• Biomolecules & Therapeutics
• /
• v.25 no.4
• /
• pp.374-382
• /
• 2017

Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates. Along these differences are the male-specific increased expressions of postsynaptic proteins which are the NMDA and AMPA receptors in the prefrontal cortex. The vGluT1 presynaptic proteins, but not GAD, were upregulated in both sexes of TERT-tg mice, although it is more significantly pronounced in the male group. Here, we confirmed that the behavioral effect of TERT overexpression in mice was male-specific, suggesting that the aberration of this gene and its downstream pathways preferentially affect the functional development of the male brain, consistent with the male preponderance in ASD.

• Journal of Korea Water Resources Association
• /
• v.42 no.7
• /
• pp.525-535
• /
• 2009

In this paper a heuristic method for identifying individual pipes in water pipe networks to determine specific sections of the pipes that need to be replaced due to deterioration. An appropriate minimum pipe length is determined by selecting the pipe length that has the greatest variance of the average cumulative break number slopes among the various pipe lengths used. As a result, the minimum pipe length for the case study water network is determined as 4 m and a total of 39 individual pipe IDs are obtained. The economically optimal replacement times of the individual pipe IDs are estimated by using the threshold break rate of an individual pipe ID and the pipe break trends models for which the General Pipe Break Prediction Model(Park and Loganathan, 2002) that can incorporate the linear, exponential, and in-between of the linear and exponetial failure trends and the ROCOFs based on the modified time scale(Park et al., 2007) are used. The maximum log-likelihoods of the log-linear ROCOF and Weibull ROCOF estimated for the break data of a pipe are compared and the ROCOF that has a greater likelihood is selected for the pipe of interest. The effects of the social costs of a pipe break on the optimal replacement time are also discussed.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.7 no.1
• /
• pp.39-42
• /
• 1996

The present study analyed jitter and shimmer of the deaf in 4 different voicing conditions. Thirty-two male subjects and 27 female subjects participated in the study on a voluntary basis. The age ranged from 6 to 18 for male and 8 to 21 for female subjects. The subjects were either congenitally or prelingually deaf The four different voicing conditions included /a/ prolongation, counting, reading, and conversation. The experiment utilized CSL Visi-Pitch Model 6095(Kay Elemetrics Corp.) to sample and analyze the data. Both jitter and shimmer means were higher than the threshold values(normative data) reported. In addition, this investigation performed two separate 2-factor ANOVAs in order to determine if jitter and shimmer change as a function of gender and voicing condition. The results showed the following. First of all there was the gender effect on shimmer but not on jitter, in that male subjects 'shimmer was higher than females'. secondly, there was the voicing condition effect both on jitter and shimmer. /a/ prolongation and reading produced lower jitter than counting and conversation. /a/ prolongation produced lower shimmer than the remaining conditions. Finally, no interaction between gender and voicing condition existed.

• Korean Journal of Animal Reproduction
• /
• v.25 no.4
• /
• pp.295-304
• /
• 2001

Characterization of quantitative trait loci (QTL) was investigated in the experimental crosses between Berkshire and Yorkshire breed. A total of 525 F$_2$ progenies from 65 matting of F$_1$ Parents were produced. Phenotypic measurements included average daily gain (ADG), average back fat thickness (ABF), and loin eye area (LEA). To identify the presence of QTL for reproductive performance, birth weight (BWT) and body weight at 16 days (16DAY) were included as indirect trait. QTL segregation was deduced using 8 markers assigned to chromosome 2 (SSC2). Quantitative trait locus analyses were performed using interval mapping by regression under line-cross model. Presence of imprinting was tested under the statistical model that separated the expression of paternally and maternally inherited alleles. To set the evidence of QTL presence, significance thresholds were derived by permutation following statistical tests, respectively. Genome scan revealed significant evidence for three quantitative trait loci (QTL) affecting growth and body compositions, of which two were identified to be QTL with imprinting expression mode near the ICF II gene region. For average back fat thickness (ABF), a paternally expressed QTL was found on chromosome 2 (SSC2). A paternally expressed QTL affecting loin eye area (LEA) was found in the region of SSC2 where evidence of imprinted QTL was found for average back fat thickness (ABF). For average daily gain (ADG), QTL expressed with Mendelian mode was found on chromosome 2 (SS2). Also, QTL affecting average daily gain (ADC), was identified to be expressed with Mendelian express mode.

• Clean Technology
• /
• v.14 no.2
• /
• pp.136-143
• /
• 2008

The objective of this study is to investigate the visibility of plume at the Y power plant stack, which fires the orimulsion as a fuel. The plume contains numerous primary particles under $1\;{\mu}m$ size and inorganic ions possibly inferred by the chemicals of secondary aerosol formation. We evaluated the visibility of the plume using the modified PLUVUE-II model. The monitoring data on the particle size distribution (PSD) and secondary aerosols of sulfate were applied to estimate and evaluate the main factors of plume opacity. The chemical reactions were applied to the model for the secondary aerosol formation of $(NH_4)_2SO_4(s)$. The maximum plume length was estimated by an optic method using threshold contrast. The results showed that the plume length was strongly dependent upon the PSD and $(NH_4)_2SO_4(s)$ concentration of the plume emitted from the stack.

• Journal of Korea Water Resources Association
• /
• v.46 no.2
• /
• pp.205-218
• /
• 2013

The likelihood of rip current at Haeundae beach according to wave parameters, such as wave height, period, direction, and tidal elevation, was estimated by using numerical simulations with a Boussinesq model, FUNWAVE. To examine the estimation, the rip current occurred on 12th June, 2011 at Haeundae beach was simulated based on observations. For the estimation, the following procedure was carried out. First, extensive numerical simulations of nearshore circulations are performed under various random sea conditions according to the wave parameters. Second, from the numerical results, cross shore components of two-wave-period averaged velocities over the nearshore area were computed, and their seawardly maximum was defined as rip current velocity of the area. Third, using time series of the rip current velocity, we computed the ratio of the simulation time and the time period in which the rip current velocity exceed a threshold velocity for rip-current accidents, and thus the ratio was quantified as the likelihood of rip current at Haeundae beach for the input wave parameters. From the resultant estimations, it was found that the rip current likelihood increases as wave height and period increase, and tidal elevation decreases.

• Journal of the Institute of Electronics Engineers of Korea SC
• /
• v.42 no.2 s.302
• /
• pp.11-18
• /
• 2005

To detect vehicles in image, first the image is transformed with the steerable pyramid which has independent directions and levels. Feature vectors are the collection of filter responses at different scales of a steerable image pyramid. For the detection of vehicles in image, feature vectors in feature points of the vehicle image is used. First the feature points are selected with the grid points in vehicle image that are evenly spaced, and second, the feature points are comer points which m selected by human, and last the feature points are corner Points which are selected in grid points. Next the feature vectors of the model vehicle image we compared the patch of the test images, and if the distance of the model and the patch of the test images is lower than the predefined threshold, the input patch is decided to a vehicle. In experiment, the total 11,191 vehicle images are captured at day(10,576) and night(624) in the two local roads. And the $92.0\%$ at day and $87.3\%$ at night detection rate is achieved.

• Tuberculosis and Respiratory Diseases
• /
• v.46 no.3
• /
• pp.386-393
• /
• 1999

Objective : Cardiopulmonary exercise testing in patients with heart and lung problems is used to assess functional capacity, evaluate responses to medical treatment, plan for exercise therapy, assess progression of disease process, and determine prognosis. Particularly in the patients with lung cancer, the exercise pulmonary function test gives significant physiologic assessment of the lung resection candidate. Common exercise modalities are running and cycling. Until now, the comparison of two tests mainly has been done in normal person and patients with cardiac diseases. This study is designed to compare the treadmill and bicycle exercise pulmonary function test in patients with respiratory diseases. Methods : Twenty one patients underwent a progressively incremental exercise test to the symptom-limited stage with the treadmill (Vmax29 Sensor Medics, USA) and the bicycle(model No. 2,900 Sensor Medics, USA) with 7 days apart between the two tests. Measurements were made of the metabolic, cardiorespiratory parameters, blood gases, and symptoms. Results : The results of the treadmill exercise showed significant elevation in the $VO_2$max, VEmax, and anaerobic threshold compared to those of bicycle exercise. In contrast, the results of the breathing and heart rate reserve showed the reverse. Conclusion : These results suggest that the type of exercise should be taken into consideration when interpreting exercise test in patients with respiratory diseases.

• Journal of Navigation and Port Research
• /
• v.27 no.2
• /
• pp.137-143
• /
• 2003

The prevention of marine accidents has been a important topic in marine society for long time, and various safety policies and countermeasures have been developed and applied to prevent those accidents. In spite of these efforts, however, significant marine accidents have taken place intermittently. Ship is being operated under a highly dynamic environments, and many factors are related with ship's collision, whose factors are interacting. So, the analysis on ship's collision causes are very important to prepare countermeasures which will ensure the safe navigation. This study analysed the ship's collision data over the past 10 years(1991-2000), which is compiled by Korea Marine Accidents Inquiry Agency. The analysis confirmed that‘ship's collision’is occurred most frequently and the cause is closely related with human factor. The main purpose of this study is to analyse human factor. For this, the structure of human factor is analysed by the questionnaire methodology. Marine experts were surveyed based on major elements that were extracted from the human factor affecting to ship's collision. FSM has been widely adopted in modeling a dynamic system which is composed of human factors. Then, the structure analysis on the causes of ship's collision using FSM are performed. This structure model could be used in understanding and verifying the procedure of real ship's collision. Furthermore it could be used as the model to prevent ship's collision and reduce marine accidents.

• Journal of KIISE:Software and Applications
• /
• v.27 no.2
• /
• pp.193-200
• /
• 2000

The extraction of face regions is required for Head Gesture Interface which is a natural user interface. Recently, many researchers are interested in using color information to detect face regions in image sequences. Two most widely used color models, HSI color model and YIQ color model, were selected for this study. Actually H-component of HSI and I-component of YIQ are used in this research. Given the difference in the color component, this study was aimed to compare the performance of face region detection between the two models. First, we search the optimum range of facial color for each color component, examining the detection accuracy of facial color regions for variant threshold range about facial color. And then, we compare the accuracy of the face box for both color models by using optimal facial color and motion information. As a result, a range of $0^{\circ}{\sim}14^{\circ}$ in the H-component and a range of $-22^{\circ}{\sim}-2^{\circ}$ in the I-component appeared to be the most optimum range for extracting face regions. When the optimal facial color range is used, I-component is better than H-component by about 10% in accuracy to extract face regions. While optimal facial color and motion information are both used, I-component is also better by about 3% in accuracy to extract face regions.