• Journal of Ginseng Research
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• 제45권2호
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• pp.325-333
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• 2021

Background: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. Enhancing hippocampal neurogenesis by promoting proliferation and differentiation of neural stem cells (NSCs) is a promising therapeutic strategy for AD. 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) are small, bioactive compounds found in ginseng that can promote NSC proliferation and neural differentiation in vitro. However, it is currently unknown whether PPD or OA can attenuate cognitive deficits by enhancing hippocampal neurogenesis in vivo in a transgenic APP/PS1 AD mouse model. Here, we administered PPD or OA to APP/PS1 mice and monitored the effects on cognition and hippocampal neurogenesis. Methods: We used the Morris water maze, Y maze, and open field tests to compare the cognitive capacities of treated and untreated APP/PS1 mice. We investigated hippocampal neurogenesis using Nissl staining and BrdU/NeuN double labeling. NSC proliferation was quantified by Sox2 labeling of the hippocampal dentate gyrus. We used western blotting to determine the effects of PPD and OA on Wnt/GSK3β/β-catenin pathway activation in the hippocampus. Results: Both PPD and OA significantly ameliorated the cognitive impairments observed in untreated APP/PS1 mice. Furthermore, PPD and OA significantly promoted hippocampal neurogenesis and NSC proliferation. At the mechanistic level, PPD and OA treatments resulted in Wnt/GSK-3β/β-catenin pathway activation in the hippocampus. Conclusion: PPD and OA ameliorate cognitive deficits in APP/PS1 mice by enhancing hippocampal neurogenesis, achieved by stimulating the Wnt/GSK-3β/β-catenin pathway. As such, PPD and OA are promising novel therapeutic agents for the treatment of AD and other neurodegenerative diseases.

• Korean Journal of Radiology
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• 제24권11호
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• pp.1081-1092
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• 2023

Objective: To investigate the incidence of microvascular myocardial ischemia in diabetic patients without obstructive coronary artery disease (CAD) and its relationship with angina. Materials and Methods: Diabetic patients and an intermediate-to-high pretest probability of CAD were prospectively enrolled. Non-diabetic patients but with an intermediate-to-high pretest probability of CAD were retrospectively included as controls. The patients underwent dynamic computed tomography-myocardial perfusion imaging (CT-MPI) and coronary computed tomography angiography (CCTA) to quantify coronary stenosis, myocardial blood flow (MBF), and extracellular volume (ECV). The proportion of patients with microvascular myocardial ischemia, defined as any myocardial segment with a mean MBF ≤ of 100 mL/min/100 mL, in patients without obstructive CAD (Coronary Artery Disease-Reporting and Data System [CAD-RADS] grade 0-2 on CCTA) was determined. Various quantitative parameters of the patients with and without diabetes without obstructive CAD were compared. Multivariable analysis was used to determine the association between microvascular myocardial ischemia and angina symptoms in diabetic patients without obstructive CAD. Results: One hundred and fifty-two diabetic patients (mean age: 59.7 ± 10.7; 77 males) and 266 non-diabetic patients (62.0 ± 12.3; 167 males) were enrolled; CCTA revealed 113 and 155 patients without obstructive CAD, respectively. For patients without obstructive CAD, the mean global MBF was significantly lower for those with diabetes than for those without (152.8 mL/min/100 mL vs. 170.4 mL/min/100 mL, P < 0.001). The mean ECV was significantly higher for diabetic patients (27.2% vs. 25.8%, P = 0.009). Among the patients without obstructive CAD, the incidence of microvascular myocardial ischemia (36.3% [41/113] vs. 10.3% [16/155], P < 0.001) and interstitial fibrosis (69.9% [79/113] vs. 33.3% [8/24], P = 0.001) were significantly higher in diabetic patients than in the controls. The presence of microvascular myocardial ischemia was independently associated with angina symptoms (adjusted odds ratio = 3.439, P = 0.037) in diabetic patients but without obstructive CAD. Conclusion: Dynamic CT-MPI + CCTA revealed a high incidence of microvascular myocardial ischemia in diabetic patients without obstructive CAD. Microvascular myocardial ischemia is strongly associated with angina.

• 수산해양교육연구
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• 제21권1호
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• pp.96-105
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• 2009

Recently, the logistics companies are constructing distribution market for logistics service in hinterland which is convenient for management and activity of logistics. Since the expansion of hinterland has physical constraints and related to the adjacent cities, it is vital to select value added types of logistics in the business. This study determines the priority of logistics business types in the hinterland of Busan's new port using DHP, and also it suggests future types of logistics business by comparing result of study with the enterprises located in the hinterland. As a result, the inter-modal transport business has higher weight than the storage business. The distribution manufacturing business also has relatively high weight. Therefore, the inter-modal business and storage business need to keep a present status in hinterland, and the distribution manufacturing business should consolidate the role.

• Wind and Structures
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• 제14권5호
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• pp.465-480
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• 2011

In this paper, a stabilized large eddy simulation technique is developed to predict turbulent flow with high Reynolds number. Streamline Upwind Petrov-Galerkin (SUPG) stabilized method and three-step technique are both implemented for the finite element formulation of Smagorinsky sub-grid scale (SGS) model. Temporal discretization is performed using three-step technique with viscous term treated implicitly. And the pressure is computed from Poisson equation derived from the incompressible condition. Then two numerical examples of turbulent flow with high Reynolds number are discussed. One is lid driven flow at Re = $10^5$ in a triangular cavity, the other is turbulent flow past a square cylinder at Re = 22000. Results show that the present technique can effectively suppress the instabilities of turbulent flow caused by traditional FEM and well predict the unsteady flow even with coarse mesh.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권10호
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• pp.2632-2649
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• 2012

Most approaches to human action recognition is limited due to the use of simple action datasets under controlled environments or focus on excessively localized features without sufficiently exploring the spatio-temporal information. This paper proposed a framework for recognizing realistic human actions. Specifically, a new action representation is proposed based on computing a rich set of descriptors from keypoint trajectories. To obtain efficient and compact representations for actions, we develop a feature fusion method to combine spatial-temporal local motion descriptors by the movement of the camera which is detected by the distribution of spatio-temporal interest points in the clips. A new topic model called Markov Semantic Model is proposed for semantic feature selection which relies on the different kinds of dependencies between words produced by "syntactic " and "semantic" constraints. The informative features are selected collaboratively based on the different types of dependencies between words produced by short range and long range constraints. Building on the nonlinear SVMs, we validate this proposed hierarchical framework on several realistic action datasets.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권10호
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• pp.2679-2691
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• 2012

In this paper, a high accuracy stereo reconstruction method for surgery instruments positioning is proposed. Usually, the problem of surgical instruments reconstruction is considered as a basic task in computer vision to estimate the 3-D position of each marker on a surgery instrument from three pairs of image points. However, the existing methods considered the 3-D reconstruction of the points separately thus ignore the structure information. Meanwhile, the errors from light variation, imaging noise and quantization still affect the reconstruction accuracy. This paper proposes a method which takes the structure information of surgical instruments as constraints, and reconstructs the whole markers on one surgical instrument together. Firstly, we calibrate the instruments before navigation to get the structure parameters. The structure parameters consist of markers' number, distances between each markers and a linearity sign of each instrument. Then, the structure constraints are added to stereo reconstruction. Finally, weighted filter is used to reduce the jitter. Experiments conducted on surgery navigation system showed that our method not only improve accuracy effectively but also reduce the jitter of surgical instrument greatly.

• Journal of Information Processing Systems
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• 제5권4호
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• pp.167-174
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• 2009

Nowadays, it has become common to equip a device with Bluetooth. As such devices become pervasive in the world; much work has been done on forming them into a network, however, almost all the Bluetooth Scatternet Formation Algorithms assume devices are homogeneous. Even the exceptional algorithms barely mentioned a little about the different characteristics of devices like computational abilities, traffic loads for special nodes like bridge nodes or super nodes, which are usually the bottleneck in the scatternet. In this paper, we treat the devices differently not only based on the hardware characteristics, but also considering other conditions like different classes, different groups and so on. We use a two-phase Scatternet Formation Algorithm here: in the first phase, construct scatternets for a specified kind of devices; in the second phase, connect these scatternets by using least other kinds of devices as bridge nodes. Finally, we give some applications to show the benefit of classification.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.161-165
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• 2014

The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidine in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in terms of preparation, viscosity and in vitro release. The viscosity of the gellan gum formulations in solution increased with increasing concentrations of gellan gum. In vitro study showed that the release of ranitidine from these gels was characterized by an initial phase of high release (burst effect) and translated to the second phase of moderate release. Single photon emission computing tomography technique was used to evaluate the stomach residence time of gel containing $^{99m}Tc$ tracer. The animal experiment suggested in situ gel had feasibility of forming gels in stomach and sustained the ranitidine release from the gels over the period of at least 8 h. In conclusion, the in situ gel system is a promising approach for the oral delivery of ranitidine for the therapeutic effects improvement.

• International Journal of Automotive Technology
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• 제8권3호
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• pp.299-308
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• 2007

This study proposes a two-layer hierarchical control system that integrates active front wheel steering and four wheel braking torque control to improve vehicle handling performance and stability. The first layer is a robust model matching controller (R-MMC) based on linear matrix inequalities (LMIs), which optimizes an active front steering angle compensation and a desired yaw moment control, and calculates reference wheel slip for the target wheel according to the desired yaw moment. The second layer is a moving sliding mode controller (MSMC) that can track the reference wheel slip in a predetermined time by commanding proper braking torque on the target wheel to achieve the desired yaw moment. Since vehicle sideslip angle measurement is difficult to achieve in practice, a sliding mode observer (SMO) that requires only vehicle yaw rate as the measured input is also developed in this study. The performance and robustness of the SMO and the integrated control system are demonstrated through comprehensive computer simulations. Simulation results reveal the satisfactory tracking ability of the SMO, and the superior improved vehicle handling performance, stability and robustness of the integrated control vehicle.

• 한국도서관정보학회지
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• 제25권
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• pp.405-439
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• 1996

During his reign, Kwang-Hae-Kun has done various works to promote literature and book acquisition. Among those works is the establishment of a special office called 'Tok Seo Dang' as he was enthroned in 1608, though it was demolished in 1622. And 'Seo Chuk Kyo In To Kam' was built to recover the scattered and lost books. He encouraged the people to collect and publish books by rewarding those who were engaged in a sort of library works. Their primary responsibility was to collect rare and essential resources, seek the material even in China and publish them using metal printing type. They even sought the diaries and newsletters which the individuals kept at their house. The collected materials were first copied and then kept in 'Shilok' shrine. Among the imported books are Dae Myung Hoi Chon, Chon Choo Sa Chon, Tong Kam Chan Yo, Du Si Tong Chon, Ok Hae, Mun Seon, Hak Hae, Lim Geo Man Rok and some were without titles. Majority of the compiled materials were medical books and geographies like Shin Cheung Tong Kak Yeu Chi Seung Ram, Tong Eui Po Kam, etc. Because of this strenuous effort, they were able to collect and retrieve lots of books and materials between 1608 and 1623. Majority of the published books were of Confucianism(13) which were followed by Political and Legal items(5), Historical documents(3), literature (3), etc. Regarding our library history, one should never forget Kwang-Hae-Kun's significant and remarkable contribution to it.