• 대한한의학회지
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• 제36권2호
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• pp.36-42
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• 2015

Objectives: This study was carried out to analyze the single dose toxicity of Mecasin(Gami-Jakyak Gamcho buja Decoction) pharmacopuncture in muscle of Sprague-Dawley rats. Methods: All experiments were performed at the Medvill, an institution acknowledged to conduct non-clinical studies, under the Good Laboratory Practice (GLP) regulations. Sprague-Dawley rats were chosen in this pilot study. The reason Sprague-Dawley rats were chosen is that they have been widely used in safety test in the field of medicine, so the results can be easily compared with many other databases. Doses of Mecasin pharmacopuncture, 0, 500, 1,000, and 2,000mg/kg, were registered to the experimental groups, and a dose of normal saline solution, 10 ml/kg, was registered to the control group. Mecasin pharmacopuncture and normal saline were injected into the thigh of the rats by disposable syringes at intervals of six hours twice a day. This study was performed under the approval of the Institutional Animal Ethic Committee. Results: There is no death or abnormality in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To inspect abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The above outcomes suggest that treatment with Mecasin pharmacopuncture is relatively safe. Further evaluations and studies on this subject are needed to prove more concrete evidence.

• 한국콘텐츠학회논문지
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• 제12권7호
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• pp.378-393
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• 2012

본 연구는 십 수 년 간 언론매체를 통해 돔구장 건설 관련한 담론이 어떻게 형성되고 또 재생산되었는지를 파악하고자 하였다. 특히 신문을 중심으로 한 언론매체들이 돔구장과 관련하여 그동안 어떠한 사회적 담론을 구성했는지를 과정적 맥락적인 관점에서 바라봄으로써 돔구장과 관련된 정치적, 경제적, 그리고 사회문화적 맥락에 대한 논리적인 이해와 해석을 시도하고자 하였다. 이를 통해 본 연구는 크게 세 가지 측면의 사회적 담론이 형성되었음을 확인할 수 있었다. 첫 번째로, 돔구장 건립을 찬성하고 지지하는 '찬성'담론이 형성되었다. 여기에서 가장 핵심적인 담론은 야구발전과 중흥을 염원하는 '야구계의 숙원사업', 그리고 도시 이미지 제고와 지역경제 발전으로 대변되는 '돔구장 건설의 경제적 효과'였다. 두 번째로 돔구장 건설을 반대하고 비판하는 '반대' 담론이 형성되었다. 반대담론의 중심에는 '사업절차의 투명성 부족'과 '수익 타당성 부재'라는 인식이 강하게 자리 잡았다. 돔구장 건설에 대한 찬성과 반대의 대립구도 속에서 세 번째로 민 관이 '소통'과 '참여'를 통해 야구장 문제를 합리적으로 해결해야 한다는 거버넌스 담론이 등장하게 되었다.

• 현장농수산연구지
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• 제12권1호
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• pp.63-75
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• 2010

유엔환경기구는 잔류성유기오염물질(persistent organic pollutants, POPs)의 생산 및 유통을 억제하기 위한 국제금지협약을 2001년 5월 22일 채택하였다. 이 협약은 151개 승인국 중 59개국으로부터 비준을 얻어 2004년 5월 17일 발효되었다. 한국은 2001년 10월 4일 승인한 이후 본 협약의 비준에 대비하여 등재된 물질에 대한 체계적인 조사를 시행하였다. 문헌 및 사례조사를 통하여 특정면제품목의 가능성이 chlordane, dichloro diphenyl trichloroethane (DDT), hexachlorobenzenes (HCB), heptachlor, polychlorinated biphenyls (PCBs)에서 발견되었다. 하지만 보다 상세한 추후 조사에 의하여 특정면제품목의 작성 없이 본 협약에 가입할 수 있게 되었다.

• 동의생리병리학회지
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• 제21권5호
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• pp.1185-1193
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• 2007

Ginsing polysaccharide, known to have an immune regulating effect, was administered to 23 randomly selected healthy male subjects with a mean age of 23 years in accordance with an IRB approval. Then, these subjects underwent physico-chemical tests and serum proteome was analyzed from the blood sample taken from these subjects. Analyses of proteome involved image analysis, protein sections and protein identification in sequence after two-dimensional electrophoresis was carried out. During the physico-chemical test, 4 subjects were excluded from the study. In the proteome analysis, identified were 5 spots such as SP40, 40, Cytokeratin 9, hypothetical protein LOC544932, Apolipoprotein E ,similar to Human albumin, which showed differences in the amount of protein expression. In conclusion, changes of 5 proteins were remarkable before and after administration of ginsing polysaccharides. In certain cases, hepatic and renal slight injury occurred. Thus, further clinical study on dosage regimen would be necessary for securing the basis for concentration-dependent effectiveness and safety.

• 한국임상약학회지
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• 제24권2호
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• pp.135-143
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• 2014

Purpose: Aim of this study was to gather and evaluate perceptions of investigators, IRB members, and IRB administrators on the appropriateness of IRB review process and bioethical oversight system of national R&D (NR&D) projects. Method: Investigators, IRB members, and IRB administrators at 17 different institutions were surveyed using convenience sampling and survey questionnaires were partially group-specialized to consider any differences between the groups. Results: Participants included 29 investigators, 37 IRB members, and 17 administrators with response rate of 100% (83 of 83). According to the responses obtained, insufficient preparation time for constructing protocol and gaining IRB approval was one of the main problems in the IRB review process (investigator 79.3%, IRB administrator 88.2%). Also, discrepancy between NR&D and IRB's protocol formats was another major issue (IRB members 96.4%, IRB administrator 100%) and most investigators (89.7%) had to modify the original NR&D protocol to obtain IRB approval. Moreover, it was reported that 13.8% of investigators and 31.3% of IRB administrators did not submit midyear reports to IRB and for bioethical issues of NR&D projects, 17.2% of investigators did not include information on project status and safety issues in the annual reports. Conclusion: In conclusion, for successful and ethical completion of R&D projects, revision of both IRB review process and NR&D project protocol formats as well as implementation of appropriate bioethical oversights are necessary.

• 한국임상약학회지
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• 제26권2호
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• pp.137-149
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• 2016

Objective: Online pharmacies were introduced in some countries such as United States of America or Canada. They can provide benefits to consumer because they can buy and take conveniently drugs without limitation of location or time. In Korea, online pharmacies are illegal and only pharmacists can sell drugs to consumers or patients. Therefore, we investigated the knowledge of online pharmacy and the possible problem in Korea to survey pharmacists. Methods: We developed questionnaire based on previous articles about online pharmacy and surveyed nation-wide pharmacists by mail or e-mail. The data was analyzed by SPSS and Microsoft Excel. P-values less than 0.05 were statistically significant. Results: 175 pharmacists involved in this study. About introduction of online pharmacies, 53.1% were opposition while 10.3% were approval and 36.6% were conditional. Although online pharmacies were introduced, 46.3% pharmacists do not have a plan to start online pharmacy. However, the approval and tends about starting online pharmacies were higher in younger pharmacists (20s, 30s) (p < 0.05). The criteria of permission about opening online pharmacies were 100% pharmacist license regardless of holding off-line pharmacy. 53.7% pharmacists responded education about taking medication is impossible. When online pharmacies are introduced, 65.1% pharmacists responded traditional pharmacies are affected negatively. Pharmacists concerned that the competition with large-sized distribution corporations, reduced reliance between pharmacists and patients, illegal transaction of counterfeit drugs, increased misuse of drugs. Conclusion: These results showed that Korea pharmacists have negative standard on online pharmacies. Therefore it is required to be more cautious before introducing online pharmacy and it need strict watching system and continuous education and study for safety after introducing online pharmacy.

• 대한한방부인과학회지
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• 제22권1호
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• pp.243-262
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• 2009

Purpose: In recent, there have been a lot of studies exploring effective methods to relieve pains and sufferings of women delivered of child. The ultimate purpose of the study is to investigate the developmental trends of the complementary alternative medicine(CAM, hereafter), which has increasingly obtained the approval of the women and therefore established the academic foundations in effect. Methods: Systematic analysis with diverse written materials concerning the complementary alternative medicine was carried out. For the analysis, materials related with the issue of the study were searched at the Pubmed, the Korea Education & Research Information Service. Results: 1. One of the results of interest is the verification of the fact in that diverse complementary therapies are nowadays substantially applied to the many situations of delivery and childbirth. 2. The results showed clearly that CAM has several prominent influences on the whole process of the delivery: from the reduce of the pains and the time for delivery, to increasement of the satisfactional level of the mother. 3. According to the results, the emphasis of CAM is mainly placed not just on the relieving of pains and sufferings of the mothers, but on empowering them to face them with self-confidence. 4. The results of the study suggest strongly that the professionals should provide mothers with useful information and methods to help them to get through the pains during the delivery period. Conclusion: The result of the study is to suggest persuasively that more systematic attention should be paid to the researches exploring effectiveness and stability and safety of CAM.

• 대한한의학회지
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• 제43권3호
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• pp.150-163
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• 2022

Objectives: This research aimed to develop a guideline for evaluating safety and performance of electronic warm-acupuncture apparatus. With the development of medical devices like electronic warm-acupuncture apparatus with improved performance, convenience and safety measures compared to traditional warm-acupuncture needling, safety and performance guideline is a necessity. Methods: By referring to existing standards and guidelines of other electronic devices for Korean medicine with heating function, guideline for safety and performance assessment of electronic warm-acupuncture apparatus was drafted Results: The guideline, presents explanation for adequate temperature and settings of the apparatus, and safety measurements providing against thermal runaway situations along with guidelines for the manual. Guideline for detailed test method for the performance of the apparatus such as accuracy of temperature increase and the timer, and safety unit was also provided. The test items and suggested test methods for the requirements of biological, electrical and electromagnetic safety were referred to Korean approval documents of ministry of Food and Drug Safety. Conclusion: We proposed the relevant items to verify performance and safety of warm-acupuncture apparatus to assure patient safety and improve the quality of currently developing devices for application in clinical field.

• The Korean Journal of Pain
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• 제20권1호
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• pp.40-45
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• 2007

Background: Caudal block is useful when anesthesia for surgery or treatment for chronic pain is needed, but this procedure has a failure rate of up to 25% even when it performed byan experienced physician. This high failure rate is usually due to improper needle placement. Methods: After gaining approval of the ethics committee, 46 patients received caudal blocks under ultrasound guidance; these were performed after the anatomical structures in the sacral hiatus had been measured with ultrasound. All these procedures were performed by the same anesthesiologist. The position and direction of the needle were identified using fluoroscopy by injecting a radio-opaque contrast through the needle. The time taken from thelidocaine injection to verification of the needle was measured and the planned nerve block was then carried out. Results: All cases of needle insertion into the sacral canal under ultrasound guidance were successful. The average duration of the procedure and the trial count were $134.1{\pm}10.1seconds$ and $1.2{\pm}0.1$, respectively. In 12 of the 46 cases (26%), the needle deviated either left or right in the sacral canal, so the direction of the needle had to be adjusted. The distance between two cornua, the depth of the sacral hiatus and the thickness and length of the sacrococcygeal ligament were $17.1{\pm}0.4$, $3.9{\pm}0.3$, $2.3{\pm}0.1$ and $24.9{\pm}0.9mm$, respectively. Conclusions: Ultrasound guidance can increase the success rate of inserting a needle into the sacral canal. However, even when ultrasound is used, the needle can deviate either left or right in the sacral canal.

• 대한약침학회지
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• 제18권4호
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• pp.38-44
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• 2015

Objectives: Radix Ginseng has been used for thousands of years to treat a wide variety of diseases. Radix ginseng has also been used as a traditional medicine for boosting Qi energy and tonifying the spleen and lungs. Traditionally, its effect could be obtained orally. Nowadays, a new method, the injection of herbal medicine, is being used. This study was performed to investigate the single-dose intravenous toxicity of water-soluble ginseng pharmacopuncture (WSGP) in Sprague-Dawley (SD) rats. Methods: All experiments were carried out at Biotoxtech, an institute authorized to perform non-clinical studies under the regulation of Good Laboratory Practice (GLP). At the age of six weeks, 40 SD rats, 20 male rats and 20 female rats, were allocated into one of 4 groups according to the dosages they would receive. The WSGP was prepared in the Korean Pharmacopuncture Institute under the regulation of Korea-Good Manufacturing Practice (K-GMP). Dosages of WSGP were 0.1, 0.5 and 1.0 mL/animal for the experimental groups, and normal saline was administered to the control group. The rat's general conditions and body weights, the results of their hematological and biochemistry tests, and their necropsy and histopathological findings were investigated to identify the toxicological effect of WSGP injected intravenously. The effect was examined for 14 days after the WSGP injection. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech. Results: No deaths were found in this single-dose toxicity test on the intravenous injection of WSGP, and no significant changes in the rat's general conditions and body weights, the results on their hematological and biochemistry test, and their necropsy findings were observed during the test. The local area of the injection site showed minial change. The lethal dose was assumed to be over 1.0 mL/animal in both sexes. Conclusion: These results indicate that WSGP is safe at dosages up to 1 mL/animal.