• Journal of the Korea Convergence Society
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• v.8 no.9
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• pp.9-16
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• 2017

In this paper, sub-microwave oscillator sensor is proposed to non-invasively monitor the glucose concentration level of the human biological tissue by oscillation frequency variation. Inductive slot in the ground plane of the microstrip line is combined with the biological tissue, to realize the resonator as a part of the oscillator sensor. The phantom box mimicking the human tissue is introduced for simulation of the resonator which resonance frequency correspondingly shifts up on three step glucose concentration levels(0, 400, 800 mg/dL). Oscillator sensor circuit is fabricated as a prototype. Pig tissues instead of human is used. Oscillation frequency shift of about 14 MHz per glucose level of 400 mg/dL has been successfully measured around 1,100 MHz. This proves that the proposed sensor is applicable to a blood glucose sensor.

• Journal of Biomedical Engineering Research
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• v.30 no.5
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• pp.418-427
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• 2009

As many people are westernizing their life style and food consumption habits, a number of patients who have malignant tumors which grow very rapidly and hazardously destroy the human body are increasing. Ultrasonic hyperthermia is not only one of the tumor treatment methods which employs the non-radioactive ultrasonic waves to increase the temperature at the tumor region up to $40\sim45^{\circ}C$ to destroy and suppress tumor cells but also has been proved by many studies. Due to the rapid development of High Intensity Focused Ultrasound(HIFU), the ultrasound hyperthemia extensively boosts its applications in clinical field. For those reasons, Computed simulation factor should be needed before inspection to patients. To prove efficiency of ultrasonic hyperthermia, precise acoustic field measurement considering tissue characteristics and a heating experiment with tissue mimicking material phantom were conducted for effectiveness of simulation program. Finally, in this study, the computer simulation program verified the anticipated temperature effects induced by ultrasound hyperthermia. In the near future, it is hoped that this simulation program could be utilized to improve the efficiency of ultrasound hyperthermia.

• Radiation Oncology Journal
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• v.20 no.2
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• pp.186-192
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• 2002

Purpose : Measurement of transmission dose is useful for in vivo dosimetry. In this study, previous algorithm for estimation of transmission dose was modified for use in cases with tissue deficit. Materials and Methods : The beam data was measured with flat solid phantom in various conditions of tissue deficit. New algorithm for correction of transmission dose for tissue deficit was developed by physical reasoning. The algorithm was tested in experimental settings with irregular contours mimicking breast cancer patients using multiple sheets of solid phantoms. Results : The correction algorithm for tissue deficit could accurately reflect the effect of tissue deficit with errors within ${\pm}1.0\%$ in most situations and within ${\pm}3.0\%$ in experimental settings with irregular contours mimicking breast cancer treatment set-up. Conclusion : Developed algorithm could accurately reflect the effect of tissue deficit and irregularly shaped body contour on transmission dosimetry.

• The Journal of the Acoustical Society of Korea
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• v.39 no.6
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• pp.576-584
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• 2020

In order to obtain basic information for using polyvinyl alcohol (PVA) gel as a tissue mimicking phantom for temperature visualization, the temperature change characteristics due to the focused ultrasound were examined for different concentration of PVA. To obtain the basic acoustic characteristics, the speed of sound, the attenuation coefficient, and the density depending on the PVA concentration were measured, and the thermodynamic characteristics, such as thermal conductivity and heat capacity, were measured. The range of temperature rising in the vicinity of the focal point due to the focused ultrasound was observed using a thermochromic film that changes color at 30 degree or more, and the discolored area was obtained by image processing of the recorded image. As the concentration of PVA increases in the given range of 2 wt% ~ 16 wt%, the area that rises above 30 degree inside the gel increases linearly. It is confirmed that the discolored area increases as the power applied to the focused ultrasonic transducer increases. These results showed good agreement with the simulation results using the finite element method.

• Journal of Sensor Science and Technology
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• v.18 no.5
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• pp.377-384
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• 2009

The ultrasonic hyperthermia for oncology has been developed and studied. The HIFU(high intensity focused ultrasound) is the most recent method to treat the tumor by using ultrasound. In this study, an insertion-type transducer for treating a prostate cancer, which can focus the ultrasonic beam mechanically and electrically, was designed and developed. The developed transducer was composed of three arrays, and each array has 32 elements. For the purpose of the mechanical focusing, both side arrays are slanted to the center array by $15^{\circ}$. With this structure, NFL(near field length) was set up as 30 mm. The PZT-4 and two matching layers were used, and the backing layer was excepted to prevent energy losses. The acoustic field analysis and the heating test were performed to evaluate the performance of developed transducer. The shape of an acoustic field, peak pressure, and acoustic pressure distribution were compared with numerical simulation. The NFL was 32 mm, the beam width was 5 mm, focal area was $40\;mm^2$, and peak pressure was 5.5 MPa. With heating by using developed transducer, the temperature increased up to $33^{\circ}C$ at focal zone. As a result of this study, the usefulness of suggested transducer for prostate cancer hyperthermia was confirmed by the acoustic field analysis and the heating test with TMM(tissue mimicking) phantom.