• Title/Summary/Keyword: The skin safety

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Evaluation of Airborne Volatile Organic Compounds Concentrations During Nail Art Practicing for College Students (대학 네일아트 실습 중 발생하는 휘발성 유기화합물의 공기 중 농도 평가)

  • Park, Yunkyung;Choi, Inja;Choi, Hyeyoung;Ahn, Jaekyoung;Choi, Sangjun;Kim, Sujin;Kim, Hyunseo
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.29 no.4
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    • pp.452-463
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    • 2019
  • Objectives: The purpose of this study is to evaluate airborne concentrations of volatile organic compounds(VOCs) during nail art practice by college students. Methods: Personal samples for students were measured using passive samplers(OVM 3500) during three kinds of practice, including polish nail, gel nail and acrylic French sculpture at two universities located in Gyeongsangbuk-do Province. We also monitored area concentrations using active samplers and real-time total VOC monitors(ppbRAE 3000). All samples were analyzed with a gas chromatography flame ionized detector. Statistical analysis for monitored data were conducted using a web-based Bayesian toolkit, EXPOSTATS(www.expostats.ca). Results: Twenty-four personal samples and ten area samples were collected and five chemicals(acetone, butyl acetate, ethyl acetate, ethyl methacrylate(EMA) and methyl methacrylate(MMA)) were detected. Acetone was detected in all personal samples and ranged from 2.58 ppm to 50.3 ppm. EMA was detected in all personal and area samples with a maximum concentration of 9.78 ppm during acrylic French sculpture. Personal exposure levels to acetone, butyl acetate and mixtures were significantly higher with high occupant density (p<0.05). Geometric mean (GM) concentrations of 3.61 ppm for EMA personal samples were significantly higher than that of area samples, 1.5 ppm (p<0.05). Since there was no local ventilation, total VOC concentration continued to increase as the practice progressed. Conclusions: In order to minimize VOCs exposure for trainees, it is necessary to introduce a local ventilation system and maintain adequate occupant density.

A Comparison Review of Domestic and Imported Cosmetics on Quality Test in Korea Market (위수탁 검사의뢰 국산 및 수입화장품의 비교고찰)

  • Hwang, Young Sook;Choi, Chae Man;Chung, Sam Ju;Park, Ae Sook;Kim, Hyun Jung;Kim, Jung Hun;Jung, Kwon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.40 no.4
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    • pp.331-339
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    • 2014
  • This study is aimed to provide the primary data about safety of cosmetics products using indirect preference of korean cosmetics customer and numerical comparison of applied area. For this study, we collected 9,879 cosmetics products which were inspected in cosmetics research team from January, 2010 to December, 2012. The domestic cosmetics was 645 cases (6.5%) and Imported cosmetics was 9,234 cases (93.5%). As manufacturing country, the France has 4,342 cases (44.0%) and the next ranking were like those, Germany 1,637 cases (16.6%), U.S.A 1,476 cases (14.9%), Republic of Korea 645 cases (6.5%), Italy 557 cases (5.6%), and etc 1,222 cases (12.4%). By the year, the cases of test cosmetics have decreased from 3,784 cases (2010), 3,394 cases (2011) to 2,701 cases (2012), the relative ratio of common cosmetics part was drop in but the other group (functional cosmetics and hair dye related products) was increased. The largest market share product was Skin care 5,470 cases (55.4%) and the next order was like those, Make up 1,908 cases (19.3%), Hand & Foot 1,026 cases (10.4%), Hair Care 616 cases (6.2%), Bath 361 cases (3.7%), and etc 498 cases (5.0%). In domestic cosmetics, the greatest proportion was Skin care and the others were Hair Care > Makeup > Hand & Foot > Bath, but the proportion was evidently changed in imported cosmetics, Skin care > Makeup > Hand & Foot > Hair Care > Bath. It is necessary to set the priority of the international quality standards to identify trends from domestic consumers directly or indirectly. Compare the ratio of category and human application parts from domestic and imported cosmetics, we utilize leverage as the basis for future-oriented cosmetic safety.

Driver's Status Recognition Using Multiple Wearable Sensors (다중 웨어러블 센서를 활용한 운전자 상태 인식)

  • Shin, Euiseob;Kim, Myong-Guk;Lee, Changook;Kang, Hang-Bong
    • KIPS Transactions on Computer and Communication Systems
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    • v.6 no.6
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    • pp.271-280
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    • 2017
  • In this paper, we propose a new safety system composed of wearable devices, driver's seat belt, and integrating controllers. The wearable device and driver's seat belt capture driver's biological information, while the integrating controller analyzes captured signal to alarm the driver or directly control the car appropriately according to the status of the driver. Previous studies regarding driver's safety from driver's seat, steering wheel, or facial camera to capture driver's physiological signal and facial information had difficulties in gathering accurate and continuous signals because the sensors required the upright posture of the driver. Utilizing wearable sensors, however, our proposed system can obtain continuous and highly accurate signals compared to the previous researches. Our advanced wearable apparatus features a sensor that measures the heart rate, skin conductivity, and skin temperature and applies filters to eliminate the noise generated by the automobile. Moreover, the acceleration sensor and the gyro sensor in our wearable device enable the reduction of the measurement errors. Based on the collected bio-signals, the criteria for identifying the driver's condition were presented. The accredited certification body has verified that the devices has the accuracy of the level of medical care. The laboratory test and the real automobile test demonstrate that our proposed system is good for the measurement of the driver's condition.

Evaluation of safety by skin dosimetry in Intraoperative Radiotherapy for breast cancer patients (유방암 환자의 수술 중 방사선치료 시 피부선량 측정을 통한 안전성 평가)

  • Jung, In Ho;Kim, Joon Won;Park, Kwang Woo;Ha, Jin Sook;Jeon, Mi Jin;Cho, Yoon Jin;Kim, Sei Joon;Kim, Jong Dae;Shin, Dong Bong
    • The Journal of Korean Society for Radiation Therapy
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    • v.27 no.1
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    • pp.13-22
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    • 2015
  • Purpose : We investigated the safety of Intrabeam$^{TM}$ system, X-ray unit for Intraoperative Radiotheray (IORT) by measuring surface dose using Optically Stimulated Luminescent Dosimeter(OSLD). Materials and Methods : 30 patients were selected, who were in breast cancer patients and had an operation of breast conserving surgery (BCS). At the inner surface of tumor bed, 20 Gy were described, and 5 Gy at 1cm depth from the inner surface. Along the size of tumor bed which could be decided after resection of tumor, the size of applicator were determined. Usual treatment time were from 18 to 40 minutes. For the measurement of surface doses, OSLD were placed at superior(U1,2), inferior(D1,2), lateral(L1,2) and medial(M1,2) directions from the center of applicator. Each direction, two OSLD were placed at 0.5 cm and 1.5 cm from the center. Mean, maximum, and minimum doses were analyzed to be compared. Results : Mean values were U1 $2.23{\pm}0.80Gy$, U2 $1.54{\pm}0.53Gy$, D1 $1.73{\pm}0.63Gy$, D2 $1.25{\pm}0.45Gy$, L1 $1.95{\pm}0.82Gy$, L2 $1.38{\pm}0.42Gy$, M1 $2.03{\pm}0.70Gy$, and M2 $1.51{\pm}0.58Gy$. Maximum values were 4.34 Gy at U1, and Minimum values were 0.45 Gy at M2. 13.3 % of patient (4pts out of 30) were reported that surface dose were over 4 Gy. Conclusion : The fact that skin dose of all patients were less than 5 Gy based on OSLD measurement showed the safety of Intrabeam$^{TM}$ system. In the relatively small breast volume, the tendency that surface dose was increased had been shown, which was analyzed by the data of patients who irradiated over 4Gy at skin surface. Therefore, for appropriate indication for IORT, it is suggested that breast volume as well as the size and position of tumor should be carfully considered.

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Effect of Relative Density and Fines Content on Pullout Resistance Performance of Drilled Shafts (상대밀도와 세립분 함유율이 현장타설말뚝의 인발저항 성능에 미치는 영향에 관한 연구)

  • You, Seung-Kyong;Hong, Gigwon;Jeong, Minwoo;Shin, Heesoo;Lee, Kwang-Wu;Ryu, Jeongho
    • Journal of the Korean Geotechnical Society
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    • v.34 no.4
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    • pp.37-47
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    • 2018
  • This paper described a results of direct shear test and pullout test by using soil supported by drilled shafts in order to evaluate the effect of relative density and fines content on pullout resistance performance of drilled shafts. The result of direct shear test showed that the variation characteristics of internal friction angle and cohesion could be confirmed quantitatively. The result of pullout test also showed that the effect of relative density and fines content on pullout resistance performance of drilled shafts was confirmed. That is, the contribution of the internal friction angle and cohesion of soils on the pullout resistance performance of drilled shafts was found to vary, when the fines content was about 13% based on results direct shear test and pullout test. Therefore, at design of drilled shafts, the effect of skin friction resistance should be considered on the influence factor of strength parameters ($c-{\phi}$) according to the fines content of soil.

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites

  • Kim, Ji Hye;Lee, Ji Ho;Ye, Young-Min;Lee, Jae-Hyun;Park, Jung Won;Hur, Gyu-Young;Kim, Joo-Hee;Lee, Hyn-Young;Shin, Yoo Seob;Yang, Eun-Mi;Park, Hae-Sim
    • Allergy, Asthma & Immunology Research
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    • v.10 no.6
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    • pp.675-685
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    • 2018
  • Purpose: This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR. Methods: A total of 45 patients aged ${\geq}60years$ with HDM-induced AR who had ${\geq}3$ A/H ratio on skin prick test and/or ${\geq}0.35IU/L$ to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15). Rhinoconjunctivitis total symptom score (RTSS), rhinoscopy score, Korean rhinoconjunctivitis quality of life questionnaire, rhinitis control assessment test, asthma control test scores, and adverse reactions, were assessed at the first visit (V1) and after 1 year of treatment (V5); for immunological evaluation, serum levels of HDM-specific immunoglobulin A/IgE/IgG1/IgG4 antibodies and basophil response to HDMs were compared between V1 and V5 in both groups. Results: There were no significant differences in demographics, RTSS, skin reactivity to HDMs, or serum total/specific IgE levels to HDMs (P > 0.05, respectively) between the 2 groups. Nasal symptom score and RTSS decreased significantly at year 1 in the 2 groups (P < 0.05). There were no significant differences in percent decrease in nasal symptom score and RTSS at year 1 between the 2 groups (P > 0.05); however, rhinoscopic nasal symptom score decreased significantly in the SLIT-treated group (P < 0.05). Immunological studies showed that serum specific IgA levels (not specific IgE/IgG) and CD203c expression on basophils decreased significantly at V5 in the SLIT-treated group (P = 0.011 and P = 0.001, respectively), not in the control group. The control group required more medications compared to the treatment group, but there were no differences in adverse reactions. Conclusions: It is suggested that HDM-SLIT for 1 year could induce symptom improvement and may induce immunomodulation in elderly rhinitis patients.

Randomized Double-blind Human Trial to Evaluate Efficacy and Safety of Rhus verniciflua Stokes (Lacca Sinica Exsiccata) and Eucommia ulmoides Oliver (Eucommiae Cortex) Extract Combination (ILF-RE) on Improvement of Liver Function (옻나무-두충추출혼합물(ILF-RE)의 간기능 개선에 대한 유효성 및 안전성을 평가하기 위한 무작위배정 이중눈가림 인체적용시험)

  • Youn, Young;Baek, Hyang-Im;Jin, Hee-Yeon;Jeong, Da-Young;Shen, Lei;Joo, Jong-Cheon;Park, Soo-Jung
    • The Korea Journal of Herbology
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    • v.35 no.1
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    • pp.45-55
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    • 2020
  • Objectives : The purpose of this study is to determine whether Rhus verniciflua Stokes with Latin name Lacca Sinica Exsiccata, and Eucommia ulmoides Oliver with Latin name Eucommiae Cortex Extract Combination (ILF-RE) improves laboratory test results in participants with liver function disorder. Methods : This study was conducted at Woosuk university Korean medicine hospital where participants with high serum alanine transaminase (ALT) levels from 45 to 135 U/L were enrolled. Subjects received ILF-RE 3.6 g (1.2 g/day as ILF-RE) or placebo 3.6 g for 12 weeks. It was confirmed that urushiol was not detected in ILF-RE. The primary outcomes were the decrement degree of serum ALT and gamma-glutamyl transferase (GGT) levels between two groups. The secondary outcomes were the decrement degree of serum aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LD), total bilirubin, total cholesterol, triglyceride (TG) and fatty liver index (FLI) levels between two groups. Adverse events, skin prick tests, laboratory tests, and vital signs were observed and analyzed to confirm the safety of ILF-RE.1) Results : In the ILF-RE group, the liver function index ALT, GGT, lipid metabolism index TG, and fatty liver index FLI were significantly decreased compared to the placebo group. There was no significant difference in ILF-RE group in terms of adverse events, severe adverse events, skin prick test, laboratory test, and vital signs compared with placebo group. Conclusions : ILF-RE was found to be effective in improving liver function. In addition, no clinically significant adverse events or body changes were observed during this study.

The Effects of Sunscreen Use Patterns and Awareness by Type on Product Satisfaction (자외선 차단제 유형에 따른 사용 인식 요인과 재구매 및 만족도 조사에 관한 연구)

  • Lee, Na-Young;You, Seon-Hee;Li, Shun-Hua
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.5
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    • pp.363-371
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    • 2019
  • In this study, 340 Korean women were surveyed to analyze the impact of the type of sunscreen and use status on the satisfaction of products and resale. Studies have shown that indoor activity is higher than outdoor activity, and both simple and complex sunscreen is often used to compensate for skin tone. Out of single sunscreen, sun cream was used and air cushion was used a lot. Although product usability and UV protection indices were important factors in purchasing, 30% experienced side effects while product satisfaction and willingness to repurchase were high. The recognition of safety, Effectiveness, convenience, usability, satisfaction, and repurchase were all higher than that of composite UV-blocking products, and among subcomponents of product usage recognition, the level of convenience, efficacy, usability, and safety affected satisfaction and repurchase in order. Consequently, the perception of simple UV protection products was higher when using products for UV protection, and its convenience had a significant impact on satisfaction and resale.

The Oriental and Occidental bibliographic Study of Psoriasis (乾癬에 對한 東.西醫 文獻的 硏究)

  • Kim, Nam-Kwen;Hwang, Chung-yeon;Lim, Gye-sang
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.12 no.1
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    • pp.154-178
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    • 1999
  • Psoriasis is the recurrent disease of skin and till now its mechanism, pathogenesis and treatment are not clearly discovered. So, like these papers, we must investigate more safety and effective treatment of psoriasis. And I obtained the following condusions from the Oriental and Occidental bibliographic investigation. 1. In Oriental medicine. Baikbi, Pungsun, Eunselbyong, Songpisun, Baikselpung were the other names of Psoriasis. 2. In Occidental medicine, genetic factors, aggravation and inducible factors, biochemical factors, immunologic factors, disorder of epidermal kinetics, vascular malformation of dermis were cosidered to the pathogenic factors of psoriasis. 3. In Oriental medicine, the pathogenic factors of psoriasis were divided two parts. One is exogenous pathogenic factors which including the blood-heat, blood dryness, blood stasis, deficiency of liver and kidney, inharmony of impulsive and appointed pulsation, deficiency of blood. The other is exogenous pathogenic factors which including the wind-evil, wind-wetness, wind-heat, wind-cold, wetness-heat, cold-wetness, heat-evil. 4. In Occidental medicine, external applicative medicine, internal medicine, ultraviolet therapy, ultraviolet - external applicative medicine compound therapy and etc. were used the therapy of psoriasis. 5. In Oriental medicine, clean away heat and cooling blood, aliment the blood and moisturize, activating blood and expelling blood stasis, harmonize and invigorate the liver and kidney, invigorate the kidney, aliment the blood and moisturize the skin, aliment the blood and expelling the wind, expelling the wind and wetness, clean away heat and expelling wind, expelling the wind and scatter the cold, clean away heat and expelling the wetness, heat up the meridian and scatter the cold, clean away heat and remove the toxin and etc. were used the method of internal therapy of psoriasis. 6. Until Qing dynasty, wind expelling effective prescriptions like Bangpungtongsungsan, Sopungsan. Supungsunkisan and etc. were used and recently Yanghyelgeupungtang, Hwalhyelgeupungtang, Samultanggagam and etc. were used the internal therapy of psoriasis. 7. In the external therapy of psoriasis, Yuhonggo, Pungyugo, Sekryupiyeongo were used the plaster therapy and Folium Rerillae, Camphora, Fructus, Xanthii, Herba Spirodelae compound prescription were used the cleansing therapy, Okgisan, Chiunsan, Galmyogo, Hobunsan, Muisan, Madugo, Jeyugohengin were used the rubbing skin therapy. Rangdok Radix Aconiti, Bijeonilchoalkwang were used the attaching therapy, the extract of Rhizoma Et Radix Veratri was used the spreading pouder therapy. 8. In the acupuncture therapy of psoriasis, the Jelgol, chok Samni(S36), Kansa(P5), Haegye(S41), Wijung(B40) and etc. were used the acupuncture point, and the angle of helix incision threapy that disinfect and cut the angle of helix and plaster the Semen Glycine and Squama Manitis were used.

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Comparison of In Vitro, Ex Vivo, and In Vivo Antibacterial Activity Test Methods for Hand Hygiene Products (손 위생 제품에 대한 in vitro, ex vivo, in vivo 항균 시험법 비교)

  • Daeun Lee;Hyeonju Yeo;Haeyoon Jeong
    • Journal of Food Hygiene and Safety
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    • v.39 no.1
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    • pp.35-43
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    • 2024
  • Numerous methods have been applied to assess the antibacterial effectiveness of hand hygiene products. However, the different results obtained through various evaluation methods have complicated our understanding of the real efficacy of the products. Few studies have compared test methods for assessing the efficacy of hand hygiene products. In particular, reports on ex vivo pig skin testing are limited. This study aimed to compare and characterize the methodologies applied for evaluating hand hygiene products, involving in vitro, ex vivo, and in vivo approaches, applicable to both leave-on sanitizers and wash-off products. Our further aim was to enhance the reliability of ex vivo test protocols by identifying influential factors. We performed an in vitro method (EN1276) and an in vivo test (EN1499 and ASTM2755) with at least 20 participants, against Serratia marcescens or Escherichia coli and Staphylococcus aureus. For the ex vivo experiment, we used pig skin squares prepared in the same way as those used in the in vivo test method and determined the optimal treated sample volumes for sanitizers and the amount of water required to wash off the product. The hand sanitizers showed at least a 5-log reduction in bacterial load in the in vitro test, while they showed little antibacterial activity in the in vivo and ex vivo tests, particularly those with a low alcohol content. For the hand wash products, the in vitro test was limited because of bubble formation or the high viscosity of the products and it showed low antibacterial activity of less than a 1-log reduction against E. coli. In contrast, significantly higher log reductions were observed in ex vivo and in vivo tests, consistently demonstrating these results across the two methods. Our findings revealed that the ex vivo and in vivo tests reflect the two different antibacterial mechanisms of leave-on and wash-off products. Our proposed optimized ex vivo test was more rapid and more precise than the in vitro test to evaluate antibacterial results.