• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7129-7138
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• 2015

Background: The polycystic ovary syndrome (PCOS), characterized by hyperandrogenism and chronic anovulation, is a common endocrine disorder in women. PCOS, which is associated with polycystic ovaries, hirsutism, obesity and insulin resistance, is a leading cause of female infertility. In this condition there is an imbalance in female sex hormones. All the sequelae symptoms of PCOS gradually lead to cancer in the course of time. It is heterogeneous disorder of unknown etiology so it is essential to find the exact cause. Materials and Methods: In this study both invasive and non-invasive techniques were employed to establish the etiology. Diagnosis was based on Rotterdam criteria (hyperandrogenism, ovulatory dysfunction, PCOM) and multiparameters using buccal samples and dermatoglypic analysis and cytogenetic study for 10 cases and four age and sex matched controls. Results: In clinical analysis we have observed the mean value of total testosterone level was 23.6nmol/L, total hirsutism score was from 12-24, facial acne was found in in 70% patients with 7-12 subcapsular follicular cysts, each measuring 2-8 mm in diameter. In dermatoglypic analysis we observed increases in mean value ($45.9^{\circ}$) of ATD angle when compared with control group and also found increased frequency (38%) of Ulnar loops on both fingers (UU), (18%) whorls on the right finger and Ulnar loop on left finger (WU) and (16%) arches on right and left fingers (AA) were observed in PCOS patients when compared with control subjects. Features which could be applied as markers for PCOS patients are the presence of Ulnar loops in middle and little fingers of right and left hand. The buccal micronucleus cytome assay in exfoliated buccal cells, we found decrease in frequency of micronuclei and significant increases in frequency of karyolysed nuclei in polycystic ovarian syndrome patients. Chromosome aberration analysis revealed a significant increase in frequency of chromosome aberrations (CAs) in PCOS patients when compared with controls. Conclusions: From this present work it can be concluded that non-invasive technique like dermatoglypics analysis and buccal micronucleus cytome assays with exfoliated buccal cell can also be effective biomarkers for PCOS, along with increased CAs in lymphocytes as a sign of genetic instability. There is a hypothesis that micronuclei and chromosomal aberrations could have a predictive value for cancer. From this present work it can be concluded to some extent that non-invasive technique like dermatoglypics and buccal cell analysis can also be effective for diagnosis.

• 만화애니메이션 연구
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• 통권17호
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• pp.21-35
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• 2009

독일이 의장국으로 있는 유럽연합(EU)에서는 회원국 전체가 홀로코스트를 부인하는 것을 범죄행위로 규정하는 방안을 추진하고 있다. 이미 유럽의 11개 나라에서 역사왜곡을 범죄로 보고, 이에 대한 책임을 묻고 있다. 그러나 일본에서는 국민통합이라는 이름아래 교과서문제나 헌법개정, 야스쿠니 참배 등을 주장하며 국가주의적인 움직임이 커지고 있다. 역사교과서의 개악을 주도하는 우익들의 논리는 과거 침략의 역사를 미화하고 정당화하는 데 그치지 않고, 전쟁의 피해자로서의 일본을 강조하여 오히려 피해자라는 국민적 공감대를 형성해가고 있다. 특히, 일반대중들의 깊은 관심을 끌어내고 있는 만화분야에서는 고바야시 요시노리와 야마노 샤린의 만화작품을 통해 우익들의 논리를 확대 재생산하고 있다. 본 논문에서는 '만화 일본사회의 역사왜곡의 실태'와 '일본우익의 논리와 만화의 상호작용'이라는 큰 틀 안에서 일본 만화의 현황에 대해 역사적, 사회적 그리고 문화적 측면에서 구체적으로 살펴본다. 특히 일본 우경화의 실태와 배경 그리고 왜 국가주의와 보수주의가 고조되었는지를 살펴보고, 일본 우익들의 정신적 뿌리를 이루고 있는 야스쿠니 신사와 우익단체의 주도로 집필된 새로운 역사 교과서에 객관적으로 접근하였다. 그리고 역사왜곡의 대표적 작품인 '고바야시 요시노리'의 "전쟁론"과 야마노 샤린의 "혐한론"을 집중 검토하여 문제의 실상을 보다 심층적으로 분석하였다. 이 과정을 통해 허위 과장된 문제를 정면으로 제시하여 앞서 언급한 두 작품을 역사의 실증으로 분석함으로써 일부 만화가들이 가지고 있는 우리 역사에 대한 편견과 왜곡을 체계적이고 이론적인 대응 논리로 만화가들의 극복과제를 제시하였다.

• 한국산학기술학회논문지
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• 제20권11호
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• pp.56-65
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• 2019

본 연구는 12주간 여성노인이 체중을 이용한 복합운동(저항운동 30분, 유산소운동(30)) 참여가 그들의 신체구성(체중, 체지방률, 제지방, 신체질량지수, 근육량)과 심혈관요인(상완-발목 맥파속도, 동맥협착도)에 미치는 영향을 연구하였다. 연구의 목적을 달성하기 위해 연구에 참여한 대상자는 총 32명으로 운동그릅 16명, 통제그룹 16명으로 무선할당하였다. 운동집단은 주3회 60분씩 복합운동을 실시 하였으며, 통제그룹은 같은 기간 동안 평소와 동일한 환경에서 생활하였다. 본 연구의 통계분석은 동질성을 확보하기 위해서 모든 사전 변인들에 t-검증을 실시하였고 동질성이 확보되서 분산분석방법을 사용하였으며 유의수준은 0.05로 하였다. 연구결과 복합운동에 참여한 운동그룹과 통제그룹간에 신체구성에 대한 것은 통계적으로 유의한 차이를 보이지 않았다. 하지만 심혈관계 요인 중 복합운동 그룹의 상완-발목맥파속도 오른쪽(baPWV-Right(p=.001)), 상완-발목맥파속도 왼쪽(baPWV-Left(p=.001))은 통계적으로 유의한 감소를 나타냈고, 통제그룹은 통계적으로 유의한 차이를 보이지 않았다. 이상의 결과를 살펴보면 65세이상 여성노인이 12주간 체중을 이용한 복합운동에 참여하면 맥파속도(baPWV-Right)가 감소하고 심혈관 질환을 예방하여 노인들의 삶의 질을 높일 수 있을 것이다.

• 한국안전학회지
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• 제23권6호
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• pp.131-137
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• 2008

SCP(Sand Compaction Pile) method that forms a composite ground by driving compacted sand piles into the soft ground. This method is one of the soil improvement techniques for reinforcing and strengthening soft ground deposits. This thesis describes the investigation on the behavior of soft ground reinforced with SCP by low improvement ratio. Direct shear test and consolidation test carried out to verified behavior of composite ground reinforced with SCP. Test results were discussed with reference to the amount of consolidation settlement, variation of shear resistance with area replacement ratio and effect of the stress concentration. And, laboratory model loading test carried out to verified the effect of the location and failure mode of reinforced embankment. Residual shear strength varies with the area replacement and constrict load in the low replacement ratio. Calculated stress concentration ratio overestimate than proposed valve by experimental, theoretical and analytical method. As regards the location, improving right below of the top of the slope was more effective than below of the toe of the slope. This thesis carried out to obtain fundamental information of behavior of the composit ground. Hereafter, centrifuge test that reproduce stress state of the in-situ must be necessary through the further study about pile penetration, reinforce position and construct time.

• Journal of Chest Surgery
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• 제21권5호
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• pp.816-827
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• 1988

Since 1978, We have experienced 87 cases of Fontan operations and the candidates of that increased in numbers recently with the improvement of the diagnostic and operative technique. We studied the prerequisite factors and hemodynamics of 22 cases of Fontan operations, done during the last one year period, which were 3 tricuspid atresia, 16 functional single ventricle and 3 anatomic single ventricle. The mean age was 68 months and the mortality rate 24%, and 9 patients of under 4 years of age were operated with 22.2% mortality rate, but the youngest, 16 months of age, patient survived well without problems. The preoperative pulmonary artery pressure[PAP], pulmonary vascular resistance[PVR] and postoperative right atrial pressure[RAP], left atrial pressure[LAP] value influenced the mortality, but age, preoperative Hb, preoperative PaO2 and pulmonary artery index[PAI] did not. There were favorable survival tendency in under 15mmHg of preop. PAP, 2a of preop. PVR and under 25cmHyO of postop. RAP, under 15cmHyO of postop LAP. The younger, the more pleural effusion and the longer postoperative admission days. The higher preop. Hb related to the higher postop. transpulmonary pressure gradient and the lower preop. PaO2 and PAI. The higher preop. PaO2, the less pleural effusion and postop. admission days. Preop. PAP closely related to preop. PVR and postop. LAP and high PVR increased the pleural effusion and postop. admission days. The larger PAI, the larger CI. We concluded that there were so many factors influencing the postoperative condition, but preop. PAP, PVR, Hb, postop. RAP and LAP were the most ones.

• Structural Engineering and Mechanics
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• 제86권1호
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• pp.109-118
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• 2023

Any place where exercise is common, such as a club, sports hall, or school, is considered a place for teaching sports. When doing sports, a very safe environment for sports should be chosen. The athlete should consider the safety of sports facilities and equipment, and if there is a defect, he should refrain from exercising in these places. The safety of sports facilities is very effective in creating people's sports activities, with the benefits of staying away from physical harm, enjoying sports, and having mental peace. Everyone has the right to participate in sports and recreation and to ensure that they enjoy a safe environment. The ability to manage and solve issues that may arise plays the most critical role in creating a safe environment. The quality of construction materials used for the construction of sports facilities is of great importance. In this work, the resistance and water repellency of concrete constituents for the construction of sports buildings have been investigated by nanoscience. Nano-concrete material solves the main problem of concrete surfaces, i.e., the entry of water and humidity into the structure. It also gives it a self-cleaning ability with its water repellency. Nanoparticles are placed between pores and cover the cracks, which causes roughness in the surface structure of concrete. The high roughness of the surface of the coated concrete caused its super-hydrophobicity. In hydrophobic surfaces, the higher the contact angle, the more hydrophobic the surface will be. In order to investigate the hydrophobic properties, silica nanoparticles, silica nanoparticles, and fly ash were prepared on concrete, and their properties were analyzed.

• 한국표면공학회지
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• 제29권2호
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• pp.81-92
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• 1996

The cementless fixation of bone ingrowth by porous coatings on artificial hip joint prostheses are replacing polymethylmethacrylate(PMMA) bone cement fixations. However, the major interests in the field of porous metal coating are environmental corrosivity accelerated by metal ion release, deterioration in the mechanical property of the coating, and the mechanical failure of the coatings as well as the substrate. Therefore, the selection of right materials for coatings and the development of porous coating techniques must be accomplished. Because of the existing problems in Ti and Ti alloys which are used extensively, this study is focused on the plasma spraying technique for coating on super stainless steel substrate. In order to determine the optimum conditions which satisfy the requirement for the porous coatings, under the plasma spraying, we selected the experimental parameters which extensively influenced on the characteristics of the coating through the pre-examination. Spray distance has been selected among 120, 160, and 200mm and primary gas flow rate among 70, 100, and 130 SCFH. Current and secondary gas($H_2$) flow rate was fixed at 400A, and 15 SCFH respectively. To understand the characteristics of the coatings, surface morphology, cross-sectional micro-structure, surface roughness, residual stress, and corrosion resistance were elucidated and the best conditions for the bone ingrowth improvement on artificial hip joint prostheses were found.

• International Journal of Concrete Structures and Materials
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• 제6권4호
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• pp.247-250
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• 2012

Composites are somewhat more difficult to model than an isotropic material such as iron or steel due to the fact that each layer may have different orthotropic material properties. In finite element literature the asphalt mixes are represented by using rectangular meshes, not the actual picture of their cross-sections. Asphalt aggregate size and distribution in the asphalt concrete sample, aggregate shape, and fractured surface effects are ignored. In this research, the actual image of the sample including all these effects were directly considered in the finite element. The samples, were cut into cross-sections and were scanned. The image-processing toolbox of Labview was utilized in obtaining the rectangular gray images of the scanned images. In the rectangular sample the aggregates were white and the asphalt binders were black. The grayscale images were converted by LABVIEW into the format required by ANSYS as an input file, with the same dimensions. The nodes at the bottom of the model were constrained in both x and y directions. Left and right edges were symmetry and top was free. Certain amount of pressure was applied along the top surface to simulate the tire pressure.

• 공학교육연구
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• 제21권1호
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• pp.77-89
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• 2018

The chromosomes of all the world are the same in all 24 pairs, but the key, skin color and appearance are different. Also, it is the resistance of adult disease, diabetes, cancer. In 1953, Watson, Crick of Cambridge University experimentally discovered a DNA double helix structure, and in 1962, They laureates the Nobel Prize. In 1964, Temin, University of Wisconsin, USA, experimentally identified the ability to copy gene information from RNA to DNA and received the Nobel Prize in 1975. In this paper, we analyzed 24 pairs of DNA chromosomes using mathematical matrices based on the combination order sequence of four groups, and designed the Taegeuk pattern genetic code for the first time in the world. In the case of normal persons, the middle Yin-Yang taegeuk is designed as a block circulant Jacket matrix in DNA, and the left-right and upper-lower pairs of east-west and north-south rulings are designed as pair complementary matrices. If (C U: A G) chromosomes are unbalanced, that is, people with disease or inheritance become squashed squirming patterns. In 2017, Professor Michel Young was awarded a Nobel by presenting a biological clock and experimentally explained the bio-imbalance through a yellow fruit fly experiment.This study proved mathematical matrices for balanced and unbalanced RNA.

• 마이크로전자및패키징학회지
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• 제10권4호
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• pp.81-86
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• 2003

상부 칩과 하부 기판이 모두 Si으로 구성되어 있는 플립칩 패키지 시편을 제조하여 Sn-3.5Ag 솔더범프의 electromigration 거동을 분석하였다. Sn-3.5Ag 솔더범프의 electromigration 테스트 초기부터 파단이 일어나기 직전까지는 플립칩 시편의 저항이 거의 변하지 않았으나, 파단이 발생하는 순간 저항값이 크게 증가하였다. 전류밀도 $3\times 10^4$∼$4\times 10^4$A/$\textrm{cm}^2$에서 Sn-3.5Ag 솔더범프의 electromigration에 대한 활성화 에너지는 ∼0.7 eV로 분석되었다. Sn-3.5Ag 솔더범프의 cathode 부위의 솔더/UBM 계면에서 void의 형성 및 전파에 의해 솔더범프의 파단이 발생하였다.