Quantitative Bio-Science

  • 제37권2호
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  • Pages.113-124
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  • 2018
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  • 2288-1344(pISSN)
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  • 2508-7185(eISSN)
계명대학교 자연과학연구소 (Institute of Natural Science, College of Natural Sciences, Keimyung University)
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1,3,4-Oxadiazole-2(3H)-thione as a New Scaffold for Pim Kinase Inhibitors

  • Lee, Ah Yeon (Department of Chemistry, College of Natural Sciences, Keimyung University) ;
  • Hong, Victor Sukbong (Department of Chemistry, College of Natural Sciences, Keimyung University) ;
  • Lee, Jinho (Department of Chemistry, College of Natural Sciences, Keimyung University)
  • 투고 : 2018.10.22
  • 심사 : 2018.11.04
  • 발행 : 2018.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Pim kinases are important targets for cancer therapies because they are mainly responsible for cancer metastasis and overall therapeutic treatment responses. Because of their unusual structural feature in the hinge region of the ATP-binding site, new binding motifs have been discovered and used for the development of Pim kinases inhibitors. The results of a screening of 5-membered heteroaromatic compounds and the effects of structural modifications on the inhibition of Pim kinases' activities showed the potential scaffold for Pim inhibitors. 1,3,4-Oxadiazole-2(3H)-thione was found as a new scaffold for Pim kinase inhibitors.

키워드

참고문헌

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