• 대한화학회지
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• 제32권6호
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• pp.588-592
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• 1988

키랄 보조제가 붙어있는 3-acyl-4(S)-isopropyl-1,3-thiazolidine-2-thione[4(S)-AITT]을 라세미 아민과 가아민 분해반응을 시켰을때 광학활성을 갖는 아미드(S-excess)와 아민(R-excess)이 얻어지는 입체 선택적인 반응이 관찰되었다. 이와같은 입체 선택적인 반응은 macrocyclic diamide, macrocylic sperimidine alkaloid, peptide 합성에 이용될 수 있다. 가아민 분해반응의 속도는 아민의 입체적인 영향을 많이 받았고 반응이 종료점은 노락색의 소실로 쉽게 관찰되었다. 4(S)-AITT는 4(S)-isopropyl-1,3-thiazolidine-2-thione과 carboxylic acid로부터 얻었다.

• Journal of Industrial and Engineering Chemistry
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• 제67권
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• pp.99-108
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• 2018

In this paper, novel thiadiazole-thione surfactants including 5-heptyl-1,3,4-thiadiazole-2-thione (HpSDT), 5-phenyl-1,3,4-thiadiazole-2-thione (PSDT) and 5-(2-hydroxyphenyl)-1,3,4-thiadiazole-2-thione (HPhSDT) were synthesized and originally introduced as collectors in froth flotation. Microflotation tests showed that HpSDT exhibited better flotation response to malachite than PSDT and HPhSDT, as well as excellent flotation selectivity against quartz. The contact angle results inferred that the hydrophobization intensity of these collectors toward malachite was in the order as HpSDT> PSDT> HPhSDT. ${\zeta}$-potential recommended a chemisorption of HpSDT on malachite surfaces. FTIR deduced that cupric or cuprous atoms might bond with the S and N atoms of HpSDT to form a conjugated ring. XPS further gave an additional evidence that HpSDT-Cu(I) complexes were produced on malachite surfaces via combining surface Cu atoms with HpSDT's N and S atoms, with reducing surface Cu(II) to Cu (I). The tighter orientation arrangement on malachite and stronger hydrophobicity rendered HpSDT to possess better flotation affinity toward malachite than PSDT and HPhSDT.

• 약학회지
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• 제16권2호
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• pp.85-89
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• 1972

4,4-Pentamethylene-1,3-oxazolidine-5-one-2-thione is to be obtained from 1-amino cyclohexane carboxylic acid and thiophosgene, however, it was not isolated because of its unstability. When it was treated with $C_{6}H_{5}NH_{2},$ N-phenyl-(1-aminocyclohexane) carboxylic acid and N-(1-carboxycyclohexyl), N-phenyl thiourea were obtained. When refluxed in $H_{2}O$ at pH 2, pH 12 and neutral condition, the resulting carboxylic compound, being anticipated by us, was 1-aminocyclohexane carboxylic acid. From the above results, we have got the suggestion f the chemical behavior of 4,4-pentamethylene-1,3-oxazolidine-5-one-2-thione and also some informations of the reaction mechanism between 1-aminocyclohexane carboxylic acid and thiophosgene.

• 대한화학회지
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• 제30권6호
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• pp.495-499
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• 1986

MNDO and MINDO/3 방법을 사용하여 평면분자인 4H-pyran-4-one(I), 4H-pyran-4-thione(II), 4H-thiapyran-4-one (III), 4H-thiapyran-4-thione(IV)의 구조를 결정하여 기하학적구조와 물리화학적 성질 특히 많은 논의의 대상이 되어온 방향적성을 연구하였으며 마이크로파 분광실험의 결과와 잘 일치함을 밝혔다. 방향족성의 크기는 (IV) > (III) > (II) > (I)의 순위이며 이것은 탄소원자보다 전기음성도가 월등하게 큰 산소원자가 전자 비편재화를 방해하는데 기인되는것이었고 또 쌍극자모멘트의 크기 순위는 (II) > (IV) > (I) > (III) 카르보닐기 (C=O 또는 C=S)의 길이순위임을 알았다

• Archives of Pharmacal Research
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• 제18권5호
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• pp.356-360
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• 1995

Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones hvae been synthesized by known methods (Coerdeler et al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-ary-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione which on further reaction with different ${\alpha},{\;}{\beta}-unstaturated$ carbonyl compounds and aryl-cyanamide ydrochloride affordered the related adducts. Some of these compounds show appreciable antithyroidal activity.

• Archives of Pharmacal Research
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• 제23권2호
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• pp.99-103
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• 2000

Acid and base catalyzed intramolecular cyclizations of N-benzoylthioureidoacetal, contain-ing four functional groups adjacent to thiourea such as benzocarbamoyl, acetal, thioure and amide, were investigated. The condensation reaction of N-benzoyl thiocarbamoylgly-cine amide in the presence of 10% aqueous NaOH provided 1-(2,2-dimethoxy)ethyl-imi- dazolidine-2-thione exclusively. In the presence of pyridine, it was transformed to 2- thiohydantoin. N-Benzoyl thiocarbamoyl glycine amide was completely transformed to an iminothiazolidine exclusively in the presence of Lewis acid such as borontrifluoride ether-ate or trimethylsilyl iodide. 1-(2,2-Dimethoxy)ethyl-imidazolidine-2-thione was transformed to imidazole[2,1-b]thiazole and pyrazino[5,1-a]imidazole in the presence of $BF_3$.$ET_2$O and formic acid, respectively.

• Bulletin of the Korean Chemical Society
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• 제29권3호
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• pp.604-608
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• 2008

A series of N-alkenyl pyrrolidine-2-thiones were synthesized by the reaction between pyrrolidine-2-thione and various aldehydes such as n-propanal, isopropanal, n-butanal, n-hexanal, n-octanal and phenylacetaldehyde in 32-86% yields using microwave irradiation technique. Only one structural E isomers were predominantly formed within 15 minutes in chlorobenezene?/p-toluenesulfonic acid monohydrate.

• 약학회지
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• 제18권4호
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• pp.243-248
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• 1974

Nine benzoxazolin-2-thione derivatives were sunthesized as the potential antimicrobial substances. These compounds were tested for the antimicrobial activities using Staphylococcus aureus and Escherichia coli by way of tube dilution method. The three compounds of I, II and VII omjoboted the growth of S.aureus at the concentration of 1${\mu}$g/ml, and III,VI,VIII and IX exhibited considerable antimicrobial activities against S. aureus at the concentration of 10.m.u.g/ml. As to the growth of E. Coli, VII VII and VIII inhibited at the concentration of 1${\mu}$g/,l. II,III and IV exhibited considerable antimicrobial activities against E. coli at the concentration of 10${\mu}$g/ml.

• Quantitative Bio-Science
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• 제37권2호
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• pp.113-124
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• 2018

Pim kinases are important targets for cancer therapies because they are mainly responsible for cancer metastasis and overall therapeutic treatment responses. Because of their unusual structural feature in the hinge region of the ATP-binding site, new binding motifs have been discovered and used for the development of Pim kinases inhibitors. The results of a screening of 5-membered heteroaromatic compounds and the effects of structural modifications on the inhibition of Pim kinases' activities showed the potential scaffold for Pim inhibitors. 1,3,4-Oxadiazole-2(3H)-thione was found as a new scaffold for Pim kinase inhibitors.

• Bulletin of the Korean Chemical Society
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• 제28권4호
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• pp.685-688
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• 2007