• Restorative Dentistry and Endodontics
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• v.8 no.1
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• pp.123-131
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• 1982

The purpose of this study was to observe the responses of the remaining pulp tissue after pulpotomy upon the several kinds of $Ca(OH)_2$ products and the responses of periapical tissue upon some root canal filling materials after extirpation. For pulpotomy, the class V cavities were prepared on the premolars, molars and upper canines, and the pulp was amputated. Each drug was placed over the amputated tissue and cavity was sealed with zinc oxide eugenol cement. The drugs which were used for the study were Dycal (Caulk Co. U.S.A.), Cavitec (Kerr Co. U.S.A.), Calvital, Nobudyne and Neodyne (Neo Dental Chemical Products). For extirpation, the endodontic cavities were prepared on the lingual surfaces of anterior teeth, and the pulp tissues were extirpated as routine method. After enlarging, irrigation, and measuring of root length by taking X-ray, each root canal filling material was filled in the canal with gutta percha cone, and endodontic cavity was sealed with zinc oxide eugenol cement. Zinc oxide eugenol, $Ca(OH)_2$ (Eli Lilly Co. U.S.A.) and Vitapex (Neo Dental Chemical Products) were used as root canal filling materials. Animals were sacrificed after 1, 3 and 6 weeks following the operation. The teeth were decalcified in formic acid, sectioned and stained with hematoxylin eosin. Microscopic examination revealed as follows. 1. Dycal: The dentin bridge formation was observed at the 3rd week after pulpotomy. Inflammatory conditions which were infiltration of inflammatory cells and dilatation of blood vessels were kept in remaining pulp tissue at the 6th week. 2. Calvital: The dentin bridge was observed at the 1st week after pulpotomy. As the time clasped, the pulp tended to be the fibrous degeneration. 3. Cavitec, Nobudyne and Neodyne: In the case of Cavitec and Nobudyne, the incompleted and irregular dentin bridge was observed at the 6th week, and in Neodyne, was observed at the 3rd week. The severe inflammatory changes were seen in the remaining pulp tissue. As the time clasped, the fibrous degeneration tended to spread in the remaining pulp tissue. 4. $Ca(OH)_2$: Osteocementum was formed at the 3rd week, the matrix of cementum and dentin were resorted, and infiltration of lymphocytes was seen in periapical tissue when $Ca(OH)_2$ was used as canal-filling materials. S. ZOE and Vitapex The cementum like substance was seen in periapical portion at the 1st week, when ZOE and Vitapex were used as root canal filling materials. As the time elapsed, the matrix of cementum and dentin tended to be resorted. At the 6th week, the inflammatory condition of periapical tissue was continued in the case of ZOE, but was reduced in the case of Vitapex.

• Journal of the Health Care and Life Science
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• v.11 no.2
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• pp.417-424
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• 2023

This study aimed to analyze the association between hyperuricemia and hs-CRP in adults with hypercholesterolemia and abdominal obesity, utilizing data from the 7th Korea National Health and Nutrition Examination Survey. The subjects were classified into fourgroups based on hypercholesterolemia and abdominal obesity, and binary logistic regression analysis was conducted. The association between hyperuricemia and hs-CRP wasevident in the abdominal obesity group, with an OR 2.22 (95% CI 2.070-2.395). In thegroup with both conditions, the OR was 2.31 (95% CI 2.032-2.626). Stratified by gender, both conditions showed a higher OR in males 2.29 (95% CI 1.911-2.748), while in females, the abdominal obesity group exhibited a higher OR of 2.44 (95% CI 2.146-2.775), indicating a gender-specific difference. In conclusion, hyperuricemia and hs-CRP in adults with hypercholesterolemia and abdominal obesity demonstrated a significant association, suggesting their role as predictive factors for inflammatory responses.

• Journal of Microbiology and Biotechnology
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• v.18 no.3
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• pp.591-599
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• 2008

A murine model immunized by systemic and mucosal delivery of plasmid DNA vaccine expressing glycoprotein B (pCIgB) of pseudorabies virus (PrV) was used to evaluate both the nature of the induced immunity and protection against a virulent virus. With regard to systemic delivery, the intramuscular (i.m.) immunization with pCIgB induced strong PrV-specific IgG responses in serum but was inefficient in generating a mucosal IgA response. Mucosal delivery through intranasal (i.n.) immunization of pCIgB induced both systemic and mucosal immunity at the distal mucosal site. However, the levels of systemic immunity induced by i.n. immunization were less than those induced by i.m. immunization. Moreover, i.n. genetic transfer of pCIgB appeared to induce Th2-biased immunity compared with systemic delivery, as judged by the ratio of PrV-specific IgG isotypes and Th1- and Th2-type cytokines produced by stimulated T cells. Moreover, the immunity induced by i.n. immunization did not provide effective protection against i.n. challenge of a virulent PrV strain, whereas i.m. immunization produced resistance to viral infection. Therefore, although i.n. immunization was a useful route for inducing mucosal immunity at the virus entry site, i.n. immunization did not provide effective protection against the lethal infection of PrV.

• Parasites, Hosts and Diseases
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• v.49 no.4
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• pp.373-380
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• 2011

We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an allergen. In order to determine the contribution of As22U to allergic reactions, we treated mice with 6 times intra-nasal application of recombinant As22U (rAs22U). In the group challenged with rAs22U and ovalbumin (OVA), the number of eosinophils in the bronchial alveolar lavage fluid (BALF) was significantly increased, as compared to the group receiving only OVA. In addition, mice treated with rAs22U and OVA showed significantly increased airway hyperresponsiveness. Thus, severe inflammation around the airway and immune cell recruitment was observed in mice treated with rAs22U plus OVA. The levels of IL-4, IL-5, and IL-13 cytokines in the BALF increased significantly after treatment with rAs22U and OVA. Similarly, the levels of anti-OVA specific lgE and lgG1 increased in mice treated with rAs22U and OVA, compared to those treated only with OVA. The Gro-${\alpha}$ (CXCL1) gene expression in mouse lung epithelial cells increased instantly after treatment with rAs22U, and allergy-specific chemokines eotaxin (CCL11) and thymus-and-activation-regulated-chemokine (CCL17) gene expressions significantly increased at 6 hr after treatment. In conclusion, rAs22U may induce airway allergic inflammation, as the result of enhanced Th2 and Th17 responses.

• Journal of the Korea Society of Computer and Information
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• v.25 no.11
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• pp.245-253
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• 2020

This study is a longitudinal analysis of the life satisfaction of Generation X and Generation Y, with different historical backgrounds, growth backgrounds, values, and lifestyles, using data from the Korean Welfare Panel(KOWEPS). The research data is from the KOWEPS 1st year(2006) to 14th year(2019), out of 27,301 people, who conducted life satisfaction from the latest 12th to 14th year, and the responses were properly answered data from 3 years of 2,492 were used. As a result of the study, the higher the life satisfaction of both Generation X and Generation Y, the more the life satisfaction slowly increases at a slower rate as time passes. In addition, in terms of life satisfaction and rate of change, the initial value of life satisfaction was higher as the living satisfaction increased in both Generation X and Generation Y, but in the case of Generation X, the higher living satisfaction, the lower the rate of change in life satisfaction for 3 years by .327, in the case of Generation Y, the rate of change in life satisfaction was not affected. Finally, in the model of this study, a partial mediation of health condition was established between living satisfaction and life satisfaction tendency. Living satisfaction was analyzed to have a direct effect on life satisfaction and at the same time indirectly with a health condition as a parameter.

• Journal of Veterinary Clinics
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• v.26 no.5
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• pp.433-440
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• 2009

High levels of inflammatory cytokines were proposed contributors to the pathogenesis of a various inflammatory skin disorders. Therefore, investigating the immune response of the inflammatory skin disorder allows a better understanding of pathogenesis of a various inflammatory skin disorders and therapeutic approaches. The aim of this study was to analyze of the immune response in dogs with chronic inflammatory skin disease. To this aim, the present study evaluated relative mRNA expression of canine $IFN-{\gamma}$, IL-4, $TGF-{\beta}$ and IL-10 using TaqMan realtime PCR assays and semi-quantitative RT-PCR in freshly isolated peripheral blood mononuclear cells from twenty dogs with chronic inflammatory skin disease and ten normal dogs. The relative mRNA expression levels of IL-4 mRNA were significantly higher in dogs with chronic inflammatory skin disease than those in normal dogs (P < 0.01). The results of present study also showed a tendency towards increased expression of IL-10 transcripts in dogs with chronic inflammatory skin disease. However, there were no significant differences in the levels $IFN-{\gamma},\;TGF-{\beta}$ between normal and chronically inflammed dogs. In addition, the concentration of serum IgE was significantly increased in dogs with chronic inflammatory skin disease compared with those in normal dogs (P < 0.01). In histopathological examination, we found that there were markedly increased mast cell counts in chronically inflammed dogs (P < 0.05). These results suggest that the pathogenesis of chronic inflammatory skin disease might be associated with a T-cell mediated inflammatory responses characterized by a Th2-skewed immune response. Based on these results, the modulation of Th1/Th2 balance may be an effective therapeutic strategy for the treatment of chronic inflammatory skin disease.

• Journal of Environmental Health Sciences
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• v.49 no.6
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• pp.372-379
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• 2023

Background: Laundry workers are known to be exposed to organic solvents in various works including dry cleaning. Long-term exposure to organic solvents may cause adverse health effects among laundry workers. Objectives: To investigate the association between exposure to organic solvents and symptom of headache or eyestrain among laundry workers. Methods: The subjects were total 267 laundry workers who participated in the 6th Korean Working Conditions Survey (KWCS). Responses to exposure to 'inhalation of vapor from organic solvent' was categorized into two (non-exposed: rarely or absolutely not exposed during working hours; exposed: ≥1/4 working hours) or three (non-exposed; low exposure: 1/4 of the working hours; high exposure: ≥1/2 working hours) groups. Logistic regression analysis was performed to evaluate the association between exposure to organic solvents and symptom of headache or eyestrain in the last 12 months among laundry workers. Odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated for experience of the symptom of headache or eyestrain with adjustment for age, sex, education, workplace size (by the number of workers), working hours per week, and current working period (year). Results: The proportions of exposure groups, i.e., non-exposed, low exposure, and high exposure, were 80.4%, 11.1%, and 8.5%, respectively. The proportion of those who had symptom of headache or eyestrain in the last 12 months was 18.7%. There was a significant association between exposure to organic solvents and experience of headache or eyestrain (OR=3.2, 95% CI=1.4~7.4). And, the proportion of those who experienced symptom of headache or eyestrain tended to increase significantly as the level of exposure to organic solvents increased (P_trend=0.002). Conclusions: Our results suggest that exposure to organic solvents are associated with symptom of headache or eystrain among laundry workers in Korea. However, further studies with more relevant design is needed to replicate the association.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.10 no.2
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• pp.223-233
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• 2003

Purpose: The purpose of study was to identify the death orientation and cognition, attitude and nursing needs in hospice care according to training of volunteers. Method: Data were collected using a structured questionnaire which included characteristics, death orientation and cognition, attitude and nursing needs in hospice care. Data collection was done between June 1st and 20th, 2003. The participants in the study were the 86 trained hospice volunteers and 76 non-trained hospice volunteers. The data were analyzed using the SPSS/PC+ program. Result: The results are as follows: There was a significant difference in the average for the death orientation scores between non-trained hospice volunteers and trained hospice volunteers. There was a significant difference for the cognition of hospice and attitude, with higher responses being given by the hospice trained group. For the domains of nursing needs in hospice care, the highest response was to emotional needs. Conclusion: This study showed that training in hospice care was effective in changing the death orientation, cognition, attitude and nursing needs in hospice care.

• Journal of The Korean Association For Science Education
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• v.33 no.3
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• pp.650-663
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• 2013

Multidimensional scaling can be used to identify relationships among concepts, revealing the structure of the cognitive framework by measuring distances within perceptual maps. The current study sought to examine the relationships among concepts related to photosynthesis in 2,844 $3^{rd}-11^{th}$ grade science students. The questionnaire included items on 'location,' 'products,' 'reactants,' and 'environmental factors', presenting images related to each theme. Students provided responses corresponding to particular topics, and reported the extent to which the concept was related to the topic on a scale from 1 to 30. The survey results were as follows: first, students were not able to clearly distinguish between or understand the four main topics. Second, students organized their cognitive structures by closely associating related concepts after learning. Third, the presented concepts revealed a mixture of scientific and non-scientific concepts, suggesting that students needed to clearly distinguish the preconceptions through which they organized concepts, so that they are suitable for cognitive structures based on learning. Furthermore, non-scientific concepts within perceptions were consistently maintained throughout learning, affecting the proximity of scientific concepts.

• Journal of Korean Home Economics Education Association
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• v.9 no.1
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• pp.71-82
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• 1997

The aims of this research study is to clear the differences of the learning effects and the cognition of Home Economics by sex in the middle school and to collect the future-oriented educational dates, after implementing the 6th education curriculum. The results of the study are as follows ； 1. Most of students had the cognition that Home Economics is a subject matter of a needful knowledge and skill for the family life, half students a cultural subject matter for the modern life. The former was supported by female students, the latter by male students. 2. Most of students were interested in actual training fields of cooking and hand-sewing, had a strong interest about a field of physical and social-psychological growth. The differences by sex interest about significant in these fields. 3. Most of students had positive responses in the learning effects of Home Economics. The most useful field was cooking and the worst was the structure and method of sewing machine. 4. The shortage and the dissatisfaction in the learning of Home Economics were lacking of the actual training hours, the old-fashioned teaching methods and the shortage of teaching materials etc.