• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2007년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
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• pp.15-22
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• 2007

Increasing evidence indicates that microglia-driven chronic inflammatory responses playa pathological role in the central nervous system. Activation of microglia is pivotal in the initiation and progression of neuroinflammation. Inhibition of the microglial activation may provide an effective therapeutic intervention that alleviates the progression of the neurodegenerative diseases. Anti-inflammatory agents may be a useful candidate for such a therapeutic approach. Continual investigation of the mechanisms underlying microglial activation and regulation of neuroinflammation by endogenous or exogenous factors would not only lead to the discovery of novel neuroprotective agents, but also help to understand complex pathophysiology of neurodegenerative diseases.

• Journal of Chest Surgery
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• 제33권5호
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• pp.432-435
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• 2000

We report a case of primary undifferentiated cardiac sarcoma. The tumor originated from the left atrial free wall with multi-organ metastases, e.g., lung, and adrenal gland. The patient gradually grew worse with dyspnea and hemoptysis because of the obstructed left atrial outflow. Surgical resection of the left atrial sarcoma was undertaken to save the patient's life, followed by chemotherapy and brain irradiation as adjuvant therapy. The prognosis of cardiac sarcoma with metastases is very poor. However, in patients with hemodynamic instability, surgical intervention could be a therapeutic modality as palliation.

• 대한물리의학회지
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• 제12권3호
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• pp.119-130
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• 2017

PURPOSE: The purpose of this study is to determine, by conducting a 10 week hippotherapy, the effects on the physical, cognitive and psychological factors of children with intellectual disabilities. METHODS: As an intervention method, intervention was based on a program from the American Hippotherapy Association and was modified and enhanced. 16 children with intellectual disabilities was conducted horse riding intervention program and Intervention was conducted once a week for a total of 10 weeks with each session lasting 30 minutes. A doctor of rehabilitation medical treatment of D rehabilitation center, physical therapist and occupational therapist evaluated the upper limbs test, balance, gait function, Korea-mini mental state examination (MMSE) before and after hippotherapy intervention. Self-esteem scale and aggression scale was evaluated by Psychology Counseling of C psychological clinic before and after hippotherapy intervention. RESULTS: The results of this study reveal that first, there was a positive effect. Second, statistically significant differences were found in BBS, TUG, K-MMSE, 10m walking test, 6 min walking test, self-esteem scale and aggression scale (p<.05). However no statistically significant differences were found in upper limbs function and good balance analysis before and after intervention. CONCLUSION: The hippotherapy is effective way to improve the physical, cognitive and psychological factors of children with intellectual disability.

• 성인간호학회지
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• 제14권3호
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• pp.337-347
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• 2002

Purpose: The purpose of this study was to elucidate the effects of spiritual nursing intervention on anxiety and depression of the hospice patients. Method: It was devised with a quasiexperimental design using non-equivalent control group pre-post design. The data was from July 10 to September 25 in 2000 at the general hospital in CheonJu city. Subjects were 37 members of the experimental group and 30 members of the control. The tools were used Spielberger's State Anxiety Scale and Zung's Depression Inventory. The spiritual nursing intervention was carried out through Hymn, Scripture, Prayer, the therapeutic ues of self. Data were analyzed by mean, standard deviation, ${\chi}^2-test$, t-test. Result: 1. After the spiritual nursing intervention, state anxiety of the experimental group was lower than those of the control (t=-5.987, p=0.000). 2. After the spiritual nursing intervention, depression of the experimental group were lower than those of the control (t=-9.128, p=0.000). Conclusion: The hospice patients who were offered spiritual nursing intervention had lower anxiety & depression than not offered it. According to these results, it can be regarded as an effective one that relieved anxiety and depression of the hospice patients.

• 영미문화
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• 제14권1호
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• pp.73-94
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• 2014

Accounts from therapeutic culture seem often to associate the selfish, or at least self-centered quest for self-fulfillment with individual choice or satisfaction, self-expression, expressive individualism, and emotionalism. These associations point to the downside of therapy as they present it as constituting a culture of narcissism, selfishness, or irresponsibility. While some of these characterizations contain useful insights, they overlook what are maybe some of the most important features of a therapeutic outlook. This paper aims to reveal that the therapeutic imperative is not so much geared towards the realization of self-fulfillment, as it is the promotion of self-limitation. Therapeutic culture tends to posit the self in a fragile and feeble form and insist that the management of life requires the continuous intervention of therapeutic expertise. Because of this, the elevated concern with the self is underpinned by anxiety, pain, suffering, and survival, rather than seen as a positive vision of realizing the human potential. Therapeutic culture has in this way helped to construct a diminished sense of self by which one is seen as suffering from an emotional deficit and vulnerability. This paper demonstrates this downside of therapeutic culture concerning self-limitation and the sense of a diminished self by examining popular "misery memoirs." Misery memoirs are widely consumed by the general public, therefore tend to be treated by contemporary therapeutic culture as a gospel on the therapeutic ideal for self-fulfillment and self-discovery. This is, despite the existence of hidden evidence to the contrary, because of their redemptive, happy endings that show individuals overcoming difficult trials such as child abuse, incestuous rape, and domestic violence. Individual self-fulfillment and self-discovery in such stories are not achieved through the active agency of the subject but through the passive endurance of pathological symptoms and with the aid of expertise and outside support. Therefore, such stories put victims in the limited position.

• 한방재활의학과학회지
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• 제33권4호
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• pp.79-93
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• 2023

Objectives The purpose of this study is to investigate therapeutic exercise and to provide the evidence of daoyin exercise for shoulder pain. Methods Electronic databases including PubMed, EMBASE, China National Knowledge Infrastructure, Science ON, Oriental Medicine Advanced Searching Integrated System were searched up to October 2022. We selected randomized controlled trials. The quality of studies was assessed by Cochrane risk of bias tool. Meta-analysis were perfomed by Review Manager software. Results Eighteen randomized controlled trials were collected in accordance with the selection and exclusion criteria. Among the 18 trials, 7 trials used strengthening exercise, 4 trials used stablilization exercise, 5 trials used both types of intervention, and 2 trials used daoyin exercise. The study characteristics, results and method of intervention were analyzed. Meta-analysis showed that therapeutic exercise appeared to more effective than no treatment group for shoulder pain (standardized mean difference=-1.18, 95% confidence interval=-1.44 to 0.91, Z=8.82, p<0.00001; chi²=2.71, p=0.61; I²=0%). Conclusions All of 18 selected studies reported the effectiveness of therapeutic exercise for shoulder pain. Combining strengthening and stablilization exercise is considered the most efficient way for shoulder pain. Based on this study, well-designed studies should be performed to be evidence of the use of daoyin exercise for shoulder pain.

• Clinics in Shoulder and Elbow
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• 제27권2호
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• pp.237-246
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• 2024

Proximal humeral fractures (PHFs) are a common injury among the older population. An ideal therapeutic protocol has yet to be developed, and numerous clinical trials are being conducted to find the best therapeutic approach. The purpose of this study is to evaluate the current body of knowledge available via interventional clinical trials. In December 2022, interventional clinical trials relating to PHFs on Clinicaltrials.gov were screened. Trial characteristics included duration, status, intervention, phase, outcomes, location, and study design. Publications associated with each trial were searched on PubMed/Medline using the ClinicalTrials.gov registry number. The final dataset comprised 64 trials. The most common trial status was completed (36%). The majority did not have a Food and Drug Administration-defined phase (67%), was randomized (81%), involved a single facility (72%), used a parallel assignment intervention model (80%), and used an open-label approach (45%). Eleven trials were associated with a publication, and the publication rate was 17%. Average enrollment was 86 participants, and mean trial duration was 51.4 months. Europe/UK/Russia/Turkey participated in the most trials (70%). Most of the trials were initiated after 2010 (87.5%). Procedure-related interventions (55%) were most common. Disability/function was the most common primary outcome assessed (61%). The low publication rate and the multitude of trials conducted after 2010 highlight the urgency and need for trial results to be published to establish an ideal therapeutic protocol. Since the majority of the trials involved a single institution and an open-label approach, reinforcing blinding and establishing multi-centered trials can improve the validity of the clinical trial results.

• 인간행동과 음악연구
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• 제19권2호
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• pp.81-103
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• 2022

본 연구는 중추신경계 손상 환자의 우쿨렐레 활용 치료적 악기연주(Therapeutic Instrumental Music Performance, TIMP) 중재 참여에 따른 손 기능 변화를 살펴보고자 하였다. 연구 대상자는 중추신경계 손상으로 인해 손 기능 장애를 동반하는 성인 3명이며, 약 6주간 주 2회 30분씩 총 12회기 중재에 참여하였다. 우쿨렐레 중재는 손가락 동시 움직임, 손가락 협응 움직임, 손가락 개별 움직임 총 3가지 유형의 연주패턴을 기반으로 구성되었으며, 대상자의 손 기능 수준별 개별화된 중재 적용을 시행하였다. 본 연구에서는 검사도구 'Box and Block Test (BBT)', '9-Hole Peg Test (9-HPT)', 'Jebsen and Taylor Hand Function Test (JTHFT)'를 활용하여 대상자들의 사전 및 사후 손 기능을 측정하였으며, 사후 개별 인터뷰를 통해 중재 참여경험을 살펴보았다. 결과에 따르면 대상자 모두 사후검사에서 BBT 수행점수가 향상되었으며, 9-HPT 수행시간과 JTHFT 지표 중 '글씨쓰기'와 '카드 뒤집기' 영역의 수행시간이 단축되는 결과를 나타냈다. 또한, 개별 인터뷰 내용에 따르면 손의 기능적 움직임을 위해 악기를 활용함으로써 환측 손을 더욱 적극적으로 사용하고자 하는 시도가 많아지고, 손 기능 재활훈련에 대한 인식이 더욱 긍정적으로 변화되었음을 확인할 수 있었다. 이는 중추신경계 손상 환자 대상 우쿨렐레 활용 TIMP 중재가 손의 기능적 움직임 개선에 긍정적인 영향을 줄 수 있으며, 나아가 개인의 재활동기 차원에서의 긍정적인 변화도 불러일으킬 수 있음을 시사하는 바이다.

• Child Health Nursing Research
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• 제8권1호
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• pp.44-54
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• 2002

The main purpose of this methodological study was to develop an assessment tool and intervention protocol for child and family with childhood cancer at early diagnosis stage. The assessment tool and intervention protocol was developed by extensive literature review and consultation with experts. Review of nine domestic and sixty-six international journal articles were done to identify stress, interventions, coping strategies and adjustment of children with cancer and their family. Results were as follows; First, assessment at the early diagnosis stage need to include information on patient, family, and patient/family attitude toward diagnosis and treatment. Second, intervention protocol for children with cancer includes control physical symptoms, manage the side effects of chemotherapy and diagnostic or therapeutic procedures, control emotional responses, provide support and information, assist decision-making and adjust to environment. Third, intervention protocol for family includes controlling emotional responses, provision of informations, inducing family support to patient, improving family cohesion, supporting siblings and supporting spiritual growth. In conclusion, the early diagnosis stage in cancer treatment is important for child and family since this stage greatly affects the overall adjustment of child and family to live with cancer. Therefore, pediatric nurses need to be sensitive to the need of patient/family and systematically manage their needs at this stage.

• Perspectives in Nursing Science
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• 제13권2호
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• pp.59-69
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• 2016

Purpose: This paper is a review of interventions designed to promote self-awareness in the nursing area. The specific purpose was to analyze the general characteristics of self-awareness intervention studies, intervention contents, and the effects of the studies in order to present basic information for developing self-awareness interventions in the nursing area. Methods: Using "nurse/nursing" and "self-awareness" as key words, the researchers searched six electronic databases. The method proposed by Whittemore and Knafl was used. Results: Seventeen studies met the inclusion criteria. The most common research design was quasi-experimental. Nine quasi-experimental studies (52.9%), 7 qualitative studies (41.2%), and 1 mixed methodology study (5.9%) were analyzed. Most studies used group intervention and student nurses as participants. The interventions were revealed to be effective in enhancing participants' self-awareness. The reflection method was used in most intervention approaches. Conclusion: To provide therapeutic nursing care, having self-awareness is important. Future research with well-designed clinical trials applying self-awareness intervention needs to be conducted to enhance self-awareness in the nursing area.