• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10957-10960
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• 2015

Background: The CYP2C19 genotype has been found to be an important factor for peptic ulcer healing and H. pylori eradication, influencing the efficacy of proton pump inhibitors (PPIs) and the pathogenesis of gastric cancer. The aim of this study was to investigate clinical correlations of the CYP2C19 genotype in patients with gastritis, peptic ulcer disease (PUD), peptic ulcer bleeding (PUB) and gastric cancer in Thailand. Materials and Methods: Clinical information, endoscopic findings and H. pylori infection status of patients were assessed between May 2012 and November 2014 in Thammasat University Hospital, Thailand. Upper GI endoscopy was performed for all patients. Five milliliters of blood were collected for H. pylori serological diagnosis and CYP2C19 study. CYP2C19 genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis (RFLP) and classified as rapid metabolizer (RM), intermediate metabolizer (IM) or poor metabolizer (PM). Results: A total of 202 patients were enrolled including 114 with gastritis, 36 with PUD, 50 with PUB and 2 with gastric cancer. Prevalence of CYP2C19 genotype was 82/202 (40.6%) in RM, 99/202 (49%) in IM and 21/202 (10.4%) in PM. Overall H. pylori infection was 138/202 patients (68.3%). H. pylori infection was demonstrated in 72% in RM genotype, 69.7% in IM genotype and 47.6% in PM genotype. Both gastric cancer patients had the IM genotype. In PUB patients, the prevalence of genotype RM (56%) was highest followed by IM (32%) and PM(12%). Furthermore, the prevalence of genotype RM in PUB was significantly greater than gastritis patients (56% vs 36%: p=0.016; OR=2.3, 95%CI=1.1-4.7). Conclusions: CYP2C19 genotype IM was the most common genotype whereas genotype RM was the most common in PUB patients. All gastric cancer patients had genotype IM. The CYP2C19 genotype RM might be play role in development of PUD and PUB. Further study in different population is necessary to verify clinical usefulness of CYP2C19 genotyping in development of these upper GI diseases.

• Safety and Health at Work
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• v.6 no.1
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• pp.56-61
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• 2015

Frozen food processing workers work under a cold environment which can cause several adverse health effects.This study explored factors affecting workers' health in the frozen food industry in Thailand. Participants comprised 497 workers exposed to a cold working environment and 255 office workers who served as the controls. Data were collected by a survey on the work environment, and the interview of workers for abnormal symptoms. The exposed group had the following characteristics: 52.7% male, overall average age of 27 (SD 6.6) years old, attained elementary education (Grade 4 and Grade 6) (54.1%), married (48.9%), smokers (21.3%), alcohol consumption (31.0%), duration of work was between 1 and 5 years (65.2%), working 6 days a week (82.7%), 1-5 hours of overtime per week (33.8%), office workers (33.9%); work category: sizing (6.9%), peeling (28.3%) dissecting (22.2%), and in the warehouse (8.6%). The temperature in the work environment ranged from $17.2^{\circ}C$ to $19.2^{\circ}C$ in most sections, $-18.0^{\circ}C$ in the warehouse, and $25^{\circ}C$ in the office areas. Warehouse workers had more abnormal symptoms than controls including repeated pain in the musculoskeletal system (OR 11.9; 95% CI 6.12-23.45), disturbance throughout the body (OR 4.60; 95% CI 2.00-10.56), respiratory symptoms (OR 9.73; 95% CI 3.53-26.80), episodic finger symptoms (OR 13.51; 95% CI 5.17-35.33). The study results suggest that workers' health should be monitored especially with regard to back and muscle pain, respiratory symptoms, episodic finger symptoms, and cardiovascular symptoms. Health promotion campaigns such as antismoking and reduction of alcohol consumption should be established because smoking and alcohol consumption are contributing factors to the pathogenesis of Raynaud's phenomenon and peripheral vascular disorders such as hypertension and heart disease.

• Safety and Health at Work
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• v.6 no.1
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• pp.18-24
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• 2015

Background: In 2006, three farmers died at the bottom of an agricultural shallow well where the atmosphere contained only 6% oxygen. This study aimed to document the variability of levels of oxygen and selected hazardous gases in the atmosphere of wells, and to identify ambient conditions associated with the low-oxygen situation. Methods: A cross-sectional survey, conducted in June 2007 and July 2007, measured the levels of oxygen, carbon monoxide, hydrogen sulfide, and explosive gas (percentage of lower explosive limit) at different depths of the atmosphere inside 253 wells in Kamphaengphet and Phitsanulok provinces. Ambient conditions and well use by farmers were recorded. Carbon dioxide was measured in a subset of wells. Variables independently associated with low-oxygen condition (<19.5%) were identified using multivariate logistic regression. Results: One in five agricultural shallow wells had a low-oxygen status, with oxygen concentration decreasing with increasing depth within the well. The deepest-depth oxygen reading ranged from 0.0% to 20.9%. Low levels of other hazardous gases were detected in a small number of wells. The low-oxygen status was independently associated with the depth of the atmosphere column to the water surface [odds ratio (OR) = 13.5 for 8-11 m vs. <6 m], depth of water (OR = 0.17 for 3-<8 m vs. 0-1 m), well cover (OR = 3.95), time elapsed since the last rainfall (OR = 7.44 for >2 days vs. <1 day), and location of well in sandy soil (OR = 3.72). Among 11 wells tested, carbon dioxide was detected in high concentration (>25,000 ppm) in seven wells with a low oxygen level. Conclusion: Oxygen concentrations in the wells vary widely even within a small area and decrease with increasing depth.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.424-424
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• 2017

Several studies of the world have analyzed the regional rainfall trends in large data sets. However, it reported that the long-term behavior of rainfall was different on spatial and temporal scales. The objective of this study is to determine the local trends of rainfall indices in the Yom River Basin, Thailand. The rainfall indices consist of the annual total precipitation (PRCTPOP), number of heavy rainfall days ($R_{10}$), number of very heavy rainfall days ($R_{20}$), consecutive of dry days (CDD), consecutive of wet days (CWD), daily maximum rainfall ($R_{x1}$), five-days maximum rainfall ($R_{x5}$), and total of annual rainy day ($R_{annual}$). The rainfall data from twelve hydrological stations during the period 1965-2015 were used to analysis rainfall trend. The Mann-Kendall test, which is non-parametric test was adopted to detect trend at 95 percent confident level. The results of these data were found that there is only one station an increasing significantly trend in PRCTPOP index. CWD, which the index is expresses longest annual wet days, was exhibited significant negative trend in three locations. Meanwhile, the significant positive trend of CDD that represents longest annual dry spell was exhibited four locations. Three out of thirteen stations had significant decreasing trend in $R_{annual}$ index. In contrast, there is a station statistically significant increasing trend. The analysis of $R_{x1}$ was showed a station significant decreasing trend at located in the middle of basin, while the $R_{x5}$ of the most locations an insignificant decreasing trend. The heavy rainfall index indicated significant decreasing trend in two rainfall stations, whereas was not notice the increase or decrease trends in very heavy rainfall index. The results of this study suggest that the trend signal in the Yom River Basin in the half twentieth century showed the decreasing tendency in both of intensity and frequency of rainfall.

• Advances in Computational Design
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• v.7 no.2
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• pp.113-128
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• 2022

Water consumption is strongly affected by numerous factors, such as population, climatic, geographic, and socio-economic factors. Therefore, the implementation of a reliable predictive model of water consumption pattern is challenging task. This study investigates the performance of predictive models based on multi-layer perceptron (MLP), multiple linear regression (MLR), and support vector regression (SVR). To understand the significant factors affecting water consumption, the stepwise regression (SW) procedure is used in MLR to obtain suitable variables. Then, this study also implements three predictive models based on these significant variables (e.g., SWMLR, SWMLP, and SWSVR). Annual data of water consumption in Thailand during 2006 - 2015 were compiled and categorized by provinces and distributors. By comparing the predictive performance of models with all variables, the results demonstrate that the MLP models outperformed the MLR and SVR models. As compared to the models with selected variables, the predictive capability of SWMLP was superior to SWMLR and SWSVR. Therefore, the SWMLP still provided satisfactory results with the minimum number of explanatory variables which in turn reduced the computation time and other resources required while performing the predictive task. It can be concluded that the MLP exhibited the best result and can be utilized as a reliable water demand predictive model for both of all variables and selected variables cases. These findings support important implications and serve as a feasible water consumption predictive model and can be used for water resources management to produce sufficient tap water to meet the demand in each province of Thailand.

• International journal of advanced smart convergence
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• v.4 no.1
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• pp.104-113
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• 2015

This paper focuses on a temperature effects on a PV panel which has been installed in Thailand. The main objective is cleaning PV panels and reduce temperature of PV panel by water injects from waterway and experimental results of PV power what it is difference. This project is designed by PLC control system which water injects and control PV temperature, In addition, this project consists of hardware and software such as water pump, water injection and PLC control has been automatically and it can be control system manually. The automatic control system is working when PV temperature rises up over 45 degree Celsius after that the pumping machine would inject water to the surface of PV panels and it must be stop when the PV panel temperature comes down less than 45 degree Celsius. The result of actual experimental found that the control system has been done correctly under specify condition. The experimental has been shown electrical data before and after water injects on PV system found that the electrical power a bit increases and The energy has been taken from PV panel less than energy consumption equipment of control system which taken to operate the water injecting system.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2839-2843
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• 2015

Background: MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. Materials and Methods: To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with the occurrence and outcome of ALL, 208 children with ALL (median age 5.0 yr) and 101 healthy Thai children were studied by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) assay. Results: C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR= 2.6, 95%CI =1.164-5.808; P=0.028 and OR= 2.231, 95%CI =1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5945-5950
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• 2015

A 6-year retrospective cohort study was conducted among Thai hematologic malignancy (HM) patients receiving intensive chemotherapy. Of the 145 eligible patients receiving 893 chemotherapy sessions, 46.9% were female, median age was 52 years, and the most common HM diagnosis was diffuse large B-cell lymphoma (46.2%). Febrile neutropenia (FN) occurred in 14.9% of chemotherapy sessions with an incidence of 24.8 per 1,000 chemotherapy cycles per year. Independent factors associated with FN were receiving the first chemotherapy cycle [adjusted hazard ratio (aHR) 4.1], having hemoglobin ${\leq}100g/L$ (aHR 3.7) and platelet ${\leq}140,000/{\mu}L$ (aHR 2.7) on chemotherapy day and receiving acute myeloid leukemia regimens (aHR 20.8). Granulocyte colony stimulating factor was significantly associated with reduced rate of FN when given in those receiving CHOP regimen. With the median follow-up time of 16 months, the overall survival time was significantly longer in patients without FN than those with FN (61.7 vs. 20.8 months; p<0.001).

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.408-418
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• 2015

The purpose of this study is to evaluate the official medical tourism websites in several countries. We compared the websites of three countries using the 4 criteria(e.g.,contents, convenience, design, interactivity). The evaluation of accessibility and subjective perception were conducted by websites users. Total 77 cases were used for the analysis. For the statistical analysis of data, MANOVA was used. According to the MANOVA analysis, The Malaysia website received the highest mark in accessibility and subjective perception. Each of the evaluations showed a significant difference among countries.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.231-232
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• 2015

R Canis Majoris is a bright, short-period ($1^d$.1359) Algol-type eclipsing binary. For a long time, it was considered to be a low-mass binary star with $M_1=1.1M_{\odot}$ and $M_2=0.17M_{\odot}$ primary and secondary components, respectively (Tomkin, 1985). Glazunova, Yushchenko & Mkrtichian (2009) found new masses for the primary and secondary components of $M_1=1.81M_{\odot}$ and $M_2=0.23M_{\odot}$, respectively and resolved a long-standing problem with the low masses of components for this binary. Budding and Butland (2011) confirmed the results of Glazunova, Yushchenko & Mkrtichian and obtained improved orbits and masses. New spectroscopic observations of R CMa were done during 8 nights on December 2012 with the 2.4-meter telescope of the Thai National Observatory (TNO) and fibre-fed medium resolution echelle spectrograph. We obtained new, accurate orbital radial velocities of the two components of this binary system. Results of these investigations and the new orbital parameters are presented.