• Journal of the Korean Society of Mechanical Technology
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• v.20 no.6
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• pp.941-946
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• 2018

Currently, due to the development of technology, the industry is proceeding with the development of advanced materials with high performance such as light weight, heat resistance and electric conductivity. Carbon Fiber Reinforced Plastics (CFRP) is an excellent material with high heat resistance, high strength and thermal shock resistance. In order to obtain excellent hole shape in CFRP drilling, we compared the modified drill shape and the conventional carbide drill. On the other hand, we determine the proper helix angle by observing the CFRP surface according to the helix angle at the trimming of the end mill proceeding after the hole machining.

• International Journal of Highway Engineering
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• v.15 no.6
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• pp.33-39
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• 2013

PURPOSES : This research investigates traffic noise characteristics as change the transverse rumble strips shape from rectangular to cylinder at toll plaza of highway. METHODS : The traffic noise was investigated at two different places at toll plaza of highway. One is modified grooving, another is employed cylinder shape of TRS instead of rectangular shape of TRS. A measurement of traffic noise was conducted at same location and time period. The traffic volume information was gotten from office of highway office and vehicle speed was measured by speed measuring device. The traffic noise measurement was conducted from 13:00 to 23:00 and by pass-by method. Also, the traffic noise was measured behind noise barrier. Various distance from noise barrier(7.5m, 30m, 50m) and different heights(1.2m, 3m, and 5m) were parameter for measurement of traffic noise in this study. RESULTS : The class 1 vehicle was contributed from traffic volume which was increased 1,500. However, the distribution of traffic speed didn't change compare to previous investigated period. From this study, It was found that the external traffic noise was changed as function of geometric shape of TRS. The external noise from modified grooving was less than 1.2dB(A) of the current TRS. A difference of traffic noise was 20dB(A) before and after barrier. It came from a noise barrier effect as reduction of traffic noise. According to investigate a traffic noise distribution near barrier, there is similar noise characteristic as function of height at 7.5m distance from noise barrier. Also, There is no different traffic noise between 30m and 50m from source of the noise of sound barrier. CONCLUSIONS : Based on this traffic noise investigation result, there is a clear characteristic difference as changed TRS shape. The traffic noise was reduced by changed TRS shape. Specially, traffic noise was decreased although the traffic volume was increase for same investigation time and period. It is implied that cylinder type of TRS significantly reduces the traffic noise. The specification of various TRS will be studied in the future.

• Molecules and Cells
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• v.23 no.1
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• pp.1-10
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• 2007

Invading pathogens are recognized by diverse germline-encoded pattern-recognition receptors (PRRs) which are distributed in three different cellular compartments: extracellular, membrane, and cytoplasmic. In mammals, the major extracellular PRRs such as complements may first encounter the invading pathogens and opsonize them for clearance by phagocytosis which is mediated by membrane-associated phagocytic receptors including complement receptors. The major membrane-associated PRRs, Toll-like receptors, recognize diverse pathogens and generate inflammatory signals to coordinate innate immune responses and shape adaptive immune responses. Furthemore, certain membrane-associated PRRs such as Dectin-1 can mediate phagocytosis and also induce inflammatory response. When these more forefront detection systems are avoided by the pathogens, cytoplasmic PRRs may play major roles. Cytoplasmic caspase-recruiting domain (CARD) helicases such as retinoic acid-inducible protein I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5), mediate antiviral immunity by inducing the production of type I interferons. Certain members of nucleotide-binding oligomerization domain (NOD)-like receptors such as NALP3 present in the cytosol form inflammasomes to induce inflammatory responses upon ligand recognition. Thus, diverse families of PRRs coordinately mediate immune responses against diverse types of pathogens.

• IMMUNE NETWORK
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• v.14 no.4
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• pp.187-200
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• 2014

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are the most common cause of genital ulceration in humans worldwide. Typically, HSV-1 and 2 infections via mucosal route result in a lifelong latent infection after peripheral replication in mucosal tissues, thereby providing potential transmission to neighbor hosts in response to reactivation. To break the transmission cycle, immunoprophylactics and therapeutic strategies must be focused on prevention of infection or reduction of infectivity at mucosal sites. Currently, our understanding of the immune responses against mucosal infection of HSV remains intricate and involves a balance between innate signaling pathways and the adaptive immune responses. Numerous studies have demonstrated that HSV mucosal infection induces type I interferons (IFN) via recognition of Toll-like receptors (TLRs) and activates multiple immune cell populations, including NK cells, conventional dendritic cells (DCs), and plasmacytoid DCs. This innate immune response is required not only for the early control of viral replication at mucosal sites, but also for establishing adaptive immune responses against HSV antigens. Although the contribution of humoral immune response is controversial, $CD4^+$ Th1 T cells producing IFN-${\gamma}$ are believed to play an important role in eradicating virus from the hosts. In addition, the recent experimental successes of immunoprophylactic and therapeutic compounds that enhance resistance and/or reduce viral burden at mucosal sites have accumulated. This review focuses on attempts to modulate innate and adaptive immunity against HSV mucosal infection for the development of prophylactic and therapeutic strategies. Notably, cells involved in innate immune regulations appear to shape adaptive immune responses. Thus, we summarized the current evidence of various immune mediators in response to mucosal HSV infection, focusing on the importance of innate immune responses.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.9
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• pp.2225-2233
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• 1994

In order to improve the cutting ability of face mill, a model for optimal cutter shape was developed to minimize resultant cutting force by combing cutting force model and optimal technique. Wear test and surface roughness test for optimized and conventional cutter were performed. The new optimized cutter shows longer tool life of 2.29 times than conventional cutter in light cutting condition and 2.52 times in heavy cutting condition. The surface roughness of workpiece by optimized cutter is improved in heavy cutting condition, but deteriorated in light cutting condition in comparison with conventional cutter. The surface profiles of workpiece were analyzed by Fourier transformation. The distribution of cut lay left on workpiece by optimized cutter is more regular than that by the conventional cutter.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.1
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• pp.53-64
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• 1994

Rouge cutting process takes the major portion of machining operation using NC milling machine. Especially, most of the machining time is spent in this process when molds are machined. Therefore, an efficient algorithm for generating the tool path for rough cutting is suggested in this paper. The first step of the procedure is getting the volume to be machined by applying the Boolean operation on the finished model and the workpiece which have been modeling system. Basic principle of determining machining procedure is that a large tool should be used at the portion of the simple shape while a small tool should be used at the complex portion. This principle is realized by representing the volume to be machined by an octree, which is basically a set of hexahedrons, and matching the proper tools with the given octants. When the tools are matched with the octants, the tool path can be derived at the same time.

• Journal of the Korean Society of Radiology
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• v.13 no.2
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• pp.153-158
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• 2019

The purpose of this study is to compare and analyse the differences between a customized small finger made by 3D printing technology, a real small finger, and the other made from plaster of an orthotic company. The areas and the volumes of each cross-section were measured by Computer tomography(CT) and a 3D scanner and analysis of variance was performed to find out the differences of each shape. The areas of the point of 15.69mm, Distal Interphalangel Joints, were measured 30 times respectively using the caliper toll function of Picture Archiving Communication System(PASC) program. The volumes were measured by Configure Units of Meshmixer Program. There was no significant difference in the areas between three of them and there was 0.2 mm gap in the volume, which was more than the significance probability. Therefore, the result of this study shows the availability of finger orthoses made by 3D printing technology in the medical field.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.2
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• pp.38-45
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• 1999

In this paper, A novel approach on $H_{\infty}-LTR$ design scheme is presented. The proposed scheme provides a design toll which can trade-off the recovery error against the control input. In the first stage, Kalman filter is designed to shape the loop to satisfy the required performance specifications. The designed Kalman filter, together with the plant transfer function, is used as a target transfer function. In the second stage, sensitivity function weighted $H_{\infty}-LTR$suboptimal LTR is designed to recover the target loop transfer function. Simulation results of LQG/LTR, $H_{\infty}-LTR$are compared to demonstrate the good property of the proposed scheme.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.1
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• pp.117-124
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• 2010

Different to other social infrastructures, bridge elements or bridges can be damaged or collapsed and this may cause death toll and severe social and economical damage, bridges should be managed to maintain a safety level. Diverse strengthening methods is developed to improve a deteriorated bridge performance up to original design level. But rational decision-making process and methodologies to select a optimum strengthening method are absence yet in Korea. This paper therefore derived items and proposed methodologies for quantity estimate considering uncertainty to select a optimum strengthening method among conceptually designed alternatives. And also, to demonstrate the applicability and verification of the proposed approach, it was applied to select the optimum strengthening method for the deteriorated T-shape concrete girder bridge. The model and the procedure can greatly contribute to the uncertainty-oriented alternative selection.