• Natural Product Sciences
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• 제20권1호
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• pp.22-28
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• 2014

A new natural product, tetrastigmol A (1), and several known compounds as flavonoids (2 - 8), steroids (9 - 10), bergenin and its derivative (11 - 12), stilbens (13 - 15), lignan (16), benzenecarboxylic derivative (17) and two norisoprenoid (18 - 19) were isolated from the stem of Tetrastigma erubescens Planch. (Vitateae). Their structures were determined on the basis of NMR spectroscopic data. This is the first report on chemical constituents of this plant. Compounds 1, 6 - 8 and 12 - 15 showed strong antioxidant activity using two methods including DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging and lipid peroxidation inhibitory assays.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.313-319
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• 2003

It is well known that ascorbic acid (VC) is an important factor for several physiological reactions. In the skin, VC works as an anti-aging agent due to removing of oxidative stress generated by UV irradiation and stimulation of collagen synthesis. Thus, developing more effective VC derivatives is an important issue in creating anti-aging skin care products. Our study succeeded to develop a novel ascorbic acid derivative, ascorbic acid tetra-2-hexyldecanoate (VC-IP), which is a lipid-soluble pro-VC. The purpose of this study was to indicate the effects of VC-IP as pro-VC and anti-aging agent. First, it was examined whether VC-IP is converted to VC in physiological conditions. Since VC was detected from the cell extracts treated with VC-IP, it was indicated that VC-IP is a pro- VC.(omiited)

• 대한수학회논문집
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• 제32권2호
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• pp.287-304
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• 2017

Motivated mainly by certain interesting recent extensions of the generalized hypergeometric function [Integral Transforms Spec. Funct. 23 (2012), 659-683] by means of the incomplete Pochhammer symbols $({\lambda};{\kappa})_{\nu}$ and $[{\lambda};{\kappa}]_{\nu}$, we first introduce incomplete Fox-Wright function. We then define the families of incomplete extended Hurwitz-Lerch Zeta function. We then systematically investigate several interesting properties of these incomplete extended Hurwitz-Lerch Zeta function which include various integral representations, summation formula, fractional derivative formula. We also consider an application to probability distributions and some special cases of our main results.

• Journal of applied mathematics & informatics
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• 제6권2호
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• pp.523-538
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• 1999

A new preconditioning method is investigated to reduce the roundoff error in computing derivatives using Chebyshev col-location methods(CCM). Using this preconditioning causes ration of roundoff error of preconditioning method and CCm becomes small when N gets large. Also for accuracy enhancement of differentiation we use a domain decomposition approach. Error analysis shows that for this domain decomposition method error reduces proportional to the length of subintervals. Numerical results show that using domain decomposition and preconditioning simultaneously gives super accu-rate approximate values for first derivative of the function and good approximate values for moderately high derivatives.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7687-7692
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• 2014

Aim: To observe the effects of a novel all-trans retinoid acid (ATRA) derivative, N-(3-trifluoromethyl-phenyl)-retinamide (ATPR), on lung adenocarcinoma A549 cells and to explore the potential mechanism of ATPR inhibiting of A549 cell migration. Materials and Methods: The cytotoxicity of ATRA and ATPR on A549 cells was assessed using MTT assay. Wound healing assays were used to analyze the influences of ATRA, ATPR, ML-7 (a highly selective inhibitor of myosin light chain kinase (MLCK)), PMA (an activator of MAPKs) and PD98059 (a selective inhibitor of ERK1/2) on the migration of A549 cells. Expression of MLCK and phosphorylation of myosin light chain (MLC) were assessed by Western blotting. Results: ATRA and ATPR inhibited the proliferation of A549 cells in a dose- and time-dependent manner, and the effect of ATPR was much more remarkable compared with ATRA. Relative migration rate and migration distance of A549 cells both decreased significantly after treatment with ATPR or ML-7. The effect on cell migration of PD98059 combining ATPR treatment was more notable than that of ATPR alone. Moreover, compared with control groups, the expression levels of MLCK and phosphorylated MLC in A549 cells were both clearly reduced in ATRA and ATPR groups. Conclusions: ATPR could suppress the migration and invasion of A549 cells, and the mechanism might be concerned with down-regulating the expression of MLCK in the ERK-MAPK signaling pathway, pointing to therapeutic prospects in lung cancer.

• Structural Engineering and Mechanics
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• 제20권6호
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• pp.713-726
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• 2005

Based on the improved first order Taylor interval expansion, a new interval analysis method for the static or dynamic response of the structures with interval parameters is presented. In the improved first order Taylor interval expansion, the first order derivative terms of the function are also considered to be intervals. Combining the improved first order Taylor series expansion and the interval extension of function, the new interval analysis method is derived. The present method is implemented for a continuous beam and a frame structure. The numerical results show that the method is more accurate than the one based on the conventional first order Taylor expansion.

• Natural Product Sciences
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• 제26권2호
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• pp.144-150
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• 2020

Phytochemical investigation of leaves, barks and roots of Nauclea vanderguchtii led to the isolation of sixteen compounds, which includes one citric acid derivative (2), one alkaloid (16), one peptide derivative (3), and twelve triterpenes (1, 4 - 13). These compounds were identified as rotundanonic acid (1), 2-hydroxy-1,2,3-propanetricarboxylic acid 2-methyl ester (2), asperphenamate (3), lupeol (4), stigmasterol (5), betulin (6), betulenic acid (7), stigmasterol 3-O-β-D-glucopyranoside (8), quinovic acid 3β-O-α-L-rhamnoside (9), α-amyrin (10), 3-oxoquinovic acid (11), ursolic acid (12), hederagenin (13), rotundic acid (14), clethric acid (15), and naucleficine (16) by the analysis of their NMR spectroscopic data including 2D NMR spectra and by comparison of their spectroscopic data reported in the literature. Compounds 1 and 3 were isolated for the first time in the genus Nauclea, and compound 2 was isolated for the first time from the Rubiaceae family. Complete NMR assignations for 1 have been published for the first time.

• Journal of Ginseng Research
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• 제46권6호
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• pp.738-749
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• 2022

Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by ¹H-NMR, ¹³C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC₅₀ < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC₅₀ > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.

• 대한수학회보
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• 제61권1호
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• pp.93-115
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• 2024

In this paper, the Gauge-Uzawa methods for the Darcy-Brinkman equations driven by temperature and salt concentration (DBTC) are proposed. The first order backward difference formula is adopted to approximate the time derivative term, and the linear term is treated implicitly, the nonlinear terms are treated semi-implicit. In each time step, the coupling elliptic problems of velocity, temperature and salt concentration are solved, and then the pressure is solved. The unconditional stability and error estimations of the first order semi-discrete scheme are derived, at the same time, the unconditional stability of the first order fully discrete scheme is obtained. Some numerical experiments verify the theoretical prediction and show the effectiveness of the proposed methods.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.151.3-151
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• 2001

A design of PI controller to be used to control the first-order lag plus dead time process, such as a flow process, by the coefficient diagram method (CDM) is investigated. The factor of the dead time of process is first approximated to be the first-order by the Pade approximation. The response of the flow control system designed by CDM satisfy both transient and steady state specifications. However, the transient response generally still has long rise time. In order to improve the speed of the system response, a feedforward controller (FFC) is added into the PI control system. The structure of the FFC is a phase lead structure with two designed parameters and one derivative time obtained from the reaction curve of the flow process ...