• International Journal of Oral Biology
• /
• v.41 no.2
• /
• pp.83-88
• /
• 2016

Periodontitis is an inflammatory disease, which destroys the connective tissue and the alveolar bone. Recently, it has been suggested that the effect of natural substances could be induced into an anti-inflammatory environment. However, the effect of Safflower seed extract (SAF-M) associated with periodontitis has not been investigated yet. Therefore, the purpose of this study was to assess the anti-inflammatory effects of SAF-M. Cytotoxicity was assessed through MTS analysis using hGF and hPDL cells. Periodontitis was induced by injecting LPS into gingival tissue on the maxillary molars of rats ($45{\mu}g$ LPS/one time, 3 times a week for 3 weeks). SAF-M was administered daily at 30 mg/kg and 100 mg/kg. Alveolar bone resorption was evaluated through the micro-CT. hGF and hPDL cells showed differential cytotoxicity in response to SAF-M at 5 mg/ml and 1 mg/ml concentrations. Micro-CT showed reduction of the alveolar bone resorption in the SAF-M treatment group. These results suggested that SAF-M is a potential therapeutic agent for periodontitis.

• The Journal of Korean Physical Therapy
• /
• v.12 no.3
• /
• pp.407-414
• /
• 2000

Hydrotherapy is aimed at evoking short-term and long-term adaptation-mechanisms of patients. This means that a patient should be able to adapt to the changed environment. both mentally and physically. Hydrotherapy is widely used to treat patients with generalised rheumatic discases. Hydrotherapy may be applied as a single therapy. in combination with other therapeutic interventions or as one pan of a complex series of stimuli as e.g. during spa therapy. A treatment regimen in water is constructed according to the same rules as dry land exercise. However, methods specifically designed or adjusted for hydrotherapy can be used. The Halliwick is suitale in particular to facilitate arthrokinetic reactions as a part of training postural stability. The Bad Ragaz Ring is a hydortherapy modification of proprioceptive neuromuscular facilitation. Patterns of arms. logs and trunk are used to increase muscle function and flexibility. Other techniques are applicable in water too: mobilization and manipulation techniques of the joints can be integrated in hydrotherapeutic methods. The continuous research is needed for many interesting issues of hydrotherapy in new future.

• Journal of the Korean Society of Physical Medicine
• /
• v.1 no.1
• /
• pp.139-146
• /
• 2006

Purpose : This study is to understand the reactive oxygen which is expected to be a causative factor of aging condition including dementia, atherosclerosis, even cancer. Methods : The reactive oxygen is generated usually when people do very hard exercise or is under severe stressful situation or in unhealthy environment and as a protective reaction to reactive oxygen, human body releases antioxidant enzyme systems like superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), glutathion-S-transferase (GST) and non-enzymetic antioxidant systems like glutathione, ascorbate, $\beta$-carotene, vitimin E. Results : Nowadays, we are getting more interested in the generation of reactive oxygen especially in the area of physical education, food and nutrition, alternative medicine etc. Conclusion : The study of reactive oxygen in patients with musculoskeletal disease is also required and among various physical therapeutic approaches, the method of general coordinative manipulation is considered more necessary.

• BMB Reports
• /
• v.50 no.5
• /
• pp.233-234
• /
• 2017

Aberrant expression of the polypeptide N-acetyl-galactosaminyltransferase (GALNTs) has been associated with cancer, but their function(s) in metastasis remains elusive. We have recently identified GALNT14, one of the O-GalNAc glycosylation-initiating enzymes, as a prognostic marker for pulmonary relapse in breast cancer patients. Furthermore, we showed that GALNT14 promotes lung metastasis by the following novel mechanisms: 1) enhancing metastasis initiation by inhibiting the anti-metastatic effect of BMP produced from the lung stroma, 2) exploiting growth signals (e.g. FGF) supplied by macrophages, for their growth into macrometastases in the lung environment. These multi-faceted roles of GALNT14 in lung metastasis are achieved by GALNT14-mediated inhibition and activation of the BMP and FGF signaling pathways, respectively. The link among GALNT14, its downstream pathways and lung metastasis, provides us with an opportunity to develop effective therapeutic intervention for breast cancer.

• Journal of the Korean Home Economics Association
• /
• v.40 no.10
• /
• pp.123-139
• /
• 2002

The purpose of this study was to understand the adult day care center as a place for the elders and adults and to develop an initial understanding of the services and activity programs for adult day care for the cognitively-impaired in the U.S.A. The data were collected from 12 Adult Day Care Centers(ADC) from 2001 to 2002 by personal interview and the documents about the programs. ADC programs provided primarily social, recreational, and health activities and services in a group setting. Centers offered participants to socialize, enjoy peer support, and receive health and social services in a stimulating and supportive environment that promotes better physical and mental health. For this purpose those centers offered not only professional health care, occupational.speech.physical therapies but also socio-recreation and therapeutic-recreation services.

• Journal of Microbiology and Biotechnology
• /
• v.26 no.8
• /
• pp.1343-1347
• /
• 2016

Outer membrane vesicles (OMVs) are spherical nanostructures that are ubiquitously shed from gram-negative bacteria both in vitro and in vivo. Recent findings revealed that OMVs, which contain diverse components derived from the parent bacterium, play an important role in communication with neighboring bacteria and the environment. Furthermore, nanoscale proteoliposomes decorated with pathogen-associated molecules attract considerable attention as a non-replicative carrier for vaccines and drug materials. This review introduces recent advances in OMV biogenesis and discusses the roles of OMVs in the context of bacterial communication and virulence regulation. It also describes the remarkable accomplishments in OMV engineering for diverse therapeutic applications.

• International Journal of Advanced Culture Technology
• /
• v.12 no.1
• /
• pp.305-310
• /
• 2024

The purpose of this study is to implement game content within the generative artificial intelligence module Chat-GPTs, grounded in the humanistic discourse of self-reflection. This content aims to empower the dignity of the silver generation, which has been marginalized by digital technology. Simultaneously, we intend to prototype a digital psychotherapeutic tool. The development of a flexible device that adapts to the silver generation's living environment and temporal constraints is also part of our plan. However, there are still few commercially available products, and digital therapeutics developed in the form of content are virtually nonexistent. The goal is to implement game content that allows the elderly, who have been marginalized by digital technology, to find their true dignity. Simultaneously, we plan to commercialize a prototype of digital psychotherapy that can flexibly adapt to the range of living environments and time constraints of the elderly. This study has been extended based on the game content 'Daily Run' created by Hyein Kwon, an undergraduate student at Kyungil University.

• International Journal of Stem Cells
• /
• v.15 no.1
• /
• pp.60-69
• /
• 2022

Organoids show great potential in clinical translational research owing to their intriguing properties to represent a near physiological model for native tissues. However, the dependency of organoid generation on the use of poorly defined matrices has hampered their clinical application. Current organoid culture systems mostly reply on biochemical signals provided by medium compositions and cell-cell interactions to control growth. Recent studies have highlighted the importance of the extracellular matrix (ECM) composition, cell-ECM interactions, and mechanical signals for organoid expansion and differentiation. Thus, several hydrogel systems prepared using natural or synthetic-based materials have been designed to recreate the stem cell niche in vitro, providing biochemical, biophysical, and mechanical signals. In this review, we discuss how recapitulating multiple aspects of the tissue-specific environment through designing and applying matrices could contribute to accelerating the translation of organoid technology from the laboratory to therapeutic and pharmaceutical applications.

• Journal of Korean Society of Forest Science
• /
• v.104 no.1
• /
• pp.140-149
• /
• 2015

The aim of this study was to clarify the physiological and psychological effects of walking around and viewing a lake in a forest environment. The subjects included 11 male Japanese university students (age: $22.0{\pm}1.2$ years) who were randomly assigned to visit either a forest or an urban (control) setting. They were instructed to walk a predetermined 15-min course and to view the setting from a seated position for 15 min. Heart rate variability, heart rate, blood pressure, pulse rate, and salivary cortisol levels were measured to assess the subject's physiological responses to the environment. Four questionnaires (SD method, reports of "refreshed" feeling, POMS, and STAI) were administered to assess the subjects' psychological responses. It was found that walking around and viewing a lake in a forest environment can suppress sympathetic nerve activity, increase parasympathetic nerve activity, and decrease the heart rate, blood pressure, pulse rate, and cortisol levels. In addition, a forest environment can enhance the "comfortable," "soothing," "natural," and "refreshed" feelings, improve the mood state, and reduce anxiety. These results provide scientific evidence of the physiological and psychological effects of forest therapy.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.4
• /
• pp.489-499
• /
• 2016

This study examined the effects of a forest environment on internet addition and the self-esteem of internet-addicted adolescents. For comparison, the same group counseling programs were conducted in a classroom not in the forest. Twenty-four second grade students from a Middle School in S-city were grouped with 8 members in each group. Each group joined this program 6 times. The group results were then compared over a follow-up period. The dependent variables were the internet addiction scores and self-esteem scores. In the research results, the experimental group that undertook this program in the forest environment showed significantly different internet addiction scores compared to the control group immediately after the program and during the follow-up period. According to the period, the experimental group showed a significant difference in the internet addiction scores compared to the previous scores, immediately after the program and during the follow-up period. The comparison group showed no significant difference compared to the control group immediately after the program and during the follow-up period. The program in the forest environment showed a significant difference in the self-esteem scores compared to the comparison group and the control group immediately after the program and during the follow-up period. The self-esteem scores of the experimental group increased significantly compared to the comparison group and control group. In addition, the self-esteem scores of the comparison group also increased significantly, compared to the control group. The self-esteem scores of the experimental group also increased significantly, compared to the previous scores, immediately after the program and during the follow-up period. These results suggest that a natural environment, such as a forest, has therapeutic effects on decreasing the addiction symptoms' of internet addiction adolescents and also helps raise their self-esteem. Nevertheless, more study will be needed to verify what effects the forest environment have on the therapeutic mechanism on various addicts. Lastly, the constraints and implications of this research are described.