• 한방비만학회지
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• 제20권2호
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• pp.178-192
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• 2020

Objectives: The present study aimed to compare the impacts of cognitive behavioral therapy (CBT) and behavioral treatment (BT) on weight loss and psychological outcomes among patients with three different subtypes of obesity: simple obesity, obesity with binge eating disorder, and obesity with depression. Methods: Embase, PubMed, the Cochrane Central Register of Controlled Trials, Research Information Sharing Service, and Korean Studies Information Service System were systematically searched for randomized controlled trials conducted on or before May 2020, that used CBT to treat obesity. Methodological quality was assessed using Cochrane's risk of bias tool 2 and publication bias was evaluated through the funnel plot using the trim and fill method, Egger's test, and Begg and Mazumdar rank correlation test. A meta-analysis was conducted using a random-effects model and the standardized mean difference with 95% confidence interval (CI) was used to determine effect size. Results: Twenty-one randomized controlled trials with a total of 22 intervention arms and 2,590 patients were included. Our study results revealed that the effects of CBT, compared with BT, on weight loss distinctly differed across all patient subgroups. In the simple obesity group, CBT was more effective than BT (Hedges' g=0.138, CI=0.012~0.264); however, in the obesity with binge eating disorder group, BT was more effective than CBT (Hedges' g=-0.228, CI=-0.418~-0.038); in the obesity with depression group, the effect of CBT was not statistically different from that of BT (Hedges' g=0.276, CI=-0.307~0.859). Further studies with larger sample sizes are required to confirm the outcomes observed in this study. Conclusions: Our results indicated that the effects of CBT on obesity treatment vary based on patient subtype. Therefore, our findings suggest that CBT or BT should be selectively recommended as a treatment strategy for different obesity subtypes.

• 한국산학기술학회논문지
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• 제15권12호
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• pp.7239-7247
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• 2014

본 연구는 저빈도 반복경두개자기자극(rTMS)이 만성 뇌졸중 환자의 인지기능에 미치는 영향을 알아보기 위해 실시하였다. MMSE-K와 한국어판 BCRS-K를 통해서 선별된 만성 뇌졸중 환자 30명을 대상으로 3개의 군으로 무작위로 나누었다. 실험군 I(n=10)은 소리만 동일시간 적용하게 하였고, 실험군 II(n=10)은 손상 측에 1 Hz rTMS를, 실험군 III(n=10)은 손상반대측에 1 Hz rTMS를 적용하여 주 5회, 1일 20분, 2주간 중재하였다. 인지기능의 변화를 알아보기 위해서 중재 전, 1주 후, 2주 후, 3개월 후 시점에서 CERAD-K 점수를 측정하였다. 연구 결과 즉각 기억단어는 실험군 I에 비교하여 실험군 II와 실험군 III에서 2주 후와 3개월 후에 통계학적으로 유의한 차이를 보였고(p<.05), 재인 기억단어에서는 실험군 III에서 2주 후와 3개월 후에 통계학적으로 유의한 차이가 나타났다(p<.05). 지연 기억단어는 실험군 I에 비해 실험군 III에서 3개월 후에 통계학적으로 유의한 차이를 보였다(p<.05). 따라서 본 연구결과를 통해서 뇌졸중 환자에서 저빈도 rTMS의 적용이 인지재활에 긍정적인 영향을 줄 수 있을 것으로 생각된다.

• 대한지역사회작업치료학회지
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• 제8권3호
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• pp.59-67
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• 2018

목적 : 본 연구는 작업에 기반을 둔 집단 요리활동 프로그램이 지역아동센터 비장애 아동의 실행기능에 미치는 효과를 알아보고자 하였다. 연구방법 : 지역아동센터를 이용하는 만 6~9세 아동 6명이 2017년 7월부터 2017년 8월까지 본 연구에 참여하였다. 본 연구는 단일 집단 사전-사후 설계로, 지역아동센터 아동들을 대상으로 집단 요리활동 프로그램을 진행하였다. 중재 전 후에 스트룹 아동 색상-단어 검사(STROOP Color and Word Test), 아동 색 선로 검사(Children's Color Trails Test), 운동처리기술평가(Assessment of Motor and Process Skills)를 사용하여 아동들의 실행기능을 평가하여 프로그램의 효과를 측정하였다. 결과 : 중재 전과 비교하여 중재 후 스트룹 아동 색상-단어 검사와 운동처리기술평가의 처리기술 점수가 통계적으로 유의하게 향상되었다(p<.05). 아동 색 선로 검사에 있어 중재 전 점수와 중재 후 점수 간에 통계적으로 유의한 차이가 나타나지 않았다(p>.05). 결론 : 본 연구는 지역아동센터 비장애 아동을 대상으로 한 집단 요리활동 프로그램 중재가 인지적 억제 실행기능과 수행 실행기능에 효과가 있음을 제시하였다. 본 연구는 작업에 기반을 둔 중재 접근이 지역사회의 다양한 대상들에게 적용될 수 있음을 시사한다.

• 대한지역사회작업치료학회지
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• 제10권2호
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• pp.25-36
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• 2020

목적 : 본 연구는 주간보호센터를 이용하는 경도 치매노인을 대상으로 맞춤형 작업 중재를 적용하여 이러한 작업 중재가 효과가 있는지 확인하였다. 연구방법 : 본 연구는 B지역의 주간보호센터를 이용하는 경도 치매노인 29명을 대상으로 단일군 전·후 실험설계를 적용하였고, 일주일에 한 번, 60분씩 총 10회기를 진행하였다. 중재는 크게 집단 활동과 개인 활동으로 이루어졌으며, 개인 활동은 경도 치매노인과 담당자가 상의하여 작업 목표를 선정하고 목표를 달성하기 위해 필요한 다양한 활동들을 일대일로 시행하였다. 맞춤형 작업 중재의 효과는 CERAD 평가, 버그 균형 척도(Berg Balance Scale; BBS), 노인우울척도(Geriatric Depression Scale; GDS) 등을 통해 확인하였다. 결과 : 중재 이후 인지기능 변화에서는 MMSE-KC의 총점과 시간 지남력, 집중력, 구성회상, 길 만들기 B에서, 신체기능 변화에서는 BBS의 선 자세에서 앉기와 두 눈을 감고 잡지 않고 서 있기에서, 우울 변화에서는 GDS 점수에서 유의한 차이가 나타났다(p<.05). 결론 : 맞춤형 작업 중재는 경도 치매노인의 인지기능과 신체기능의 향상, 우울의 감소에 효과가 있는 것으로 나타났다. 이를 통해 경도 치매노인에게 적용할 수 있는 하나의 중재로 맞춤형 작업 중재를 제안하는 근거를 마련하였다.

• 국제물리치료학회지
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• 제1권1호
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• pp.5-9
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• 2010

The purpose of this study is to investigate the effects of group exercise program on depression in the elders with dementia. Subjects of this research were selected from the patients of Hyoja hospital(Yongin, Korea). They were elders with dementia having minor to moderate degrees of cognitive function. Twenty-four subjects were randomly assigned into two groups, each with 12 people; exercise group and the control group. The control group only performed general physiotherapy, while the exercise group performed exercise program and general physiotherapy for 8 weeks. Depression of the exercise group and the control group were measured at baseline before the study, at 4 weeks, and at 8 weeks after the study. Depression was measured by Geriatric Depression Scale Short Form Korea Version(GDSSF-K). Firstly, when comparing the levels of depression within the same group, depression was significantly lower in the exercise group, after the group exercise program. However, depression of the control group did not show significant changes before or after the study. Secondly, when comparing the levels of depression of the control group and the exercise group, differences between the levels measured before the study and 8 weeks after the study, was a statistically significant decrease of depression. Thirdly, effects of group exercise program according to the applied period were analyzed showing 8 weeks of group exercise to be more beneficial than 4 weeks. People who performed continuous group exercise program showed decrease in depression compared to the absence of group exercise program. This can infer beneficial effects of group exercise program. Group exercise program had desirable influence on decreasing the level of depression.

• 국제물리치료학회지
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• 제4권1호
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• pp.479-487
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• 2013

This study is intended to examine the tDCS and Morris Water maze training in Alzheimer's disease(AD) rats on Tau protein expression. Experiment groups were divided into four groups and assigned 16 rats to each group. Group I was a control group(AD induced by scopolamine); Group II was a experimental control group(AD injured by scopolamine and treatment tacrine); Group III was a group of tDCS application after AD injured by scopolamine; Group IV was a group of morris water maze training after AD injured by scopolamine. In cognition test, the outcome of group II was significantly lower than the groups(p<.001). and group III, IV were significantly low result at 14 days(p<.05). In histological finding, the experimental groups were destroy of micro vessels and finding of cell atropy and swelling. Group III, IV were decreased in degeneration of liver and kidney cells. In immuno- histochemistric response of BDNF and tau protein in hippocampus, BDNF expression of Group II was more increase than the other groups. and increase of BDNF expression was III, IV were higher than group I at 21 days. Tau protein expression of Group II was more decrease than the other groups. and decrease of Tau protein expression was III, IV were lower than group I at 21 days. These result suggest that improved tDCS and morris water maze training after scopolamine induced is associated with dynamically altered expression of BDNF and Tau protein in hippocampus and that is related with cognitive function.

• 대한불안의학회지
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• 제15권1호
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• pp.13-19
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• 2019

Objective : The purpose of this study was to investigate consensus relative to treatment strategies for psychosocial treatment in panic disorder, that represents one subject addressed by the Korean guidelines for treatment of panic disorder 2018. Methods : The executive committee developed questionnaires relative to treatment strategies for patients with panic disorder based on guidelines, algorithms, and clinical trials previously published in foreign countries and Korea. Seventy-two (61.0%) of 112 experts on a committee reviewing panic disorder responded to the questionnaires. We classified the consensus of expert opinions into three categories (first-line, second-line, and third-line treatment strategies), and identified treatment of choice using the Chi-square test and 95% confidence intervals. Results : For psychosocial treatment of panic disorder, individual and group cognitive behavior therapy (CBT) were recommended treatments of choice, and mindfulness based cognitive therapy (MBCT) was recommended as first line strategy. There was statistically significant consensus among experts regarding usefulness of each component of CBT and MBCT, for treatment of patients with panic disorder. Conclusion : Results, that reflect recent studies and clinical experiences, may provide the guideline for psychosocial treatment strategies for panic disorder.

• 한국노년학
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• 제28권4호
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• pp.1279-1295
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• 2008

본 연구는 치매노인들을 대상으로 집단미술치료 프로그램을 실시하여 인지기능의 하위영역과 자아존중감에 미치는 효과를 알아보고자 하였다. 연구대상은 서울시 ${\bigcirc}{\bigcirc}$노인종합노인복지관 내의 케어센터에 의뢰된 노인들 중 MMSE-K 총점이 19점 이하인 경증치매 여자노인 4명이었다. 연구기간은 2008년 1월15일부터 2008년 4월30일까지 1회기 60분씩 주 1회, 총 15회기를 실시하였고, 연구도구로는 MMSE-K(한국형 간이정신상태검사)와 Rosenberg의 Self-Esteem Scale(자아존중감 척도)을 사전, 사후에 실시하였다. 자료 분석은 사전 사후 검사한 결과의 단순 평균값 비교를 위한 기술통계와 Wilcoxon 비모수 통계를 이용하여 검증하였다. 본 연구결과를 통해 다음과 같은 결론을 얻었다. 첫째, 집단미술치료가 치매노인들의 인지기능에 효과가 있는 것으로 나타났다. 간이정신상태검사의 사전 사후 점수에 대하여 평균 16.75에서 19.75로 향상되었으며, Wilcoxon 비모수 통계를 이용한 검증결과 p값이 .046으로 통계적으로 유의하게 나타났으며, 하위영역별로 지남력, 기명력, 집중 및 계산, 언어기능, 이해 및 판단은 사전, 사후 검증에서 평균점수는 향상되었지만, 통계적 유의도는 없었으며, 기억회상은 사전 사후 검증에서 평균 0.70이 향상되었고, Wilcoxon 비모수 통계를 이용한 검증결과 p값이 .043으로 통계적으로 유의하게 나타났다. 둘째, 집단미술치료가 치매노인들의 자아존중감에 효과가 있는 것으로 나타났다. Self-Esteem Scale 사전 사후 검증에서 평균 20.75에서 24.25로 향상되었으며, 통계결과 p값이 .048로 통계적으로 유의하여 프로그램의 효과성이 입증되었다.

• 약학회지
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• 제37권5호
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• pp.442-452
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• 1993

Previous experimental and clinical investigations suggest a possible role of new nootropic drug, oxiracetam, in improving cognitive performances in patients affected by organic brain syndrome. In this study, the cognitive and behavioral effects of oxiracetam treatment in patients with clinical symptoms of organic brain syndrome were evaluated. Sixty-six patients were enrolled and assigned to either oxiracetam or placebo, according to a randomized, double-blind design between two patient-groups. Either oxiracetam or placebo was orally given bid for 8 weeks ; daily dose of oxiracetam was 1600mg. All the patients, enrolled in this study, were diagnosed as having mild to moderate cognitive dysfunction as defined by a baseline Mini Mental State ExaminationKorean version (MMSE-K) score between 14 and 25. The patients under-went, at baseline, 4 weeks and 8 weeks after, routine laboratory study (CBC, SMA12, U/A, EKG) and the following neuropsychological tests ; MMSE-K, modified Korean Wechsler Intelligence Scale(MKWIS), Nurses' Observation Scale for Geriatric patients(NOSGER). Fifteen patients of whom were dropped out or excluded from the analysis because of poor compliance or violation of the protocol. Fiftyone patients (aged 54~78 years, male 25, female 26) were analyzed (vascular dementia, 30 ; senile dementia of Alzheimer type, 9 ; mixed type, 5 ; other cause, 7). Statistical analysis of the data demonstrated that the two groups were comparable at baseline. At the end of each study period the oxiracetam group scored significantly better on the majority of the tests evaluating cognitive function, psychometricity and the improvement rating scale of subjective symptoms than placebo group, in which worsening trends or no changes were seen on the whole. No side effects were noted during oxiracetam treatment. The present study, showing positive clinical findings after oxiracetam therapy, confirmed that this drug can be useful pharmacological treatment in organic brain syndrome.

• The Journal of Korean Physical Therapy
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• 제35권5호
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• pp.156-161
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• 2023

Purpose: This study examined the effects of subjective visual vertical perception and head orientation on static balance control. Methods: The subjects were 25 young and healthy adults. The vertical perception was measured using a subjective visual vertical (SVV), and the Center of pressure (COP) parameter was analyzed by continuously measuring the movement of the COP to determine the changes in static postural control. The group was divided based on a deviation of 3° in SVV (11 of SVV≥3°, 14 of SVV<3°) and measured with different head orientations: front, up, down, left, and right in the upright and tandem positions, respectively. Results: In the upright position, the SVV≥3° group had significantly larger values for all COP parameters (Sway length, Surface, Delta X, Delta Y, and Average speed) compared to the SVV<3° group (p<0.05). In the tandem stance, only the Ellipse Surface value was significantly larger among the COP parameters in the group with SVV≥3° compared to the group with SVV<3°(p<0.05). In contrast, the other COP parameters were not significantly different (p>0.05). The effects of static balance control on the head orientation were not statistically significant (p>0.05), and the interactions between the subjective vertical perception and head orientation were not significant (p>0.05). Conclusion: These results suggest that pathological deviations in SVV are associated with impaired static balance performance. This study can provide a therapeutic rationale for using visuospatial cognitive feedback training to improve the static balance.