' frequent symptoms were 'Stuffy nose', 'Feeling bloated', 'Oliguria', 'Shoulder pain', 'Chronic fatigue' 'Eyestrain' and these symptoms were matched with the Syndrome Differentiation of Qi-Deficiency and Dampness and Phlegm. In the results from this study, there were no significant differences between Qi-Deficiency and Dampness and Phlegm. Conclusions : It is hard to conclude that teeth-mark tongue could be only one to diagnose Qi-Deficiency or Dampness and Phlegm with 3 examinations.

• 대한한의진단학회지
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• 제17권3호
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• pp.189-202
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• 2013

Objectives The aim of this study is to analyze the characteristics of the tongue coating pattern in the elderly patients with xerostomia. Methods Ninety-six elderly patients with xerostomia were recruited by advertisement and they visited the oral diseases clinics at Kyung Hee University Korean Medicine Hospital and Kyung Hee University Hospital at Gangdong from November, 2011 to August, 2013. After signifying the assent, the subjects who passed screening were enrolled this study. The subjects were evaluated on their clinical characteristics of xerostomia using visual analogue scale for xerostomia, dry mouth questionnaire, unstimulated salivary flow rate. In addition, Yin-deficiency questionnaire was used to evaluate the Yin-deficiency state and Winkel tongue coating index and Digital Tongue imagin system were used to measure the tongue coating of patients. Results The proportion of women was higher than that of men, and there were few smokers in this study population. This population had chronic and relatively severe xerostomia symptoms. Also, thin coating pattern was showed in this elderly patients with xerostomia and this result was regarded to the influence of Yin-deficiency. The thin coating patten was observed in the group with higher Yin-deficiency score. There was no difference in tongue coating between the hyposalivation and normosalivation group. Conclusion In the elderly patients with xerostomia, Yin-deficiency is might be considered as one of the main cause of xerostomia. Hence, it is thought that this patients showed the thin coating pattern. This results could be used in diagnosis and treatment for the elderly patients with xerostomia in traditional Korean medicine.

• 대한한의학회지
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• 제20권2호
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• pp.37-42
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• 1999

In Oriental medicine, the subjective process of diagnosis often makes it difficult to explain the indications objectively, in spite of its excellent therapeutic value. The authors' objective Was to present more objective indications of Chongpesagan-tang(淸肺瀉肝湯), a prescription predominantly used to treat stroke in Oriental Medicine, We analyzed clinical symptoms of 105 patients who were hospitalized in the Department of Circulatory Internal Medicine, College of Oriental Medicine. Kyung Hee University, Seoul, who were given Chongpesagan-tang and improved without side effects, The symptoms analyzed included general symptoms which are usually checked in the process of Oriental Medicine Diagnosis: the so called Four Diagnosis(四診). We rearranged and selected symptoms which were predominantly found among other symptoms. We found some symptoms of which the patients frequently complained: sweating 84%, red tongue 74%, white tongue coat 65%, constipation 35%, tight pulse 21%, headache 20%, thirst 20%, chest discomport 17%, etc, We believe that these suggest an objective indication of Chongpesagantang.

• Annals of Clinical Neurophysiology
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• 제6권2호
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• pp.85-91
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• 2004

Background: Needle electromyography (EMG) and motor evoked potential (MEP) of the genioglossus (tongue) are difficult to perform in evaluations of the craniobulbar region in amyotrophic lateral sclerosis (ALS). Therefore, we investigated the yields of needle EMG and MEP recorded from the upper trapezius, since it receives innervation from the lower medulla and upper cervical cord. Methods: Needle EMG and MEP of the upper trapezius were obtained in 17 consecutive ALS patients. The needle EMG parameters recorded included abnormal spontaneous activity and motor unit action potential (MUAP) morphology. An upper motor neuron (UMN) lesion was presumed when either response to cortical stimulation was absent, or the central conduction time was delayed (>mean+2SD). Results: Of the five patients with bulbar-onset ALS, four had abnormalities in the upper trapezius and four in the tongue by needle EMG. In contrast, of the 12 patients with limb-onset ALS, 11 had abnormalities in the upper trapezius, and only five in the tongue. When MEP was performed, it was found that three of the five patients with bulbar symptoms and three of the six patients with isolated limb involvement had abnormal MEP findings. Conclusions: Electrophysiological studies of the upper trapezius are more sensitive those of the tongue in patients without bulbar symptoms. Thus, needle EMG and MEP of the upper trapezius are alternative tools for assessing bulbar and rostral neuraxial involvement in the diagnosis of ALS.

• 대한두경부종양학회지
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• 제29권2호
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• pp.65-67
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• 2013

Osteomyelitis is an infection of bone or bone marrow, caused by pyogenic bacteria or mycobacterium. Osteomyelitis can be acute or chronic, inflammatory process of the bone and its structures. Chronic osteomyelitis will result in variable sclerosis and deformity of the affected bone. With an infection of the bone, the subsequent inflammatory response will elevate this overlying periosteum, leading to a loss of the nourishing vasculature, vascular thrombosis, and bone necrosis, resulting occasionally in formation of sequestra. These become areas that are more resistant to systemic antibiotic therapy due to lack of the normal Havesian canals that are blocked by scar tissue. At this aspect, not only systemic antibiotic therapy, but also surgical debridement maybe required to remove the affected bone and prevent disease propagation to adjacent areas. We experienced a patient who diagnosed tongue cancer and underwent wide partial glossectomy few years before, with an ulcerative lesion around right retromolar trigon. We diagnosed cancer recurrence because PET indicated hot uptake on mandible which was nearby previous tongue tumor site. The patient received hemiglossectomy via paramedian mandibulotomy, partial mandibulectomy and fibula osteocutaneous free flap reconstruction. But final diagnosis was mandible osteomyelitis on pathology report. Here, we present the case with a review of the related literatures.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권3호
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• pp.182-187
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• 2002

Matrix metalloproteinase(MMP) is the proteolytic enzyme of the extracellular matrix. MMPs play a role in the invasion and metastasis of malignant tumor, but it is not known whether the expression of MMPs in squamous cell carcinoma of the tongue is related to the prognostic factors of this tumor. In this study, 32 paraffin-embedded tumor specimens were examined immunohistochemically using monoclonal antibodies of MMP-2, MMP-3, MMP-10 and MMP-13. The possible relationships between the expressions of the MMPs and TNM staging, the differentiation of tumor cells, size of tumor mass and lymph node metastasis were anlaysed statistically. The results were as follows. 1. The expression of MMP-2 increased according to TNM staging (P<0.05) and lymph node metastasis (P<0.05) and the expression of MMP-2 was not affected by the differentiation of tumor cells or tumor size. 2. The expression of MMP-3 increased with increasing tumor size (P<0.05). However it was not related to TNM staging, the differentiation of tumor cells or lymph node metastasis. 3. The expression of MMP-10 was unrelated to TNM staging, differentiation of tumor cells, lymph node metastasis or tumor size. 4. The expression of MMP-13 increased as tumor size increased (P<0.05). However it was not related to TNM staging, the differentiation of tumor cells or lymph node metastasis. We concluded that the expression patterns of MMP-2, MMP-3, and MMP-13 may play a role in the diagnosis, treatment plan and prognostic evaluation of malignant tumors of the tongue.