• Clinical and Experimental Reproductive Medicine
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• v.49 no.4
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• pp.225-238
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• 2022

The ultimate goal of human assisted reproductive technology is to achieve a healthy pregnancy and birth, ideally from the selection and transfer of a single competent embryo. Recently, techniques for efficiently evaluating the state and quality of preimplantation embryos using time-lapse imaging systems have been applied. Artificial intelligence programs based on deep learning technology and big data analysis of time-lapse monitoring system during in vitro culture of preimplantation embryos have also been rapidly developed. In addition, several molecular markers of the secretome have been successfully analyzed in spent embryo culture media, which could easily be obtained during in vitro embryo culture. It is also possible to analyze small amounts of cell-free nucleic acids, mitochondrial nucleic acids, miRNA, and long non-coding RNA derived from embryos using real-time polymerase chain reaction (PCR) or digital PCR, as well as next-generation sequencing. Various efforts are being made to use non-invasive evaluation of embryo quality (NiEEQ) to select the embryo with the best developmental competence. However, each NiEEQ method has some limitations that should be evaluated case by case. Therefore, an integrated analysis strategy fusing several NiEEQ methods should be urgently developed and confirmed by proper clinical trials.

• Clinical and Experimental Reproductive Medicine
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• v.45 no.1
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• pp.52-55
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• 2018

This study retrospectively assessed whether time-lapse data relating to developmental timing and morphology were associated with clinical outcomes, with the eventual goal of using morphokinetic variables to select embryos prospectively for cryopreservation. In this study, we examined the clinical outcomes of single vitrified-warmed blastocyst transfer cycles that were cultured in a time-lapse incubation system. The morphokinetic variables included uneven pronuclei, an uneven blastomere, multinucleation, and direct, rapid, and irregular division. A total of 164 single vitrified-warmed blastocyst transfer cycles were analyzed (102 cycles of regularly developed blastocysts and 62 cycles of blastocysts with morphokinetic variables). No significant differences in the age of females or the standard blastocyst morphology were found between these two groups. The regularly developed blastocysts showed significantly higher implantation and clinical pregnancy rates than the blastocysts exhibiting morphokinetic variables (30.4% vs. 9.7% and 37.3% vs. 14.5%, respectively; p< 0.01). The blastocysts that exhibited morphokinetic variables showed different mean development times compared with the regularly developed blastocysts. Although morphokinetic variables are known to have fatal impacts on embryonic development, a considerable number of embryos developed to the blastocyst stage. Morphokinetic variables had negative effects on the implantation and clinical pregnancy rates in vitrified-warmed blastocyst transfer cycles. These findings suggest that blastocysts cultured in a time-lapse incubation system should be considered for selective cryopreservation according to morphokinetic variables.

• Journal of Periodontal and Implant Science
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• v.35 no.4
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• pp.991-1002
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• 2005

The purpose of this study was to compare the effect of desensitizing agents applied on hypersensitive root surface following periodontal treatment. This study included 21 subjects(168 vital teeth). To evaluate dentin sensitivity, three clinical tests(tactile, air stream, cold water) were tried and three different densensitizing agents(MS coat, Elmex gel. Superseal) were individually applied. After application, reassessment was done at 1 minute, 1 week, 1 month and 3 months. The results were as follows : 1. The degree of dentin sensitivity was measured highly in the sequence of cold water, air stream and tactile and significantly decreased in all four groups with lapse of time(p<0.05). 2. There was no significant difference between all four groups in the tactile test with lapse of time. 3. There was no significant difference between three experimental groups in the air stream test with lapse of time. however, one minute later, it was measured highly in the sequence of Superseal, MS coat and Elmex 4. There was no significant difference between three experimental groups in the cold water test with lapse of time. As a result of this study, all of three agents were significantly effective in reducing dentin hypersensitivity and these agents could be positively employed to patients complaining of dentin hypersensitivity following periodontal treatment.

• Proceedings of the KIEE Conference
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• 1999.07d
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• pp.1639-1641
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• 1999

This paper deals with the seasonal variation of soil resistivity and the special characteristic for ground rods by lapse of time. The ground resistance was changed by humidity, temperature of earth and earth resistance. In this experiment, we studied the resistivity during the period from June 1995 to May 1996 by the soil and the corrosion of the ground rods. As a result, the soil resistivity during the period are appeared minimum in summer and maximum in winter. The loss in weight of Fe rod appeared higher than Cu, Al, Cu-Zn, and St. In the lapse of time, Fe rod was reduced 1.2 % later two years and 1.95 % later three years in weight. Cu rod was defected oxygens of 14.7 % later two years and 30.3 % later three years by EDX.

• Geophysics and Geophysical Exploration
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• v.16 no.4
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• pp.293-299
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• 2013

The recent Multiple Lapse Time Window (MLTW) analysis of Korean Peninsula event showed that the focal depth was far greater influence factor than the velocity structure of the model, applying the analysis of the direct simulation Monte Carlo (DSMC) method. Thus, using the events with focal depth of about 10 km, this study considered 330 paths connecting 41 events and 71 stations, and re-examined uniform and depth-dependent velocity models previously studied. As a result, the residual of misfit function greatly decrease from analytic model to DSMC model, reflecting variation of the focal depth from 0 to 10 km. On the other hand, the difference of residuals for each velocity model were relatively small.

• Journal of Environmental Health Sciences
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• v.26 no.4
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• pp.122-128
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• 2000

This study was carried out to survey trihalomethane formation potential(THMFP) levels in drinking underground water and to examine its characteristics in Kunsan area. In drinking underground water, THMFP increased with the lapse of reaction time and 96hr-THMFP was the highest of THMFPs examined. In many cases, 24hr-THMFP, 48hr-THMFP and 96hr-THMFP reflected 2hr-THMFP level due to the largest composition ratio of CHCl$_3$ decreased with the lapse of reaction of CHCl$_3$ among THM individuals. CHCl$_3$ was mostly formed within early 2hour of reaction time, but CHClBr$_2$ and CHBr$_3$ continued their formation until 48 hour. Accordingly, the composition ratio of CHCl$_3$ decreased with the lapse of reaction time while that of total Br derivatives increased. 96hr-THMFPs of drinking underground water in Kunsan area ranged from N.D.(not detected)~98.80 $\mu\textrm{g}$/$\ell$ and, in general, those of western section of Kunsan area, closer to the coast, showed the higher tendency. But, from their large range of variance, it could be considered that THMFPs differ individually even in the same section depending on such factors as the difference of water stream, circumstances of management and so on. All the parameters for water quality examined(pH, KMnO$_4$ consumption;UV$_{254}$ , TOC. Cl$^{[-10]}$ ) showed very week corelation with 96h-THMFP.

• Geophysics and Geophysical Exploration
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• v.16 no.4
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• pp.217-224
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• 2013

We developed a time-lapse inversion using new cross-model constraints based on change ratio and resolution of model parameters. The cross-model constraint based on change ratio imposes the same penalty on the model parameters with equal change ratio. This constraint can emphasize the model parameters with significant change regardless of their increase or decrease. The resolution cross-model constraint imposes a small penalty on the model parameters with poor resolution, but a large penalty on the model parameters with good resolution. Thus, the model parameter with poor resolution can be effectively identified in the inversion result if they are significantly changed with time. Through the numerical tests for 3D resistivity monitoring data sets, the performance of these two cross-model constraints was confirmed. Finally, for the safety estimation of a sea dyke, we applied the developed time-lapse inversion to the 3D resistivity monitoring data that were acquired at a sea dike located in western coastal area of Korea. The result of time-lapse inversion suggested that there were no significant changes at the sea dike during the monitoring period.

• Korean Journal of Remote Sensing
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• v.25 no.6
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• pp.507-515
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• 2009

Land surface temperature (LST) is a key environmental variable in a wide range of applications, such as weather, climate, hydrology, and ecology. However, LST is one of the most difficult surface variables to observe regularly due to the strong spatio-temporal variations. So, we have developed the LST retrieval algorithm from COMS (Communication, Ocean and Meteorological Satellite) data through the radiative transfer simulations under various atmospheric profiles (TIGR data), satellite zenith angle (SZA), spectral emissivity, and surface lapse rate conditions using MODTRAN 4. However, the LST retrieval algorithm has a tendency to overestimate and underestimate the LST for surface inversion and superadiabatic conditions, respectively. To minimize the overestimation and underestimation of LST, we also developed day/night LST algorithms separately based on the surface lapse rate (local time) and recalculated the final LST by using the weighted sum of day/night LST. The analysis results showed that the quality of weighted LST of day/night algorithms is greatly improved compared to that of LST estimated by original algorithm regardless of the surface lapse rate, spectral emissivity difference (${\Delta}{\varepsilon}$) SZA, and atmospheric conditions. In general, the improvements are greatest when the surface lapse rate and ${\Delta}{\varepsilon}$ are negatively large (strong inversion conditions and less vegetated surface).

• Journal of Oral Medicine and Pain
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• v.20 no.2
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• pp.307-315
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• 1995

The purpose of this study was to assess the efficacy of several thermal therapies using ice pack, moist-hot pack and ultrasound, separately and concomitantly and to obtain the background information on the vascular changes after thermophysical therapies. The author had used 15 healthy subjects were examined and the subjects were divide into 5 groups : ice pack, moist-hot pack, ultrasound, ice pack and moist-hot pack, ice pack and ultrasound. Observation were made immediate before and 0,5,10,20,30,45,60,90 minutes after treatment. Thermography was performed in an Agema 870 thermovisio with 0.1$^{\circ}C$ difference of gradual temperature shift. The results were as follows : 1. Using ice pack only, the surface temperature of the masseter region was increased lapse of time, and most remarkably 90 minutes after the treatment. 2. Using moist-hot pack only, the surface temperature of the region was remarkably increased immediately after the treatment, but decreased lapse of time. 3. Using moist-hot pack with ice pack, the surface temperature of the face was remarkably increased immediately after the treatment, and decreased lapse of time, Hyperthermia was maintained for a longer time as compared with the group of moist-hot pack only. 4. Using ultrasound only, the surface temperature of the region was increased gradually, and most remarkably 30 minutes after the treatment, but decreased in the course of time. 5. Using ultrasound combined with ice pack, the surface temperature of the region was gradually decreased until 30 minutes after the treatment, and decrease to some extend at 45 minute. And then a gradual increase observed over the remaining period of the experiment. 6. Hyperthermia were maintained for a long time in the groups using ice pack combined with moist-hot pack and ultrasound as compared with the other groups. Our data suggest that ice pack can promote the efficacy of other thermal therapies.

• Journal of Korean Physical Therapy Science
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• v.27 no.3
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• pp.56-66
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• 2020

Background: The purpose of this study was to investigate the effects of pulsed-ultrasound intervention and continued-ultrasound on the PPT (pressure pain threshold), CK (creatine kinase) and LDH (lactate dehydrogenase) recovery of before EIMD (exercise-induced muscle damage). Design: Randomized Controlled Trial. Methods: Thirty subjects who are student in their 20s at a university participated in this study, these subjects were assigned into three groups, a control group (n=10), experiment group I (n=10), and experiment group II (n=10). The subjects in experimental group were intervened by pulsed-ultrasound and continued-ultrasound, while ones on control group weren't by any intervention after induced EIMD. Results: First, In the comparison of the PPT, there were significant variations with the lapse the time in three groups (p<.001) and there was a significant interaction of time and group (p<.001). In the among group comparison, the PPT of experimental group II was significantly larger than those of other groups (p<.01). Second, In the comparison of the CK, there were significant variations with the lapse the time in three groups (p<.001) and there was a significant interaction of time and group (p<.001). In the among group comparison, the CK of experimental group II was significantly smaller than those of other groups (p<.001). Third, In the comparison of the LDH, there were significant variations with the lapse the time in three groups (p<.001) and there was a significant interaction of time and group (p<.001). In the among group comparison, the LDH of experimental group II was significantly smaller than those of other groups (p<.001). Conclusion: The above results revealed that the continued-ultrasound intervention before an exercise had a positive effect of muscle function after EIMD. Therefore we can consider the continued ultrasound as a considerable intervention method to prevent or reduce an exercise injury.