• Bulletin of the Korean Chemical Society
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• 제32권1호
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• pp.201-207
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• 2011

Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptors and their activation induces regulation of fatty acid storage and glucose metabolism. Therefore, the $PPAR\gamma$ is a major target for the treatment of type 2 diabetes mellitus. In order to generate pharmacophore model, 1080 known agonists database was constructed and a training set was selected. The Hypo7, selected from 10 hypotheses, contains four features: three hydrogen-bond acceptors (HBA) and one general hydrophobic (HY). This pharmacophore model was validated by using 862 test set compounds with a correlation coefficient of 0.903 between actual and estimated activity. Secondly, CatScramble method was used to verify the model. Hence, the validated Hypo7 was utilized for searching new lead compounds over 238,819 and 54,620 chemical structures in NCI and Maybridge database, respectively. Then the leads were selected by screening based on the pharmacophore model, predictive activity, and Lipinski's rules. Candidates were obtained and subsequently the binding affinities to $PPAR\gamma$ were investigated by the molecular docking simulations. Finally the best two compounds were presented and would be useful to treat type 2 diabetes.

• 한국기계가공학회지
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• 제12권3호
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• pp.7-12
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• 2013

In Die casting process, the problem of die degradation is often issued. In oder to increase of die life the material degradation of die steel was investigated using test core pins. Three test core pins were positioned in front of the gate entry and observed washout and soldering resistance during Mg die casting process. The test parameters are set as different commercial die materials, coatings condition and hardness of die surface. Usign 220t magnesium die casting machine was employed to cast AZ91 magnesium alloys. After 150 shots, macroscopic observation of die surface was carried out. Additional 50 cycles later, test pins were chemically cleaned with 5% HCl aqueous solution to find out the existence of washout and soldering layers. Microstructural characterization of die surface and the die roughness measurement were performed together. Computational simulation using AnyCasting program was also beneficial to correlate the extent of die damage with the position of test pin inside die cavity. As results, the optimal combination of die steel with productive coating as well as its hardness was drawn out. it will be helpful to decide the material and condition considering increasing of tool life.

• 대한의용생체공학회:의공학회지
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• 제30권2호
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• pp.169-178
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• 2009

In this study, we suggest Korean nonlinear fitting formula (KNFF) to maximize speech intelligibility for digital hearing aids based on NAL-NL1 (NAL-nonlinear, version 1). KNFF was derived from the same procedure which is used for deriving NAL-NL1. KNFF consider the long-term average speech spectrum of Korean instead of English because the frequency characteristic of Korean is different from that of English. New insertion gains of KNFF were derived using the SII (speech intelligibility index) program provided by ANSI. In addition, the insertion gains were modified to maximize the intelligibility of high frequency words. To verify effect of the new fitting gain, we performed speech discrimination test (SDT) and preference test using the hearing loss simulator from NOISH. In the SDT, a word set as test material consists of 50 1-syllable word generally used in hearing clinic. As a result of the test, in case of moderate hearing loss with severe loss on high frequency, the SDT scores of KNFF was more improved about 3.2% than NAL-NLl and about 6% in case of the sever hearing loss. Finally we have obtained the result that it was the effective way to increase gain of mid-high frequency bands and to decrease gain of low frequency bands in order to maximize speech intelligibility of Korean.

• Nuclear Engineering and Technology
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• 제44권7호
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• pp.781-790
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• 2012

The HyperGam program was developed for the analysis of complex HPGe ${\gamma}$-ray spectra. The previous version of HyperGam was mainly limited to the analysis of ${\gamma}$-ray peaks and the manual logging of the result. In this study, it is specifically developed into a tool for the isotopic analysis of spectra. The newly developed features include nuclide identification and activity determination. An algorithm for nuclide identification was developed to identify the peaks in the spectrum by considering the yield, efficiency, energy and peak area for the ${\gamma}$-ray lines emitted from the radionuclide. The detailed performance of nuclide identification and activity determination was accessed using the IAEA 2002 set of test spectra. By analyzing the test spectra, the numbers of radionuclides identified truly (true hit), falsely (false hit) or missed (misses) were counted and compared with the results from the IAEA 2002 tests. The determined activities of the radionuclides were also compared for four test spectra of several samples. The result of the performance test is promising in comparison with those of the well-known software packages for ${\gamma}$-ray spectrum analysis.

• 한국산학기술학회논문지
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• 제13권6호
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• pp.2472-2478
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• 2012

본 연구는 반도체 산업에서 반도체장비 유지보수에 사용되어지는 반도체장비 유지보수 분야의 전문기술인력을 효과적으로 양성할 수 있는 반도체장비 유지보수의 자격종목을 개발하고자 하는데 그 목적이 있다. 연구의 목적을 달성하기 위하여 반도체장비 유지보수 분야의 국내외 실태 조사, 문헌조사를 통하여 반도체장비 유지보수 관련 교육훈련기관 및 검정 수요 예상 인력을 파악했으며, 유사자격제도(전자부품장착기능사, 전자부품장착산업기사, 생산자동화기능사, 생산자동화산업기사)를 분석하였고, 직무분석을 통하여 반도체장비유지보수기능사의 직무 및 교육내용을 분석하였다. 또한 반도체장비 유지보수 자격종목 신설에 대한 설문조사를 실시했으며, 반도체장비유지보수기능사 자격종목의 출제기준 및 채점 방법을 제시했고, 필기시험과 실기시험에 대한 모의 검정시험도 실시하였다. 이러한 결과를 토대로 반도체장비유지보수기능사에 대한 교육프로그램을 만들었으며, 자격검정을 실시할 수 있는 출제기준을 제시하였다.

• Structural Engineering and Mechanics
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• 제66권2호
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• pp.203-215
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• 2018

A large body of experiments have been conducted to date to evaluate the punching shear strength of flat slab-column connections, but it is noted that only a few of them have been considered for the development of the ACI Code provisions. The limited test results used for the development of the code provisions fall short of predicting accurately the punching shear strength of such connections. In an effort to address this shortfall and to gain an insight into the factors that control the punching shear strength of flat slab-column connections, we report a qualified database of 650 punching shear test results in this article. All slabs examined in this database were tested under gravity loading and do not contain shear reinforcement. In order to justify including any test result for evaluation punching shear database, we have developed an approved set of criteria. Carefully established set of criteria represent the actual characteristics of structures that include minimum compressive strength, effective depths of slab, flexural and compression reinforcement ratio and column size. The key parameters that significantly affect the punching shear strength of flat slab-column connections are then examined using ACI 318-14 expression. The results reported here have paramount significance on the range of applicability of the ACI Code provision and seem to indicate that the ACI provisions do not sufficiently capture many trends identified through regression of the principal parameters, and fall on the unsafe side for the prediction of the punching shear strength of flat slab-column connections.

• 한국응급구조학회지
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• 제13권2호
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• pp.87-98
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• 2009

Purpose : This study set out to compare the educational effects of a video self-instruction program for child CPR education on childcare teachers by applying the 2006 KACPR Guideline. By adopting the nonequivalent control group posttest quasi-experimental design, the study examined the educational effects on a group that did not receive instructions from the instructor, another group that received his instructions, and the other group that received an extra three-minute practice training session in addition to instructions. Methods : Data were gathered from August 6 to 18, 2008. As for research tools, the Knowledge Instrument of CPR by Connolly (2006) was used along with the National Practice Test Protocol for C1ass 1 Emergency Medical Technicians (2007) and Common Protocol for CPR (2006) to examine the performance of child CPR. By shooting the guide screen of $Resusci^{(R)}$ Junior CPR Manikin of Leardal with a video camera and using the Skill Guide Checklist of the Common Protocol for CPR (2006), the subjects' technical accuracy of chi1d CPR was evaluated. There were three subject groups: 29 childcare teachers randomly assigned to received the video self-instruction program training for chi1d CPR and no instructions from the instructor made up the control group; 22 childcare teachers randomly assigned to received the program training and instructions from the instructor made up experiment group I; 23 childcare teachers randomly assigned to received an extra three-minute practice training session in addition to the program training and the instructions made up experiment group II. The gathered data were analyzed with SPSS/PC+ (Version 14.0) in frequency, percentage, $X^2$-test, ANOVA, Scheffe test. Results : 1) There were no statistically significant differences (F=1.030, p=.362) among the groups in terms of knowledge scores after the child CPR education. 2) There were statistically significant differences (F=13.625, p=.000) among the groups in terms of performance abilities after the child CPR education. 3) There were no statistically significant differences (F=1.610, p=.207) among the groups in terms of technical accuracy of mouth-to-mouth resuscitation after the child CPR education 4) There were no statistically significant differences (F=1.484, p=.234) among the groups in terms of technical accuracy of chest compression after the child CPR education. Conclusion : The results indicate that childcare teachers can improve their performance abilities in child CPR when the instructors are active with their instructions and extra practice hours are secured through a VSI program. It's also needed to provide education with increasing concentration ratio about the items of lower knowledge points in order to help the teachers learn the accurate theory of child CPR. And there should be VSI programs of diverse conditions to increase the effects of child CPR training among childcare teachers.

• 대한지역사회영양학회지
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• 제23권2호
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• pp.148-161
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• 2018

Objectives: This study examined the effects of nutrition education and exercise therapies on the hematological status and diabetes knowledge of diabetic patients. For this purpose, a 12-week intensive management program was provided to diabetic patients participating in an exercise program in S health subcenter in Kwangju city and the effects were analyzed. Methods: The subjects were 26 diabetic patients, who provided written informed consent. As a preliminary survey, this study examined the general characteristics, physical status, obesity, blood pressure, hematological status, daily activity level, diabetes knowledge, diet performance, and barriers to diet therapy. After the 12-week intensive management program was completed, a post-test was conducted in the same way as the preliminary test. The data were analyzed with using SPSS 18.0. The data from this study are presented as the mean${\pm}$standard deviation. A paired t-test was conducted to compare differences in the means before and after the program. Statistical significance was set to p<0.05. Results: The results of the program are presented as follows. The HDL-cholesterol levels changed from $39.8{\pm}10.5mg/dL$ to $48.3{\pm}13.1mg/dL$, showing a significant increase (p<0.001). The blood sugar 2 hours after a meal changed from $175.2{\pm}67.1mg/dL$ to $140.5{\pm}42.5mg/dL$, showing a significant decrease (p=0.014). The glycosylated hemoglobin levels decreased significantly from $6.7{\pm}1.1%$ to $6.3{\pm}1.0%$ (p=0.010). The total scores of the daily activity levels increased significantly from $3.8{\pm}2.4$ to $4.8{\pm}2.5$ (p=0.040). The scores of knowledge on diabetes increased from $11.5{\pm}3.6$ to $14.0{\pm}3.8$ (p=0.001). The scores of knowledge on diet therapy changed from $6.7{\pm}2.2$ to $7.9{\pm}1.7$, showing a significant increase (p=0.027). Conclusions: The 12-week intensive management program intervened by nutrition education and exercise therapies induced positive changes to the HDL-cholesterol, blood sugar 2 hours after a meal, glycosylated hemoglobin, daily activity levels, and knowledge on diabetes.

• 한국가정과교육학회지
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• 제32권4호
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• pp.103-124
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• 2020

본 연구의 목적은 문제중심학습법을 적용한 가정과 융합교육프로그램을 중학교 식생활 단원을 중심으로 개발하고 실행하여 이 수업이 중학생들의 문제해결력에 미치는 효과를 검증하는 데 있다. 이를 위해 타교과와의 연계성을 살펴 '지속가능한 삶'을 주제로 설정하여 핵심질문을 '식품자원의 환경과의 관계, 개인차원의 영향, 해결방법은 무엇인가?로 설정하고 문제와 8차시의 수업을 개발하였다. 문제중심학습법을 적용한 가정과 융합교육프로그램을 실시한 결과, 평균점수가 3.54, 사후 평균점수가 3.96으로 통계적으로 문제해결능력(p<.001)에 유의미한 차이를 보였다. 문제해결능력의 능력요소인 원인분석, 대안개발, 계획/실행, 수행평가에서 유의미한 차이가 있었으나, 문제명료화에서 유의미한 차이가 없었다. 따라서 문제중심학습법을 적용한 가정과 융합교육프로그램은 문제해결능력에 효과적인 수업이라는 것을 확인하였다.

• PNF and Movement
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• 제15권1호
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• pp.35-40
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• 2017

Purpose: The purpose of this study was to determine the immediate effects of using the proprioceptive neuromuscular facilitation (PNF) contract-relax technique in the close kinetic chain position on the gait ability and gastrocnemius muscle tone of stroke patients. Methods: The subjects were patients who had strokes due to cerebrum infarction and hemorrhage. The subjects participated in exercise with the PNF contract-relax technique in the standing-on-elbow position with a high table, and the affected lower leg was placed in the posterior position. The PNF contract-relax technique was applied at the position in which the ankle plantar-flexors were in a sufficiently elongated position. After performing twice in each range, while the muscle was elongated, the affected side was moved further back and a new range was set. In each session, the time of contraction was set to 8 seconds, and the resting time was set to 5 seconds; however, if the patient felt tired, they received more resting time during the intervention. The Myoton Pro and 10 m walking test were used to measure the muscle tone and gait ability both pre- and post-intervention. Results: After participating in the program, the muscle tone decreased and the gait ability improved in the ankle plantar-flexors, as determined by the Myoton Pro and 10 m walking test. Conclusion: The PNF contract-relax technique can help to decrease muscle tone in ankle plantar-flexors with hypertonus and increase the gait ability in stroke patients.