• Journal of Korean Ophthalmic Optics Society
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• v.13 no.4
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• pp.65-73
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• 2008

Purpose: The purpose of this study is to investigate the effect of age in the response to long-term overnight orthokeratology (OK) lens wearing. Methods: Among volunteers, ninety-five healthy subjects who had no eye diseases and could wear OK contact lens at least for 8 hours every day were divided into three groups children, youngsters and young adults. Unaided logMAR visual acuity, refractive error, apical corneal radius, corneal asphericity and central corneal thickness were measured with different period; before and after one day, one week, two weeks, one month, three months and six months of OK lens wear. Paired student t-test, ANOVA analysis and Pearson correlation were used with a critical p value of 0.05 for statistical analysis. Results: All groups showed statistically significant (p<0.001) improvement in unaided visual acuity, a trend for flattening in the apical corneal radius, decrease in central corneal thickness and less prolate after OK lens wear. The child group showed significantly rapid change (p<0.001) in visual acuity, and apical corneal radius showed that they reached the targeted refractive change earlier compared with youngster and adult groups. The visual effect of OK lens was significantly related with the change in central corneal thickness after long-term OK lens wear, especially in child and youngster group, and central corneal thickness were highly correlated with the targeted refractive change. Conclusions: Visual acuity change is statistically correlated with the central corneal thickness change, which is highly correlated with targeted refractive change in the long-term orthokeratology and younger lens wearers showed a rapid response to OK lens wear, suggesting a reduced epithelial response with increasing age. The results found this study extends our understanding and development in the long-term orthokeratology.

• Archives of Pharmacal Research
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• v.23 no.5
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• pp.507-512
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• 2000

This study set out to improve the physical and pharmaceutical characteristics of the present formulation using an appropriate experimental design. The work described here concerns the formulation of the dispersible tablet applying direct compression method containing roxithromycin in the form of coated granules. In this study $2^3$ factorial design was used as screening test model and Central Composite Design (CCC) associated with response surface methodology was used as optimization study model to develop and to optimize the proper formulation of roxithromycin dispersible tablet. The three independent variables investigated were functional excipients like binder (X1), disintegrant (X2) and lubricant (X3). The effects of these variables were investigated on the following responses: hardness (Y1), friability (Y2) and disintegration time (Y3) of tablet. Three replicates at the center levels of the each design were used to independently calculate the experimental error and to detect any curvature in the response surface. This enabled the best formulations to be selected objectively. The effect order of each term to all response variable was X3> X2> Xl> X1＊X2> X2＊X2> X2＊X3> X3＊X3> Xl＊X3> Xl＊Xl and model equations on each response variables were generated. Optimized compositions of formula were accordingly computed using those model equations and confirmed by following demonstration study. As a result, this study has demonstrated the efficiency and effectiveness of using a systematic formulation optimization process to develop the tablet formulation of roxithromycin dispersible tablet with limited experiment.

• Journal of Korean Society for Quality Management
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• v.49 no.2
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• pp.145-159
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• 2021

Purpose: A statistical similarity evaluation to compare pharmacokinetics(PK) profile data between nonclinical and clinical experiments has become a significant issue on many drug development processes. This study proposes a new similarity index by considering important parameters, such as the area under the curve(AUC) and the time-series profile of various PK data. Methods: In this study, a new profile similarity index(PSI) by using the concept of a process capability index(Cp) is proposed in order to investigate the most similar animal PK profile compared to the target(i.e., Human PK profile). The proposed PSI can be calculated geometric and arithmetic means of all short term similarity indices at all time points on time-series both animal and human PK data. Designed simulation approaches are demonstrated for a verification purpose. Results: Two different simulation studies are conducted by considering three variances(i.e., small, medium, and large variances) as well as three different characteristic types(smaller the better, larger the better, nominal the best). By using the proposed PSI, the most similar animal PK profile compare to the target human PK profile can be obtained in the simulation studies. In addition, a case study represents differentiated results compare to existing simple statistical analysis methods(i.e., root mean squared error and quality loss). Conclusion: The proposed PSI can effectively estimate the level of similarity between animal, human PK profiles. By using these PSI results, we can reduce the number of animal experiments because we only focus on the significant animal representing a high PSI value.

• Journal of Korea Water Resources Association
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• v.43 no.8
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• pp.721-731
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• 2010

The rainfall-runoff relationship is very difficult to predict because it is complicate factor affected by many temporal and spatial parameters of the basin. In recent, models which is based on artificial intelligent such as neural network, genetic algorithm fuzzy etc., are frequently used to predict discharge while stochastic or deterministic or empirical models are used in the past. However, the discharge data which are generally used for prediction as training and validation set are often estimated from rating curve which has potential error in its estimation that makes a problem in reliability. Therefore, in this study, water stage is predicted from antecedent rainfall and water stage data for short term using three models of neural network which trained by error back propagation algorithm and optimized by genetic algorithm and training error back propagation after it is optimized by genetic algorithm respectively. As the result, the model optimized by Genetic Algorithm gives the best forecasting ability which is not much decreased as the forecasting time increase. Moreover, the models using stage data only as the input data give better results than the models using precipitation data with stage data.

• Journal of Korea Water Resources Association
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• v.33 no.2
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• pp.263-276
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• 2000

This paper is to derive the probable rainfall depths and the probable rainfall intensity formulas for Inchon Metropolitan district. The annual maximum rainfall data from 10 min. to 6 hours have been collected from the Inchon weather station. Eleven types of probability distribution are considered to estimate probable rainfall depths for 12 different storm durations at the Inchon Metropolitan district. Three tests including Chi-square, Kolmogorov-Smimov and Cramer Von Mises with the graphical analysis are adopted to select the best probability distribution. The probable rainfall intensity formulas are then determined by the least squares method using the trial and error approach. Five types of Talbot type, Sherman type, Japanese type, Unified type I, and Unified type II are considered to determine the best type for the Inchon rainfall intensity. The root mean squared errors are computed to compare the accuracy from the derived formulas. It has been suggested that the probable rainfall intensities having Unified type I for the short term duration should be the most reliable formulas by considering the root mean squared errors and the difference between computed probable rainfall depth and estimated probable rainfall depth.

• The Transactions of the Korea Information Processing Society
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• v.4 no.12
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• pp.3185-3199
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• 1997

This paper suggests techniques to reduce coding time which is a problem in traditional fractal compression and to improve fidelity of reconstructed images by determining fractal coefficient through adaptive selection of block approximation formula. First, to reduce coding time, we construct a linear list of domain blocks of which characteristics is given by their luminance and variance and then we control block searching time according to the first permissible threshold value. Next, when employing three-level block partition, if a range block of minimum partition level cannot find a domain block which has a satisfying approximation error, we choose new approximation coefficients using a non-linear approximation of luminance term. This boosts the fidelity. Our experiment employing the above methods shows enhancement in the coding time more than two times over traditional coding methods and shows improvement in PSNR value by about 1-3dB at the same com- pression rate.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.5
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• pp.1085-1092
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• 2017

In this paper, we propose a wind forecasting method that reflects wind characteristics to improve the accuracy of wind power prediction. The proposed method consists of extracting wind characteristics and predicting power generation. The part that extracts the characteristics of the wind uses correlation analysis of power generation amount, wind direction and wind speed. Based on the correlation between the wind direction and the wind speed, the feature vector is extracted by clustering using the K-means method. In the prediction part, machine learning is performed using the SVR that generalizes the SVM so that an arbitrary real value can be predicted. Machine learning was compared with the proposed method which reflects the characteristics of wind and the conventional method which does not reflect wind characteristics. To verify the accuracy and feasibility of the proposed method, we used the data collected from three different locations of Jeju Island wind farm. Experimental results show that the error of the proposed method is better than that of general wind power generation.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.41 no.3
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• pp.354-361
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• 1996

Near Infrared Reflectance Spectroscopy(NIRS) is accepted as today's most versatile method for rapid chemical analysis. The technique offers rapid multicomponent analysis. This study was conducted to improve the efficiency of quality analysis in covered barley grain, and to search for the effects of chemical components variation in covered barley grain on NIRS. Among the three groups with different range in the contents, each equation for starch contents increased standard error of prediction(SEP) and increased correlation coefficient from 0.872 to 0.883. According as, $\beta$-glucan and protein contents decreased SEP and increased correlation coefficient by expanded chemical components variation. Effective equation for ash contents analysis was obtained from group 3. Among the covered barley chemical components, starch and ash contents were required to conduct futher studies in term of accuracy and variation of contents. It was concluded that NIRS method would be applicable for the rapid determination of $\beta$-glucan and protein contents in covered barley grains.

• Journal of the Korean Society of Radiology
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• v.8 no.1
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• pp.19-26
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• 2014

This paper suggests techniques to enhance coding time which is a problem in traditional fractal compression and to improve fidelity of reconstructed images by determining fractal coefficient through adaptive selection of block approximation formula. First, to reduce coding time, we construct a linear list of domain blocks of which characteristics is given by their luminance and variance and then we control block searching time according to the first permissible threshold value. Next, when employing three-level block partition, if a range block of minimum partition level cannot find a domain block which has a satisfying approximation error, we choose new approximation coefficients using a non-linear approximation of luminance term. This boosts the fidelity. Our experiment employing the above methods shows enhancement in the coding time more than two times over traditional coding methods and shows improvement in PSNR value by about 1-3dB at the same compression rate.

• Korean Journal of Optics and Photonics
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• v.11 no.2
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• pp.123-129
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• 2000

We set up a loss measurement apparatus using cavity ring-down method to get the losses in mirror having a small absorption and scattering. The measured errors could be explained by the loss inhomogeneity of the position of the mirror included in the cavity, and we knew that the long~period measurement limit of apparatus is three days, the minimum error limit of Lhe term is 4 ppm, which were gotten by measuring the long-period and short-period decay time in both reference and test cavity. Also we determined the losses m various mirrors fabricated at our laboratory using the apparatus and we found that the losses in mirrors are quite different at their spatial positions. tions.