• Title/Summary/Keyword: Thomas More

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Regulation of methionine biosynthesis in plants; transgenic study

  • Kim, Jungsup;Thomas Leustek
    • Proceedings of the Botanical Society of Korea Conference
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    • 2002.04a
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    • pp.73-82
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    • 2002
  • The committing step in Met and S-adenosyl-L-methionine (SAM) synthesis is catalyzed by cystathionine ${\gamma}$ -synthase (CGS). Transgenic Arabidopsis thaliana overexpressing CGS under control of 35S promoter show increased soluble Met and its metabolite S-methylmethionine, but only at specific stages of development. CGS-overexpressing seedlings are resistant to ethionine. Similar results were obtained with transgenic potato plants overexpressing Arabidopsis CGS. Several of the transgenic lines show silencing of CGS resulting in deformed p]ants with a reduced capacity for reproductive growth similar as transgenic plants by antisense RNA (CGS[-]). Exogenous feeding of Met to the CGS[-] and CGS[+] silenced plants partially restores their growth. Similar morphological deformities are observed in plants cosuppressed for SAM synthetase, even though such plants accumulate 250 fold more soluble Met than wild type and they overexpress CGS. The results suggest that the abnormalities associated with CGS and SAM synthetase silencing are due in part to a reduced ability to produce SAM, and that SAM may be a regulator of CGS expression.

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A Route-Splitting Approach to the Vehicle Routing Problem

  • Kang Sungmin;Thomas L. Joseph
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2004.10a
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    • pp.389-392
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    • 2004
  • The column generation process for the set-partitioning model of the vehicle routing problem requires repeated solutions of column generation subproblems which has a combinatorial structure similar to that of the traveling salesman problem. This limits the size of the problem that can be addressed. We introduce a new modeling approach, termed route-splitting, which splits each vehicle route into segments, and results in more tractable subproblems. A lower bounding scheme that yields an updated bound at each iteration of the column generation process is developed. Implementation issues, including a technique of controlling columns in the master problem, are explored. Lower bounds are computed on standard benchmark problems with up to 199 customers.

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Seismic behavior evaluation of exterior beam-column joints with headed or hooked bars using nonlinear finite element analysis

  • Rajagopal, S.;Prabavathy, S.;Kang, Thomas H.K.
    • Earthquakes and Structures
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    • v.7 no.5
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    • pp.861-875
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    • 2014
  • This paper studies the response of seismic behavior of reinforced concrete exterior beam-column joints under reversal loading with different anchorages and joint core details. The joint core was detailed without much confinement (group-I) and/or with proposed X-cross bars in the core (group-II). The beam longitudinal reinforcement's anchorages were designed as per ACI 352 (headed bars), ACI 318 (conventional $90^{\circ}$ bent hooks) and IS 456 ($90^{\circ}$ bent hooks with extended tails). The nonlinear finite element analysis response of the beam-column joints was studied, along with initial and progressive cracks up to failure. The experimental and analytical results were compared and presented in this paper to make more scientific conclusions.

Optimal Tuning of a Fuzzy Controller Using Boxs“Complex”Algorithm

  • Whalen, Thomas;Schott, Brian
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1993.06a
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    • pp.1350-1353
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    • 1993
  • A fuzzy control system typically requires“tuning,”or adjuctment of the parameters defining its linguistic variables. Automating this process amounts to applying a second“metacontrol”layer to drive the controller and plant to desired performance levels. Current methods of automated tuning rely on a single crisp numeric functional to evaluate control system performance. A generalization of Box's complex algorithm allows more realistic tuning based on lexicographic aggregation of multiple ordinal scales of performance, such as effectiveness and efficiency. The method is presented and illustrated using a simple inverted pendulum control system.

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Enhanced Properties of Extra-fine Nickel Steels for PM Gears

  • Stephenson, Thomas F.;Korotkin, Maria;Metcalfe, Shawn
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09a
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    • pp.393-394
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    • 2006
  • Highly compressible Ni-Mo steels are attractive materials for PM due to high sinter density and ease of processing. Extra-fine Ni admixed PM steels have demonstrated improved mechanical properties and rolling contact fatigue resistance due to a more uniform microstructure and increased Ni diffusion during sintering. Sinter densities of single press single sinter XF Ni-Mo steels can approach $7.5\;g/cm^3$ at moderate compaction pressures. Leaner alloys based on extra-fine Ni powder are possible depending on the performance requirements of the PM steel part. Extra-fine Ni steels are particularly attractive for the growing market of high performance PM gears and sprockets.

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Total Correction of Tetralogy of Fallot Review of 100 consecutive patients (Fallot 사징증의 완전교정에 대한 임상 경험: 100례 보고)

  • 박국양
    • Journal of Chest Surgery
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    • v.18 no.4
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    • pp.598-604
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    • 1985
  • One hundred consecutive patients with the Tetralogy of Fallot underwent total correction at National Medical Center during the period 1977 to 1984, Oct. During this study period, we adopted more active policy towards reconstruction of right ventricular outflow tract across pulmonary valve. The mortality was 48% for patients less than 15 kg and 19% in patients above 15kg. Initially Bretschneider`s solution was used as cardioplegia, which was replaced by St. Thomas` solution since 1983, Jan. After then overall mortality dropped to 9% compared to 45% of initial learning period. Heart block occurred In 11 patients, 10 of whom died of combined low cardiac output syndrome. Pure low cardiac output syndrome was noted in 18 patients, most of whom responded to medical measures well except 4 patients. Recently sepsis of Serratia marcescence, which occurred explosively during several months to open heart surgery patients, attacked 3 tetralogy patients resulting in 2 hospital deaths. Our experience has shown that body weight, choice of cardioplegia and accumulation of experience as well as advance of operative and postoperative techniques are still important factors affecting survival rate at initial learning period.

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ON EULERIAN q-INTEGRALS FOR SINGLE AND MULTIPLE q-HYPERGEOMETRIC SERIES

  • Ernst, Thomas
    • Communications of the Korean Mathematical Society
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    • v.33 no.1
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    • pp.179-196
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    • 2018
  • In this paper we extend the two q-additions with powers in the umbrae, define a q-multinomial-coefficient, which implies a vector version of the q-binomial theorem, and an arbitrary complex power of a JHC power series is shown to be equivalent to a special case of the first q-Lauricella function. We then present several q-analogues of hypergeometric integral formulas from the two books by Exton and the paper by Choi and Rathie. We also find multiple q-analogues of hypergeometric integral formulas from the recent paper by Kim. Finally, we prove several multiple q-hypergeometric integral formulas emanating from a paper by Koschmieder, which are special cases of more general formulas by Exton.

A bivariate extension of the Hosking and Wallis goodness-of-fit measure for regional distributions

  • Kjeldsen, Thomas Rodding;Prosdocimi, Ilaria
    • Proceedings of the Korea Water Resources Association Conference
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    • 2015.05a
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    • pp.239-239
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    • 2015
  • This study presents a bivariate extension of the goodness-of-fit measure for regional frequency distributions developed by Hosking and Wallis [1993] for use with the method of L-moments. Utilising the approximate joint normal distribution of the regional L-skewness and L-kurtosis, a graphical representation of the confidence region on the L-moment diagram can be constructed as an ellipsoid. Candidate distributions can then be accepted where the corresponding the oretical relationship between the L-skewness and L-kurtosis intersects the confidence region, and the chosen distribution would be the one that minimises the Mahalanobis distance measure. Based on a set of Monte Carlo simulations it is demonstrated that the new bivariate measure generally selects the true population distribution more frequently than the original method. An R-code implementation of the method is available for download free-of-charge from the GitHub code depository and will be demonstrated on a case study of annual maximum series of peak flow data from a homogeneous region in Italy.

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Call for emergency action to limit global temperature increases, restore biodiversity, and protect health Wealthy nations must do much more, much faster

  • Atwoli, Lukoye;Baqui, Abdullah H.;Benfield, Thomas;Bosurgi, Raffaella;Godlee, Fiona;Hancocks, Stephen;Horton, Richard;Laybourn-Langton, Laurie;Monteiro, Carlos Augusto;Norman, Ian;Patrick, Kirsten;Praities, Nigel;Rikkert, Marcel GM Olde;Rubin, Eric J.;Sahni, Peush;Smith, Richard;Talley, Nicholas J.;Turale, Sue;Vazquez, Damian
    • Animal Bioscience
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    • v.34 no.11
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    • pp.1723-1726
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    • 2021

Performance of novel dynamic installed anchors during installation and monotonic pullout

  • Kim, Youngho;Rosher, Lachlan Thomas
    • Geomechanics and Engineering
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    • v.18 no.2
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    • pp.153-159
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    • 2019
  • This paper examines the results from three-dimensional dynamic finite element analysis undertaken to develop a new dynamically installed anchor (DIA). Several candidate shapes of new DIAs were selected after an investigation into previous researches of existing DIA designs. The performances of selected DIAs during the installation and loading in non-homogeneous clay were investigated through large deformation finite element (LDFE) analyses. Findings were compared to the current anchors in operation (i.e., Torpedo and Omni-Max DIA) to assess the viability of the new designs in the field. Overall, the anchor embedment depths of the novel DIAs lied under the results of OMNI-Max DIA. And also, the tracked anchor trajectory confirmed that, the novel DIAs dove deeper with stiffer travelling angle, compared to the OMNI-Max DIA. These elements are more critical and beneficial especially in a field where the achieved embedment depths are generally low.