• Proceedings of the Korean Society of Toxicology Conference
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• 2006.11a
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• pp.32-33
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• 2006

There is compelling evidence that chronic inflammation predisposes to biliary tract cancer. Previously we found that aspirin use and variants in the PTGS2 gene, both of which are closely linked to inflammation, were associated with biliary tract cancer risk in a population-based study in China. To test the inflammation hypothesis further, we examined the associations of variants in 20 genes involved in the inflammation pathway with risk of biliary tract cancer and stones in a large population-based case-control study in Shanghai, China. We genotyped 56 single nucleotide polymorphisms (SNPs)from 20 inflammation genes in 411 biliary tract cancer cases (237 gallbladder cancers, 127 extrahepatic bile duct cancers, and 47 ampullary cancers), 895 subjects with biliary stones, and 786 population controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cls) for the association of individual SNPs and haplotypes with biliary stones and biliary tract cancer risk. Of the 56 SNPs examined, 20 showed some associations with biliary cancer and stones. Specifically, variants of the IL8, IL8RB, RNASEL, TGF-beta, and TNF-alpha genes were associated with gallstone risk, while variants in the IL1A, IL10, VEGF, and RNASEL genes were associated with gallbladder cancer risk. Adjustment for multiple comparisons did not materially change these results. Of the 10 genes with multiple SNPs, we inferred halotypes; only one haplotype in the IL8RBgene was associated with gallstones. The haplotype frequency was significantly different between bile dict cancer cases and control (p=0.007). A haplotype comprising 3 SNPs in the IL8RB gene (rs2230054, rs1126579, rs1126580) was associated with a 54% increased risk of bile duct stones (95% CI 1.14-2.07, p=0.02), relative to the most frequent haplotype. In summary, common variants in immune-related genes influencing inflammatory responeses were associated with gallstones and biliary tract cancer, lending further support to the role of inflammation in the pathogenesis of biliary stones and biliary tract cancer. Future larger studies with more complete gene coverage are needed to confirm these results.

• Journal of Korean Neurosurgical Society
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• v.49 no.3
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• pp.147-152
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• 2011

Objective : The aim of this study was to evaluate the reliability and validity of the Pediatric Functional Assessment of Cancer Therapy Questionnaire Brain Tumor Survivor (version 2.0) Aged 13 years and older (Parent Form) (pedsFACT-BrS parent of adolescent). Methods : The pedsFACT-BrS parent of adolescent was translated and cross-culturally adapted into Korean, following standard Functional Assessment of Chronic Illness Therapy (FACIT) methodology. The psychometric properties of the pedsFACT-BrS parent of adolescent were evaluated in 170 brain tumor patient's mothers (mean age=43.38 years). Pretesting was performed in 30 mothers, and the results indicated good symptom coverage and overall comprehensibility. The participants also completed the Child Health Questionnaire Parent Form 50 (CHQ-PF-50), Neuroticism in Eysenck Personality Questionnaire, and Karnofsky score. Results : In validating the pedsFACT-BrS parent of adolescent, we found high internal consistency, with Cronbach's ${\alpha}$ coefficients ranging from 0.76 to 0.94. The assessment of test-retest reliability using intraclass correlation coefficient revealed satisfactory values with ICCs ranging from 0.84 to 0.93. The pedsFACT-BrS for parent of adolescent also demonstrated good convergent and divergent validities when correlated with the Child Health Questionnaire Parent Form 50 (CHQ-PF-50) and the Neuroticism in Eysenck Personality Questionnaire. The pedsFACT-BrS parent of adolescent showed good clinical validity, and effectively differentiated between clinically distinct patient groups according to the type of treatment, tumor location, shunt, and Karnofsky score of parent proxy report. Conclusion : We confirmed that this reliable and valid instrument can be used to properly evaluate the quality of life of Korean adolescent brain tumor patients by their parents' proxy report.

• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.1
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• pp.76-86
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• 2012

The purpose of this study is to investigate the environmental equity of the accessibility to public transportation services in the city of Daegu. The 2005 census data as well as bus stop and subway station datasets were integrated for building the GIS database. Public transportation service areas were then identified by a coverage method. Mann Whitney U test was used for statistically comparing the socioeconomic characteristics over different levels of access to the public transportation services. Both Dong-gu, Suseong-gu, Dalseo-gu, and Buk-gu located outside of the city had worse accessibility than others while Jung-gu, Seo-gu, and Nam-gu had better accessibility than others. There appeared no environmental inequity pattern in terms of the percentages of men, women, and teenagers over the city of Daegu whereas there existed some environmental inequity pattern in terms of the percentages of people above the age of 65 and people below poverty line. This environmental inequity pattern would be caused by some factors. Firstly, the lower income class has tended to reside in the declined or blighted areas far away from public transportation facilities since this class can not afford to pay expensive rents and land prices around the main roads with higher accessibility. Many old people belonging to the lower income class also reside in the declined or blighted areas. Secondly, there has been no law to locate bus stops and subway stations considering residents' socioeconomic characteristics and the spatial distribution of public transportation facilities has been not managed systematically by the city government. This research would shed insight on building the public transportation policy to locate bus stops and subway stations and to select the routes of buses and subways considering the spatial distribution of residents' socioeconomic characteristics.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.7 no.4
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• pp.98-109
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• 2004

This study was conducted to develop revegetation methods for the restoration of the steep slopes by recycling of bark compost and mushroom media. In general, bark compost and mushroom media can be used as soil media for the restoration works, because they can increase infiltration of rainfall and give enough porous to breathe and elongate for the root growth as well as environmental value. This experiment was carried out to know the effect of soil media composed by different ratio of mushroom media for the restoration of steep rock-exposed slopes, and to certificate how soil media(PEC) will be effective to germinate and grow for native plants. The main results of the study are summarized as follows; 1. In percent coverage, the soil media PEC1 is more valuable than PEC2. The seed mixtures recommended by Government of Transportation and Construction can be used at PEC1 and PEC2, but it will be more useful if the total amount of seed are reduced and seed mixtures are altered in a direction of native plants. 2. The soil media is under 20 mm tested by Yamanaka Hardiness Tester which is available for the seed germination and growth. 3. The surface cracks are not occurred in PEC1 and PEC2, but more than 30 cracks per 1 square meter are occurred at soil media which is constructed by normal soil-seed-fertilizer hydro-seeding methods. 4. The soil moisture contents are over 20 percent level during 15 day. Such moisture content in soil media will be effective for the plant growth. By using Terra-Control, PEC can maintain enough soil moisture. 5. The eroded soils from $60^{\circ}$ slopes by artificial rainfall with the intensity of 20 mm/hr in one day after seeding are estimated under 1%. By the results of erosion test, it comes to the conclusion that soil media of PEC can be adapted at steep rock exposed slopes.

• Journal of KIISE:Databases
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• v.36 no.1
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• pp.8-21
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• 2009

A wireless sensor network is a computer network which consists of spatially distributed devices, called sensor nodes. In wireless sensor networks, energy efficiency is a key issue since sensor nodes must resides upon limited energy. To retrieve sensor information without dealing with the network issues, a sensor network is treated as conceptual database on which query can be requested. When multiple queries are requested for processing in a wireless sensor network, energy consumption can be significantly reduced if common partial results among similar queries can be effectively shared. In this paper, we propose an energy efficient multi-query processing technique based on the coverage relationship between multiple queries. When a new query is requested, our proposed technique derives an equivalent query from queries running at the moment, if it is derivable. Our technique first computes the set of running queries that may derive a partial result of the new query and then test if this set covers all the result of the new query attribute-wise and tuple-wise. If the result of the new query can be derived from the results of executing queries, the new query derives its result at the base station instead of being executed in the sensor network.

• The KIPS Transactions:PartA
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• v.13A no.4 s.101
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• pp.335-342
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• 2006

As PRC linear interpolation algorithm is applied after analysed and verified in this paper, the unknown location of a user can be identified by using PRC information of multi-DGPS reference station. The PRC information of each GPS satellite is not varying rapidly, which makes it possible to assume that PRC information of each GPS satellite varies linearly. So, the PRC regeneration algorithm with linear interpolation can be applied to improve the accuracy of finding a user's location by using the various PRC information obtained from multi-DGPS reference station. The desirable PRC is made by the linear combination with the known position of multi-DGPS reference station and PRC values of a satellite using signals from multi-DGPS reference station. The RTK-GPS result was used as the reference. To test the performance of the linearly interpolated PRC regeneration algorithm, multi-channel DGPS beacon receiver was built to get a user's position more exactly by using PRC data of maritime DGPS reference station in RTCM format. At the end of this paper, the result of the quantitative analysis of the developed navigation algorithm performance is presented.

• Pediatric Infection and Vaccine
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• v.25 no.1
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• pp.26-34
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• 2018

Purpose: This study aimed to investigate the changes in the occurrence of rotavirus gastroenteritis (RGE) after the introduction of rotavirus vaccine and estimate rotavirus vaccine effectiveness in hospitalized children. Methods: We compared the retrospective data of 671 patients with acute gastroenteritis (AGE) admitted to the Department of Pediatrics, Hanyang University Seoul Hospital from January 1, 2014, to December 31, 2015, with retrospective data of 1,243 patients admitted to the same institution with AGE from January 1, 2004, to December 31, 2005. The vaccine effectiveness was estimated using a case-positive control test-negative study. Results: The proportion of RGE in AGE was significantly lower in 2014 to 2015 (9.0%, 48/531) than in 2004 to 2005 (22.7%, 282/1,243) (P<0.001). In particular, there was a significant decrease in the 6- to 11-, 12- to 23-, and 24- to 35-month-old groups (P<0.001), whose rotavirus vaccination rates were higher than the remaining age groups. The monthly distribution of patients with RGE in 2004 to 2005 was higher from November to May, peaked in January, followed by December and February. In 2014 to 2015, the monthly distribution of patients with RGE slightly peaked in January. In 2014 to 2015 study, the complete rotavirus vaccination rate was 66.0% (332/503) and incomplete vaccination rate was 6.2% (31/503). Presumed rotavirus vaccine effectiveness was 83.3% (95% confidence interval [CI], 60.5% to 92.9%) in the complete vaccination group and 27.4% (95% CI, -163.7% to 80.0%) in the incomplete group. Conclusions: The proportion of RGE in AGE has markedly decreased since the introduction of rotavirus vaccines, and improving vaccination coverage will further reduce the burden of RGE in Korea.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.582-590
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• 2016

The purpose of this study is to investigate the relationship between suicidal attitude and suicidal ideation of college students and also to provide the fundamental data in order to strengthen both the standard and the recommendation of media coverage in Korea. A total of 249 college students over the age of 18 years in B city and G do were enrolled for this study. The data were collected between June 9 and July 7 of 2014 and analyzed by using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and multiple regression with SPSS 21.0. The mean score of a message of suicidal motivation reports 2 was $51.06{\pm}10.55$, which was the highest. The score of suicidal ideation was $10.41{\pm}12.88$. There were sign&ificant differences in suicidal thought with respect to school system, family income, pocket money, time of physical activity, smoking, and smart-phone usage in university students. It was shown that suicidal thoughts were significantly correlated with message of simple suicidal reports 1(r=.303, p<.001), message of suicidal motivation reports 2(r=.251, p<.001), and message of suicidal mourning man reports 3(r=.225, p<.001). As the suicidal attitude have a close association with reports of suicide, it is necessary that studies on a variety of factors influencing suicidal thoughts of students be repeated.

• Journal of Advanced Navigation Technology
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• v.25 no.5
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• pp.397-402
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• 2021

The real-name electric fishing gear system is one of the important policy capable to build 'abundant fishing ground' and to protect marine environment. And, fishing gear automatic-identification system is one of IoT services that can implement above-mentioned policy by using communication such as low power wide area (LPWA) and multi-sensing techniques. Fishing gear automatic -identification system can gather the location data and lost/hold data from electric buoy floated in sea and can provide them to fishermen and monitoring center in land. We have developed the communication modules and electric buoy consisted of fishing gear automatic-identification system. In this paper, we report the test results of communication distance between electric buoy and wireless node installed in fish boat and location error of electric buoy. It is confirmed that line of sight (LOS) distance between electric buoy and wireless node is obtained to be 62 km, which is two times of the desired value, and location error is obtained to be CEP 1 m, which is smaller than the desired value of CEP 5 m. Therefore, it is expected that service area and accuracy of the developed fishing gear automatic-identification system is more extended.

• Tunnel and Underground Space
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• v.28 no.6
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• pp.596-608
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• 2018

As urban infrastructure is aging, the possibility of accidents due to the failures or breakdowns of infrastructure increases. Especially, aging underground infrastructures like sewer pipes, waterworks, and subway have a potential to cause an urban ground sink. Urban ground sink is defined just as a local and erratic collapse occurred by underground cavity due to soil erosion or soil loss, which is separated from a sinkhole in soluble bedrock such as limestone. The conventional measurements such as differential settlement gauge, inclinometer or earth pressure gauge have a shortcoming just to provide point measurements with short coverage. Therefore, these methods are not adequate for monitoring of an erratic subsidence caused by underground cavity due to soil erosion or soil loss which occurring at unspecified time and location. Therefore, an alternative technology is required to detect a change of underground physical condition in real time. In this study, the feasibility of a novel magnetic resonance based monitoring method is investigated through laboratory tests, where the changes of path loss (S21) were measured under various testing conditions: media including air, water, and soil, resonant frequency, impedance, and distances between transmitter (TX) and receiver (RX). Theoretically, the transfer characteristic of magnetic field is known to be independent of the density of the medium. However, the results of the test showed the meaningful differences in the path loss (S21) under the different conditions of medium. And it is found that the reflection coefficient showed the more distinct differences over the testing conditions than the path loss. In particular, input reflection coefficient (S11) is more distinguishable than output reflection coefficient (S22).