• Title/Summary/Keyword: Th2 responses

Search Result 487, Processing Time 0.027 seconds

The Differences In Knowledges Activated inLaboratory and Earth Environmental Contexts (실험실맥락과 지구환경맥락의 문제해결에서 활성화되는 지식의 차이)

  • Lee, Myeong-Je;Kim, Chan-Jong;Choe, Seung-Eon
    • Journal of The Korean Association For Science Education
    • /
    • v.13 no.2
    • /
    • pp.257-271
    • /
    • 1993
  • Four science concepts were selected from high school earth science textbook to investigate the differences in students knowledges activated in laboratory and earth environmemtal contexts. Two items, one is for laboratory and the other for earth environmental contexts, were develped for each selected concept. Students' responses were analyzed in terms of 'Common Activated Knowledges' (CAK), 'Specific Activated Knowledges'(SAK) across students' cognitive frames, grades and sexes. As contextual differences of the problems increased, gender contributed more than other variables to the frequencies of activating CAK and SAK. Context effects were also reported across cognitive frames for CAK, but SAK became more avtivated when the contextual differences of the items become smaller. As a whole, students with laboratory cognitive frames showed more significant context effects than others. Students in 11th grade, with scientific frames and with earth science cognitive frames showed relatively small context effects. The results of the study showed that sciene concepts learned in a laboratory context are not usually transferred spontaneously to earth environmental contexts. Special instructional strategies should developed to overcome the context effects.

  • PDF

기술ㆍ가정교과 의생활 영역에 대한 여고생들의 학습 요구

  • 조은영
    • Journal of Korean Home Economics Education Association
    • /
    • v.15 no.4
    • /
    • pp.23-35
    • /
    • 2003
  • The purpose of this research is to analyse the composition of theories and practical activities in clothing and textiles in Technologyㆍ Home economics textbooks in the 7th National Curriculum and find out learning requirement of students in the area. For this research, a survey was conducted using questionnaires with 280 high school students living in Daegu and the rate of response was 78.9%. The results of this study are as follows. 1. After analysing the curriculum of Practical Arts subject in elementary school and Technology´ Home Economics subject in secondary school, we could find out that more emphasis is put on practical activities in elementary school and high school. On the other hand, theories are considered more important in middle school. 2. Students have similar preference both for theories and for practical activities as a way of learning in class and show positive responses to practical activities unless they´re giving too much pressure as a part of performance test. 3. According to their learning requirement. several teaching-learning contents in clothing and textiles in Technology Home economics are selected such as materials,. clothes designs, how to set dressed well, how to make a reasonable purchase on clothes, and the process of manufacturing various clothes, etc. Therefore it would be desirable to provide the students with the learning opportunity to the extent where even the students who haven´t chosen the selected-advanced course can take part in class actively.

  • PDF

Measures for Activating Cyber Agricultural Consulting (사이버 농업 컨설팅 활력화 방안)

  • Oh, Dae-Min;Choi, Young-Chang
    • Journal of Agricultural Extension & Community Development
    • /
    • v.7 no.2
    • /
    • pp.289-293
    • /
    • 2000
  • The way society works in the 21st century differs from that of 20th century, since the people are brought-up to speed regarding current technologies. The www.aflos.pe.kr site and direct e-mailing system were very useful in delivering floricultural information to extension educators, producers, and variety of individuals. The author’s one year experience indicated that extension educators and farmers are receptive to internet technologies, and extension educators have increased the knowledge base of their clientele by responding through direct e-mails. The internet and direct e-mailing systems were popular and powerful way of transferring floricultural information, especially agricultural extension manpower were limited because of localization of extension educators by changing national status to local governments and decreased number of extension educators through government restructuring. The direct e-mailing to approximately 503 individuals resulted about $1{\sim}3%$ responses and the number of phone calls, however virus protection software for e-mail, internet, file servers and desktops to provide the integrated real-time detection of viruses were needed. For more effective operation of direct e-mailing in the future, more specified target groups and specialized organization such as perennials, bulbs, flowering potted plants. and cut flowers. At the same time, things that have worked for last century should not be replaced with new technology, specifically, the value in one-on-one meetings should not be replaced, but rather serve as a supplement.

  • PDF

A Study on Traits and Relation Type of Old and New with Design strategy of Conversion Design (신.구요소의 관계유형 분석에 의한 컨버전디자인의 전략과 그 특성)

  • Lo, Jung-Eun;Park, Chan-Il
    • Korean Institute of Interior Design Journal
    • /
    • v.16 no.6
    • /
    • pp.36-46
    • /
    • 2007
  • Regeneration of old buildings is one of the most imperative responses to the 21th century issue of sustainable urban architectural environment. In particular, creative circulation of generation which conversion means highlights the conversion as a new design method. In this study, by examining buildings built over the last decade, the mutual relationship between old elements of existing buildings and new elements of newly required functions was analyzed and types of relationships such as 'alien insertion', 'mediate intervention', 'endogenous expansional enveloping', 'contrastive confliction' and 'over-layering' were defined. In addition, design strategies including the paradoxical curio, fore-grounding and unification were derived from each relationship. Finally, according to the relation type and design strategy, this study suggests several features of conversion design; (1) maximization of symbolism using unfamiliarities - emphasizing futuristic or contextual symbol with intentional contrasts by preserving the work or using contemporary addition; (2) time confusion using neutral space - meeting the need by harmonizing and cooperating existing elements and new elements; (3) mutual emphasizing by individualization - revealing differences between old and new for an aesthetical tension; (4) synchronism by constructional combination - making the one unity of different layers; (5) expansion by enveloping - experience of visual reverse and creation of extra space by roofing above building groups. The reconversion should be continuously researched in the future since conversion is a sustainable design method for the future of architecture.

The Rocking Response of Three Dimensional Rectangular Liquid Storage Tank (3차원 구형 액체 저장 Tank의 Rocking응답)

  • 김재관;박진용;진병무;조양희
    • Journal of the Earthquake Engineering Society of Korea
    • /
    • v.2 no.1
    • /
    • pp.23-34
    • /
    • 1998
  • A dynamic fluid-structure-soil interaction analysis method is developed to investigate the effects of translational and/or rocking motions on the seismic response of flexible rectangular liquid storage tanks founded on the deformable ground. The governing equation for the dynamics of 3-D rectangular tanks subjected to the translational and/or rocking motion is abtained by applying Rayleigh-Ritz method. The dynamic stiffness matrices of a rigid rectangular foundation resting on the surface of a stratum overlaid bedrock are calculated by hyperelement method. The seismic responses of 3-D flexible tank model founded on the deformable ground is calculated by combining the governing equation for the fluid-tank system with the dynamic stiffness matrix of th rigid surface foundation.

  • PDF

Antitumor and Immunomodulatory Effects of Chungsangbohahwan on Murine Melanoma-induced Lung Metastasis (청상보하환(淸上補下丸)이 흑색종(黑色腫)의 폐전이(肺轉移) 억제(抑制) 및 면역조절작용(免疫調節作用)에 미치는 영향(影響))

  • Ha, Jee-Yong;You, Byeong-Gil
    • THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
    • /
    • v.4 no.1
    • /
    • pp.159-175
    • /
    • 1998
  • In order to investigate the antitumor effect by Chungsangbohahwan after B-16 cells were transplanted in C57BL/6 mice, and the immune responses in mice induced by methotrexate, the extract of Chungsangbohahwan was orally administered to the mice for 21 days. Experimental studies were performed for measurance of metastasis, cell cytotoxicity in vitro, natural killer cell activity, productivity of interleukin-2. The results were summarized as follows: 1. Inhibition of metastasis in Chungsangbohahwan-treated group was higher than control group with significance on 7th day and 14th day. 2. On the MTT assay, cell viability was significantly inhibited by $5{\mu}g/well$, $2.5{\mu}g/well$, $1.25{\mu}g/well$, and $0.625{\mu}g/well$ of Chungsangbohahwan concentration inhibited cell viability significantly(P<0.05). $IC_{50}$ for cell viability was $2.17{\mu}g/well$. 3. Natural killer cell activity in Chungsangbohahwan-treated group was significantly increased on 100:1, 50:1 E/T(effect cell/target cell) ratio(P<0.05). 4. Production of interleukin-2 in Chungsangbohahwan-treated group was significantly increased(P<0.05).

  • PDF

An Investigation on Science Teachers' Evaluation Practices in the Secondary Schools (중등학교 과학교사들의 학습 평가에 관한 실태조사)

  • Kim, Ho-Jin;Kwack, Dae-Oh;Sung, Min-Wung
    • Journal of The Korean Association For Science Education
    • /
    • v.20 no.1
    • /
    • pp.101-111
    • /
    • 2000
  • The present study was carried out to investigate the actual condition of the evaluation of science learning in the secondary school, and to develop the basic data for the improvement of the science learning assessment. Various questions for three evaluative domains were asked to 51 science teachers with the questionnaire during the in-service training course for certificate on summer in 1998. The cognition of the table of specification appeared high as 98% responses to the questionnaire, but the teachers' ability to distinguish behavioral elements was low as 47% responses. The evaluative rate of three domains for knowledge, skill and attitude appeared as 45%, 35% and 20% evaluation in both diagnostic and formative evaluation and 40%, 40% and 20% evaluation in summative evaluation. The evaluation of process skill appeared a tendency depending on laboratory reports as 61%, and was higher rather than in the formative evaluation or summative evaluation. In the evaluation of attitude domain, about a half of teachers answered that they evaluated the domain with laboratory reports as 43%, and some teachers evaluated the domain with teacher's observation as 33%. Also there were a few teachers who did not evaluate the attitude domain as 8%. The rate for the elements of the process skill appeared 86% responses in the interpretation of data, 31% in the observative ability, 18% in the predictive ability, 14% in the classified ability, 12% in the measuring and data-investigating ability, 4% in the discussion ability, and 2% in the investigating ability. We could find out that many teachers had given higher rate in the evaluation of process skill and attitude rather than before the present study, therefore there was more improvement in the evaluation for process skill and attitude domain after the 6th curriculum.

  • PDF

The effect of rhinovirus on airway inflammation in a murine asthma model

  • Kim, Eugene;Lee, Huisu;Kim, Hyun Sook;Won, Sulmui;Lee, Eu Kyoung;Kim, Hwan Soo;Bang, Kyongwon;Chun, Yoon Hong;Yoon, Jong-Seo;Kim, Hyun Hee;Kim, Jin Tack;Lee, Joon Sung
    • Clinical and Experimental Pediatrics
    • /
    • v.56 no.11
    • /
    • pp.482-489
    • /
    • 2013
  • Purpose: The aim of the present study was to investigate the differences in lower airway inflammatory immune responses, including cellular responses and responses in terms of inflammatory mediators in bronchoalveolar lavage fluid (BALF) and the airway, to rhinovirus (RV) infection on asthma exacerbation by comparing a control and a murine asthma model, with or without RV infection. Methods: BALB/c mice were intraperitoneally injected with a crude extract of Dermatophagoides farinae (Df ) or phosphate buffered saline (PBS) and were subsequently intranasally treated with a crude extract of Df or PBS. Airway responsiveness and cell infiltration, differential cell counts in BALF, and cytokine and chemokine concentrations in BALF were measured 24 hours after intranasal RV1B infection. Results: RV infection increased the enhanced pause (Penh) in both the Df sensitized and challenged mice (Df mice) and PBS-treated mice (PBS mice) (P<0.05). Airway eosinophil infiltration increased in Df mice after RV infection (P<0.05). The levels of interleukin (IL) 13, tumor necrosis factor alpha, and regulated on activation, normal T cells expressed and secreted (RANTES) increased in response to RV infection in Df mice, but not in PBS mice (P<0.05). The level of IL-10 significantly decreased following RV infection in Df mice (P<0.05). Conclusion: Our findings suggest that the augmented induction of proinflammatory cytokines, Th2 cytokines, and chemokines that mediate an eosinophil response and the decreased induction of regulatory cytokines after RV infection may be important manifestations leading to airway inflammation with eosinophil infiltration and changes in airway responsiveness in the asthma model.

Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis

  • Kou, Yiming;Wan, Mingming;Shi, Wei;Liu, Jie;Zhao, Zhilei;Xu, Yongqing;Wei, Wei;Sun, Bo;Gao, Feng;Cai, Linjun;Jiang, Chunlai
    • Journal of Microbiology and Biotechnology
    • /
    • v.28 no.6
    • /
    • pp.1022-1029
    • /
    • 2018
  • Tuberculosis (TB) remains a serious health issue around the word. Adenovirus (Ad)-based vaccine and modified vaccinia virus Ankara (MVA)-based vaccine have emerged as two of the most promising immunization candidates over the past few years. However, the performance of the homologous and heterologous prime-boost immunization regimens of these two viral vector-based vaccines remains unclear. In the present study, we constructed recombinant Ad and MVA expressing an Ag85B-TB10.4 fusion protein (AdH4 and MVAH4) and evaluated the impact of their different immunization regimens on the humoral and cellular immune responses. We found that the viral vector-based vaccines could generate significantly higher levels of antigen-specific antibodies, $IFN-{\gamma}$-producing splenocytes, $CD69^+CD8^+$ T cells, and $IFN-{\gamma}$ secretion when compared with bacillus Calmette-$Gu{\acute{e}}rin$ (BCG) in a mouse model. AdH4-containing immunization regimens (AdH4-AdH4, AdH4-MVAH4, and MVAH4-AdH4) induced significantly stronger antibody responses, much more $IFN-{\gamma}$-producing splenocytes and $CD69^+CD8^+$ T cells, and higher levels of $IFN-{\gamma}$ secretion when compared with the MVAH4-MVAH4 immunization regimen. The number of $IFN-{\gamma}$-producing splenocytes sensitive to $CD8^+$ T-cell restricted peptides of Ag85B (9-1p and 9-2p) and Th1-related cytokines ($IFN-{\gamma}$ and $TNF-{\alpha}$) in the AdH4-MVAH4 heterologous prime-boost regimen immunization group was significantly higher than that in the other viral vector-based vaccine- and BCG-immunized groups, respectively. These results indicate that an immunization regimen involving AdH4 may have a higher capacity to induce humoral and cellular immune responses against TB in mice than that by regimens containing BCG or MVAH4 alone, and the AdH4-MVAH4 prime-boost regimen may generate an ideal protective effect.

The Influences of Spiritual Care Nursing Education Towards Death and Dying (영적간호 교육이 간호학생들의 죽음에 대한 태도변화에 미치는 영향)

  • Kim Chung nam;Park Kyung min
    • Journal of Korean Public Health Nursing
    • /
    • v.13 no.1
    • /
    • pp.114-127
    • /
    • 1999
  • In order to care the persons who are dying a nurse should first solve her / his own conflicts about death. and be aware of their own concepts of death and dying. In order to find out patient's spiritual needs and to give better spiritual nursing care. a nurse should know her / his own spiritual needs and be aware of their own concepts of spiritual nursing problems. To improve nurse's understanding towards death and dying and nurse's knowledge towards spiritual needs and spiritual nursing care. 14 weeks(two hours a week) spiritual nursing care education was given to 3th grade baccalaureate nursing college student. Before and after spiritual nursing care education. 30 items of prepared questionare focused on the attitudes toward death and dying was asked. Pre and post results are as follow ; 1. The dying patient's emotional and physical needs. There was no significant difference between pre and post educated groups. Both of the situations. they agreed upon$(69.64\%)$ that the dying patients have high emotional and physical needs to solve. 2. Telling the truth of dying process. There was no significant difference between pre educated group$(53.33\%)$ and post educated group$(55.95\%)$. 3. Attitudes of medical personnels. There was no significant difference between pre$(51.49\%)$ and post educated groups $(53.87\%)$. These responses indicate that nursing college student didn't have enough experiences on dying patients care. 4. General attitudes on death and dying. Number of nursing students who were thinking positively toward death and dying were Increased (pre $39.68\%$. post $45.44\%$) and who were thinking negatively toward death and dying were also decreased (pre $37.30\%$. post $33.93\%$). 5. Attitudes toward mechanical assistance for life-expanding of helpless patient. There was a significant difference between pre and post educated groups. About $34.13\%$ of them approved upon mechanical assistance for life and about $33.14\%$ of them disapproved. 6. Attitudes of family members of dying patient. There was no significant difference between pre and post educated groups. About $45.24\%$ of both groups, agreed upon that the family members feel annoyed with dying patients and about $22.42\%$ of both groups disagreed. Whether they received the spiritual nursing education or not, they were aware of that the family members feel annoyed with dying patients. 7. Special facility and educational preparation for dying patient. There was a significant difference between pre$(82.14\%)$ and post$(90.87\%)$ educated groups. These responses indicated that after they received the education, they felt more about the necessity of special facility and educational preparation for the death and dying patients. 8. Special facility and welfare system for the old. There was a significant difference between pre$(58.33\%)$ and post$70.64\%$ educated groups. There responses indicated that after they received the education, they felt more about the necessity of special facility and welfare systems for the old.

  • PDF