• Title/Summary/Keyword: Timothy

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Towards improved floor spectra estimates for seismic design

  • Sullivan, Timothy J.;Calvi, Paolo M.;Nascimbene, Roberto
    • Earthquakes and Structures
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    • v.4 no.1
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    • pp.109-132
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    • 2013
  • Current codes incorporate simplified methods for the prediction of acceleration demands on secondary structural and non-structural elements at different levels of a building. While the use of simple analysis methods should be advocated, damage to both secondary structural and non-structural elements in recent earthquakes have highlighted the need for improved design procedures for such elements. In order to take a step towards the formation of accurate but simplified methods of predicting floor spectra, this work examines the floor spectra on elastic and inelastic single-degree of freedom systems subject to accelerograms of varying seismic intensity. After identifying the factors that appear to affect the shape and intensity of acceleration demands on secondary structural and non-structural elements, a new series of calibrated equations are proposed to predict floor spectra on single degree of freedom supporting structures. The approach uses concepts of dynamics and inelasticity to define the shape and intensity of the floor spectra at different levels of damping. The results of non-linear time-history analyses of a series of single-degree of freedom supporting structures indicate that the new methodology is very promising. Future research will aim to extend the methodology to multi-degree of freedom supporting structures and run additional verification studies.

RUMEN DEGRADABILITY OF ITALIAN RYEGRASS (Lolium multiflorum, L) HARVESTED AT THREE DIFFERENT GROWTH STAGES IN SHEEP

  • Fariani, A.;Warly, L.;Matsui, T.;Fujihara, T.;Harumoto, T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.7 no.1
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    • pp.41-48
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    • 1994
  • This experiment was carried out in order to evaluate the chemical composition and rumen degradation characteristics of Italian ryegrass harvested at three different growth stages, i,e. pre-blooming, early-blooming and late-blooming. Degradation values were obtained by incubation of the samples using the nylon bag technique on the rumen of sheep fed a normal diet (Timothy hay with 200 g/d concentrate per head) for 12, 24, 36, 48 and 72 hours, respectively. Neutral detergent fiver (NDF) content was highest at late-blooming (64.4%) while no difference was found among the pre-blooming and early-blooming (49.4% vs 48.3%). However, acid detergent fiber (ADF) content markedly increased from 30.0% at pre-blooming to 35.4% and 46.4% at early-blooming and late-blooming, respectively. Lignin and silica contents also increased as advancing maturity of the grass, Rumen degradation of dry matter (DM) significantly reduced (p < 0.05) as advancing maturity of the grass. Ruman degradation cellulose and ADF at pre-blooming were significantly higher (p < 0.05) than those of early-blooming and late-blooming. However, no significant differences were observed among the early-blooming and late-blooming. With advancing maturity, rumen degradation of NDF and hemicellulose significantly reduced (p < 0.05) at the incubation times.

Development of Highly Selective Fluorescent Chemosensors for Fluoride Ion (불소 이온 감지용 형광 센서의 개발)

  • Kim, Tae-Hyun;Kim, In-Ja;Yoo, Min-Ji;Swager, Timothy M.
    • Journal of the Korean Chemical Society
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    • v.51 no.3
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    • pp.258-264
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    • 2007
  • Novel fluoride sensory systems have been successfully developed. Previously developed method of the fluoride-induced lactonization to fluorescent molecules was detailed, and newly developed fluoride-induced aromatic cyclization scheme was introduced. Based on the strategies using the specific affinity of fluoride to silicon, our systems are highly selective for fluoride ion. Incorporation of the developed sensor to a conjugated polymer has successfully enhanced its sensitivity to fluoride ion.

The Use of E-journals by Health Researchers: A Case Study of the Nigerian Institute of Medical Research (NIMR)

  • Olayemi, Olalekan Moses;Abolarinwa, Timothy Shola;Olayemi, Kemi Jummai
    • Journal of Information Science Theory and Practice
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    • v.5 no.3
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    • pp.61-70
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    • 2017
  • This study investigated the use of e-journals by health researchers in the Nigerian Institute of Medical Research (NIMR). A descriptive survey method was adopted for the study and a questionnaire was used for data collection. The study population was comprised of fifty-four (54) respondents who are health researchers in the institute. The data collected were presented and analyzed using tables, frequency distribution, simple percentages, and charts. The result of the study revealed that all the respondents are aware of the availability of e-journals and attest to making use of them. The study revealed that electronic journals were mostly used for the purpose of conducting research work and the PDF format was preferred for downloading e-journals. However, it was observed that low Internet connectivity and intermittent electricity supply constitute a major obstacle to the use of e-journals. The study, therefore, recommended that the institute's management invest more resources on network connectivity, particularly its bandwidth, and ensure reliable power supply.

Evaluating the Existence of Small Compressed Binucleated Squamous Cells in ASC-H

  • Okodo, Mitsuaki;Okayama, Kaori;Kitamura, Hiroshi;Shiina, Natsuko;Caniz, Timothy;Ono, Midori;Yabusaki, Hiromi
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.10
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    • pp.4665-4669
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    • 2016
  • Purpose: To evaluate the legitimacy of a diagnosis of ASC-H in 5 cases which were followed up monthly for over 2 years with both cytology and HPV testing. Methods: Some 5 cases out of a total of 25.0 self-sampled Pap test patients diagnosed as ASC-H provided 119 specimens over 2 years, with HPV-DNA testing perormed using a E6 primer. Results: Cases 1, 2 and 3 showed SIL after the ASC-H diagnosis, while cases 4 and 5 showed and maintained NILM. Cases 1, 2 and 3 were further characterized by small atypical compressed binucleated cells, in which HPV was detected by in situ PCR. Case 4 showed a high N/C ratio in cells in sheets with a mild increase in chromatin. Case 5 demonstrated a high N/C ratio in small cells with no increase in chromatin. Conclusion: The finding of a compressed binucleated cells can define the difference between degenerated endocervical columnar cells and small atypical cells suggestive of HSIL. When small compressed binucleated squamous cells are detected, there may be a chance of continuing HPV infection and undetected SIL.

C-Sphere Strength-Size Scaling in a Bearing-Grade Silicon Nitride

  • Wereszczak, Andrew A.;Kirkland, Timothy P.;Jadaan, Osama M.;Strong, Kevin T.;Champoux, Gregory J.
    • Journal of the Korean Ceramic Society
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    • v.45 no.9
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    • pp.507-511
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    • 2008
  • A "C-sphere" specimen geometry was used to determine the failure strength distributions of a commercially-available bearing-grade silicon nitride ($Si_3N_4$) with ball diameters of 12.7 and 25.4 mm. Strengths for both diameters were determined using the combination of failure load, C-sphere geometry, and finite element analysis and fitted using two-parameter Weibull distributions. Effective areas of both diameters were estimated as a function of Weibull modulus and used to explore whether the strength distributions predictably scaled between each size. They did not. That statistical observation suggested that the same flaw type did not limit the strength of both ball diameters indicating a lack of material homogeneity between the two sizes. Optical fractography confirmed that. It showed there were two distinct strength-limiting flaw types common to both ball diameters, that one flaw type was always associated with lower strength specimens, and that a significantly higher fraction of the 25.4-mm-diameter C-sphere specimens failed from it. Predictable strength-size-scaling would therefore not result as a consequence of this because these flaw types were not homogenously distributed and sampled in both C-sphere geometries.

Kinematic properties of the Ursa Major Cluster

  • Kim, YoungKwang;Lee, Young Sun;Beers, Timothy C.
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.2
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    • pp.30.3-31
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    • 2015
  • We present a kinematic analysis of 172 likely member galaxies of the Ursa Major Cluster. In order to understand the dynamical state of the cluster, we investigate the correlation of the cluster morphology with rotation, the velocity dispersion profile, and the rotation amplitude parallel to the global rotation direction. Both the minor axis and the rotation are very well-aligned with the global rotation axis in the outer region at half radius (> 0.5 $R_{max}$), but not in the inner region. The cluster exhibits low velocity dispersion and rotation amplitude profiles in the inner region, but higher in the outer. Both profiles exhibit outwardly increasing trends, suggesting an inside-out transfer of angular momentum of dark matter via violent relaxation, as revealed by a recent off-axis major-merging simulation. From Dressler-Schectman plots in the plane of galactic positions, and velocity versus position angle of galaxy, we are able to divide the Ursa Major Cluster into two substructures: Ursa Major South (UMS) and Ursa Major North (UMN). We derive a mass of $3.2{\times}10^{14}M_{\odot}$ for the cluster through the two-body analysis by the timing argument with the distance information (37 for UMN and 36 for UMS) and the spin parameter of ${\lambda}=0.049$. The two substructures appear to have passed each other 4.4 Gyr ago and are moving away to the maximum separation.

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Preliminary Design of the G-CLEF Flexure Control Camera System

  • Oh, Jae Sok;Park, Chan;Park, Sung-Joon;Kim, Kang-Min;Chun, Moo-Young;Yu, Young Sam;Lee, Sungho;Szentgyorgyi, Andrew;Norton, Timothy;Podgorski, William;Evans, Ian;Mueller, Mark;McMuldroch, Stuart;Uomoto, Alan;Crane, Jeffrey;Hare, Tyson
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.2
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    • pp.56.1-56.1
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    • 2015
  • The GMT-Consortium Large Earth Finder (G-CLEF) is the very first light instrument of the Giant Magellan Telescope (GMT) and an optical-band echelle spectrograph. The Flexure Control Camera (FCC) is one of the major contributions of KASI's for the spectrograph project. FCC system includes the Fiber Mirror monitoring and the on- and off-slit mode auto-guidance algorithm. In this study, we present the modified design of the FCC optics and opto-mechanics after the G-CLEF Preliminary Design Review (PDR) held in Cambridge in April 2015.

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An Information-Intensive Approach to the Molecular Pharmacology of Cancer

  • John N. Weinstein;Timothy G. Myers;Patrick M. O′Connor;Stephen H. Friend;Albert J. Fornace Jr;Kurt W. Kohn;Tito Fojo;Susan E. Bates;Lawrence V. Rubinstein;N. Leigh Anderson;John K. Buolamwini;Wiliam W. van Osdol;Anne P. Monks;Dominic A. Scudiero;Edward A. Sausville;Daniel W. Zaharevitz;Barry Bunow;Vellarkda N. Viswanadhan;Georage S. Johnson;Robert E. Wittes;Kennety D. Paull
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2001.08a
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    • pp.139-149
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    • 2001
  • Since 1990, the National Cancer Institute(NCI) has screened more than 60.000 compounds against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory concentration (GI$_{50}$) values encode unexpectedly rich, detailed information on mechanisms of drug action and drug resistance. Each compound's pattern is like a fingerprint, essentially unique among the many billions of distinguishable possibilities. These activity patterns are being used in conjunction with molecular structural features of the tested agents to explore the NCI's database of more than 460, 000 compounds, and they are providing insight into potential target molecules and modulators of activity in the 60 cell lines. For example, the information is being used to search for candidate anticancer drugs that are not dependent on intact p53 suppressor gene function for their activity. It remains to be seen how effective this information-intensive strategy will be at generating new clinically active agents.s.

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Seasonal Changes in the Ovary of the African Lungfish Protopierus annectens (Pices : Sarcopterygii) in the Flood Plains of River Niger in Etsako East Local Government Area of Nigeria

  • Onyedineke, Nkechi E.;Otuogbai, Timothy;Elakhame, Luckey A.;Erekaife, Joyce O.
    • Journal of Aquaculture
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    • v.15 no.1
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    • pp.43-48
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    • 2002
  • We investigated the gonadosomatic index (GSI), germ cell development, reproductive cycle of the Afriean lungfish Protorierus annecteus (Owen) by histological observations and morphometric data. Samples were collected from the river Orie and its flood of Nigeria, from January to December 2000. The fish is dioecious and oviparous. Monthly changes in the gonadosomatic index (GSI) showed a similar pattern to change in the mean oocyte diameter and the reproductive cycle. The reproductive period occurred from March to July-August; the spawning period was once a year between truly and August, and the main spawning occurred in August when active and voracious feeding occurred during the rainy season. In the resting (dormant) stage after spawning, fish stopped feeding and aestivated during the dry season from December to February. The reproductive cycle of the species can be divided into five successive stages, quiescent stage (March to April), developing/maturing stage (April to lune), ripe/spawning stage (July to August), post-spawning stage (September to November), and resting (dormant) stage (December to February).