• 한국응용곤충학회지
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• 제46권2호
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• pp.213-219
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• 2007

보리두갈래진딧물 [Schizaphis graminum (Rondani)] 의 발육실험은 $15-32.5^{\circ}C$, 상대습도 $65{\pm}5%$, 광주기 16L:8D 조건에서 조사하였다. 진딧물의 발육 중 약충 사충률은 $15^{\circ}C$에서 $32.5^{\circ}C$까지 조사했을 때, 어린약충기간의 사충률이 대부분을 차지하였고, 온도가 높아지면서 사충률이 점차적으로 감소하였다. 그러나 $30^{\circ}C$부터 다시 증가하여, $32.5^{\circ}C$에서 다른 온도보다 사충률이 높게 나타났다. 진딧물의 전체 약충 발육기간을 보면 $30^{\circ}C$에서 4.9 일로 가장 짧았고 $15^{\circ}C$에서 13.8 일로 가장 길었다. $15^{\circ}C$에서 $30^{\circ}C$까지 온도가 증가함에 따라 발육기간이 짧아지는 경향을 보이지만, $32.5^{\circ}C$부터 다시 발육기간이 6.4 일로 길어졌고, $35^{\circ}C$에서는 모든 약충이 죽어서 발육기간에 포함하지 않았다. 발육영점온도는 $6.8^{\circ}C$이었고, 유효 적산온도는 105.9일도였다. 온도별 발육율은 Sharpe and DeMichele 의 모델을 변형시켜 Schoolfield 등이 제시한 온도별 발육모형에 잘 부합되어 보리두갈래 진딧물의 발육모형을 적용하는데 적합한 것으로 생각한다. 생리적 연령에 따른 발육완성시기를 Weibull function을 이용했을 때 온도별 발육시기의 누적발육률을 비교적 잘 설명하였다.

• 마케팅과학연구
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• 제19권4호
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• pp.1-10
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• 2009

本研究的目的是对咖啡店的 "重要性"（顾客在光顾咖啡店以前的感知）和积极或消极的 "满意度"（顾客在光顾咖啡店以后的感受）之间的差距进行分类, 并分析这些差距对对购买行为的影响. 为此, 我使用重要性和满意度之间的差距作为选择咖啡店的解释变量, 并通过使用有序Probit模型（OPM）来实证分析差距对购买行为（整体满意度和愿意到再次光顾）的影响方向和大小. 先前使用IPA的研究评估了差距影响的方向和大小的象限, 但是在分析差距对顾客的影响方面却失败了. 在本研究中, 我评估了积极和消极的差距对顾客满意度和愿意去再光顾的影响. 通过使用OPM,我量化了积极和消极的差距对顾客整体满意度和愿意去再光顾的影响. 每个人的支出, 光顾的频率和购买咖啡的地方对顾客整体满意度有最积极的影响. 光顾的频率, 在每人的支出之后, 然后是购买咖啡的地方对顾客整体满意度有最积极的影响. 因此每个人的支出和光顾的频率对顾客整体满意度有最积极的影响. 这一发现意味着一个在咖啡店每次或每周花费5000韩元的顾客的实际的满意度越高（差距), 其整体满意度和愿意去再光顾就越高. 虽然经济效益对总体满意度和愿意去再光顾有显著影响, 但是大专和大学的学生仍然愿意去咖啡馆并愿意消费5000韩元, 因为他们不只是购买咖啡本身而且将咖啡店作为其他活动的场所, 例如工作, 和朋友见面或是放松的地方. 学院和大学的学生还可以在咖啡店通过个人电脑上网, 看电影, 学习, 因此, 咖啡馆应对顾客提供适当的设施和服务. 咖啡店品牌的积极差距对愿意去再光顾有积极的影响表明顾客满意度越高, 顾客越愿意去再光顾. 另一方面, 这一因素的消极差距意味着顾客满意度越低, 顾客再光顾的意愿也越低. 因此, 在本研究中, 与其他评估的因素相比, 品牌因素对满意度有较大的影响. 鉴于国内咖啡文化变得越来越高级, 大专院校的学生对这一趋势也很敏感, 所以学生有很多可选择的品牌. 在韩国最高级的咖啡店, 外墙是玻璃建造的并可以打开, 内部是充满异国情调的开放式厨房. 这些高级咖啡店作为标志的功能复合大专院校学生的品味. 韩国咖啡店已成为一个文化品牌. 从品牌因素来看, 为了让顾客觉得这些咖啡店是高级的, 高质量的设备和提供更好服务的措施应当建立起来. 韩国咖啡馆作为蓬勃发展的行业品牌竞争加剧的结果表明, 提供与竞争对手不同的额外服务是有必要的. 顾客可以免费使用扫描仪. 另一个可以用来提高品牌的战略是提供和经营为集体学习而准备的讨论会议室. 如果咖啡馆采取这些类型的策略, 学院/大学的学生将更有可能认为他们承担的费用是值得的, 随后, 他们将可能更满足这些咖啡馆的品牌, 并更愿意再次光顾. 性别和学习年数对总体满意度和再光顾的意愿有最消极的营销. 女学生比男学生更容易满足和再光顾. 三, 四年级的学生比一, 二年级的学生更容易满足和再光顾. 喝咖啡的学生, 单独在咖啡店看书, 用笔记本电脑是很容易被注意到的. 高年级学生为了有效地利用时间用于自我发展和寻找工作往往独自光顾咖啡店. 从积极的差距来看, 经济效率这一因素对总体满意度和愿意再光顾有最大的影响. 与咖啡价格一起, 学生实际满意度（差距）越高, 总体满意度和再光顾的意愿也越高. 有消极差距的经济效率队再光顾有消极营销的结果表明较小的消极差距可以让再光顾的意愿更高. 在持续恶化的市场环境中, 坐落在大专院校附近的咖啡店采取诸如积分或会员卡, 和信用卡 公司的战略联盟, 发展套餐菜单或季节菜单和免费咖啡服务这些战略来提高竞争力. 就消极差距而言产品功率也有消极的影响, 这表明较高的负差距会导致较低的再光顾的意愿. 因为还有更多的客户比前几十年, 在这十年里更喜欢咖啡, 新一代的客户, 即学院/大学的学生, 希望除了咖啡还有更重菜单项目. 因此, 咖啡店应当增加配菜项目, 如华夫饼, 糕, 蛋糕, 三明治和沙拉. 例如, 星巴克韩国正在努力加强卖草莓糕, 艾草香味, 南瓜产品, 并提供免费的咖啡或奶油. 总而言之, 咖啡馆应注重提高其经济效率, 品牌和产品功率, 以加强大专院校学生的满意度. 由于店铺毗邻学大专院校可享受地缘优势, 就经济效率, 品牌和产品功率而言提供不同的服务, 很可能会提高客户满意度和回访. 咖啡厅的品牌, 因此, 应不断创新和变化, 以满足顾客的愿望. 由于这项研究只是针对在首尔的大专院校的学生, 需要针对不同地区和年龄组的比较研究来概括本研究的结果和建议.

• 대한간호학회지
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• 제25권2호
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• pp.372-389
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• 1995

The frequency with which administration of chemotherapy for gynecological cancer treatment is used has increased along with the use of surgery and radiotherapy Among the various side effects of chemotherapy, stomatitis causes a problem of function and sensation in the oral cavity. This oral discomfort can be categorized into two components ; perceived oral symptoms and observed oral symptoms. If the oral problem continues, it may cause infection, bleeding and nutritional deficiencies. As a result of this condition, compliance with the treatment process can be affected as well as the prognosis for the cancer patients. But as the oral discorrfort usually appears after chemotherapy, it is often not reported to the health care personnel as a patient problem. Without problem identification of the oral discomfort and ability to assess the problem, effective intervention cannot be planned. Therefore, this study was conducted to identify the pattern and the degree of oral discomfort due to cancer chemotherapy and thus to provide data for identification of the patient problem and for nursing assessment. The design of this study was a longitudinal de-scriptive study The subjects were in - patients who received chemotherapy under the diagnosis of gynecological cancer between Mar. 15, 1994 and May 15, 1994 at a general hospital in Seoul, Korea. The number of subjects was 64 and they were divided into two groups, one of 41 (A : 5FU & Neoplatin), the other of 23(B : Neoplatin, Cytoxan, Adriamycin), according to the treatment regimen. The data were collected for 24 days using self-re-port instruments. The instruments were the 「Perceived Oral Symptom Assessment Tool」 and 「Observed Oral Symptom Assessment Tool」 developed by this researcher. Data were analyzed using the SPSS-PC program, ANOVA, t-test, paired t-test and the Pearson Correlation Coefficient were applied. The results of this study are as follows : 1. In A regimen the peak time for perceived oral symptom scores was the fifth day after chemotherapy, and the tenth day for observed oral symptom scores. Both of the problems started on first day of chemotherapy and were not resolved completely until the 24th day after treatment. 2. In B regimen, the peak time for perceived oral symptom scores was on the seventh day after chemotherapy, and the eighth day for observed oral symptom scores. It was noted that perceived oral symptom scores were higher than observed oral symptom scores consistently for 24 days. Both also started on first day of chemotherapy, and were not resolved completely until the 24th day after chemotherapy. 3. There were no differences statistically in perceived oral symptom scores between A and B regimen. The loss of appetite and xerostomia caused the most severe discomfort in both of these two groups. 4. The were no differences statistically in observed oral symptom scores between the A and B regi moil. In the A regimen, the highest observed symptom scores were the lips, gingiva, tongue and buccal membrane in that order. But in the B regimen, the highest observed symptom scores were tongue, lips, buccal membrane and gingiva in that order. 5. In A regimen, the patients who had gingival edema and dentures had significantly higher perceived oral symptom scores. And those who had gingival edema and bleeding, foul odor and aphthous stomatitis had significantly higher observed oral symptom scores. 6. In B regimen, the patients who had the experience of stomatitis in the last course of chemotherapy had significantly higher perceived oral symptom scores. Those who had gingival edema had significantly higher observed oral symptom scores. 7. In the A regimen there was no correlation between lab values for lymphocytes and albumin with perceived oral symptom scores and observed oral symptom scores. In the B regimen, there was a significant negative correlation between lymphocytes and albumin with the observed oral symptom scores, but not between perceived oral symptom scores and lymphocytes and albumin values. In conclusion, the nurse should expect that the patient undergoing chemotherapy will complain severely about subjective discomfort and before objective physical change is observed. Also the patients who have chronic oral problems such as dentures, gingival edema and bleeding, foul odor, aphthous stomatitis will complain of severe oral discomfort due to chemotherapy.

• 지능정보연구
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• 제23권2호
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• pp.71-88
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• 2017

언어모델은 순차적으로 입력된 자료를 바탕으로 다음에 나올 단어나 문자를 예측하는 모델로 언어처리나 음성인식 분야에 활용된다. 최근 딥러닝 알고리즘이 발전되면서 입력 개체 간의 의존성을 효과적으로 반영할 수 있는 순환신경망 모델과 이를 발전시킨 Long short-term memory(LSTM) 모델이 언어모델에 사용되고 있다. 이러한 모형에 자료를 입력하기 위해서는 문장을 단어 혹은 형태소로 분해하는 과정을 거친 후 단어 레벨 혹은 형태소 레벨의 모형을 사용하는 것이 일반적이다. 하지만 이러한 모형은 텍스트가 포함하는 단어나 형태소의 수가 일반적으로 매우 많기 때문에 사전 크기가 커지게 되고 이에 따라 모형의 복잡도가 증가하는 문제가 있고 사전에 포함된 어휘 외에는 생성이 불가능하다는 등의 단점이 있다. 특히 한국어와 같이 형태소 활용이 다양한 언어의 경우 형태소 분석기를 통한 분해과정에서 오류가 더해질 수 있다. 이를 보완하기 위해 본 논문에서는 문장을 자음과 모음으로 이루어진 음소 단위로 분해한 뒤 입력 데이터로 사용하는 음소 레벨의 LSTM 언어모델을 제안한다. 본 논문에서는 LSTM layer를 3개 또는 4개 포함하는 모형을 사용한다. 모형의 최적화를 위해 Stochastic Gradient 알고리즘과 이를 개선시킨 다양한 알고리즘을 사용하고 그 성능을 비교한다. 구약성경 텍스트를 사용하여 실험을 진행하였고 모든 실험은 Theano를 기반으로 하는 Keras 패키지를 사용하여 수행되었다. 모형의 정량적 비교를 위해 validation loss와 test set에 대한 perplexity를 계산하였다. 그 결과 Stochastic Gradient 알고리즘이 상대적으로 큰 validation loss와 perplexity를 나타냈고 나머지 최적화 알고리즘들은 유사한 값들을 보이며 비슷한 수준의 모형 복잡도를 나타냈다. Layer 4개인 모형이 3개인 모형에 비해 학습시간이 평균적으로 69% 정도 길게 소요되었으나 정량지표는 크게 개선되지 않거나 특정 조건에서는 오히려 악화되는 것으로 나타났다. 하지만 layer 4개를 사용한 모형이 3개를 사용한 모형에 비해 완성도가 높은 문장을 생성했다. 본 논문에서 고려한 어떤 시뮬레이션 조건에서도 한글에서 사용되지 않는 문자조합이 생성되지 않았고 명사와 조사의 조합이나 동사의 활용, 주어 동사의 결합 면에서 상당히 완성도 높은 문장이 발생되었다. 본 연구결과는 현재 대두되고 있는 인공지능 시스템의 기초가 되는 언어처리나 음성인식 분야에서 한국어 처리를 위해 다양하게 활용될 수 있을 것으로 기대된다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제13권1호
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• pp.117-128
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• 2002

목 적：10대 임신의 보다 정확한 역학적 접근을 위한 일련의 연구의 첫 단계로, 우선 의료 일선에서 10대 산모를 돌보고 있는 산부인과 전문의들을 대상으로 하여, 이들이 현장에서 인지하고 있는 10대 임신의 현황과 문제점 및 정신과 자문에 대해 파악코자 본 연구를 시행하였다. 방 법：10대 임신의 빈도, 특성, 출산과 중절의 결정과정, 산모 및 신생아의 산부인과적, 정신과적 문제점, 정신과 자문 필요성을 중심으로 한 구조화된 설문지를 작성하여 전국 2800명의 산부인과 전문의에게 우편으로 배포한 후 회수된 349명의 자료를 분석하였다. 결 과：(1) 10대 임신의 빈도는 약간 증가한다는 추세였으며, 10대 임신모가 처음 병원을 방문하는 시기는 임신초기와 중기가 가장 많았으며, (2) 임신의 원인으로는 강압적이나 난잡한 성 관계보다는 지속적인 성 관계 에 의한 우발적 임신이 가장 많았다. (3) 출산하게 된 원인은 임신중절시기를 놓쳐서가 가장 많았다. (4) 10대 임신모의 정신심리학적 문제로는 지능저하나 성폭행피해 보다는 성 지식의 부재나 비행소녀가 많았다. (5) 10대 임신모에 대한 상담 역할은 대부분 산부인과 의사 본인이 담당하였고 정신과전문의나 전문 상담인력과 연계하는 일은 비교적 드물었다. 대부분 정신과 자문의뢰 필요성은 느끼나 ‘보호자나 환자의 거부’때문에 현실적으로 어렵다고 하였다. (6) 10대 임신에 관한 가장 절실한 예방대책으로는 피임교육이라고 응답하였다. 결 론：본 연구의 결과를 토대로 추후 10대 임신모를 대상으로 한 체계화된 면담기법을 이용하여, 10대임신의 위험요인을 분명히 하고, 이들의 사회적응에 관련된 정신과적인 접근방안과 나아가 10대 임신의 예방방안에 관한 구체적인 연구가 산과의사와 연계하에 이루어져야 되리라 본다.고 지능 수치가 상대적으로 낮아 학습 및 학교 생활 적응에 어려움이 더 많을 것이므로 적극적인 치료개입이 필요할 것으로 생각되었다.모두 능력의 향상을 보였으나, 간섭이 있는 주의력 검사에서는 산소흡입군만이 유의한 호전을 보였다. 또한 처치 전후의 변화율((치료후값-치료전값)/치료전값 *100)을 계산하여, 산소군과 공기군 간의 통계적 유의성을 평가한 결과, 공기 흡입군에 비해 산소흡입군이 스트룹 검사의 간섭시행, 그리고, 선로잇기검사의 B부분의 수행에서 유의한 차이를 보여, 산소흡입이 전두엽의 수행능력과 관련된 주의력의 호전에 보다 유의한 기여를 할 가능성이 있음을 보여주었다. 2) 기억능력평가：16가지의 기억능력 평가 도구 소척도값 중에서, 산소흡입군은 흡입 전에 비해 11개의 소검사 항목들에서 보다 우수한 수행을 보여 주었고, 공기흡입군은 7개 영역에서 유의한 호전이 있었다. 처치전후의 각 소척도 값의 변화율을 계산하여, 산소군과 공기군 간의 통계적 유의성을 평가한 결과, 단기기억소척도의 점수에서만, 두 군간에 유의한 통계적 차이가 발견되었다. 결 론：주의력과 기억능력에 미치는 산소효과를 검증하기 위해, 대조군비교-이중맹검 임상실험을 실시하여, 반복검사로 인한 효과, 위약효과 등을 배제하였다. 그 결과 양쪽 검사 모두에서 어느 정도의 반복검사 및 위약효과가 확인되었으나, 주의력에서는 전두엽의 실행능력(executive function)과 관련되는 검사들에서 산소흡입이 특이한 효과를 보여준다는 것이 확인되었고, 기억능력에서는 단기기억능력 평가에서 산소흡입군이 대조군보다 유의한 효과를 보여주는 것으로 평가되었다. 이러한 연구결과는 산소흡입이 전두엽과 관련된 수행능력, 작동기억능력 향상에 도움이 될 가능성이 있음을 시사하는 결과라고 생각된다.증 1명(5%)이었다.

• IMMUNE NETWORK
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• 제3권1호
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• pp.1-7
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• 2003

Type II collagen (CII), major component of hyaline cartilage, has been considered as an auto-antigen in rheumatoid arthritis (RA). However, the clinical and biological significances with regard to the CII autoimmunity need to be clarified in human RA. The presence of antibodies to CII has been identified in sera, synovial fluid, and cartilage of patients with RA. In our study, the increased titer of IgG anti-CII in sera was well correlated with C-reactive protein, suggesting that this antibody may reflect the inflammatory status of RA. The titer of anti-CII antibodies (anti-CII Abs) tended to be higher in early stages of diseases. In our extending study, among 997 patients with RA, 269 (27.0%) were positive for circulatory IgG antibody to CII, those levels were fluctuated over time. It is hard to assess the significant amount of T cell responses to CII and CII (255~274) in RA. By using a sensitive method of antigen specific mixed lymphocyte culture, we can detect the presence of CII-reactive T cells in peripheral blood mononuclear cells of RA patients. Sixty seven (46.9%) of 143 patients showed positive CII reactive T cell responses to CII or CII (255~274). The frequencies of CII reactive T cells were more prominent in inflamed synovial fluid (SF) than in peripheral blood. These T cells could be clonally expanded after consecutive stimulation of CII with feeding of autologous irradiated antigen presenting cells (APC). Moreover, the production of Th1-related cytokine, such as IFN-${\gamma}$, was strongly up-regulated by CII reactive T cells. These data suggest that T cells responding to CII, which are probably presenting the IFN-${\gamma}$ producing cells, may play an important role in the perpetuation of inflammatory process in RA. To evaluate the effector function of CII reactive T cells, we investigated the effect of CII reactive T cells and fibroblasts-like synoviocytes (FLS) interaction on the production of pro-inflammatory cytokines. When the CII reactive T cells were co-cultured with FLS, the production of IL-15 and TNF-${\alpha}$ from FLS were significantly increased (2 to 3 fold increase) and this increase was clearly presented in accord to the expansion of CII reactive T cells. In addition, the production of IFN-${\gamma}$ and IL-17, T cell derived cytokines, were also increased by the co-incubation of CII reactive T cells with FLS. We also examined the impact of CII reactive T cells on chemokines production. When FLS were co-cultured with CII stimulated T cells, the production of IL-8, MCP-1, and MIP-1${\alpha}$ were significantly enhanced. The increased production of these chemokines was strongly correlated with increase the frequency of CII reactive T cells. Conclusively, immune response to CII was frequently found in RA. Activated T cells in response to CII contributed to increase the production of proinflammatory cytokines and chemokines, which were critical for inflammatory responses in RA. The interaction of CII-reactive T cells with FLS further augmented this phenomenon. Taken together, our recent studies have suggested that autoimmunity to CII could play a crucial role not only in the initiation but amplification/perpetuation of inflammatory process in human RA.

• 한국잡초학회지
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• 제12권3호
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• pp.261-270
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• 1992

Many herbicides that are applied at the soil before weed emergence inhibit plant growth soon after weed germination occurs. Plant growth has been known as an irreversible increase in size as a result of the processes of cell divison and cell enlargement. Herbicides can influence primary growth in which most new plant tissues emerges from meristmatic region by affecting either or both of these processes. Herbicides which have sites of action during interphase($G_1$, S, $G_2$) of cell cycle and cause a subsequent reduction in the observed frequency of mitotic figures can be classified as an inhibitor of mitotic entry. Those herbicides that affect the mitotic sequence(mitosis) by influencing the development of the spindle apparatus or by influencing new cell plate formation should be classified as causing disruption of the mitotic sequence. Sulfonylureas, imidazolinones, chloroacetamides and some others inhibit plant growth by inhibiting the entry of cell into mitosis. The carbamate herbicides asulam, carbetamide, chlorpropham and propham etc. reported to disrupt the mitotic sequence, especially affecting on spindle function, and the dinitroaniline herbicides trifluralin, nitralin, pendimethalin, dinitramine and oryzalin etc. reported to disrupt the mitotic sequence, particularly causing disappearence of microtubles from treated cells due to inhibition of polymerization process. An inhibition of cell enlargement can be made by membrane demage, metabolic changes within cells, or changes in processes necessary for cell yielding. Several herbicides such as diallate, triallate, alachlor, metolachlor and EPTC etc. reported to inhibit cell enlargement, while 2, 4-D has been known to disrupt cell enlargement. One potential danger inherent in the use of soil acting herbicides is that build-up of residues could occur from year to year. In practice, the sort of build-up that would be disastrous is unikely to occur for substances applied at the correct soil concentration. Crop injury caused by soil applied herbicides can be minimized by (1) following the guidance of safe use of herbicides, particularly correct dose at correct time in right crop, (2) by use of safeners which protect crops against injury without protecting any weed ; interactions between herbicides and safeners(antagonists) at target sites do occur probably from the following mechanisms (1) competition for binding site, (2) circumvention of the target site, and (3) compensation of target site, and another mechanism of safener action can be explained by enhancement of glutathione and glutathione related enzyme activity as shown in the protection of rice from pretilachlor injury by safener fenclorim, (3) development of herbicide resistant crops ; development of herbicide-resistant weed biotypes can be explained by either gene pool theory or selection theory which are two most accepted explanations, and on this basis it is likely to develop herbicide-resistant crops of commercial use. Carry-over problems do occur following repeated use of the same herbicide in an extended period of monocropping, and by errors in initial application which lead to accidental and irregular overdosing, and by climatic influence on rates of loss. These problems are usually related to the marked sensitivity of the particular crops to the specific herbicide residues, e.g. wheat/pronamide, barley/napropamid, sugarbeet/ chlorsulfuron, quinclorac/tomato. Relatively-short-residual product, succeeding culture of insensitive crop to specific herbicide, and greater reliance on postemergence herbicide treatments should be alternatives for farmer practices to prevent these problems.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1811-1815
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• 2014

Background: In clinical trials with no upper age limit, the proportion of older patients is usually small, probably reflecting the more conservative approach adopted by clinicians when treating the elderly. An exploratory analysis of elderly patients in the RECORD-1 Trial showed that patients ${\geq}$ 65 y.o. had superior median PFS than overall RECORD-1 population (5.4 months and 4.9 months, respectively). We investigated the efficacy, relative benefit and safety of Everolimus (EVE) as sequential therapy after failure of VEGFr-TKI therapy for older patients with metastatic renal cell cancer (mRCC), in daily practice. Materials and Methods: 172 consecutive IRB approved patients with mRCC (median age 65, M:F 135/37, 78% clear cell) who received salvage EVE at 39 tertiary institutions between October 2009 and August 2011 were included in this analysis. Some 31% had progressed on sunitinib, 22% on sorafenib, 1% on axitinib, 41% on sequential therapy, and 5% had received other therapy. Patients with brain metastases were not included and 95% of the patients had a ECOG (Eastern Cooperative Oncology Group) performance status (PS) of 0 or 1. Previous radiotherapy was an exclusion criterion, but prior chemotherapy was permitted. Adequate organ function and hematologic parameters were mandatory. EVE administration was approved by the institutional review board at each participating institution and signed informed consent was obtained from all patients. Results: Median time of the whole cohort to last follow-up was 3.5 months (range 0.4-15.2 months). Forty four percent were continuing to take EVE at last followup. There were 86 (50%) patients ${\geq}$ 65 y.o. and 86 (50%) <65 y.o. The percentage of patients who showed PR/SD was higher in the older group than in the younger one (5.9%/61.2% vs 1.2%/46.5%, respectively). Median survival of older patients was also significantly longer (3.5 +/- 0.31 vs 3.1 +/- 0.34, hazard ratio=0.45, CI; 0.255-0.802). Analysis using Cox regression model adjusted for gender, PS, number of metastases, site of metastases, histology, smoking history and age detected an association between age and PFS (p=0.011). The frequency of adverse events in elderly patients treated with EVE was no greater than that in younger patients, although such toxicity may have had a greater impact on their quality of life. Conclusions: Older patients should not generally be excluded from accepted therapies (mTOR inhibitors after failure of VEGFr-TKI therapy) for mRCC.

• 대한방사선기술학회지:방사선기술과학
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• 제37권2호
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• pp.93-100
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• 2014

최근 무선 LAN통신 기능을 이용하여 보다 간편하고 빠르게 디지털 방사선 영상을 획득할 수 있는 디지털 무선 이동촬영장치가 개발되어 많은 편의성을 제공하고 있다. 응급 또는 중환자를 대상으로 시행하는 이동촬영(Portable)검사 특성상 발생할 수 있는 초점-격자 간 중심변위와 피사체의 검출기내 위치변위가 영상화질에 미치는 영향을 평가하여 디지털 무선 검출기의 가이드라인을 제시하고자 한다. 본 연구에서 사용된 장비는 Elmo-T6 Digital Mobile X선시스템(SIMAZU사), el' Tor($14{\times}17$"Wireless detector), 격자(10:1), Chest & head phantom을 사용하였다. 선량증가에 따른 후처리 영상과 초점-격자 간 중심변위와 두부팬텀의 위치변위 영상을 획득한 후 디지털 영상분석 프로그램 Image J를 사용하여 영상을 비교분석 평가하였다. 선량증가에 따른 영상의 변화에서 0.5 mAs의 선량에서는 영상이 거칠고, 적정선량인 1~2 mAs에서 시각적으로 영상의 차이를 알 수 없었고, 특히 2.5 mAs 부터 픽셀 평균값이 급격히 감소하여 대조도에 영향을 미치는 것으로 나타났다. 3 mAs 이상에서는 폐부분의 포화현상으로 대조도가 떨어졌다. Image J 프로그램을 이용한 분석결과 초점-격자 간과 두부팬텀의 중심의 위치변위가 커질수록 낮은 픽셀값의 빈도수가 증가하여 표면도의 윤곽형태가 사라져 대조도에 영향을 미치는 것으로 나타났다. 중환자의 특성상 환자 자세의 어려움, 움직임, 호흡 및 X선관의 변위, 촬영거리의 적용여부에 따라 영상화질을 변화시킬 수 있다는 사실을 방사선사는 정확히 인지하여 검사에 임해야 할 것으로 사료된다.

• The Korean Journal of Pain
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• 제6권2호
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• pp.192-198
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• 1993

In 1984, a magnetic resonance spectrometer(magnetic resonance analyser, MRA $I_{TM}$) was developed by Sigrid Lipsett and Ronald J. Weinstock in the USA, Biomedical applications of the spectrometer have been examined by Dr. Hoang Van Duc(pathologist, USC), and Nakamura, et al(Japan). From their theoretical views, the biophysical functions of this machine are to analyse and synthesize a healthy tissue and organ resonance pattern, and to detect and correct an abnormal tissue and organ resonance pattern. All of the above functions are based on Quantum physics. The healthy tissue and organ resonance patterns are predetermined as standard magnetic resonance patterns by digitizing values based on peak resonance emissions(response levels or high pitched echo-sounds amplified via human body). In clinical practice, a counter or neutralizing resonance pattern calculated by the spectrometer can correct a phase-shifted resonance pattern(response levels or low pitched echo-sounds) of a diseased tissue and organ. By administering the counter resonance pattern into the site of pain and trigger point, it is possible to readjust the phase-shifted resonance pattern and then to alleviate pain through regulation of the neurotransmitter function of the nervous system. For assessing clinical effectiveness of pain relief with MRA $I_{TM}$ this study was designed to estimate pain intensity by the patient's subjective verbal rating scale(VRS such as graded to no pain, mild, moderate and severe) before application of it, to evaluate an amount of pain relief as applied the spectrometer by the patients subjective pain relief scale(visual analogue scale, VAS, 0~100%), and then to observe a continuation of pain relief following its application for managing acute and chronic pain in the 102 patients during an 8 months period beginning March, 1993. An application time of the spectrometer ranged from 15 to 30 minutes daily in each patient at or near the site of pain and trigger point when the patient wanted to be treated. The subjects consisted of 54 males and 48 females, with the age distribution between 23~40 years in 29 cases, 41~60 years in 48 cases and 61~76 years in 25 cases respectively(Table 1). The kinds of diagnosis and the main site of pain, the duration of pain before the application, and the frequency of it's application were recorded on the Table 2, 3 and 4. A distinction between acute and chronic pain was defined according to both of the pain intervals lasting within and over 3 months. The results of application of the spectrometer were noted as follows; In 51 cases of acute pain before the application, the pain intensities were rated mild in 10 cases, moderate in 15 cases and severe in 26 cases. The amounts of pain relief were noted as between 30~50% in 9 cases, 51~70% in 13 cases and 71~95% in 29 cases. The continuation of pain relief appeared between 6~24 hours in two cases, 2~5 days in 10 cases, 6~14 days in 4 cases, 15 days in one case, and completely relived of pain in 34 cases(Table 5~7). In 51 cases of chronic pain before the application, the pain intensities were rated mild in 12 cases, moderate in l8 cases and severe in 21 cases. The amounts of pain relief were noted as between 0~50% in 10 cases, 51~70% in 27 cases and 71~90% in 14 cases. The continuation of pain relief appeared to have no effect in two cases. The level of effective duration was between 6~12 hours in two cases, 2~5 days in 11 cases, 6~14 days in 14 cases, 15~60 days in 9 cases and in 13 cases the patient was completely relieved of pain(Table 5~7). There were no complications in the patients except a mild reddening and tingling sensation of skin while applying the spectrometer. Total amounts of pain relief in all of the subjects were accounted as poor and fair in 19(18.6%) cases, good in 40(39.2%) cases and excellent in 43(42.2%) cases. The clinical effectiveness of MRA $I_{TM}$ showed variable distributions from no improvements to complete relief of pain by the patient's assessment. In conclusion, we suggest that MRA $I_{TM}$ may be successful in immediate and continued pain relief but still requires several treatments for continued relief and may be gradually effective in pain relief while being applied repeatedly.