• Proceedings of the Korean Society of Applied Pharmacology
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• 2001.11a
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• pp.90-90
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• 2001

CCAP법을 이용하였을 때 SAM에서 taurine의 뇌 분포용적은 정상생쥐보다 85 % 감소하였다. 그리고 10, 15, 30초 동안의 뇌 분포용적은 linear regression을 나타내었다. 또한 intravenous injection technique의 결과, SAMP8에서의 sucrose space가 정상생쥐에 비하여 감소하였음을 알 수 있었다. 반면에 choline의 경우는 정상생쥐보다 SAMP8의 뇌분포용적이 73% 증가하였다.

• The Journal of the Korea Contents Association
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• v.16 no.5
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• pp.172-179
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• 2016

Korea society in the 1980s is the timing of the hybrid intermingled with the continuous industrialization in the 1970s and the democratic aspirations of the 1990s. Korean films in the '80s codified a tension and conflict patterns of the industrialization and democratization in the style such as film space. The purpose of this study is to consider how this aspect of industrialization and democratization in the '80s was codified in Korean films of the '80s. Specifically, it focuses on the style representing the urban space in Korean films of the '80s. This study looks at the changing pattern of the Korea Society through the 1980s by analyzing the space configuration form of Good Windy Day(1980) and Chil-su And Man-su(1988). Good Windy Day to finalize the '70s and Chil-su And Man-su to greet the '90s show the hybrid aspect of the '80s. In particular, the urban space style of the two films codified the political, economic and social culture of Korea as a whole.

• Clinical and Experimental Pediatrics
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• v.50 no.6
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• pp.543-548
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• 2007

Purpose : The anthropometric data of newborns published by Lubchenco et al in the 1960's have been most commonly used in Korea as a standard of newborn growth. We hypothesized that Lubchenco's data have limitations for Korean premature infants born in the 2000's. We analyzed and compared the data of birth weight, length, and head circumference. Methods : The medical records of 1,159 premature infants of 26 to 35 weeks of gestational age born at Il-Sin Christian Hospital of Busan from January 2,000 to August 2,006 were reviewed. The anthropometric data from total 1,010 premature infants were analyzed after excluding the data from infants whose gestational age were estimated by other than ultrasonogram, and infants with major congenital anomalies or chromosomal anomaly, born from foreign parent, and extreme outliers. Results : In the birth weights by gestational age, our 90 percentile values were lower than Lubchenco's 90 percentile values for all gestational age studied, particularly for less than 30 weeks the 90 percentile curve was drawn at the area as that of Lubchenco' 75 percentile. And our 10 percentile values were higher than Lubchenco's 10 percentile values for all gestational age studied. In the birth length and head circumference by gestational age, our 90 percentile values were lower than Lubchenco's 90 percentile values for all gestational age studied, and the 90 percentile curve was drawn at the area as that of Lubchenco's 75 percentile. And our 10 percentile values were higher than Lubchenco's 10 percentile values for all gestational age studied. Conclusion : It is unreasonable to apply Lubchenco's data published before 4th decades to present Korean premature infants and have a risk to underestimate intrauterine growth retardation or small for gestational age and large for gestational age. Considering for the possibility of increasing the mortality and morbidity of premature infants due to delayed diagnosis and treatment by these underestimating, our anthropometric data of premature infant is expected to contribute to lower the mortality and morbidity of premature infants.

• BMB Reports
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• v.52 no.12
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• pp.706-711
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• 2019

Cisplatin (Cis-DDP) is one of the most widely used anti-cancer drugs. It is applicable to many types of cancer, including lung, bladder, and breast cancer. However, its use is now limited because of drug resistance. p90 ribosomal S6 kinase (p90RSK) is one of the downstream effectors in the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) pathway and high expression of p90RSK is observed in human breast cancer tissues. Therefore, we investigated the role of p90RSK in the Cis-DDP resistance-related signaling pathway and epithelial-mesenchymal transition (EMT) in breast cancer cells. First, we discovered that MDA-MB-231 cells exhibited more Cis-DDP resistance than other breast cancer cells, including MCF-7 and BT549 cells. Cis-DDP increased p90RSK activation, whereas the inactivation of p90RSK using a small interfering RNA (siRNA) or dominant-negative kinase mutant plasmid overexpression significantly reduced Cis-DDP-induced cell proliferation and migration via the inhibition of matrix metallopeptidase (MMP)2 and MMP9 in MDA-MB-231 cells. In addition, p90RSK activation was involved in EMT via the upregulation of mRNA expression, including that of Snail, Twist, ZEB1, N-cadherin, and vimentin. We also investigated NF-κB, the upstream regulator of EMT markers, and discovered that Cis-DDP treatment led to NF-κB translocation in the nucleus as well as its promoter activity. Our results suggest that targeting p90RSK would be a good strategy to increase Cis-DDP sensitivity in triple-negative breast cancers.

• Journal of Korean Foot and Ankle Society
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• v.19 no.4
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• pp.142-150
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• 2015

Purpose: Restoration of ankle stability through the strengthening exercise of peroneus muscles is considered an important factor for achievement of successful outcomes, in the rehabilitation program following ankle ligament injuries. However, there were few definitive data on normal muscle strength, including eversion power by peroneus muscles. This study was conducted to evaluate the muscle strength of ankle joint measured using an isokinetic dynamometer in normal Koreans. Materials and Methods: Sixty adults (120 ankles) were recruited and divided into three groups (20 in their twenties, 20 in thirties, and 20 in forties). Each group consisted of 10 males and 10 females. The selection criteria were no history of ankle injury and no evidence of instability. The peak torque, total work, and deficit ratio were measured using the Biodex$^{TM}$ (Biodex Medical Systems). Differences in muscle strength by age, gender and dominant versus non-dominant side were analyzed. Results: The peak torque of dorsiflexion was average 31.5 Nm at $30^{\circ}/s$ of angular velocity and 18.8 Nm at $90^{\circ}/s$; average 69.3 Nm ($30^{\circ}/s$) and 42.4 Nm ($90^{\circ}/s$) on plantarflexion; average 19.6 Nm ($30^{\circ}/s$) and 10.8 Nm ($90^{\circ}/s$) on inversion; average 12.9 Nm ($30^{\circ}/s$) and 8.0 Nm ($90^{\circ}/s$) on eversion. The deficit ratio of strength in women was average 61.1% of men on dorsiflexion; average 66.2% on plantarflexion; average 48.5% on inversion; average 55.4% on eversion. The deficit ratio in non-dominant foot was average 88.6% of dominant foot on dorsiflexion; average 90.1% on plantarflexion; average 85.1% on inversion; average 85.6% on eversion. Conclusion: The muscle strength of the ankle joint showed a tendency to weaken with age. There were significant differences in muscle strength by gender and dominancy. Further studies for comparison of patients with ankle instability, a comparison between before and after surgery for instability, the correlation between clinical outcomes and the recovery in muscle strength will be needed.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.8
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• pp.1931-1939
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• 1993

The wave propagation characteristics of laminated composites subjected to a transverse high-velocity impact of a steel ball is investigated. For this purpose, high-velocity impact experiments were conducted to obtain the strain response histories, and a finite element analysis based on the higher-order shear deformation theory in conjunction with the static contact law is used. Test materials for investigation are glass/epoxy laminated composite materials with $[0^{\circ}/45^{\circ}/0^{\circ}/-45^{\circ}]_{2s}$ and $[90^{\circ}/-45^{\circ}/90^{\circ}-45^{\circ}/90^{\circ}]_{2s}$ stacking sequences. As a result, the strain responses obtained from the experiments represented the wave propagation characteristics in the transversely impact, also the wave propagation velocities obtained from high-velocity impact experiments and wave propagation theory agree well.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2004.10a
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• pp.90-90
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• 2004

• Proceedings of the Korean Vacuum Society Conference
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• 2004.02a
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• pp.90-90
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• 2004

• Proceedings of the Materials Research Society of Korea Conference
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• 1998.08a
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• pp.90.2-90
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• 1998

• Composites Research
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• v.14 no.3
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• pp.1-9
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• 2001

A new non-destructive fatigue prediction model of the composite laminates is developed. The natural frequencies of fatigue-damaged laminates under extensional loading are related to the fatigue life of the laminates by establishing the equivalent flexural stiffness reduction as a function of the elastic properties of sublaminates. The flexural stiffness is derived by relating the 90-ply elastic modulus reduction, and using the laminate plate theory to the degraded elastic modulus and the intact elastic modulus of other laminates. The natural frequency reduction model, in which the dominant fatigue mode can be identified from the sensitivity scale factors of sublaminate elastic properties, provides natural frequency vs. fatigue cycle curves for the composite laminates. Vibration tests were also conducted on $[{90}_2/0_2]_s$ carbon/epoxy laminates to verify the natural frequency reduction model. Correlations between the predictions of the model and experimental results are good.