• Bulletin of the Korean Chemical Society
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• 제17권9호
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• pp.831-835
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• 1996

New dynemicin A mimics with methyl group 2a and 2b were synthesized, and acid-induced hydrolyzed to see an electronic effect of substituent for epoxide opening. The model 2a with methyl group at C3 position was more rapidly transformed to diol 16a than 2b with methyl group at C2. This result suggests that any substituent at C3 position plays more important role than any substituent at C2 position in the dynemicin A mimic activation.

• 한국멀티미디어학회:학술대회논문집
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• 한국멀티미디어학회 2002년도 춘계학술발표논문집(하)
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• pp.1093-1098
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• 2002

본 연구실에서 개발한 MIMIC(Motion Interface & Motion Information Capture system)은 동작자의 동작을 획득하고, 동작의 의미를 이해할 수 있도록 설계된 시스템이다. 비전 센서로부터 입력된 영상을 분석하여 동작자의 머리와 두 손, 두 발의 정보를 찾는다. 그리고, 이 정보를 기반으로 팔꿈치나 무릎 등의 중간 관절을 추정한 후 20개의 관절을 가지는 3차원 인체 모델을 구성한다. 이 인체 모델은 동작자의 동작을 실시간으로 흉내낸다. 그러므로, 기존의 마커프리 모션캡쳐 시스템과 달리 완벽한 인체를 구성하기 위한 중간 관절까지 생성함으로써 동작자의 동작을 더욱 자연스럽게 구현할 수 있다.

• 한국정밀공학회지
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• 제26권11호
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• pp.29-34
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• 2009

• Annals of Clinical Neurophysiology
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• 제7권1호
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• pp.63-64
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• 2005

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 춘계학술발표대회
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• pp.514-516
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• 2021

본 연구는 심혈관계 질환 진단에 주고 사용되는 PTT 를 계산할 때 필요한 PPG 신호가 없을 경우 ECG 신호만을 사용하여 PTT 값을 예측하는 방법을 제안한다. MIMIC-I 데이터셋에서 2 채널 심전도 데이터와 광전용적맥파 데이터를 확보하여 제안하는 방법을 적용하였을 때, RMSE 0.07116 으로 예측하였다. 본 연구는 향후 단일 생체신호만 측정할 수 있는 제한된 상황에서 대안으로 활용될 수 있을 것이다.

• 한국산업융합학회 논문집
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• 제25권3호
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• pp.443-449
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• 2022

In this study, in order to improve the disadvantages of the environmental error of the infusion set that performs infusion therapy in the existing clinical practice and to maximize the user's convenience by miniaturizing the existing infusion pump system, the structure of the muscle pump of the human vein was imitated. As a double check valve method, a method for preventing the backflow of fluid and discharging a constant fluid in one direction by external pressure was proposed. The proposed bio-mimic muscle pump uses a check valve that controls the flow of fluid in one direction and a silicone tube with elasticity, and a chamber is constructed. A peristaltic pump for applying intermittent pressure to the tube chamber was constructed using a multi-cam structure roller. In order to verify the performance of the proposed pump, optimization was performed while changing the number of multi-cam rollers and adjusting the speed of the roller driving motor, and the reproducibility of the instantaneous discharge amount and the continuous discharge amount of the pump was compared and tested. The performance of the muscle pump proposed in this study was verified through experiments that it can inject up to 1L of fluid within 12 hours, and that it is possible to inject the fluid with an accuracy of ±0.1ml. Real-time monitoring of the fluid injection volume through the bio-mimic muscle pump proposed in this study not only increases the convenience of the administrator, but also provides a precise fluid administration environment to more patients at a low cost, and additionally applies bubble detection and occlusion detection technology If so, it is believed that a safer medical environment can be provided to patients.

• 한국수자원학회논문집
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• 제45권6호
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• pp.531-544
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• 2012

본 연구에서는 주어진 호우사상을 베타분포로 적절히 표현하기 위한 매개변수의 결정 방법을 제시하였다. 이를 위해 첨두에 대한 고려를 추가한 경우와 그렇지 않은 경우, 실제 우량주상도 및 첨두를 중심으로 재배열된 수정 우량주상도를 사용하는 경우 등을 고려하여 그 특성을 비교 검토하였다. 본 연구는 서울 지점의 2010년 독립 호우사상과 1961~2010년 사이의 연 최대치 독립 호우사상을 대상으로 베타분포를 적용하고, 그 결과를 분석하였다. 그 결과를 정리하면 다음과 같다. 첫째, 베타분포를 이용하여 실제 호우사상의 우량주상도 형태를 유사하게 표현하기 위해서는 첨두에 대한 추가적인 고려가 필요한 것으로 확인되었다. 둘째, 첨두를 중심으로 시간강우를 좌우 순차적으로 재배열한 수정 우량주 상도를 이용하는 경우가 실제 우량주상도를 이용하는 경우보다 실제 강우의 시간분포 특성에 보다 가까운 베타분포를 유도함을 확인하였다.

• Restorative Dentistry and Endodontics
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• 제26권4호
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• pp.341-349
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• 2001

Dental caries is the most common oral disease. There are many factors contributing to its development, but complete understanding and prevention are not fully known. However, it is possible to remineralize the early enamel curious lesion by fluoride containing remineralization solution. Recently the pH-cycling model has been used to examine the effect of fluoride solution on remineralization of artificial caries in vitro as it can closely simulate the conditions encountered in vivo within a carefully controlled environment. The aim of this study was to evaluate the remineralizing effects of supersaturated buffer solutions under pH-cycling model. The specimen with 3mm-diameter was made using mature bovine incisors which has no caries and has sound enamel surface. Early curious lesions were produced by suspending each specimens into demineralization solution at pH 5.0 for 33 hours and the specimen whose surface hardness value ranged from 25 to 45 VHN were used. The pH cycling treatment regimen consisted of 5 min soaks of three treatment solutions four times per days for 15 days and the continuous cycling of demineralization and remineralization were carried out for 15 days. Following the pH-cycling treatment regimen, the specimens' surface microhardness were measured by the Vickers hardness test (VHN) and analyzed by ANOVA and Duncan's multiple-range test. 1. The surface microhardness value of supersaturated solution, Senstime, and Gagline groups were increased after pH cycling, and that of supersaturated solution was significantly Increased compared to saline group(P<0.05). 2. The surface remineralization effect of fluoride containing solutions was accelerated by saliva under pH-cycling mode 3. The pH cycling model was considered appropriate to mimic the intra-oral pH changes when evaluating demineralization and remineralization in vitro. Under the results of above study, salivary remineralization effect can be improved by fluoride containing remineralization solution. The pH-cycling model was considered appropriate to mimic the intra-oral pH changes when evaluating demineralization and remineralization in vitro.

• 한국IT서비스학회지
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• 제11권4호
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• pp.135-151
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• 2012

Traditionally in IS studies, the relationship between construct and its measurement items tends to be assumed to be reflective, meaning that the measurements are a reflection of the construct. In reality, however, the nature of the construct can be often formative, which means that its measurement items describe and define the construct rather than vice versa. The purpose of this study was to investigate theoretical and empirically-analysed differences between formative construct and reflective construct through comprehensive interdisciplinary literature review. And then on the basis of these differences, we intended to derive the rule of specifying whether the construct is formative or reflective and propose the methodology of testing the validity(content validity, construct validity, internal consistency and external construct) of formative construct and its measurements, differentiated from that in the case of reflective construct. Also, we suggested the concrete statistical testing methods such as VTT(Vanishing Tetrad Test), MIMIC(Multiple Indicators and Multiple Causes) test and multi-collinearity test. In order to examine the applicability of this methodology to developing the constructs for performance evaluation of IS(Information Systems), we tried to identify its attribute(formative or reflective) and test the validity for the construct arbitrarily chosen among them which had been derived in our previous IS performance evaluation study by using this methodology. The result of the examination was that the methodology proposed in this study was significantly valid and effective in the area of IS performance evaluation.

• Clinical and Experimental Reproductive Medicine
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• 제47권1호
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• pp.20-33
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• 2020

Objective: The differences between type 1 and type 2 diabetes mellitus (T1DM and T2DM) in terms of their adverse effects on male reproductive parameters have never been elucidated. This study aimed to distinguish between the effects of the DM types in mice treated with multiple low doses of streptozotocin (STZ) to mimic human T1DM and coadministered a high-fat diet (HFD) to mimic human T2DM. Methods: The T1DM mice were intraperitoneally injected with STZ (40 mg/kg body weight) for 5 days. The T2DM mice received an HFD for 14 days prior to STZ injection (85 mg/kg body weight), followed by continuous feeding of an HFD. Male reproductive parameters were evaluated. Results: The reproductive organs of the DM mice weighed significantly less than those of controls, and the seminal vesicles plus prostates of the T1DM mice weighed less than those of the T2DM mice. Increased sperm abnormalities and incomplete DNA packaging were observed in the DM groups. Sperm concentration and the proportion of normal sperm were significantly lower in the T1DM group. The seminiferous histopathology of DM mice was classified into seven types. The penises of the DM mice were smaller than those of the controls; however, tunica albuginea thickness and the amount of penile collagen fibers were increased in these mice. Round germ cells were abundant in the epididymal lumens of the mice with DM. Conclusion: T1DM adversely affected reproductive parameters to a greater extent than T2DM.