• Journal of Ginseng Research
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• v.44 no.6
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• pp.833-842
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• 2020

Background: Ulcerative colitis (UC) is a commonly encountered large intestine disease in the contemporary world that terminates into colorectal cancer; therefore, the timely treatment of UC is of major concern. Panax ginseng Meyer is an extensively consumed herbal commodity in South East Asian countries, especially Korea. It exhibits a wide range of biologically beneficial qualities for almost head-to-toe ailments in the body. Epimedium koreanum Nakai (EKN) is also a widely used traditional Korean herbal medicine used for treating infertility, rheumatism, and cardiovascular diseases. Materials and methods: Separately the anti-inflammatory activities of both red ginseng extracts (RGEs) and EKNs had been demonstrated in the past in various inflammatory models; however, we sought to unravel the anti-inflammatory activities of the combination of these two extracts in dextran sulfate sodium (DSS)-induced ulcerative colitis in mice model because the allopathic remedies for UC involve more side effects than benefits. Results: Our results have shown that the combination of RGE + EKN synergistically alleviated the macroscopic lesions in DSS-induced colitic mice such as colon shortening, hematochezia, and weight loss. Moreover, it restored the histopathological lesions in mice and decreased the levels of proinflammatory mediators and cytokines through the repression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP-3) expression. In vitro, this combination also reduced the magnitude of nitric acid (NO), proinflammatory mediators and cytokine through NF-κB and mitogen-activated protein kinase (MAPK) pathways in RAW 264.7 mouse macrophage cells. Conclusion: In the light of these findings, we can endorse this combination extract as a functional food for the prophylactic as well as therapeutic treatment of UC in humans together with allopathic remedies.

• The Journal of Society for e-Business Studies
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• v.17 no.4
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• pp.57-68
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• 2012

As the functions and technology of IT security solution has been diversified and complicated, it is necessary to make the functions standardized. The common criteria (CC) evaluation and certification scheme was introduced with this background in 2000. For over 10 years after the introduction of CC evaluation and certification scheme, many security solution vendors have developed functions following the security functional requirement in CC. Most of CC evaluators and developers think that CC has helped to enhance the security of the solution. So, it is a right time to prove the affirmative effects of CC in quantity. In this research, we compare two cases, the security status of the solution before and after the experience of CC evaluation, and analyze the results. We made the questionnaire for the domestic solutions vendors. We show that CC has made positive effects on the security of the solution quantitatively using statistical analysis. This research is meaningful security enhancement of domestic security solutions.

• Journal of the Korean Geotechnical Society
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• v.28 no.5
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• pp.27-39
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• 2012

In this paper, a series of centrifuge tests were performed to evaluate the seepage characteristic of reinforced embankment. The centrifuge models simulated an actual embankment reinforced by enlargement of levee cross-section. The centrifuge models have the same conditions except the locations of enlargement with low permeable material : water-side and land-side. In addition, the prototype embankment is constructed on low permeable clay layer. In the case of water-side reinforcement, the reinforced zone makes water head down and the saturated zone of embankment propagates slowly. In the case of land-side reinforcement embankment, the saturated zone enlarged relatively faster but the amount of exit water at land-side toe was very small because of the land-side reinforcement zone. The low permeable clay foundation layer was being continuously saturated by the inflow from the embankment as well as the uplift flow from the permeable layer induced by the excess pore water pressure.

• Journal of the Korean Geotechnical Society
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• v.30 no.6
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• pp.5-21
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• 2014

It has been pointed out that the collapses of unsaturated road embankments caused by earthquake are attributed to high water content caused by the seepage of the underground water and/or the rainfall infiltration. Hence, it is important to study influences of water content on the dynamic stability and deformation mode of unsaturated road embankments for development of a proper design scheme including an effective reinforcement to prevent severe damage. This study demonstrates dynamic centrifugal model tests with different water contents to investigate the effect of water content on deformation and failure behaviors of unsaturated road embankments. Based on the measurement of displacement, the pore water pressure and the acceleration during dynamic loading, dynamic behavior of the unsaturated road embankments with about optimum water content and the higher water content than the optimum one have been examined. In addition, an image analysis has revealed the displacement field and the distributions of strains in the road embankment, by which deformation mode of the road embankment with higher water content has been clarified. It has been confirmed that in the case of higher water content the settlement of the crown is large mainly owing to the volume compression underneath the crown, while the small confining pressure at the toe and near the slope surface induces large shear deformation with volume expansion.

• 한국벤처창업학회:학술대회논문집
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• 2007.11a
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• pp.143-174
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• 2007

The objective of Starts-up education rears leading company that minimize a risk & connect them with successful idea. Internet Starts-up education is serviced in public & civil parts, it is insufficient to reach successful Starts-up support. This study is targeting on review the present condition of the Internet Starts-up education, research which it sees Internet Starts-up education actual condition investigation through investigation student of education satisfactorily and education contents and the plan to grope an Starts-up education progress coat problem and developmental plan it did. The current events point which has become research result escape first, age of the students of education, followed in educational background and, education motive and education experience presence education satisfactory boat song it appeared in these demand different, base grudge the form which is various it fixed and the education was demanded. Second, currently the department of pedagogy joining in establishment leader against the technical element which is advanced swip, the education reinforcement against an enterprise accomplishment ability back human factor, an enterprise propulsion environment and an enterprise item back enterprise environment element was demanded. Time after support and consulting, completion lifestyle community construction, completion lifestyle for item connection support and the trade name net after third, establishing an enterprise we the king, after toe ring back educating which carries on shoulder the importance of the civil official was embossed. The study which it sees led and like this investigation analysis the education progress for the successful support of the Internet Starts-up and time after connection setup construction it led and the plan which it will put out advancement of Starts-up education and it groped.

• Korean Journal of Applied Biomechanics
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• v.23 no.4
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• pp.285-294
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• 2013

The purpose of this study was to provide fundamental information for success factors of techniques through kinematic analysis including coordination of lower extremities and landing stability according to the success and failure of $540^{\circ}$ Dwihuryeochagi in Taekwondo. Twenty Taekwondo athletes: ten success group (S, age: $22.3{\pm}1.8$ yrs, height: $172.1{\pm}5.4$ cm, body mass: $64.4{\pm}4.2$ kg) and ten failure group (F, age: $22.3{\pm}1.8$ yrs, height: $172.1{\pm}5.4$ cm, body mass: $64.4{\pm}4.2$ kg) participated in this study. Three-dimensional motion analysis using a system of 3 video cameras with a sampling of 60 fields/s was performed during the competition of $540^{\circ}$ Dwihuryeochagi. Motions were divided into five events: pivot foot landing (E1), pivot foot toe off (E2), COM max height (E3), kick impact (E4) and landing (E5). At E1, the stride width was greater for S than for F (p<.05) while the time was greater for S than for F during P4 (p<.05). At E4, knee angle was greater for S than for F (p<.05). At E5, hip angle was greater for S than for F (p<.05) while kick distance was greater for S than for F (p<.05). Furthermore, at P3, the time would be related to kicking velocity (p<.05), while at P4, the time, range of hip angle and knee angle would be related to kick distance (p<.05). At P1, COM horizontal velocity would be related to COM vertical velocity of P1 and P2 (p<.05). Based on the findings, success factors of $540^{\circ}\acute{y}$ Dwihuryeochagi were COM horizontal velocity of P1, COM vertical velocity of P2, the time, kick distance, velocity, angle of lower extremities and coordination of P3-P4.

• Geotechnical Engineering
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• v.12 no.5
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• pp.79-88
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• 1996

In this study, prediction of soil behavior under vacuum preloading with vertical drain is explored on the basis of numerical models and toe results were compared with field measurements. Reasonable prediction of the time rate of settlements and pore pressure dissipation under vacuum preloading is the maj or concern. The conventional method for vatsuum preloading is based on modeling vacuum preloading as surcharge loading for the consolidation analysis. However, this modeling may violate the real behavior of soils under vacuum loading since the total stress in the analysis varies due to the modeled surcharge loading whereas in'.situ total stress of soils under vacuum loading is constant. In this study a new method is suggested. Instead of modeling vacuum loading as surcharge loading, negative hydraulic head is applied at the surface drain boundary to simulate the vacuum preloading. Comparisons of predictions and field measurements of soil behavior under vatsuum preloading are presented and the usefulness of the new modeling technique is demonstrated.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.3
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• pp.71-84
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• 1985

Using a saturated-unsaturated transient flow equation the change of hydraulic heads within a dike due to tidal fluctuation is investigated in this study. The calculation is done by the use of a software computer program called FLUMP, which is based on a FEM technique and useful to the analyses of unsaturated flow problems. Some of the program has been supplemented in this study for the application to the rise of a tide. It is assumed that a dike is composed of two materials, that the tide rises and falls with a constant amplitude of 10 meters, and that water tables are located at 0m, 5m, and lam from the minimum tidal level. For these conditions the hydraulic heads are calculated for 8 cycles(96 hours) of tidal changes. It is known from the analysis that the hydraulic heads change with tidal level in some extent and that the amplitudes of the head varies depending on the location within the dike: the maximum amplitude shows near the toe of the dike, the amplitude decreases with increasing distance from the upstream face, and beyond a certain location the heads are unaffected by the tidal differences. Assuming that the dike has been completed in a moment the hydraulic heads are nearly stabilized in 96 hours towards some constant values corresponding to a specified water table.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.245-248
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• 1997

Operative interventions for the management of osteonecrosis of the femoral head (ONFH) include core drilling, with or without vascularized fibular bone grafting. Nevertheless, their clinical results have not been consistently satisfactory. Recently, a new surgical procedure that incorporates cementation with polymethylmethacrylate (PMMA) after core drilling has been tried clinically. In this study, a biomechanical analysis using a finite element method(FEM) was undertaken to evaluate surgical methods and their underlying surgical parameter. Our finite element models included five types. They were (1) normal model (Type I), (2) necrotic model (Type II), (3) core decompressed model (Type III). (4) fibular bone grafted model (Type IV), and (5) cemented with PMMA model (Type V). The geometric dimensions of the femur were based on digitized CT-scan data of a normal person. Various physiological loading conditions and surgical penetration depths by the core were used as mechanical variables to study their biomechanical contributions in stress transfer within the femoral head region. In addition. the peak von Mises stress(PVMS) within the necrotic cancellous bone of the femoral head was obtained. The fibular bone grafted method and cementation method provided optimal stress transfer behaviors. Here. substantial increase in the low stress level was observed when the penetration depth was extended to 0mm and 5mm from the subchondral region. Moreover, significant decrease in PVMS due to surgery was observed in the fibular bone grafted method and the cementation method when the penetration depths were extended up to 0 and 5mm from the subchondral region. The drop in PVMS was greater during toe-off than during heel-strike (57% vs. 28% in Type IV and 49% vs. 22% in Type V). Both the vascularized fibular bone grafting method (Type IV) and the new PMMA technique (Type V) appear to be very effective in providing good stress transfer and reducing the peak Von-Mises stress within the necrotic region. Overall results show that fibular bone grafting and cementation methods are quite similar. In light of above results, the new cementation method appears to be a promising surgical alternative or the treatment of ONFH. The use of PMMA for the core can be less prone to surgical complication as opposed to preparation of fibular bone graft and can achieve more immediate fixation between the core and the surrounding region.

• Archives of Plastic Surgery
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• v.36 no.4
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• pp.411-416
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• 2009

Purpose: Malignant melanoma is recognized as the most serious skin cancer. We examined anatomical distribution and 5 - year survival rate of each stage of malignant melanoma on lower leg. Methods: We retrospectively analyzed the medical records of 91 patients(46 males and 45 females) with malignant melanoma on lower leg from 1985 to 2008. Age, sex, anatomical distribution and 5 - year survival rates of each stage of malignant melanoma on lower leg were investigated. Also, 5 - year survival rates of each stage and invasion depth of malignant melanoma on heel pad were investigated. Results: On lower leg, most frequently 32 cases(35.1%) occurred on heel pad, 27 cases(29.7%) occurred on dorsum of foot, 18 cases(19.8%) in toe and 14 cases(15.4%) on others in lower leg. We used the excision margin as 3 ~ 5 cm. After wide excision, in stage III, IV, the patients underwent the immunologic / chemo - therapy. The incidences of each stage were 22 cases(24.2%) in stage I, 47(51.6%) in II, 17(18.7%) in III and 5(5.5%) in IV. The 5 - year survival rates of each stage were 85%, 53.2%, 47.1% and 40%. On heel pad, the incidences of each stage were 5 cases(15.6%) in stage I, 19 cases(59.4%) in II, 7 cases(21.9%) in III and 1 case(3.1%) in IV. The 5 - year survival rates of each stage were 80%, 63.2%, 42.9% and 100%. On heel pad, incidence of local recurrence was 2 and 5 - year survival rate of this case was 100%. And systemic recurrence was 9 and 5 - year survival rate of this case was 55.6%. Conclusion: The 5 - year survival rate of malignant melanoma on heel pad was higher than previous study. To maintain the weight - bearing function of foot, we recommend the active reconstructive surgery for heel pad reconstruction after wide excision of heel pad malignant melanoma.