• Title/Summary/Keyword: To 2

Search Result 458,241, Processing Time 0.41 seconds

In vitro and in vivo anti-inflammatory activities of Korean Red Ginseng-derived components

  • Baek, Kwang-Soo;Yi, Young-Su;Son, Young-Jin;Yoo, Sulgi;Sung, Nak Yoon;Kim, Yong;Hong, Sungyoul;Aravinthan, Adithan;Kim, Jong-Hoon;Cho, Jae Youl
    • Journal of Ginseng Research
    • /
    • v.40 no.4
    • /
    • pp.437-444
    • /
    • 2016
  • Background: Although Korean Red Ginseng (KRG) has been traditionally used for a long time, its anti-inflammatory role and underlying molecular and cellular mechanisms have been poorly understood. In this study, the anti-inflammatory roles of KRG-derived components, namely, water extract (KRG-WE), saponin fraction (KRG-SF), and nonsaponin fraction (KRG-NSF), were investigated. Methods: To check saponin levels in the test fractions, KRG-WE, KRG-NSF, and KRG-SF were analyzed using high-performance liquid chromatography. The anti-inflammatory roles and underlying cellular and molecular mechanisms of these components were investigated using a macrophage-like cell line (RAW264.7 cells) and an acute gastritis model in mice. Results: Of the tested fractions, KGR-SF (but not KRG-NSF and KRG-WE) markedly inhibited the viability of RAW264.7 cells, and splenocytes at more than 500 mg/mL significantly suppressed NO production at $100{\mu}g/mL$, diminished mRNA expression of inflammatory genes such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interferon-${\beta}$ at $200{\mu}g/mL$, and completely blocked phagocytic uptake by RAW264.7 cells. All three fractions suppressed luciferase activity triggered by interferon regulatory factor 3 (IRF3), but not that triggered by activator protein-1 and nuclear factor-kappa B. Phospho-IRF3 and phospho-TBK1 were simultaneously decreased in KRG-SF. Interestingly, all these fractions, when orally administered, clearly ameliorated the symptoms of gastric ulcer in HCl/ethanol-induced gastritis mice. Conclusion: These results suggest that KRG-WE, KRG-NSF, and KRG-SF might have anti-inflammatory properties, mostly because of the suppression of the IRF3 pathway.

The design and construction with the JES method used steel elements for under pass in korea and the practical use of the JES method (강재 엘리먼트를 이용한 기계식 UNDER PASS 공법(JES 공법)의 국내 적용 사례 및 활용 방안 연구)

  • Jeong, Gyeong-Hwan;Jung, Sun-Tae;Kim, Do-Hyeong;Kim, Jung-Sung;Hwang, Young-Chul;Park, Min-Kwan
    • Proceedings of the KSR Conference
    • /
    • 2009.05a
    • /
    • pp.1498-1508
    • /
    • 2009
  • Recently, the expansion of roads are necessary because the population and vehicles have rapidly increased, but those are restricted because of the limited site. JES(Jointed Element Structure) method is the method of the new cross-structure, which is element-traction method which draws and excavates elements under the existing structure with high accuracy within a short time. Also JES(Jointed Element Structure) method has a facility of the economical execution, a small effect on the train-service during construction period and no limit of the crossing length under the trade In this study, the tractive force and settlement are compared with the upper element, side wall element and the lower element respectively in the section which the JES method is applied In the case of element located at left side wall, the tractive force measured by a guage is double or more than the tractive force calculated by a formula. It is expected that many boulder contented in the ground contrary to the site investigation data cause high tractive force. For comparison of the settlement, the settlement as excavating the upper element is the largest in all steps. It is expected that this is the same as the cause of high tractive force. Also in this study, the practical use of the JES method when some under pass structures are extended in the future is studied.

  • PDF

The Clinical Effects of an Herbal Antimicrobial Feed Additive in Growing Chickens (천연물 유래 항생제 대체 사료첨가제의 육계 임상 효능에 대한 연구)

  • Oh, Hong-Geun;Park, Hyun;Kim, Youn-Chul;Lee, Hyun-A;Kim, Ok-Jin
    • Journal of Veterinary Clinics
    • /
    • v.27 no.1
    • /
    • pp.17-22
    • /
    • 2010
  • The natural herbal antimicrobial additive, Flavo-$SK^{TM}$, was developed by Zoonosis Research Center of Wonkwang University. The purpose of this study was to evaluate the effects of Flavo-$SK^{TM}$ on the health status and performance of growing chickens. This study was conducted on the growing chickens (n=20,000) for 31 days in a growing chickens husbandry. The animals were divided with two groups; Flavo-$SK^{TM}$ treated group (n=10,000) and commercial diet feeding group (n=10,000). The Flavo-$SK^{TM}$ treated animals had provided with commercial diet adding the Flavo-$SK^{TM}$ as 0.29%. During the study period, we compared clinical signs, weight increase rate, diet consumption amount, gross finding, necropsy findings and histopathological findings between the treated group and non treated group. As the results of this clinical trial, the natural herbal antimicrobial additive, Flavo-$SK^{TM}$, showed the effects on disease reduction. It is suggested that Flavo-$SK^{TM}$ has the antimicrobial effects.

Residues of Tolclofos-methyl, Azoxystrobin and Difenoconazole in Ginseng Sprayed by Safe Use Guideline (안전사용기준에 따라 살포된 살균제 Tolclofos-methyl, Azoxystrobin 및 Difenoconazole의 인삼 중 잔류량)

  • Kim, Jang-Eok;Kim, Tae-Hwa;Kim, Young-Hwan;Lee, Ju-Hee;Kim, Jin-Su;Paek, Seung-Kyoung;Choi, Su-Yeon;Youn, Young-Nam;Yu, Yong-Man
    • Korean Journal of Medicinal Crop Science
    • /
    • v.16 no.6
    • /
    • pp.390-396
    • /
    • 2008
  • The aim of this work is to assess the safety of fungicide tolclofos-methyl, difenoconazole and azoxystrobin in ginseng sprayed by safe use guideline. When tolclofos-methyl was sprayed on ginseng by safe use guideline, the residue amounts (MRL) of it in ginseng was 0.13 mg/kg which is below than 0.3 mg/kg, maximum residue limit established by Korea Food & Drug Administration (KFDA). The residue amounts of ginseng parts, head part was 0.37 mg/kg and main body part was 0.13 mg/kg. In case of difenoconazole, the residue amounts in ginseng was 0.81 mg/kg. which was exceed the MRL, 0.2 mg/kg. By the analyze results of ginseng part, the residues of head and main body part were 3.01 and 0.40 mg/kg, respectively. In experiment of vinyl mulching, the residue amount of difenoconazole in ginseng was 0.05 mg/kg. The residue amounts of azoxystrobin in ginseng sprayed by safe use guideline was 0.14 mg/kg. This residue was not exceed the MRL 0.5 mg/kg. The residue amounts by ginseng parts was 0.51 mg/kg for head part and 0.28 mg/kg for main body part. In case of vinyl mulching, the residue amount of azoxystrobin was 0.02 mg/kg.

Real-time Spatial Recommendation System based on Sentiment Analysis of Twitter (트위터의 감정 분석을 통한 실시간 장소 추천 시스템)

  • Oh, Pyeonghwa;Hwang, Byung-Yeon
    • The Journal of Society for e-Business Studies
    • /
    • v.21 no.3
    • /
    • pp.15-28
    • /
    • 2016
  • This paper proposes a system recommending spatial information what user wants with collecting and analyzing tweets around the user's location by using the GPS information acquired in mobile. This system has built an emotion dictionary and then derive the recommendation score of morphological analyzed tweets to provide not just simple information but recommendation through the emotion analysis information. The system also calculates distance between the recommended tweets and user's latitude-longitude coordinates and the results showed the close order. This paper evaluates the result of the emotion analysis in a total of 10 areas with two keyword 'Restaurants' and 'Performance.' In the result, the number of tweets containing the words positive or negative are 122 of the total 210. In addition, 65 tweets classified as positive or negative by analyzing emotions after a morphological analysis and only 46 tweets contained the meaning of the positive or negative actually. This result shows the system detected tweets containing the emotional element with recall of 38% and performed emotion analysis with precision of 71%.

Mechanism of Collector Adsorption on Monazite (Monazite 界面上의 捕集劑 吸着機能에 關한 硏究)

  • Hyung Sup Choi;Ki Up Whang
    • Journal of the Korean Chemical Society
    • /
    • v.7 no.2
    • /
    • pp.91-95
    • /
    • 1963
  • The basic studies of adsorption characteristics of collector on monazite were made by electrophoretic measurement and by determination of the adsorption of some typical flotation collectors. By above measurements made on monazite, it is concluded that $H^+\;and\;OH^-$ are identified to act as potential determining ions and thus the electrical properties of monazite is controlled by the pH of the solution. Therefore, anionic collectors are adsorbed on positively charged surfaces and cationic collectors on negatively charged surfaces, which in turn controls the effective flotation condition with respective collectors for this mineral. These results have been correlated with its flotation behavior obtained by Hallimond tube test.

  • PDF

The Effects of Pretreatment on the Lipid Oxidation of Korean Geoduck Muscle during Frozen Storage (코끼리 조개의 동결저장 중 지질의 변화에 미치는 전처리의 효과)

  • YOU Byeong-Jin;CHOI Heong-Gil;JEONG In-Hak;LEE Kang-Ho
    • Korean Journal of Fisheries and Aquatic Sciences
    • /
    • v.26 no.4
    • /
    • pp.296-304
    • /
    • 1993
  • The effects of pretreatment on the lipid oxidation of korean geoduck muscle during storage at $-20^{\circ}C$ were investigated. In the lipid compositions of geoduck muscle, neutral, glycolipid, and phospholipid contents were $46.1\%,\;4.5\%\;and\;49.5\%$, respectively. And the content of phospholipid decreased to $39.9\%$ by blanching. In the fatty acids composition, $C_{16:0},\;C_{20:5}\;and\;C_{22:6}$ fatty acids were major portions and their contents showed, respectively, $10\%$ of total fatty acids amount or more. $C_{18:0},\;C_{16:1},\;C_{18:1},\;C_{14:0}\;and\;C_{20:1}$ fatty acids were also important fatty acids and their amounts were so much as $5\%$ or more. The polyunsaturated fatty acid contents were relatively high as $39.25\%{\sim}42.60\%$. POV in RM and VM samples increased gradually and showed 3.72meq/kg, or 3.00meq/kg after 90 days storage, respectively. However, in case of samples pretreated by blanching, there was slightly increase of POV throughout storage. From the results above, it was suggested that the pretreatment of blanching was effective in retardation of lipid oxidation for the longterm storage.

  • PDF

AN EVALUATION OF MECHANICAL PROPERTIES OF LIGHT-CURED RESTORATIVE COMPOSITES BY INDENTATION AND COMPRESSION TEST (압입과 압축에 의한 광중합형 수복용 복합레진의 기계적 성질 평가)

  • Lee, Yong-Woo;Yu, Mi-Kyung;Cho, Young-Gon;Bae, Tae-Sung;Lee, Kwang-Won
    • Restorative Dentistry and Endodontics
    • /
    • v.24 no.3
    • /
    • pp.511-518
    • /
    • 1999
  • This study was performed to evaluate the mechanical properties of light-cured restorative composites by compression and indentation tests. Five commercially available light-activated composites (Heliomolar : HM, Aelitefil : AF, Amelogen : AG, Clearfil AP-X : CF, Z100 ZH) were used Disc specimens of 12mm in diameter and 1 mm in thickness and Cylindrical specimens of 3mm in diameter and 6mm in length were prepared for the indentation and compressive test, respectively. All specimens were immersed in distilled water at $37^{\circ}C$ for 30 days. An indentation test of 68-degree trigonal diamond pyramid was made under 10 g load for 15 seconds and an Knoop indentation test was made under 50 g load for 15 seconds. Hardness numbers, characteristic indentation depths and permanent deformation were measured during indentation of the 68-degree trigonal diamond pyramid compressive test was carried out at a crosshead speed of 0.5mm/min. The results obtained were summarized as follows, 1. The highest hardness value was obtained in the CF group and the lowest value was obtained in the HM group. Hardness values showed no significant, difference between AG group and HM group but other groups showed the significant differences in each group(p<0.05). 2. Hardness number by Knoop pyramid were higher than those of 68-degree trigonal diamond pyramid. 3. Plastic deformation during the indentation of 68-degree trigonal diamond pyramid was the lowest in the CF group and the largest in the HM group. Results of Tukey test showed the significant difference between CF group and others; also between ZH and AF groups and AG and HM groups(p<0.05) 4. The highest compressive strength was obtained in the CF group and the lowest compressive strength was obtained in the ZH group. Compressive strength values showed no significant difference between CF group and ZH group but other groups showed the significant differences in each group(p<0.05).

  • PDF

A Critical Review On the Profiles of Korean Female Labor Force: 1960-2000 (한국 여성노동력의 성격변화와 노동정책: 1960-2000)

  • Kim, Mi-Sok
    • Korea journal of population studies
    • /
    • v.29 no.1
    • /
    • pp.133-156
    • /
    • 2006
  • This paper tries to explore the overall profile of Korean female labor force over the period of 1960-2000. A particular emphasis is put on portraying major over-time characteristics of female labor force, following five different political regimes--that of Park, J.H.(1960 and 1970s), of Chon D.H. (early and late 1980s), of Roh T.W. (late 1980-early 1990s), of Kim,Y.S. (early 1990-1ate 1990s), and of Kim. D. J. (late 1990-early 2000s), respectively. Discussions have centered around: 1) utilization of young single girls from rural areas during the early industrialization process of 1960-1985; 2) the beginning of married women's entry into labor market and issues of the socalled &M-curve& thesis in Korean experiences since 1990s; 3) the emergence and enlargement of non-regular workers; and 4) the launching of labor related legal measures such as the Equal Employment Act of 1988 and its successive revisions, the Maternity Leave Acts, the On-the-Job Chi1dcare Centers, and the prohibition of sexual harassments on the job setting, and so on. All in all, although it is undeniable that the Korean female labor force has experienced much progress over the period of time in terms of &equality and protection& issues, overall industrial reality we are facing with has not been so prosperous in the sense that most women workers have become the victims of industrial polarization, as time goes by.

Effect of Packaging Material and Storage Temperature on the Quality of Tomato and Plum Fruits (포장재 및 저장온도가 토마토와 자두의 품질에 미치는 영향)

  • 이세희;이명숙;이용우;염형준;선남규;송경빈
    • Food Science and Preservation
    • /
    • v.11 no.2
    • /
    • pp.135-141
    • /
    • 2004
  • To examine the quality changes of tomato and plum fruits during storage under various storage conditions, the rate of weight loss, pH change, titratable acidity, Hunter a value, firmness, and anthocyanin content were determined during storage. Tomato and plum fruits were stored at 4$^{\circ}C$ and 25$^{\circ}C$. Tomato fruits were packaged with high density polyethylene film (HDPE) and polyvinylidene chloride film (PVDC), and plum fruits were packaged with HDPE. Tomato fruits packaged with PVDC and plum fruits packaged with HDPE at 4$^{\circ}C$ were the most desirable in terms of weight loss. Titratable acidity of tomato fruits decreased with increasing storage time regardless of temperature and packaging method. Hunter a value of tomato fruits stored at 25$^{\circ}C$ increased regardless of packaging method, while it was not changed for tomato fruits stored at 4$^{\circ}C$. Firmness of plum fruits stored at 25$^{\circ}C$ significantly decreased during storage and anthocyanin content increased. Microbial numbers of tomato fruits increased during storage, but its rate was retarded during storage when tomato fruits were packaged with HDPE and stored at 4$^{\circ}C$. These results suggest that cold chain system and appropriate packaging could maintain the quality and prolong the shelf life of fresh produce.