• Journal of the Korean Applied Science and Technology
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• v.26 no.3
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• pp.350-356
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• 2009

The objection of this research is to conform of practicable possibility and recycling of producing junk after citrus fruits is processed. In the middle of practicable possibility, with verification of antibiosis that tactiling sensibility in a microorganism. With extracting d-limonene oil that have 70${\sim}$90% a component of oil out of junk citrus peel, making certain the about 12000ppm(1.2%) concentration of it. By means of antibiosis property over the a pathogenic bacterium as well as a residence bacterium, considerating the limit of application against daily living supplies needs to antibiosis. Antibiosis effect of a stationing bacterium in the body permanently and by means of antibiosis verification of special bacteria Propionibacterium Acnes that causative skin trouble is selected, in based the antibiotic sencitivity test check up result of minimal inhibitory concentration(MIC).

• Journal of Auto-vehicle Safety Association
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• v.14 no.4
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• pp.70-76
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• 2022

This paper investigates the effects of age, gender, and situational factors on take-over performance in automated driving. The existing automated driving systems still consider a driver as a fallback-ready user who is receptive to take-over requests. Thus, we need to understand the impact of situations and human factors on take-over performance. 34 drivers drove on a simulated track, consisting of one baseline and four event scenarios. The data, including the brake reaction time and the standard deviation of lane position, and physiological data, including the heart rate and skin conductance, were collected. The analysis was performed using repeated-measures ANOVA. The results showed that there were significant age, gender, and situational differences in the takeover performance and mental workload. Findings from this study indicated that older drivers may face risks due to their degraded driving performance, and female drivers may have a negative experience on automated driving.

• Journal of the Korean Applied Science and Technology
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• v.25 no.4
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• pp.477-484
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• 2008

It is inevitable to use chemical germicidal agents like paraben, imidazolidinyl urea and phenoxyethanol to preserve the emulsions which is usually used in cosmetics. Although these chemical preservatives are good enough to reduce the microbiological contamination, they are irritative, allergenic to the skin. Several kinds of polyols are used in cosmetics as moisturizer and solvent. In this study, we evaluate the effects of polyols on anti-microbial activities, safety and resistant index. MIC(minimal inhibitory concentration) of polyols determined against 6 germs including Staphylococcus aureus. The order of MIC was PG $\cong$ DPG $\cong$ 1,3BG > HG > 1,2-PD > 1,2-HD $\cong$ 1,2-OD. The $2{\sim}3\;wt%$ of 1,2-HD(hexanediol) shows good anti-microbial effects in emulsions without allergenic response. Resistant index of 1,2-HD was less than 2 and this value was smaller than that of chemical preservatives. The mechanism of antimicrobilogical effect might be disturb the membrane of germs by investigating using electron microscope. Added to that, using this paradigm, low preservative contents, paraben-free system, and even preservative-free systems can be expected from these results.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.2
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• pp.109-115
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• 2016

Hataedock is a Korean medical treatment that administers herbal extracts orally to newborn infants. This method is used for alleviating harmful heat and excreting fetal wastes by meconium. The purpose of this study was to evaluate anti-inflammatory effect of Hataedock method with Douchi on 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD). The 3-week-old NC/Nga mice were divided into 3 groups: the control group (Ctrl), the AD-induced group (AE), and the Hataedock-treated group (GT). Only the GT group was treated with Hataedock at the 3rd week. After 28 days from Hataedock treatment, we induced AD-like dermatitis to the AE and GT group by DNFB. The effects of Hataedock were evaluated by immunohistochemical method. In the epithelium, PKC-positive reaction of the GT group was decreased by 57%. In the dermal papillae, IL-4-positive reaction was decreased by 34%. In the dermis, the distribution of degranulated mast cells was decreased and substance P-positive reaction was decreased by 49%. In the skin tissue, edema was decreased and MMP-9-positive reaction was decreased by 71%. Tissue damage such as epithelial cell hyperplasia, infiltration of granulocyte and lymphocyte, and capillary distribution were also decreased. The Hataedock method with Douchi maintained skin barrier and inhibited skin-damaging factors via regulating Th2 differentiation. In conclusion, Hataedock has a potential for preventative treatment of AD. Further studies are necessary to investigate the immune-regulating mechanism and verify the safety and efficacy of the Hataedock method.

• The Journal of Pediatrics of Korean Medicine
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• v.26 no.1
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• pp.70-78
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• 2012

Objectives Recently, vitamin D supplements to breast-fed infants are being encouraged in Korea, and other countries. However, the reliability and validity assessment of supplements is insufficient. Therefore, this study suggests new Korean guidelines for vitamin D supplements of breast-fed infant. Methods The roles of Vitamin D for bone metabolism in children and the correlation between breast milk and Vitamin D were examined throughout domestic and international literature review. In addition, the efficacy and safety of vitamin D supplements were reviewed. Results Preventive effects of rickets by vitamin D supplementation remain unclear. Furthermore, concerns about the safety of vitamin D supplements intake have been raised. Korean guideline suggests breast-fed infants can get vitamin D through the skin safely, but maternal intake of vitamins through sunbath and diet is more effective and safe. Conclusions Limiting sunlight excessively and applying foreign countries' medical guideline for vitamin D supplements are not valid to apply as a domestic guideline for Korean breast-fed infants without considering ethnic and cultural characteristics.

• Korean Journal of Clinical Pharmacy
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• v.15 no.2
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• pp.94-99
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• 2005

The aim of this study was to evaluate the safety and efficacy of treatment of mesoglycan. This study was conducted between September 2003 and May 2004. A total of 292 patients with vascular disorders including cerebral infarction were enrolled. The patients were administered with 50-100mg of mesoglycan by an oral route everyday for eight weeks. Subjective physicians' assessments of efficacy had ratings of 'improvement', 'invariability', 'exacerbation' and 'not being able to assess'. An improvement was observed in 241 patients out of 274; 18 patients were rules out. The efficacy rate was influenced statistically significantly by the duration of therapy (p=0.0392) and daily mean drug dose (p<0.0001). The adverse events were reported in 8 patients (9 cases) out of 292 patients: skin/appendages disorders (0.7%), liver/biliary system disorders (0.7%), cardiovascular system disorders (0.7%), neurologic disorders (0.3%). respiratory disorders (0.3%) and gastrointestinal system disorders (0.3%). There showed no serious adverse events. These results indicate that mesoglycan was well tolerated and effective for the prevention of vascular disorders.

• The Journal of Korean Medicine
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• v.33 no.3
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• pp.95-104
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• 2012

Objectives: There are some controversies over the safety of herbal medication in relation to liver function. This report, therefore, aimed to analyze the safety issue of herbal medications by scrutinizing the liver function tests (LFT) results of 82 psoriasis patients on herbal medications for 3 months at an oriental medical clinic. Methods: We tested psoriasis patients' liver function periodically with Reflotron Plus of Roche during the herbal medication. Then we statistically analyzed the LFT results to see if there was any negative change. Results: Statistical analysis on the LFT results of 82 psoriasis patients showed no meaningful change caused by herbal medication over 3 months. Conclusions: From this result we conclude that herbal medication for 3 months does no harm to patients' liver function.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.2
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• pp.133-140
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• 2014

PURPOSE: The purpose of this study was to compare the effect of current density on penetration depth, tissue concentration and transdermal transport of methylene blue(MB) by iontophoretic transdermal delivery. METHODS: Twenty-four male Sprague-Dawley rats were randomly divided into 1 mA($0.11mA/cm^2$), 2 mA($0.22mA/cm^2$), 4 mA($0.44mA/cm^2$), and 8 mA($0.89mA/cm^2$) groups. These rats were exposed to anodic iontophoresis of 1% MB using a direct current for 15 minutes. The penetration depth were measured using light microscopy from cryosections of skin tissue. The tissue concentration and transdermal transport were measured using biochemical analysis from target skin tissues. The data were analyzed with one-way analysis of variance. RESULTS: The significant differences in the penetration depth, tissue concentration and transdermal transport were detected among the groups(p<.001). Post hoc comparisons of the penetration depth, tissue concentration and transdermal transport of he 2 mA, 4 mA, and 8 mA iontophoresis groups were greater than in the 1 mA iontophoresis group(p<.05). There was no significant difference, however, among 2 mA, 4 mA, and 8 mA iontophoresis group. CONCLUSION: There was no difference in the efficiency of iontophoresis from 2 mA($0.22mA/cm^2$) to 8 mA($0.89mA/cm^2$). Higher current density can cause skin injury and discomfort sensation. In general, $0.5mA/cm^2$ is proposed to be the maximum iontophoretic current which should be used on human. The appropriate current amplitude should be selected by considering the safety current density and the depth of the target tissue.

• Journal of the Korean Geosynthetics Society
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• v.18 no.4
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• pp.167-180
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• 2019

Friction piles are being constructed in Southeast Asia (Myanmar, Cambodia, Vietnam, etc.) where the soft ground is deep, and many cases of friction piles are accumulated in terms of experience. In this study, we used the results of four static load test and load transfer test conducted in Myanmar sites to analyze the skin friction of soil layer. In addition, we proposed a relationship chart with skin friction measured in the N-value of Standard Penetration Test (SPT) and the load transfer test result of the single drilled shaft. In the case of Myanmar sites, the range of soil layers was deeper than domestic sites, so the conventional formula of skin friction using the N-value of SPT is different from domestic sites. In sandy layer, fs = 0.096 N in Myanmar sites showed a similar result of the domestic fs = 0.106 N. In clayey layer, fs = 0.315 N, in Myanmar sites showed about 5.0 times higher than the domestic fs = 0.062 N. The results of this study are based on limited data. Therefore, if we analyze the results of more load transfer tests, we can suggest a conventional formula for skin friction according to the N-value. It is expected to be used as important basic data in the future.

• Journal of the Korea Safety Management & Science
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• v.16 no.3
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• pp.101-110
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• 2014

This study tried to identify the effects of ergonomic risk factors for absence from work of fire fighters in Korea. A self-administered questionnaire was prepared for this study. The questionnaire consisted of several parts such as 'general information', 'work-related factors', 'physical & chemical risk factors', 'ergonomic risk factors', and 'absence information'. A total of 7,098 fire fighters participated in this study. The data obtained from the survey was mainly analyzed by logistic regression. A total of 856 out of 7,098 fire fighters experienced absence from work. The risk factors such as gender, age, marital status, education level, total work year, work area. position, job rotation, noise, dust, organic solvent, skin contact with chemical substance, toxic waste, regional vibration, manual material handling, continuous standing posture, awkward working posture were associated with absence from work. Specifically, awkward working posture and manual material handling from ergonomic risk factors were major risk factors for absence from work.