• Molecules and Cells
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• v.44 no.3
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• pp.160-167
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• 2021

The determinant factors of an organism's size during animal development have been explored from various angles but remain partially understood. In Caenorhabditis elegans, many genes affecting cuticle structure, cell growth, and proliferation have been identified to regulate the worm's overall morphology, including body size. While various mutations in those genes directly result in changes in the morphological phenotypes, there is still a need for established, clear, and distinct standards to determine the apparent abnormality in a worm's size and shape. In this study, we measured the body length, body width, terminal bulb length, and head size of mutant worms with reported Dumpy (Dpy), Small (Sma) or Long (Lon) phenotypes by plotting and comparing their respective ratios of various parameters. These results show that the Sma phenotypes are proportionally smaller overall with mild stoutness, and Dpy phenotypes are significantly stouter and have disproportionally small head size. This study provides a standard platform for determining morphological phenotypes designating and annotating mutants that exhibit body shape variations, defining the morphological phenotype of previously unexamined mutants.

• Journal of the Korean Society of Physical Medicine
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• v.16 no.3
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• pp.21-27
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• 2021

PURPOSE: This study examined the relationship between the severity of a hallux valgus (HV) deformity and the kinetic three-dimensional ground reaction force (GRF) through a motion analysis system with force platforms in individuals with a HV deformity during normal speed walking. METHODS: The participants were 36 adults with a HV deformity. The participants were asked to walk on a 6 m walkway with 40 infrared reflective markers attached to their pelvic and lower extremities. A camera capture system and two force platforms were used to collect kinetic data during gait. A Vicon Nexus and Visual3D motion analysis software were used to calculate the kinetic GRF data. RESULTS: This research showed that the anterior maximal force that occurred in the terminal stance phase during gait had a negative correlation with the HV angle (r = -.762, p < .01). In addition, the HV angle showed a low negative correlation with the second vertical maximal force (r = .346, p < .05) and a moderate positive correlation with the late medial maximal force (r = .641, p < .01). CONCLUSION: A more severe HV deformity results in greater abnormal translation of the plantar pressure and a significantly reduced pressure force under the first metatarsophalangeal joint.

• Journal of Korea Society of Industrial Information Systems
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• v.14 no.4
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• pp.30-36
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• 2009

In this paper, we develop the next generation mobile system based on SBC(Server Based Computing). SBC is one of the popular topic and only one server system is used as multiple personal systems with a terminal, a monitor and a keyboard. The advantages of this system are easy-upgrade, low costs and convenience for each user. But it is difficult to design and manufacture the multimedia streaming system and devices control system for external devices. In this paper, we represent and develops the Mobile system based on SBC and the test performances shows that our system has good performances of multimedia system and security for internet.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.31 no.2
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• pp.55-65
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• 2023

Due to extreme urbanization, ground transportation in the city center is saturated, and problems such as the lack of expansion infrastructure and traffic congestion increase social costs. To solve this problem, a 3D mobility platform, Urban Air Mobility (UAM), has emerged as a new alternative. A vertiport is a physical space that conducts a similar role to an airport terminal. Vertiport consists of take-off and landing facilities (TLOF, Touchdown and Lift-Off area), space for boarding and disembarking from UAM aircraft (gates), taxiways, and passenger terminals. The type of vertiport (structure, number of facilities) and concept of operations are key variables that determine the number of UAM aircraft that can be accommodated per hour. In this study, a capacity calculation method was presented using an optimization technique (Deterministic Integer Linear Programming). The absolute capacity of the vertiport was calculated using an optimization technique, and a sensitivity analysis was also performed.

• International Journal of Stem Cells
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• v.17 no.1
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• pp.30-37
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• 2024

The lung is a complex organ comprising a branched airway that connects the large airway and millions of terminal gas-exchange units. Traditional pulmonary biomedical research by using cell line model system have limitations such as lack of cellular heterogeneity, animal models also have limitations including ethical concern, race-to-race variations, and physiological differences found in vivo. Organoids and on-a-chip models offer viable solutions for these issues. Organoids are three-dimensional, self-organized construct composed of numerous cells derived from stem cells cultured with growth factors required for the maintenance of stem cells. On-a-chip models are biomimetic microsystems which are able to customize to use microfluidic systems to simulate blood flow in blood channels or vacuum to simulate human breathing. This review summarizes the key components and previous biomedical studies conducted on lung organoids and lung-on-a-chip models, and introduces potential future applications. Considering the importance and benefits of these model systems, we believe that the system will offer better platform to biomedical researchers on pulmonary diseases, such as emerging viral infection, progressive fibrotic pulmonary diseases, or primary or metastatic lung cancer.

• Journal of KIISE:Information Networking
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• v.34 no.5
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• pp.405-422
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• 2007

Recently, according to the network environment, there are many researches for home network. Nowadays, in home network, the method that access control policy is managed for each home device by using ACL is popular, and EAM (Extranet access management) is applied as a solution. In addition, the research about secure OS is ongoing based on open operating system and the research of user authentication mechanisms for home network using home server is also in progress. However, these researches have some problems as follows; First, the transmission scope of expected access technology in home network is wide, so unauthenticated outside terminal can access the home network. Second, user is inconvenient because user need to set the necessary information for each device. Third, user privacy and convenience are not considered. OSGi provides a service platform for heterogeneous technologies in home network environment. Here, user access control is one of the core parts which should have no problems such as above items, but there are no concrete researches yet. Thus in this paper, we propose an access control policy management framework and access control operation based on RBAC for user access control in home network environment in which OSGi service platform is operated. First, we list the consideration which is not clearly mentioned in OSGi standard, and then we solve these above problems through new framework. In addition, we propose the effective and economical operation method which reduces the policy change frequency for user access control by using RBAC concept though limited resource of home gateway. Besides, in this paper, these proposed policies are defined separately as user-role assignment policy and permission-role assignment policy, and user decide their own policies. In conclusion, we provide the scheme to enhance the user convenience and to solve the privacy problem.

• Journal of Platform Technology
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• v.6 no.1
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• pp.17-23
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• 2018

Taxi's queue for entering into taxi stand makes traffic jam and congestion around taxi stand. If we make that taxi waits in another place around taxi stand, and can approach to taxi stand when it gets in its turn, these traffic jam and congestion around taxi stand can be reduced. In this paper, we propose entry sequence operating system for taxi stand to reduce traffic jam and congestion around taxi stand. In this system, taxi driver can request his sequence number, and the system issues sequence number to driver. When it is time to approach to taxi stand due to issued sequence number, the proposed system notifies to taxi driver via taxi terminal. Taxi getting the proposed service can wait in another place around taxi stand, and can approach to taxi stand after receiving notify for approaching. Therefore, the proposed system in this paper can reduce traffic jam and congestion around taxi stand because it can reduce or get rid of taxi's queue around taxi stand. We implement the taxi stand approach sequence management system proposed in this paper for taxi stand installed in Chungju-Si, Chungbuk. We use Google Cloud service and Android platform for implementing.

• Journal of KIISE:Computing Practices and Letters
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• v.12 no.1
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• pp.9-20
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• 2006

Web Map Service on mobile environment, provided with cost effective mobile GIS contents and user preferred POIs(Points of interests), is strongly required at this moment when mobile and portable Internet is rapidly spreaded on mobile user community as information technology and mobile HW are evolved in its speed, bandwidth and features. As the mobile and portable Internet becomes popular in mobile services, LBS(Location Based Service) is positioned on a mobile client as one of the best information infra services. Recently mobile GIS (Geographic Information System) comes in service to support LBS, but it is constrained and limited on its system configuration and its presentation methodology of a map, and also it depends on its run time environment. In this paper, we made an effort to design and implement a GIS computing platform with server based thin client for mobile WMS(Web Map Service). For its cost effective Platform which could be easily building up POIs and GIS contents, we're not using commercial GIS solution but NGII's (National Geographic Information Institute's) DXF numerical map, and representing the maps, GIS contents and POIs by SVG(Scalable Vector Graphics) recommended by OGC(OpenGis Consortium). We're also adapting de facto standard of XML web service technology such as WSDL, SOAP to provide real time mobile GIS service on PDA as well as mobile terminal by applying a GPS receiver for a user's location information on mobile environment.

• Journal of Hospice and Palliative Care
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• v.13 no.3
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• pp.181-189
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• 2010

Purpose: Recently, health policy making is increasingly based on evidence. Therefore, Korean Terminal Cancer Patient Information System (KTCPIS) was developed to meet such need. We aimed to report its developmental process and statistics from 6 months data. Methods: Items for KTCPIS were developed through the consultation with practitioners. E-Velos web-based clinical trial management system was used as a technical platform. Data were collected for patients who were registered to 34 inpatient palliative care services, designated by Ministry of Health, Welfare, and Family Affairs, from $1^{st}$ of January to $30^{th}$ of June in 2009. Descriptive statistics were used for the analysis. Results: From the nationally representative set of 2,940 patients, we obtained the following results. Mean age was $64.8{\pm}12.9$ years, and 56.6% were male. Lung cancer (18.0%) was most common diagnosis. Only 50.3% of patients received the confirmation of terminal diagnosis by two or more physicians, and 69.7% had an insight of terminal diagnosis at the time of admission. About half of patients were admitted to the units on their own without any formal referral. Average and worst pain scores were significantly reduced after 1 week when compared to those at the time of admission. 73.4% faced death in the units, and home-discharge comprised only 13.3%. Mean length of stay per admission was $20.2{\pm}21.2$ days, with median value of 13. Conclusion: Nationally representative data on the characteristics of patients and their caregiver, and current practice of service delivery in palliative care units were obtained through the operation of KTCPIS.

• Journal of Life Science
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• v.32 no.12
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• pp.956-961
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• 2022

Plant Chloroplast have several advantages as an expression platform of biopharmaceuticals over conventional expression platforms such as mammalian cells, yeast and bacteria. First, plants do not serve as a host for mammalian infectious virus and have endotoxin like bacteria which can cause anaphylactic shock. In addition, high copy number of chloroplast genome allows for chloroplast transformants to reach the high level of expression of heterologous genes. Moreover, the integration of transgenes into specific region of chloroplast genomes makes chloroplast transformants unaffected by positional effect which can be frequently observed from nuclear transformants, resulting in loss of transgene expressions. Antimicrobial peptides (AMPs) are a kind of innate immunity which is found from bacteria to humans. Unlike conventional antibiotics, very less dosage of AMPs can have catastrophic effect on bacterial survival. Further, the repeated use of AMPs does not trigger the development of bacterial resistance. Moricin, one of the AMPs, was isolated from Bombyx mori, a silkworm moth. The C-terminal of moricin consists largely of basic amino acids, and the N-terminal has an α-helix structure. Moricin was chosen and expressed in a SUMO/SUMOase without leaving any unwanted amino acids which could potentially affect the anti-bacterial activity of the moricin. The transformation vector used in this study has already been created in this lab for the expression in both prokaryotic systems such as E. coli and chloroplast. The expressed moricin was purified using Ni columns and SUMOase, and the antibacterial activity of the purified moricin was confirmed using an agar diffusion assay.