• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.17 no.2 s.119
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• pp.121-129
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• 2007

There has been much effort to find suitable methods for structural analysis in the mid-frequency region where traditional low frequency methods have increasing uncertainties whilst statistical energy analysis is not strictly applicable. Systems consisting of relatively stiff beams coupled to flexible plates have a particularly broad mid-frequency region where the beams support only a few modes whilst the plate has a high modal density and modal overlap. A system of two parallel beams coupled to a plate is investigated based on the wave method, which is an approximate method. Muller's method is utilised for obtaining complex roots of a dispersion wave equation, which does not converge in the conventional wave method based on a simple iteration. The wave model is extended from a single-beam-plate system, to a plate with two identical beams which is modelled using a symmetric-antisymmetric technique. The important hypothesis that the coupled beam wavenumber is sufficiently smaller than the plate free wavenumber is experimentally verified. Finally, experimental results such as powers and energy ratios show the validity of the analytical wave models.

• Journal of Korean Neurosurgical Society
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• v.62 no.1
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• pp.123-129
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• 2019

Objective : Ventriculoperitoneal (VP) shunt surgery is a common and effective treatment for hydrocephalus and cerebrospinal fluid disorders. Infection remains a major cause of morbidity and mortality after a VP shunt. There is evidence that a deep skin flora microbiome may have a role to play in post-operative infections. In this technical note, we present a skin preparation technique that addresses the issue of the skin flora beyond the initial incision. Methods : The patient is initially prepped, as standard, with. a single layer of 2% CHG+70% isopropyl alcohol. The novel stage is the 'double incision' whereby an initial superficial incision receives a further application of povidone-iodine prior to completing the full depth incision. Results : Of the 84 shunts inserted using the double-incision method (September 2015 to September 2016), only one developed a shunt infection. Conclusion : The double incision approach to skin preparation is a unique operative stage in VP shunt surgery that may have a role to play in reducing acute shunt infection.

• Transactions of the Korean Society of Mechanical Engineers
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• v.12 no.5
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• pp.1158-1174
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• 1988

A numerical technique is developed for the solution of fully developed turbulent recirculating flow in the passage of variable area using the non-orthogonal coordinate transformation. In the numerical analysis, primitive pressure-velocity finite difference equations were solved by SIMPLER algorithm with 2-equation turbulence model and algebraic stress model (ASM). QUICK scheme on the differencing of convective terms which is free from the inaccuracies of numerical diffusion has been applied to the variable grids and the results compared with those from HYBRID scheme. In order to test the effect of streamline curvatures on turbulent diffusion Lee and Choi streamline curvature correction model which has been obtained by modifying the Leschziner and Rodi's model is testes. The ASM was also employed and the results are compared to those from another turbulence model. The results show that difference of convective differencing schemes and turbulence models give significant differences in the prediction of velocity fields in the expansion region and outlet region of the combustor, however show little differences in the parallel flow region.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.61-70
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• 2009

We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on $Ba^{2+}$ blockage of the inward rectifier potassium channel, Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary(CHO) cells and used the whole cell patch-clamp technique to record $K^+$ currents in the absence and presence of externally applied $Ba^{2+}$. Wild type Kir2.1 was blocked by externally applied $Ba^{2+}$ in a voltage and concentration dependent manner. Mutants of Y145 in the selectivity filter showed little change in the kinetics of $Ba^{2+}$ blockage. The estimated $K_d(0)$ was 108 ${\mu}M$ for Kir2.1 wild type, 124 ${\mu}M$ for a concatameric WT-Y145V dimer, 109 ${\mu}M$ for a WT-Y145L dimer, and 267 ${\mu}M$ for Y145F. Mutant channels T141A and S165L exhibit a reduced affinity together with a large reduction in the rate of blockage. In S165L, blockage proceeds with a double exponential time course, suggestive of more than one blocking site. The double mutation T141A/S165L dramatically reduced affinity for $Ba^{2+}$, also showing two components with very different time courses. Mutants D172K and D172R(lining the central, aqueous cavity of the channel) showed both a decreased affinity to $Ba^{2+}$ and a decrease in the on transition rate constant(${\kappa}_{on}$). These results imply that residues stabilising the cytoplasmic end of the selectivity filter(T141, S165) and in the central cavity(D172) are major determinants of high affinity $Ba^{2+}$ blockage in Kir 2.1.